Análise do reparo de defeitos ósseos preenchidos com β- trifosfato de cálcio associado a implantes de titânio puro

Detalhes bibliográficos
Ano de defesa: 2009
Autor(a) principal: Mottin, Roberta Weirich
Orientador(a): Heitz, Cláiton
Banca de defesa: Não Informado pela instituição
Tipo de documento: Dissertação
Tipo de acesso: Acesso aberto
Idioma: por
Instituição de defesa: Pontifícia Universidade Católica do Rio Grande do Sul
Porto Alegre
Programa de Pós-Graduação: Não Informado pela instituição
Departamento: Não Informado pela instituição
País: Não Informado pela instituição
Palavras-chave em Português:
Link de acesso: http://hdl.handle.net/10923/560
Resumo: Concerning the necessity of form and function restoration from bone structures which had been lost through pathologies, traumas or iatrogenicity has been widely studied. The researches have been trying to develop new materials in order to recover or maintain the bone volume as well as quality into regions which have lost their proper anatomic conformations, being biomaterials the most suitable ones as a viable alternative as bone substitutes. β- tricalcium phosphate granule (β-TCP) is an inorganic composite which combines active biodegradability with osteoconductivity properties. The present study aims to develop a histological descriptive analysis on the repair of bone defects filled with β-TCP associated to pure titanium implants into cavities prepared in the calvarium bone of rats. Eighteen male adult rats were randomly selected and divided into three groups of six rats each, according to their period of death: 15, 30 and 60 days. Four bone defects were made into the calvarium bone of the rats and filled with: (a) β-TCP, (b) clot, (c) β-TCP + pure titanium screw and (d) pure titanium screw. The samples were cut and histologically evaluated. The analysis moved through the presence and volume of connective tissue and newly formed bone, as well as the presence or absence of remaining material (β-TCP) into the defect. It was verified an acceleration of the new bone formation process in the presence of β-TCP. The results suggest the biocompatibility and osteoconductivity of the biomaterial, even when associated to pure titanium implantes.
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spelling Mottin, Roberta WeirichHeitz, Cláiton2011-12-27T14:14:38Z2011-12-27T14:14:38Z2009http://hdl.handle.net/10923/560Concerning the necessity of form and function restoration from bone structures which had been lost through pathologies, traumas or iatrogenicity has been widely studied. The researches have been trying to develop new materials in order to recover or maintain the bone volume as well as quality into regions which have lost their proper anatomic conformations, being biomaterials the most suitable ones as a viable alternative as bone substitutes. β- tricalcium phosphate granule (β-TCP) is an inorganic composite which combines active biodegradability with osteoconductivity properties. The present study aims to develop a histological descriptive analysis on the repair of bone defects filled with β-TCP associated to pure titanium implants into cavities prepared in the calvarium bone of rats. Eighteen male adult rats were randomly selected and divided into three groups of six rats each, according to their period of death: 15, 30 and 60 days. Four bone defects were made into the calvarium bone of the rats and filled with: (a) β-TCP, (b) clot, (c) β-TCP + pure titanium screw and (d) pure titanium screw. The samples were cut and histologically evaluated. The analysis moved through the presence and volume of connective tissue and newly formed bone, as well as the presence or absence of remaining material (β-TCP) into the defect. It was verified an acceleration of the new bone formation process in the presence of β-TCP. The results suggest the biocompatibility and osteoconductivity of the biomaterial, even when associated to pure titanium implantes.A necessidade de restabelecimento da forma e da função de estruturas ósseas perdidas por patologias, traumas ou iatrogenias tem sido amplamente estudada. As pesquisas têm procurado desenvolver novos materiais com o intuito de recuperar ou manter volume e qualidade óssea em regiões que perderam suas conformações anatômicas adequadas, sendo os biomateriais uma alternativa viável como substitutos ósseos. O grânulo β- trifosfato de cálcio (β-TCP) é um composto inorgânico que combina a propriedade de biodegradabilidade ativa com a osteocondutividade. O presente trabalho tem como objetivo fazer uma análise histológica descritiva do reparo de defeitos ósseos preenchidos com β-TCP associado a implantes de titânio puro, em cavidades confeccionadas em calotas cranianas de ratos. Foram selecionados randomicamente 18 ratos, machos adultos e a seguir divididos em três grupos de seis ratos cada, de acordo com o período de morte: 15, 30 e 60 dias. Na calota craniana de cada rato foram confeccionados quatro defeitos ósseos preenchidos com: (a) β-TCP, (b) coágulo, (c) β-TCP + parafuso de titânio puro e (d) parafuso de titânio puro. As amostras foram cortadas e avaliadas histologicamente. Foi analisada a presença e volume de tecido conjuntivo frouxo e de tecido ósseo imaturo, bem como a presença ou ausência de material remanescente (β-TCP) no defeito. Verificou-se a aceleração do processo de neoformação óssea na presença do β- TCP. Os resultados sugerem a biocompatibilidade e osteocondutividade do biomaterial, mesmo quando associado a implantes de titânio puro.Made available in DSpace on 2011-12-27T14:14:38Z (GMT). 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dc.title.pt_BR.fl_str_mv Análise do reparo de defeitos ósseos preenchidos com β- trifosfato de cálcio associado a implantes de titânio puro
title Análise do reparo de defeitos ósseos preenchidos com β- trifosfato de cálcio associado a implantes de titânio puro
spellingShingle Análise do reparo de defeitos ósseos preenchidos com β- trifosfato de cálcio associado a implantes de titânio puro
Mottin, Roberta Weirich
ODONTOLOGIA
MATERIAIS BIOCOMPATÍVEIS
TRAUMATOLOGIA BUCOMAXILOFACIAL
FOSFATO
title_short Análise do reparo de defeitos ósseos preenchidos com β- trifosfato de cálcio associado a implantes de titânio puro
title_full Análise do reparo de defeitos ósseos preenchidos com β- trifosfato de cálcio associado a implantes de titânio puro
title_fullStr Análise do reparo de defeitos ósseos preenchidos com β- trifosfato de cálcio associado a implantes de titânio puro
title_full_unstemmed Análise do reparo de defeitos ósseos preenchidos com β- trifosfato de cálcio associado a implantes de titânio puro
title_sort Análise do reparo de defeitos ósseos preenchidos com β- trifosfato de cálcio associado a implantes de titânio puro
author Mottin, Roberta Weirich
author_facet Mottin, Roberta Weirich
author_role author
dc.contributor.author.fl_str_mv Mottin, Roberta Weirich
dc.contributor.advisor1.fl_str_mv Heitz, Cláiton
contributor_str_mv Heitz, Cláiton
dc.subject.por.fl_str_mv ODONTOLOGIA
MATERIAIS BIOCOMPATÍVEIS
TRAUMATOLOGIA BUCOMAXILOFACIAL
FOSFATO
topic ODONTOLOGIA
MATERIAIS BIOCOMPATÍVEIS
TRAUMATOLOGIA BUCOMAXILOFACIAL
FOSFATO
description Concerning the necessity of form and function restoration from bone structures which had been lost through pathologies, traumas or iatrogenicity has been widely studied. The researches have been trying to develop new materials in order to recover or maintain the bone volume as well as quality into regions which have lost their proper anatomic conformations, being biomaterials the most suitable ones as a viable alternative as bone substitutes. β- tricalcium phosphate granule (β-TCP) is an inorganic composite which combines active biodegradability with osteoconductivity properties. The present study aims to develop a histological descriptive analysis on the repair of bone defects filled with β-TCP associated to pure titanium implants into cavities prepared in the calvarium bone of rats. Eighteen male adult rats were randomly selected and divided into three groups of six rats each, according to their period of death: 15, 30 and 60 days. Four bone defects were made into the calvarium bone of the rats and filled with: (a) β-TCP, (b) clot, (c) β-TCP + pure titanium screw and (d) pure titanium screw. The samples were cut and histologically evaluated. The analysis moved through the presence and volume of connective tissue and newly formed bone, as well as the presence or absence of remaining material (β-TCP) into the defect. It was verified an acceleration of the new bone formation process in the presence of β-TCP. The results suggest the biocompatibility and osteoconductivity of the biomaterial, even when associated to pure titanium implantes.
publishDate 2009
dc.date.issued.fl_str_mv 2009
dc.date.accessioned.fl_str_mv 2011-12-27T14:14:38Z
dc.date.available.fl_str_mv 2011-12-27T14:14:38Z
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dc.publisher.none.fl_str_mv Pontifícia Universidade Católica do Rio Grande do Sul
Porto Alegre
publisher.none.fl_str_mv Pontifícia Universidade Católica do Rio Grande do Sul
Porto Alegre
dc.source.none.fl_str_mv reponame:Repositório Institucional PUCRS
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