HLA e doença renal policística autossômica dominante numa população do estado do Paraná, sul do Brasil

• Ano de defesa: 2016
• Autor(a) principal: Franchetti, Soraya Barrionuevo Franzener
• Tipo de documento: Dissertação
• Tipo de acesso: Acesso aberto
• Idioma: por
• Instituição de defesa: Universidade Estadual de Maringá; Brasil; Programa de Pós-Graduação em Ciências da Saúde; UEM; Maringá, PR; Centro de Ciências da Saúde
• Palavras-chave em Português: Doença renal policística; Antígenos leucocitários humanos (HLA); Rim policístico autossômico dominante; Controle; Paraná; (Estada); Brasil.; Autosomal dominant polycystic kidney; HLA; Case-control; (State); Brazil.; Ciências da Saúde; Medicina
• Link de acesso: http://repositorio.uem.br:8080/jspui/handle/1/2057

The autosomal dominant polycystic kidney disease (ADPKD) is a disease of genetic origin. The progressive increase of the kidneys occurs by the formation of cysts and that affects the functionality of the renal parenchyma. The formation of cysts can occur in other regions, such as liver, pancreas, seminal vesicle. Some complications are associated with kidney volume as hypertension, macroscopic hematuria, nephrolithiasis, increased cysts and pain. Several studies have shown the influence of HLA in the development and / or protection against some diseases. The aim of this study was to investigate the associations between HLA-A, HLA-B, HLA-C, HLA-DQ and HLA-DR genes with ADPKD. The research included 68 patients with ADPKD and 375 patients without clinical diagnosis of the disease on dialysis, matched for age, gender and age, using the PCR-SSO method (polymerase chain reaction-sequence specific oligonucleotide) of LABType® One Lambda kit, CA, USA, coupled with the Luminex technology. Association was found in the genes: HLA-A*26 (OR = 2.09), HLA-B*07 (OR = 2.08), HLA-B*38 (OR = 2.34) and HLA-B*55 (OR = 3.76) and haplotype HLA-A*26-HLA-C*07 (OR = 3.41). The results suggest susceptibility to the presence ADPKD certain HLA alleles.