Análise do reparo de defeitos ósseos preenchidos com β- trifosfato de cálcio associado a implantes de titânio puro
Ano de defesa: | 2009 |
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Autor(a) principal: | |
Orientador(a): | |
Banca de defesa: | |
Tipo de documento: | Dissertação |
Tipo de acesso: | Acesso aberto |
Idioma: | por |
Instituição de defesa: |
Pontifícia Universidade Católica do Rio Grande do Sul
Porto Alegre |
Programa de Pós-Graduação: |
Não Informado pela instituição
|
Departamento: |
Não Informado pela instituição
|
País: |
Não Informado pela instituição
|
Palavras-chave em Português: | |
Link de acesso: | http://hdl.handle.net/10923/560 |
Resumo: | Concerning the necessity of form and function restoration from bone structures which had been lost through pathologies, traumas or iatrogenicity has been widely studied. The researches have been trying to develop new materials in order to recover or maintain the bone volume as well as quality into regions which have lost their proper anatomic conformations, being biomaterials the most suitable ones as a viable alternative as bone substitutes. β- tricalcium phosphate granule (β-TCP) is an inorganic composite which combines active biodegradability with osteoconductivity properties. The present study aims to develop a histological descriptive analysis on the repair of bone defects filled with β-TCP associated to pure titanium implants into cavities prepared in the calvarium bone of rats. Eighteen male adult rats were randomly selected and divided into three groups of six rats each, according to their period of death: 15, 30 and 60 days. Four bone defects were made into the calvarium bone of the rats and filled with: (a) β-TCP, (b) clot, (c) β-TCP + pure titanium screw and (d) pure titanium screw. The samples were cut and histologically evaluated. The analysis moved through the presence and volume of connective tissue and newly formed bone, as well as the presence or absence of remaining material (β-TCP) into the defect. It was verified an acceleration of the new bone formation process in the presence of β-TCP. The results suggest the biocompatibility and osteoconductivity of the biomaterial, even when associated to pure titanium implantes. |
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Mottin, Roberta WeirichHeitz, Cláiton2011-12-27T14:14:38Z2011-12-27T14:14:38Z2009http://hdl.handle.net/10923/560Concerning the necessity of form and function restoration from bone structures which had been lost through pathologies, traumas or iatrogenicity has been widely studied. The researches have been trying to develop new materials in order to recover or maintain the bone volume as well as quality into regions which have lost their proper anatomic conformations, being biomaterials the most suitable ones as a viable alternative as bone substitutes. β- tricalcium phosphate granule (β-TCP) is an inorganic composite which combines active biodegradability with osteoconductivity properties. The present study aims to develop a histological descriptive analysis on the repair of bone defects filled with β-TCP associated to pure titanium implants into cavities prepared in the calvarium bone of rats. Eighteen male adult rats were randomly selected and divided into three groups of six rats each, according to their period of death: 15, 30 and 60 days. Four bone defects were made into the calvarium bone of the rats and filled with: (a) β-TCP, (b) clot, (c) β-TCP + pure titanium screw and (d) pure titanium screw. The samples were cut and histologically evaluated. The analysis moved through the presence and volume of connective tissue and newly formed bone, as well as the presence or absence of remaining material (β-TCP) into the defect. It was verified an acceleration of the new bone formation process in the presence of β-TCP. The results suggest the biocompatibility and osteoconductivity of the biomaterial, even when associated to pure titanium implantes.A necessidade de restabelecimento da forma e da função de estruturas ósseas perdidas por patologias, traumas ou iatrogenias tem sido amplamente estudada. As pesquisas têm procurado desenvolver novos materiais com o intuito de recuperar ou manter volume e qualidade óssea em regiões que perderam suas conformações anatômicas adequadas, sendo os biomateriais uma alternativa viável como substitutos ósseos. O grânulo β- trifosfato de cálcio (β-TCP) é um composto inorgânico que combina a propriedade de biodegradabilidade ativa com a osteocondutividade. O presente trabalho tem como objetivo fazer uma análise histológica descritiva do reparo de defeitos ósseos preenchidos com β-TCP associado a implantes de titânio puro, em cavidades confeccionadas em calotas cranianas de ratos. Foram selecionados randomicamente 18 ratos, machos adultos e a seguir divididos em três grupos de seis ratos cada, de acordo com o período de morte: 15, 30 e 60 dias. Na calota craniana de cada rato foram confeccionados quatro defeitos ósseos preenchidos com: (a) β-TCP, (b) coágulo, (c) β-TCP + parafuso de titânio puro e (d) parafuso de titânio puro. As amostras foram cortadas e avaliadas histologicamente. Foi analisada a presença e volume de tecido conjuntivo frouxo e de tecido ósseo imaturo, bem como a presença ou ausência de material remanescente (β-TCP) no defeito. Verificou-se a aceleração do processo de neoformação óssea na presença do β- TCP. Os resultados sugerem a biocompatibilidade e osteocondutividade do biomaterial, mesmo quando associado a implantes de titânio puro.Made available in DSpace on 2011-12-27T14:14:38Z (GMT). No. of bitstreams: 2 000421417-0.pdf: 1029774 bytes, checksum: b13be7b63536734c3e35db63b16fc0db (MD5) license.txt: 581 bytes, checksum: 44ea52f0b7567232681c6e3d72285adc (MD5)Pontifícia Universidade Católica do Rio Grande do SulPorto AlegreODONTOLOGIAMATERIAIS BIOCOMPATÍVEISTRAUMATOLOGIA BUCOMAXILOFACIALFOSFATOAnálise do reparo de defeitos ósseos preenchidos com β- trifosfato de cálcio associado a implantes de titânio puroinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/masterThesisPontifícia Universidade Católica do Rio Grande do SulFaculdade de OdontologiaPrograma de Pós-Graduação em OdontologiaMestrado2009porreponame:Repositório Institucional PUCRSinstname:Pontifícia Universidade Católica do Rio Grande do Sul (PUCRS)instacron:PUC_RSinfo:eu-repo/semantics/openAccessORIGINAL000421417-0.pdfTexto Completoapplication/pdf1029774http://meriva.pucrs.br:8080/jspui/bitstream/10923/560/1/000421417-0.pdfb13be7b63536734c3e35db63b16fc0dbMD51LICENSElicense.txttext/plain581http://meriva.pucrs.br:8080/jspui/bitstream/10923/560/2/license.txt44ea52f0b7567232681c6e3d72285adcMD52TEXT000421417-0.pdf.txt000421417-0.pdf.txtExtracted texttext/plain46447http://meriva.pucrs.br:8080/jspui/bitstream/10923/560/3/000421417-0.pdf.txt95795074fad93aebae59256b15bbb316MD5310923/5602017-09-28 11:05:34.671oai:meriva.pucrs.br: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ório InstitucionalPRIhttp://repositorio.pucrs.br/oai/request?verb=Identifyopendoar:27532017-09-28T14:05:34Repositório Institucional PUCRS - Pontifícia Universidade Católica do Rio Grande do Sul (PUCRS)false |
dc.title.pt_BR.fl_str_mv |
Análise do reparo de defeitos ósseos preenchidos com β- trifosfato de cálcio associado a implantes de titânio puro |
title |
Análise do reparo de defeitos ósseos preenchidos com β- trifosfato de cálcio associado a implantes de titânio puro |
spellingShingle |
Análise do reparo de defeitos ósseos preenchidos com β- trifosfato de cálcio associado a implantes de titânio puro Mottin, Roberta Weirich ODONTOLOGIA MATERIAIS BIOCOMPATÍVEIS TRAUMATOLOGIA BUCOMAXILOFACIAL FOSFATO |
title_short |
Análise do reparo de defeitos ósseos preenchidos com β- trifosfato de cálcio associado a implantes de titânio puro |
title_full |
Análise do reparo de defeitos ósseos preenchidos com β- trifosfato de cálcio associado a implantes de titânio puro |
title_fullStr |
Análise do reparo de defeitos ósseos preenchidos com β- trifosfato de cálcio associado a implantes de titânio puro |
title_full_unstemmed |
Análise do reparo de defeitos ósseos preenchidos com β- trifosfato de cálcio associado a implantes de titânio puro |
title_sort |
Análise do reparo de defeitos ósseos preenchidos com β- trifosfato de cálcio associado a implantes de titânio puro |
author |
Mottin, Roberta Weirich |
author_facet |
Mottin, Roberta Weirich |
author_role |
author |
dc.contributor.author.fl_str_mv |
Mottin, Roberta Weirich |
dc.contributor.advisor1.fl_str_mv |
Heitz, Cláiton |
contributor_str_mv |
Heitz, Cláiton |
dc.subject.por.fl_str_mv |
ODONTOLOGIA MATERIAIS BIOCOMPATÍVEIS TRAUMATOLOGIA BUCOMAXILOFACIAL FOSFATO |
topic |
ODONTOLOGIA MATERIAIS BIOCOMPATÍVEIS TRAUMATOLOGIA BUCOMAXILOFACIAL FOSFATO |
description |
Concerning the necessity of form and function restoration from bone structures which had been lost through pathologies, traumas or iatrogenicity has been widely studied. The researches have been trying to develop new materials in order to recover or maintain the bone volume as well as quality into regions which have lost their proper anatomic conformations, being biomaterials the most suitable ones as a viable alternative as bone substitutes. β- tricalcium phosphate granule (β-TCP) is an inorganic composite which combines active biodegradability with osteoconductivity properties. The present study aims to develop a histological descriptive analysis on the repair of bone defects filled with β-TCP associated to pure titanium implants into cavities prepared in the calvarium bone of rats. Eighteen male adult rats were randomly selected and divided into three groups of six rats each, according to their period of death: 15, 30 and 60 days. Four bone defects were made into the calvarium bone of the rats and filled with: (a) β-TCP, (b) clot, (c) β-TCP + pure titanium screw and (d) pure titanium screw. The samples were cut and histologically evaluated. The analysis moved through the presence and volume of connective tissue and newly formed bone, as well as the presence or absence of remaining material (β-TCP) into the defect. It was verified an acceleration of the new bone formation process in the presence of β-TCP. The results suggest the biocompatibility and osteoconductivity of the biomaterial, even when associated to pure titanium implantes. |
publishDate |
2009 |
dc.date.issued.fl_str_mv |
2009 |
dc.date.accessioned.fl_str_mv |
2011-12-27T14:14:38Z |
dc.date.available.fl_str_mv |
2011-12-27T14:14:38Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
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info:eu-repo/semantics/masterThesis |
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masterThesis |
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http://hdl.handle.net/10923/560 |
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openAccess |
dc.publisher.none.fl_str_mv |
Pontifícia Universidade Católica do Rio Grande do Sul Porto Alegre |
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Pontifícia Universidade Católica do Rio Grande do Sul Porto Alegre |
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