Evolução temporal da incidência do câncer de mama na cidade de Goiânia de acordo com o grupo etário e análise geoespacial

• Ano de defesa: 2010
• Autor(a) principal: Freitas, Nilceana Maya Aires
• Orientador(a): Júnior, Ruffo de Freitas
• Banca de defesa: Moreira, Marise Amaral Rebouças, Moraes, Verdeli Alves de, Nazário, Afonso Celso Pinto, Thuler, Luis Cláudio Santos
• Tipo de documento: Tese
• Tipo de acesso: Acesso aberto
• Idioma: por
• Instituição de defesa: Universidade Federal de Goiás
• Programa de Pós-Graduação: Programa de Pós-graduação em Ciências da Saúde (FM)
• Departamento: Faculdade de Medicina - FM (RG)
• País: Brasil
• Palavras-chave em Português: Brasil; Câncer de mama; Epidemiologia; Incidência; Distribuição espacial; Goiânia
• Palavras-chave em Inglês: Spatial distribution; Breast cancer; Epidemiology; Incidence
• Área do conhecimento CNPq: CLINICA MEDICA::CANCEROLOGIA
• Link de acesso: http://repositorio.bc.ufg.br/tede/handle/tede/3268

OBJECTIVE: To study the behavior of breast cancer incidence in the city of Goiania/Goias, during the specified period of years, according to the age group and geospatial distribution. METHODS: In order to achieve our objectives, we conducted three distinctive studies, as described below: Study I: This study sought to verify the Average Annual Percentage Change (AAPC) of breast cancer incidence in Goiania, per decade of life. It used the database of the Population Based Cancer Registries of Goiania (RCBPGo), between 1988 and 2003. During this period, it was registered 3,310 new cases of female breast cancer. The incidence of both crude and standardized rates, this is adjusted by Segi’s World population, were calculated per age groups at each 10 years. Poisson Regression was used to calculate the AAPC for these age groups. Study II: Studied breast cancer incidence trends in young women, in Goiania, during the same period of time (1988 to 2003). The women were divided in three age groups: young women, younger than 39 years old;; women between 40 and 59 years old;; and women above 60 years old. To conduct this study, the annual incidence was calculated by the respective age groups. It was calculated the AAPC and the linear regression. The latter was used to obtain the correlation coefficient and the determination coefficient. Study III: The database of the Population Based Cancer Registries of Goiania (RCBPGo) was updated in this study until 2006;; therefore, this analysis covered a period of 19 years, in which there were 4,155 new cases of breast cancer. Each incident case was distributed geospatially, and the truncated incidences of women above 30 years old was calculated in each sanitary district. It was also calculated the AAPC for the districts and the change in the female population growth in each district. RESULTS: In Study I, it was observed that the AAPC of the total crude rate incidence was of 7.18% per year (IC 95% = 6.1 – 8.3;; p < 0.001), from 1988 to 2003;; and that the AAPC of the standardized incidence was of 4.86% per year (IC 95% = 3.8 – 5.9;; p < 0.001). The age group which presented the highest growth was the group of women between the age of 50 and 59 (6.3%;; IC 95% = 4.5 – 8.0;; p < 0.001). There was a significant raise of the AAPC breast cancer incidence for all age groups, except the age group of 20 to 29 year old women (p = 0.13). In Study II the AACP of the women until 39 years old (the group of young women) was of 5.22% (IC 95% = 2.91 – 7.54), and it was lower than the one observed in women above 40 years old. The coefficient of determination of young women incidence was R2 = 0.52 (p < 0.003). The Study III demonstrated that the total truncated incidence during the 19 year period of study was of 86/100,000 cases. Campinas Centre was the district with the highest incidence with 118/100,000 cases of breast cancer. The Northwest district presented the highest AAPC of 20% (IC 95% = 7.2 – 36.4;; p = 0.02). In spite of that, the highest population growth happened in the West district with rates of 71%. CONCLUSION: Within the period studied, the incidence of breast cancer in Goiania increased significantly in all age groups. Such growth, however, happened in an uneven way in the different sanitary districts. The highest incidences were observed in the Centre and South districts. The raise of breast cancer incidence presented low correlation with the female population growth in all the districts of Goiania. This founding, therefore, indicates that the causes of such raise should be further studied in this population.