Estudo fitoqu?mico e avalia??o da atividade biol?gica de Tibouchina pereirae Aubl. (Melastomataceae)

Detalhes bibliográficos
Ano de defesa: 2013
Autor(a) principal: Dias, ?uder Reis lattes
Orientador(a): Branco, Alexsandro
Banca de defesa: Não Informado pela instituição
Tipo de documento: Dissertação
Tipo de acesso: Acesso aberto
Idioma: por
Instituição de defesa: Universidade Estadual de Feira de Santana
Programa de Pós-Graduação: Mestrado Acad?mico em Recursos Gen?ticos Vegetais
Departamento: DEPARTAMENTO DE CI?NCIAS BIOL?GICAS
País: Brasil
Palavras-chave em Português:
Tibouchina pereirae
Antioxidante
Antinocicep??o
Planta medicinal
Flavonoides
Palavras-chave em Inglês:
Antioxidant
Antinociception
Medicinal plant
Flavonoids
Área do conhecimento CNPq:
CIENCIAS BIOLOGICAS
Link de acesso: http://localhost:8080/tede/handle/tede/88
Resumo: The Melastomataceae family comprises 4,570 species in approximately 180 genera present in all tropical and subtropical regions of the planet. This family, in Brazil, is the sixth largest family of Angiosperms, with over 1500 species. The genus Tibouchina presents, approximately, 350 species, however, are poorly studied. The Tibouchina pereirae Aubl., a shrub, is popularly used for the treatment of kidney diseases. In this study, we show the antioxidant and antinociceptive effects of T. pereirae. The hexane (EHTP), ethanol (EETP) and aqueous (EATP) extracts were obtained by maceration from the aerial parts of T. pereirae. The flavonoid rich fraction (FFTP) was obtained from fractionation of EHTP. The analysis of FFTP by HPLC-DAD and HPLC-MS/MS led to characterization of these flavonoids. The antioxidant activity of extracts was evaluated using the 2,2-diphenyl-1-picrylhydrazyl (DPPH) assay system and the in vivo experiments were conducted on Swiss mice using the acetic acid-induced writhing test and the formalin-induced pain test. Results showed that extracts (EHTP, EETP and EATP) and FFTP present antioxidant activity, when compared to standard butylated hydroxytoluene (BHT) and ascorbic acid (AA). The EHTP and FFTP (i.p., 100mg/Kg) reduced the nociception produced by acetic acid by 90,36% and 94,74%, respectively. The FFTP reduced the formalin effects in both phases by 54, 35% and 92,05%, while the EHTP only protected the second phase by 83,39%.
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spelling Branco, Alexsandrohttp://lattes.cnpq.br/0903825832970561Dias, ?uder Reis2015-07-24T13:45:42Z2013-10-30DIAS, ?uder Reis. Estudo fitoqu?mico e avalia??o da atividade biol?gica de Tibouchina pereirae Aubl. (Melastomataceae). 2013. 80 f. Disserta??o (Mestrado Acad?mico em Recursos Gen?ticos Vegetais)- Universidade Estadual de Feira de Santana, Feira de Santana, 2014.http://localhost:8080/tede/handle/tede/88The Melastomataceae family comprises 4,570 species in approximately 180 genera present in all tropical and subtropical regions of the planet. This family, in Brazil, is the sixth largest family of Angiosperms, with over 1500 species. The genus Tibouchina presents, approximately, 350 species, however, are poorly studied. The Tibouchina pereirae Aubl., a shrub, is popularly used for the treatment of kidney diseases. In this study, we show the antioxidant and antinociceptive effects of T. pereirae. The hexane (EHTP), ethanol (EETP) and aqueous (EATP) extracts were obtained by maceration from the aerial parts of T. pereirae. The flavonoid rich fraction (FFTP) was obtained from fractionation of EHTP. The analysis of FFTP by HPLC-DAD and HPLC-MS/MS led to characterization of these flavonoids. The antioxidant activity of extracts was evaluated using the 2,2-diphenyl-1-picrylhydrazyl (DPPH) assay system and the in vivo experiments were conducted on Swiss mice using the acetic acid-induced writhing test and the formalin-induced pain test. Results showed that extracts (EHTP, EETP and EATP) and FFTP present antioxidant activity, when compared to standard butylated hydroxytoluene (BHT) and ascorbic acid (AA). The EHTP and FFTP (i.p., 100mg/Kg) reduced the nociception produced by acetic acid by 90,36% and 94,74%, respectively. The FFTP reduced the formalin effects in both phases by 54, 35% and 92,05%, while the EHTP only protected the second phase by 83,39%.A fam?lia Melastomataceae apresenta cerca de 4.570 esp?cies, distribu?das em, aproximadamente, 180 g?neros presentes em todas as regi?es tropicais e subtropicais do planeta, sendo que no Brasil ? a sexta maior fam?lia de angiospermas, com mais de 1500 esp?cies. O g?nero Tibouchina possui aproximadamente 350 esp?cies, por?m s?o muito pouco estudadas, sendo que a esp?cie Tibouchina pereirae Aubl. ? popularmente utilizada para o tratamento de problemas renais. Nesse estudo, foram avaliadas as atividades antioxidante e antinociceptiva de T. pereirae. Foram obtidos os extratos hex?nico (EHTP), etan?lico (EETP) e aquoso (EATP) a partir da macera??o das partes a?reas de T. pereirae. A fra??o rica em flavonoides (FFTP) foi obtida a partir do fracionamento do EHTP. A an?lise por CLAE-DAD e CLAE-EM/EM desta fra??o possibilitou caracterizar estes flavonoides. A atividade antioxidante dos extratos foi avaliada utilizando o sistema de ensaio 2,2-difenil-1-picrilhidrazil (DPPH) e os experimentos in vivo foram realizados em camundongos Swiss utilizando os testes de contor??o abdominal induzida por ?cido ac?tico e da formalina. Os resultados obtidos demonstraram que o EHTP, EETP e EATP, assim como a fra??o FFTP apresentaram atividade seq?estradora radicalar, quando comparados aos padr?es butilhidroxitolueno (BHT) e ?cido asc?rbico (AA). O EHTP e a FFTP reduziram a nocicep??o induzida pelo ?cido ac?tico em 90,6% e 94,74%, respectivamente. A FFTP reduziu os efeitos da formalina em ambas fases em 54,35% e 92,05%, respectivamente, enquanto que o EHTP foi ativo somente na segunda fase do teste, com uma redu??o no tempo de lambida de 83,39%.Submitted by Verena Bastos (verena@uefs.br) on 2015-07-24T13:45:42Z No. of bitstreams: 1 ?UDER REIS DIAS -DISSERTA??O MESTRADO 2013 -RGV.pdf: 1805178 bytes, checksum: fa9b0a71b8366540b825499da5adb0f8 (MD5)Made available in DSpace on 2015-07-24T13:45:42Z (GMT). No. of bitstreams: 1 ?UDER REIS DIAS -DISSERTA??O MESTRADO 2013 -RGV.pdf: 1805178 bytes, checksum: fa9b0a71b8366540b825499da5adb0f8 (MD5) Previous issue date: 2013-10-30Coordena??o de Aperfei?oamento de Pessoal de N?vel Superior - CAPESapplication/pdfhttp://tede2.uefs.br:8080/retrieve/4396/%c3%8aUDER%20REIS%20DIAS%20-DISSERTA%c3%87%c3%83O%20MESTRADO%202013%20-RGV.pdf.jpgporUniversidade Estadual de Feira de SantanaMestrado Acad?mico em Recursos Gen?ticos VegetaisUEFSBrasilDEPARTAMENTO DE CI?NCIAS BIOL?GICASTibouchina pereiraeAntioxidanteAntinocicep??oPlanta medicinalFlavonoidesAntioxidantAntinociceptionMedicinal plantFlavonoidsCIENCIAS BIOLOGICASEstudo fitoqu?mico e avalia??o da atividade biol?gica de Tibouchina pereirae Aubl. 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dc.title.por.fl_str_mv Estudo fitoqu?mico e avalia??o da atividade biol?gica de Tibouchina pereirae Aubl. (Melastomataceae)
title Estudo fitoqu?mico e avalia??o da atividade biol?gica de Tibouchina pereirae Aubl. (Melastomataceae)
spellingShingle Estudo fitoqu?mico e avalia??o da atividade biol?gica de Tibouchina pereirae Aubl. (Melastomataceae)
Dias, ?uder Reis
Tibouchina pereirae
Antioxidante
Antinocicep??o
Planta medicinal
Flavonoides
Antioxidant
Antinociception
Medicinal plant
Flavonoids
CIENCIAS BIOLOGICAS
title_short Estudo fitoqu?mico e avalia??o da atividade biol?gica de Tibouchina pereirae Aubl. (Melastomataceae)
title_full Estudo fitoqu?mico e avalia??o da atividade biol?gica de Tibouchina pereirae Aubl. (Melastomataceae)
title_fullStr Estudo fitoqu?mico e avalia??o da atividade biol?gica de Tibouchina pereirae Aubl. (Melastomataceae)
title_full_unstemmed Estudo fitoqu?mico e avalia??o da atividade biol?gica de Tibouchina pereirae Aubl. (Melastomataceae)
title_sort Estudo fitoqu?mico e avalia??o da atividade biol?gica de Tibouchina pereirae Aubl. (Melastomataceae)
author Dias, ?uder Reis
author_facet Dias, ?uder Reis
author_role author
dc.contributor.advisor1.fl_str_mv Branco, Alexsandro
dc.contributor.authorLattes.fl_str_mv http://lattes.cnpq.br/0903825832970561
dc.contributor.author.fl_str_mv Dias, ?uder Reis
contributor_str_mv Branco, Alexsandro
dc.subject.por.fl_str_mv Tibouchina pereirae
Antioxidante
Antinocicep??o
Planta medicinal
Flavonoides
topic Tibouchina pereirae
Antioxidante
Antinocicep??o
Planta medicinal
Flavonoides
Antioxidant
Antinociception
Medicinal plant
Flavonoids
CIENCIAS BIOLOGICAS
dc.subject.eng.fl_str_mv Antioxidant
Antinociception
Medicinal plant
Flavonoids
dc.subject.cnpq.fl_str_mv CIENCIAS BIOLOGICAS
description The Melastomataceae family comprises 4,570 species in approximately 180 genera present in all tropical and subtropical regions of the planet. This family, in Brazil, is the sixth largest family of Angiosperms, with over 1500 species. The genus Tibouchina presents, approximately, 350 species, however, are poorly studied. The Tibouchina pereirae Aubl., a shrub, is popularly used for the treatment of kidney diseases. In this study, we show the antioxidant and antinociceptive effects of T. pereirae. The hexane (EHTP), ethanol (EETP) and aqueous (EATP) extracts were obtained by maceration from the aerial parts of T. pereirae. The flavonoid rich fraction (FFTP) was obtained from fractionation of EHTP. The analysis of FFTP by HPLC-DAD and HPLC-MS/MS led to characterization of these flavonoids. The antioxidant activity of extracts was evaluated using the 2,2-diphenyl-1-picrylhydrazyl (DPPH) assay system and the in vivo experiments were conducted on Swiss mice using the acetic acid-induced writhing test and the formalin-induced pain test. Results showed that extracts (EHTP, EETP and EATP) and FFTP present antioxidant activity, when compared to standard butylated hydroxytoluene (BHT) and ascorbic acid (AA). The EHTP and FFTP (i.p., 100mg/Kg) reduced the nociception produced by acetic acid by 90,36% and 94,74%, respectively. The FFTP reduced the formalin effects in both phases by 54, 35% and 92,05%, while the EHTP only protected the second phase by 83,39%.
publishDate 2013
dc.date.issued.fl_str_mv 2013-10-30
dc.date.accessioned.fl_str_mv 2015-07-24T13:45:42Z
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dc.type.driver.fl_str_mv info:eu-repo/semantics/masterThesis
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dc.identifier.citation.fl_str_mv DIAS, ?uder Reis. Estudo fitoqu?mico e avalia??o da atividade biol?gica de Tibouchina pereirae Aubl. (Melastomataceae). 2013. 80 f. Disserta??o (Mestrado Acad?mico em Recursos Gen?ticos Vegetais)- Universidade Estadual de Feira de Santana, Feira de Santana, 2014.
dc.identifier.uri.fl_str_mv http://localhost:8080/tede/handle/tede/88
identifier_str_mv DIAS, ?uder Reis. Estudo fitoqu?mico e avalia??o da atividade biol?gica de Tibouchina pereirae Aubl. (Melastomataceae). 2013. 80 f. Disserta??o (Mestrado Acad?mico em Recursos Gen?ticos Vegetais)- Universidade Estadual de Feira de Santana, Feira de Santana, 2014.
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dc.publisher.none.fl_str_mv Universidade Estadual de Feira de Santana
dc.publisher.program.fl_str_mv Mestrado Acad?mico em Recursos Gen?ticos Vegetais
dc.publisher.initials.fl_str_mv UEFS
dc.publisher.country.fl_str_mv Brasil
dc.publisher.department.fl_str_mv DEPARTAMENTO DE CI?NCIAS BIOL?GICAS
publisher.none.fl_str_mv Universidade Estadual de Feira de Santana
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