Próteses odontológicas associadas a Nanopartículas de Prata biogênicas: caracterização e atividade antimicrobiana

Detalhes bibliográficos
Ano de defesa: 2024
Autor(a) principal: Santos, Mateus Leite lattes
Orientador(a): Antón, Ana Rita Sokolonski lattes
Banca de defesa: Antón, Ana Rita Sokolonski lattes, Lira, Andréa Fabiana de lattes, Gabler, Ilanna Guimarães lattes
Tipo de documento: Dissertação
Tipo de acesso: Acesso aberto
Idioma: por
Instituição de defesa: Universidade Federal da Bahia
Programa de Pós-Graduação: Programa de Pós-Graduação em Processos Interativos dos Órgãos e Sistemas (PPGORGSISTEM) 
Departamento: Instituto de Ciências da Saúde - ICS
País: Brasil
Palavras-chave em Português:
Nanotecnologia
Nanopartículas metálicas
Prótese dentária
Materiais dentários
Materiais biomédicos e odontológicos
Área do conhecimento CNPq:
CNPQ::CIENCIAS BIOLOGICAS::MICROBIOLOGIA
CNPQ::CIENCIAS DA SAUDE::ODONTOLOGIA
Link de acesso: https://repositorio.ufba.br/handle/ri/40895
Resumo: Introdução: O aumento da necessidade pelo uso de próteses dentárias faz com que as implicações deste tratamento estejam sobre o foco de muitas discussões clínicas e científicas na atualidade. Próteses mal adaptadas e traumatogênicas podem ser o fator etiológico principal de muitas enfermidades da cavidade oral. Diante disso, é necessário além de estimular a higiene, a exploração e desenvolvimento de novas tecnologias para tornar o PMMA antimicrobiano. O uso de AgNP biogênicas como tratamento de superfície da resina acrílica é uma das formas disruptivas e inovadoras de tornar uma prótese antimicrobiana. Objetivo: o presente estudo realizou a caracterização, atividade antimicrobiana, determinação da durabilidade e análise da rugosidade de corpos de prova de PMMA tratados com AgNP biogênicas. Material e métodos: Os espécimes confeccionados em resina acrílica temropolimerizável foram tratados com uma solução de AgNP biogênica sintetizada pelo fungo fusarium oxysporum em diferentes grupos de tratamento, em seguida foram analisadas as características físico-químicas da Nanopartícula, realizando teste de sensibilidade a antibióticos, ciclagem térmica, teste de contato direto modificado, avaliação de cor através de ensaio de espectofotometria e ensaio de rugosidade. Resultados: Os espécimes de resinas que receberam nanopartículas na massa total não apresentaram atividade antimicrobiana, apesar da incorporação de AgNP melhorar significativamente a rugosidade superficial da resina incolor. Os demais tratamentos de superfície apresentaram alta atividade antibacteriana e moderada atividade antifúngica. AgNP não foi capaz de provocar alterações de cor clinicamente significativas, apresentou apenas diminuição da saturação de vermelho na resina rosa. Conclusão: Os tratamentos de superfície com AgNP em resina acrílica termopolimerizável podem resistir até 30 dias na cavidade oral, não alteram a cor ou a rugosidade do material e apresentam alta atividade antimicrobiana, mais estudos precisam ser realizados para a determinação da atividade em períodos mais longos, situações mais desafiadoras e com outras espécies de NPM.
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spelling 2025-01-14T12:15:47Z2025-01-122025-01-14T12:15:47Z2024-12-21SANTOS, Mateus Leite. Próteses odontológicas associadas a nanopartículas de prata biogênicas: caracterização e atividade antimicrobiana. Orientadora: Ana Rita Sokolonski Antón. 2024. 60 f. Dissertação (Mestrado em Processos Interativos de Órgãos e Sistemas) - Instituto de Ciências da Saúde, Universidade Federal da Bahia, Salvador, 2024.https://repositorio.ufba.br/handle/ri/40895Introdução: O aumento da necessidade pelo uso de próteses dentárias faz com que as implicações deste tratamento estejam sobre o foco de muitas discussões clínicas e científicas na atualidade. Próteses mal adaptadas e traumatogênicas podem ser o fator etiológico principal de muitas enfermidades da cavidade oral. Diante disso, é necessário além de estimular a higiene, a exploração e desenvolvimento de novas tecnologias para tornar o PMMA antimicrobiano. O uso de AgNP biogênicas como tratamento de superfície da resina acrílica é uma das formas disruptivas e inovadoras de tornar uma prótese antimicrobiana. Objetivo: o presente estudo realizou a caracterização, atividade antimicrobiana, determinação da durabilidade e análise da rugosidade de corpos de prova de PMMA tratados com AgNP biogênicas. Material e métodos: Os espécimes confeccionados em resina acrílica temropolimerizável foram tratados com uma solução de AgNP biogênica sintetizada pelo fungo fusarium oxysporum em diferentes grupos de tratamento, em seguida foram analisadas as características físico-químicas da Nanopartícula, realizando teste de sensibilidade a antibióticos, ciclagem térmica, teste de contato direto modificado, avaliação de cor através de ensaio de espectofotometria e ensaio de rugosidade. Resultados: Os espécimes de resinas que receberam nanopartículas na massa total não apresentaram atividade antimicrobiana, apesar da incorporação de AgNP melhorar significativamente a rugosidade superficial da resina incolor. Os demais tratamentos de superfície apresentaram alta atividade antibacteriana e moderada atividade antifúngica. AgNP não foi capaz de provocar alterações de cor clinicamente significativas, apresentou apenas diminuição da saturação de vermelho na resina rosa. Conclusão: Os tratamentos de superfície com AgNP em resina acrílica termopolimerizável podem resistir até 30 dias na cavidade oral, não alteram a cor ou a rugosidade do material e apresentam alta atividade antimicrobiana, mais estudos precisam ser realizados para a determinação da atividade em períodos mais longos, situações mais desafiadoras e com outras espécies de NPM.Introduction: The increased need for dental prostheses means that the implications of this treatment are the focus of many clinical and scientific discussions today. Poorly adapted and traumatogenic prostheses can be the main etiological factor of many diseases of the oral cavity. Given this, it is necessary, in addition to stimulating hygiene, to explore and develop new technologies to make PMMA antimicrobial. Biogenic AgNPs as a surface treatment for acrylic resin is one of the disruptive and innovative ways to make a prosthesis antimicrobial. Objective: the present study carried out the characterization, antimicrobial activity, durability determination, and roughness analysis of PMMA specimens treated with biogenic AgNP. Material and methods: The specimens were treated with a biogenic AgNP solution synthesized by the fungus fusarium oxysporum in different treatment groups, and then the physicochemical characteristics of the Nanoparticle, performance, sensitivity test to bacteria, thermal cycling, and contact test were proven. Modified direct, color evaluation through spectrophotometry testing and roughness testing. Results: The resins that received nanoparticles in the total mass did not show antimicrobial activity, despite the incorporation of AgNP significantly improving the surface roughness of the colorless resin. The other surface treatments showed high antibacterial activity and moderate antifungal activity. AgNP was not able to cause clinically significant color changes, it only showed a decrease in red saturation in the pink resin. Conclusion: Surface treatments with AgNP on thermopolymerizable acrylic resin can resist up to 30 days in the oral cavity, do not change the color or roughness of the material, and have high antimicrobial activity. More studies need to be carried out to determine the activity over longer periods, more challenging situations, and with other NPM species.Capes - Fundação Coordenação de Aperfeiçoamento de Pessoal de Nível SuperiorporUniversidade Federal da BahiaPrograma de Pós-Graduação em Processos Interativos dos Órgãos e Sistemas (PPGORGSISTEM) UFBABrasilInstituto de Ciências da Saúde - ICSNanotechnologyMetal NanoparticlesDental ProsthesisDental MaterialsBiomedical and Dental MaterialsCNPQ::CIENCIAS BIOLOGICAS::MICROBIOLOGIACNPQ::CIENCIAS DA SAUDE::ODONTOLOGIANanotecnologiaNanopartículas metálicasPrótese dentáriaMateriais dentáriosMateriais biomédicos e odontológicosPróteses odontológicas associadas a Nanopartículas de Prata biogênicas: caracterização e atividade antimicrobianaDental prostheses pssociated with biogenic silver Nanoparticles: characterization and antimicrobial activityMestrado Acadêmicoinfo:eu-repo/semantics/masterThesisinfo:eu-repo/semantics/publishedVersionAntón, Ana Rita Sokolonskihttps://orcid.org/0000-0001-8089-4128http://lattes.cnpq.br/1228384941765961Antón, Ana Rita Sokolonskihttps://orcid.org/0000-0001-8089-4128http://lattes.cnpq.br/1228384941765961Lira, Andréa Fabiana dehttps://orcid.org/0000-0003-3945-2613http://lattes.cnpq.br/1727445128048492Gabler, Ilanna Guimarãeshttp://lattes.cnpq.br/1670478079353578https://orcid.org/0009-0003-0504-7043http://lattes.cnpq.br/5347295247563620Santos, Mateus LeiteABDELGADIR, A. et al. 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DOI: https://doi.org/10.1016/j.rsurfi.2023.100109.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da UFBAinstname:Universidade Federal da Bahia (UFBA)instacron:UFBAORIGINALMateus_Leite_Santos_Dissertação de mestrado PIOS.pdfMateus_Leite_Santos_Dissertação de mestrado PIOS.pdfapplication/pdf1430844https://repositorio.ufba.br/bitstream/ri/40895/1/Mateus_Leite_Santos_Disserta%c3%a7%c3%a3o%20de%20mestrado%20PIOS.pdf7f9a544fb4aff15f379ff5c2c579e58fMD51open accessLICENSElicense.txtlicense.txttext/plain1720https://repositorio.ufba.br/bitstream/ri/40895/2/license.txtd9b7566281c22d808dbf8f29ff0425c8MD52open accessri/408952025-01-14 09:15:48.194open accessoai:repositorio.ufba.br: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Repositório InstitucionalPUBhttps://repositorio.ufba.br/oai/requestrepositorio@ufba.bropendoar:19322025-01-14T12:15:48Repositório Institucional da UFBA - Universidade Federal da Bahia (UFBA)false
dc.title.pt_BR.fl_str_mv Próteses odontológicas associadas a Nanopartículas de Prata biogênicas: caracterização e atividade antimicrobiana
dc.title.alternative.pt_BR.fl_str_mv Dental prostheses pssociated with biogenic silver Nanoparticles: characterization and antimicrobial activity
title Próteses odontológicas associadas a Nanopartículas de Prata biogênicas: caracterização e atividade antimicrobiana
spellingShingle Próteses odontológicas associadas a Nanopartículas de Prata biogênicas: caracterização e atividade antimicrobiana
Santos, Mateus Leite
CNPQ::CIENCIAS BIOLOGICAS::MICROBIOLOGIA
CNPQ::CIENCIAS DA SAUDE::ODONTOLOGIA
Nanotecnologia
Nanopartículas metálicas
Prótese dentária
Materiais dentários
Materiais biomédicos e odontológicos
Nanotechnology
Metal Nanoparticles
Dental Prosthesis
Dental Materials
Biomedical and Dental Materials
title_short Próteses odontológicas associadas a Nanopartículas de Prata biogênicas: caracterização e atividade antimicrobiana
title_full Próteses odontológicas associadas a Nanopartículas de Prata biogênicas: caracterização e atividade antimicrobiana
title_fullStr Próteses odontológicas associadas a Nanopartículas de Prata biogênicas: caracterização e atividade antimicrobiana
title_full_unstemmed Próteses odontológicas associadas a Nanopartículas de Prata biogênicas: caracterização e atividade antimicrobiana
title_sort Próteses odontológicas associadas a Nanopartículas de Prata biogênicas: caracterização e atividade antimicrobiana
author Santos, Mateus Leite
author_facet Santos, Mateus Leite
author_role author
dc.contributor.advisor1.fl_str_mv Antón, Ana Rita Sokolonski
dc.contributor.advisor1ID.fl_str_mv https://orcid.org/0000-0001-8089-4128
dc.contributor.advisor1Lattes.fl_str_mv http://lattes.cnpq.br/1228384941765961
dc.contributor.referee1.fl_str_mv Antón, Ana Rita Sokolonski
dc.contributor.referee1ID.fl_str_mv https://orcid.org/0000-0001-8089-4128
dc.contributor.referee1Lattes.fl_str_mv http://lattes.cnpq.br/1228384941765961
dc.contributor.referee2.fl_str_mv Lira, Andréa Fabiana de
dc.contributor.referee2ID.fl_str_mv https://orcid.org/0000-0003-3945-2613
dc.contributor.referee2Lattes.fl_str_mv http://lattes.cnpq.br/1727445128048492
dc.contributor.referee3.fl_str_mv Gabler, Ilanna Guimarães
dc.contributor.referee3Lattes.fl_str_mv http://lattes.cnpq.br/1670478079353578
dc.contributor.authorID.fl_str_mv https://orcid.org/0009-0003-0504-7043
dc.contributor.authorLattes.fl_str_mv http://lattes.cnpq.br/5347295247563620
dc.contributor.author.fl_str_mv Santos, Mateus Leite
contributor_str_mv Antón, Ana Rita Sokolonski
Antón, Ana Rita Sokolonski
Lira, Andréa Fabiana de
Gabler, Ilanna Guimarães
dc.subject.cnpq.fl_str_mv CNPQ::CIENCIAS BIOLOGICAS::MICROBIOLOGIA
CNPQ::CIENCIAS DA SAUDE::ODONTOLOGIA
topic CNPQ::CIENCIAS BIOLOGICAS::MICROBIOLOGIA
CNPQ::CIENCIAS DA SAUDE::ODONTOLOGIA
Nanotecnologia
Nanopartículas metálicas
Prótese dentária
Materiais dentários
Materiais biomédicos e odontológicos
Nanotechnology
Metal Nanoparticles
Dental Prosthesis
Dental Materials
Biomedical and Dental Materials
dc.subject.por.fl_str_mv Nanotecnologia
Nanopartículas metálicas
Prótese dentária
Materiais dentários
Materiais biomédicos e odontológicos
dc.subject.other.pt_BR.fl_str_mv Nanotechnology
Metal Nanoparticles
Dental Prosthesis
Dental Materials
Biomedical and Dental Materials
description Introdução: O aumento da necessidade pelo uso de próteses dentárias faz com que as implicações deste tratamento estejam sobre o foco de muitas discussões clínicas e científicas na atualidade. Próteses mal adaptadas e traumatogênicas podem ser o fator etiológico principal de muitas enfermidades da cavidade oral. Diante disso, é necessário além de estimular a higiene, a exploração e desenvolvimento de novas tecnologias para tornar o PMMA antimicrobiano. O uso de AgNP biogênicas como tratamento de superfície da resina acrílica é uma das formas disruptivas e inovadoras de tornar uma prótese antimicrobiana. Objetivo: o presente estudo realizou a caracterização, atividade antimicrobiana, determinação da durabilidade e análise da rugosidade de corpos de prova de PMMA tratados com AgNP biogênicas. Material e métodos: Os espécimes confeccionados em resina acrílica temropolimerizável foram tratados com uma solução de AgNP biogênica sintetizada pelo fungo fusarium oxysporum em diferentes grupos de tratamento, em seguida foram analisadas as características físico-químicas da Nanopartícula, realizando teste de sensibilidade a antibióticos, ciclagem térmica, teste de contato direto modificado, avaliação de cor através de ensaio de espectofotometria e ensaio de rugosidade. Resultados: Os espécimes de resinas que receberam nanopartículas na massa total não apresentaram atividade antimicrobiana, apesar da incorporação de AgNP melhorar significativamente a rugosidade superficial da resina incolor. Os demais tratamentos de superfície apresentaram alta atividade antibacteriana e moderada atividade antifúngica. AgNP não foi capaz de provocar alterações de cor clinicamente significativas, apresentou apenas diminuição da saturação de vermelho na resina rosa. Conclusão: Os tratamentos de superfície com AgNP em resina acrílica termopolimerizável podem resistir até 30 dias na cavidade oral, não alteram a cor ou a rugosidade do material e apresentam alta atividade antimicrobiana, mais estudos precisam ser realizados para a determinação da atividade em períodos mais longos, situações mais desafiadoras e com outras espécies de NPM.
publishDate 2024
dc.date.issued.fl_str_mv 2024-12-21
dc.date.accessioned.fl_str_mv 2025-01-14T12:15:47Z
dc.date.available.fl_str_mv 2025-01-12
2025-01-14T12:15:47Z
dc.type.driver.fl_str_mv Mestrado Acadêmico
info:eu-repo/semantics/masterThesis
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format masterThesis
status_str publishedVersion
dc.identifier.citation.fl_str_mv SANTOS, Mateus Leite. Próteses odontológicas associadas a nanopartículas de prata biogênicas: caracterização e atividade antimicrobiana. Orientadora: Ana Rita Sokolonski Antón. 2024. 60 f. Dissertação (Mestrado em Processos Interativos de Órgãos e Sistemas) - Instituto de Ciências da Saúde, Universidade Federal da Bahia, Salvador, 2024.
dc.identifier.uri.fl_str_mv https://repositorio.ufba.br/handle/ri/40895
identifier_str_mv SANTOS, Mateus Leite. Próteses odontológicas associadas a nanopartículas de prata biogênicas: caracterização e atividade antimicrobiana. Orientadora: Ana Rita Sokolonski Antón. 2024. 60 f. Dissertação (Mestrado em Processos Interativos de Órgãos e Sistemas) - Instituto de Ciências da Saúde, Universidade Federal da Bahia, Salvador, 2024.
url https://repositorio.ufba.br/handle/ri/40895
dc.language.iso.fl_str_mv por
language por
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