O papel da paridade e da idade materna à primeira gestação na associação entre menarca precoce e síndrome metabólica em mulheres de meia idade e idosas

• Ano de defesa: 2020
• Autor(a) principal: Rocha, Tiago Novais
• Tipo de documento: Dissertação
• Tipo de acesso: Acesso aberto
• Idioma: por
• Instituição de defesa: Universidade Federal do Rio Grande do Norte; Brasil; UFRN; PROGRAMA DE PÓS-GRADUAÇÃO EM CIÊNCIAS DA REABILITAÇÃO
• Palavras-chave em Português: Menarca; Mulheres; Fatores de risco; Síndrome metabólica; Gravidez
• Link de acesso: https://repositorio.ufrn.br/handle/123456789/30383

Introduction: Metabolic syndrome (MetS) is a common condition in older ages. However, it seems to be associated with factors present in the early stages of life, such as early menarche. Other factors such as age at first pregnancy and parity seem to be associated with increased cardiovascular risk in women, but their role in the association between early menarche and MetS has not yet been studied. Objective: To analyze an association between early menarche and MetS in middle-aged women, and to verify whether the maternal age at first pregnancy and the parity to use as mediating variables. Methods: This is an observational, analytical, cross-sectional study, composed of 428 women aged between 40 and 80 years. The age at first pregnancy, parity and early menarche (≤ 11 years of age) were assessed by selfreport, and an MetS was assessed using the criteria recommended by the NCEP ATP III (Systemic arterial hypertension, high triglycerides, high HDL, high fasting blood glucose and waist circumference> 88 cm). The association between early menarche and MetS were assessed by binary logistic regression analysis adjusted for the covariables age, smoking, family income, education and physical exercise. The role of age at first pregnancy and multiparity on an early menarche and MS relationship were assessed through mediation analysis adjusted by the same covariables. Results: There was an association between early menarche and MS (OR: 2,262 95% CI: 1,145; 4,465), indicating that early menarche increases twice the chance of a middle-aged and elderly woman presenting with MetS. Through mediation analysis it was possible to verify that menarche has a direct effect on MetS (Effect: 0,8076 CI 95%: 0,1070; 1,5082), and two potential mediators, only the maternal age at first pregnancy was a significant path (Effect: 0,0654 CI 95%: 0,0035; 0,2205). Conclusion: The results of this research show that there is an association between early menarche and MetS and that maternal age at first pregnancy is registered as a mediating variable in this association. These results point to the need for public policies aimed at children and adolescents in order to eliminate or lessen the adverse effects of teenage pregnancy on women's health.