Avalia??o de par?metros reprodutivos com o uso de gonadotrofina cori?nica humana (hCG) e deslorelina em um programa de transfer?ncia de embri?o equino

Detalhes bibliográficos
Ano de defesa: 2012
Autor(a) principal: Silva, Paula Cardoso de Almeida lattes
Orientador(a): Jacob, Julio Cesar Ferraz lattes
Banca de defesa: Dell' Aqua Junior, Jos? Antonio, Mello, Marco Roberto Bourg de
Tipo de documento: Dissertação
Tipo de acesso: Acesso aberto
Idioma: por
Instituição de defesa: Universidade Federal Rural do Rio de Janeiro
Programa de Pós-Graduação: Programa de P?s-Gradua??o em Medicina Veterin?ria (Patologia e Ci?ncias Cl?nicas)
Departamento: Instituto de Veterin?ria
País: Brasil
Palavras-chave em Português:
Palavras-chave em Inglês:
Área do conhecimento CNPq:
Link de acesso: https://tede.ufrrj.br/jspui/handle/jspui/1198
Resumo: Embryo transfer (ET) is one of the most prominent techniques in the expansion of horse breeding, enabling the production of more products of a single mare per year, thus increasing the number of animals with high genetic value. The hormonal control of ovulation can be used as a tool to optimize the reproductive parameters and reduce the costs in an ET program. This study compared the effectiveness of lower doses than those traditionally used of Deslorelin and hCG, evaluating the time between ovulation and induction, the recovery rates and embryo attachment. The study was conducted at the Department of Animal Reproduction and Evaluation of UFRRJ. We conducted follow-up of 85 estrous cycles of Breton Postier and Mangalarga Marchador mares, when the mares presenting an ovarian follicle ? 35 mm, they were divided randomly into one of three treatments: G1 (n = 32) - treatment with 1000 IU (1.0 ml iv) of hCG (Chorulon ? - Intervet Schering-Plough Animal Health), G2 (n = 28) - treatment with 0.75 mg (0.75 ml iv) Deslorelin (Botupharma) and G3 (n = 28) - Treatment with 1.0 ml saline iv. Twenty four hours after application, ultrasound evaluation of ovarian was held every six hours up to ovulation. The donors were inseminated the day after induction and embryo collection took place in nine days after ovulation. The recovered embryos were immediately transferred to recipients previously synchronized, these pregnancy diagnosis was performed at 15 and 30 days old embryo. Data regarding the time between ovulation and induction and characteristics of follicular development were analyzed using analysis of variance (ANOVA), and the averages of these data were analyzed when needed by the Tukey test. The data regarding the percentage of mares ovulated in different periods, were analyzed using the Qui-quadrado (?2) 5%. In the case of embryo recovery rate, the data were analyzed using the Fisher exact test, however in relation to pregnancy rate was not possible to perform statistical analysis due to low sample size. The percentage of ovulation in up to 36 hours for G1, G2 and G3 were 34.4%, 13.3% and 8.7%, between 36 and 42 hours were 62.5%, 56.7% and 8.7%, from 42 to 48 hours were 0%, 20% and 13%, more than 48 hours were 3.1%, 10% and 69.6% respectively. Having thus a significant difference between treated and control groups (p <0.05). The embryo recovery rate was 75% (6/8) in G1 and G2, and 44.4% (4/9) in group G3, there was no significant difference between groups (p> 0.05). The rate of pregnancy at fifteen days old embryo was 69.2% (9/13). Thus the lower doses commonly used with inducing agents in question, were effective in promoting ovulation within 48 hours, but the use of these didn't result in significant improvement in the rates of embryo recovery.
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spelling Jacob, Julio Cesar Ferrazhttp://lattes.cnpq.br/4105470945179000Dell' Aqua Junior, Jos? AntonioMello, Marco Roberto Bourg de214.823.838-88http://lattes.cnpq.br/0492292333569676Silva, Paula Cardoso de Almeida2016-09-12T18:07:34Z2012-01-25SILVA, Paula Cardoso de Almeida. Avalia??o de par?metros reprodutivos com o uso de gonadotrofina cori?nica humana (hCG) e deslorelina em um programa de transfer?ncia de embri?o equino. 2012. 63 f. Disserta??o (Mestrado em Medicina Veterin?ria, Patologia e Ci?ncias Cl?nicas) - Instituto de Veterin?ria, Universidade Federal Rural do Rio de Janeiro, Serop?dica, 2012.https://tede.ufrrj.br/jspui/handle/jspui/1198Embryo transfer (ET) is one of the most prominent techniques in the expansion of horse breeding, enabling the production of more products of a single mare per year, thus increasing the number of animals with high genetic value. The hormonal control of ovulation can be used as a tool to optimize the reproductive parameters and reduce the costs in an ET program. This study compared the effectiveness of lower doses than those traditionally used of Deslorelin and hCG, evaluating the time between ovulation and induction, the recovery rates and embryo attachment. The study was conducted at the Department of Animal Reproduction and Evaluation of UFRRJ. We conducted follow-up of 85 estrous cycles of Breton Postier and Mangalarga Marchador mares, when the mares presenting an ovarian follicle ? 35 mm, they were divided randomly into one of three treatments: G1 (n = 32) - treatment with 1000 IU (1.0 ml iv) of hCG (Chorulon ? - Intervet Schering-Plough Animal Health), G2 (n = 28) - treatment with 0.75 mg (0.75 ml iv) Deslorelin (Botupharma) and G3 (n = 28) - Treatment with 1.0 ml saline iv. Twenty four hours after application, ultrasound evaluation of ovarian was held every six hours up to ovulation. The donors were inseminated the day after induction and embryo collection took place in nine days after ovulation. The recovered embryos were immediately transferred to recipients previously synchronized, these pregnancy diagnosis was performed at 15 and 30 days old embryo. Data regarding the time between ovulation and induction and characteristics of follicular development were analyzed using analysis of variance (ANOVA), and the averages of these data were analyzed when needed by the Tukey test. The data regarding the percentage of mares ovulated in different periods, were analyzed using the Qui-quadrado (?2) 5%. In the case of embryo recovery rate, the data were analyzed using the Fisher exact test, however in relation to pregnancy rate was not possible to perform statistical analysis due to low sample size. The percentage of ovulation in up to 36 hours for G1, G2 and G3 were 34.4%, 13.3% and 8.7%, between 36 and 42 hours were 62.5%, 56.7% and 8.7%, from 42 to 48 hours were 0%, 20% and 13%, more than 48 hours were 3.1%, 10% and 69.6% respectively. Having thus a significant difference between treated and control groups (p <0.05). The embryo recovery rate was 75% (6/8) in G1 and G2, and 44.4% (4/9) in group G3, there was no significant difference between groups (p> 0.05). The rate of pregnancy at fifteen days old embryo was 69.2% (9/13). Thus the lower doses commonly used with inducing agents in question, were effective in promoting ovulation within 48 hours, but the use of these didn't result in significant improvement in the rates of embryo recovery.A transfer?ncia de embri?es (TE) ? uma das t?cnicas de maior destaque na expans?o da equideocultura, possibilitando a produ??o de maior n?mero de produtos de uma mesma ?gua por ano, aumentando assim o n?mero de animais com alto valor gen?tico. O controle hormonal do momento da ovula??o pode ser usado como uma ferramenta para otimizar os par?metros reprodutivos e reduzir os custos em um programa de TE. O presente estudo comparou a efici?ncia de doses mais baixas do que as tradicionalmente utilizadas de hCG e Deslorelina avaliando o tempo entre a indu??o e a ovula??o, as taxas de recupera??o e fixa??o embrion?ria. O estudo foi desenvolvido no Departamento de Reprodu??o e Avalia??o Animal da UFRRJ. Foi realizado o acompanhamento de 85 ciclos estrais de ?guas da ra?a Bret?o Postier e Mangalarga Marchador, onde as ?guas ao apresentarem um fol?culo ovariano ? 35 mm foram divididas de maneira aleat?ria em um dos tr?s tratamentos: G1 (n = 32) ? tratamento com 1000 UI (1,0 ml i.v.) de hCG (Chorulon? - Intervet Schering-Plough Animal Health), G2 (n = 30) ? tratamento com 0,75 mg (0,75ml i.v.) de Deslorelina (Botupharma) e G3 (n=23) ? tratamento com 1,0 ml i.v. de solu??o salina. Vinte quatro horas ap?s a aplica??o, a avalia??o ultrassonogr?fica dos ov?rios passou a ser realizada a cada seis horas at? a detec??o da ovula??o. As ?guas doadoras foram inseminadas no dia seguinte a indu??o e as coletas de embri?o aconteceram no dia 9 ap?s a ovula??o. Os embri?es recuperados foram imediatamente transferidos para receptoras previamente sincronizadas, sendo o diagn?stico de gesta??o realizado aos 15 e 30 dias de idade embrionaria. Os dados referentes ao tempo entre indu??o e ovula??o e caracter?sticas do desenvolvimento folicular, foram analisados pelo m?todo de An?lise de Vari?ncia (ANOVA), sendo as m?dias desses dados analisadas quando necess?rio pelo teste de Tukey. Os dados referentes ao percentual de ?guas ovuladas em diferentes per?odos, foram analisados atrav?s do Qui-quadrado (?2) 5%. Em se tratando da taxa de recupera??o embrion?ria, os dados foram analisados atrav?s do teste Exato de Fisher, j? em rela??o a taxa de gesta??o n?o foi poss?vel realizar an?lise estat?stica devido ao baixo n?mero amostral. Os percentuais de ovula??o em at? 36 horas nos grupos G1, G2 e G3, foram 34,4 %, 13,3% e 8,7%, entre 36 e 42 horas, 62,5%, 56,7% e 8,7%, entre 42 e 48 horas, 0%, 20% e 13%, acima de 48 horas 3,1%, 10% e 69,6%, respectivamente. Havendo dessa maneira diferen?a significativa entre os grupos tratados e o controle (p < 0,05). A taxa de recupera??o embrion?ria foi de 75% (6/8) nos grupos G1 e G2 e 44,4% (4/9) no grupo G3; n?o houve diferen?a significativa entre os grupos (p > 0,05). J? a taxa de gesta??o aos quinze dias de idade embrion?ria foi de 69,2% (9/13). Deste modo as doses inferiores ?s comumente utilizadas, dos agentes indutores em quest?o, foram eficientes em promover a ovula??o em at? 48 horas, mas o uso destes, n?o resultou em melhora significativa nos ?ndices de recupera??o embrion?riaSubmitted by Sandra Pereira (srpereira@ufrrj.br) on 2016-09-12T18:07:34Z No. of bitstreams: 1 2011 - Paula Cardoso de Almeida Silva.pdf: 463902 bytes, checksum: 375c57bac0b880fd3baf2320ee7abb93 (MD5)Made available in DSpace on 2016-09-12T18:07:34Z (GMT). No. of bitstreams: 1 2011 - Paula Cardoso de Almeida Silva.pdf: 463902 bytes, checksum: 375c57bac0b880fd3baf2320ee7abb93 (MD5) Previous issue date: 2012-01-25Coordena??o de Aperfei?oamento de Pessoal de N?vel Superior - CAPESapplication/pdfhttps://tede.ufrrj.br/retrieve/4672/2011%20-%20Paula%20Cardoso%20de%20Almeida%20Silva.pdf.jpghttps://tede.ufrrj.br/retrieve/19328/2011%20-%20Paula%20Cardoso%20de%20Almeida%20Silva.pdf.jpghttps://tede.ufrrj.br/retrieve/25637/2011%20-%20Paula%20Cardoso%20de%20Almeida%20Silva.pdf.jpghttps://tede.ufrrj.br/retrieve/32072/2011%20-%20Paula%20Cardoso%20de%20Almeida%20Silva.pdf.jpghttps://tede.ufrrj.br/retrieve/38456/2011%20-%20Paula%20Cardoso%20de%20Almeida%20Silva.pdf.jpghttps://tede.ufrrj.br/retrieve/44812/2011%20-%20Paula%20Cardoso%20de%20Almeida%20Silva.pdf.jpghttps://tede.ufrrj.br/retrieve/51218/2011%20-%20Paula%20Cardoso%20de%20Almeida%20Silva.pdf.jpghttps://tede.ufrrj.br/retrieve/57664/2011%20-%20Paula%20Cardoso%20de%20Almeida%20Silva.pdf.jpgporUniversidade Federal Rural do Rio de JaneiroPrograma de P?s-Gradua??o em Medicina Veterin?ria (Patologia e Ci?ncias Cl?nicas)UFRRJBrasilInstituto de Veterin?ria6 REFER?NCIAS ALLEN, W. 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Successful transfer of a fertilized bovine egg by nonsurgical techniques. Journal Reproductive Fertility, v. 10, p. 197-201, 1965. SULLIVAN, J. J.; PARKER, W. G.; LARSON, L. L. Duration of estrus and ovulation time in nonlactating mares given human chorionic gonadotropin during three successive estrous periods. Journal of the American Veterinary Medical Association, v. 162, p. 895 -898, 1973. TAROUCO, A. K. Estacionalidade reprodutiva de ?guas abatidas em Pelotas - RS. 1992. 80p. Disserta??o (Mestrado) - Curso de P?s-Gradua??o em Medicina Veterin?ria. Universidade Federal de Pelotas. Pelotas - RS. 1992. TROEDSSON, M. T.; LIU, I. K. M.; ING, M. G.; PASCOE, J. Smooth muscle electrical activity in the oviduct, and the effect of oxytocin, prostaglandin F2a and prostaglandin E2 on the myometrium and the oviduct of the cycling mare. Biology Reproduction, v. 1, p. 475- 488, 1995. TROEDSSON, M. H. T.; LIU, I. K. M.; CRABO, B.G. Sperm Transport and Survival In The Mare. 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M.; POTTER, G. D.; BURNS, S. J.; KRAEMER, D. C.. Fertility of donor mares following nonsurgical collection of embryos. Journal of Reproduction and Fertility. V. 27, p. 383-386, 1979. VOGELSANG, S. G.; BONDIOLI, K. R.; MASSEY, J. M. Commercial application oequine embryo transfer. Equine Veterinary Journal Suppl., v.3, p.89-91, 1985. VOSS, J. L. Human chorionic gonadotropin. In: MCKINNON, A. O., VOSS, J. L. Equine Reproduction. Pennsylvania: Lea & Febinger, Cap. 35, p. 325-328, 1993. WEBER J. A.; WOODS G. L; LICTENWALNER A. B. Relaxatory effect of prostaglandin E2 on circular smooth muscle isolated from the equine oviductal isthmus. Biology Reproduction, v. 1, p. 125-130, 1995. WILSHER, S.; KOLLING, M.; ALLEN, W.R. Meclofenamic acid extends donor-recipient asynchrony in equine embryo transfer. Equine Veterinary Journal, v. 38; n. 5; p. 428-32, 2006. WITHERSPOON, D. M.; TALBOT, D. V. M. The site of ovulation in the mare. . Journal Reproduction Fertility, Supll 23, p. 329, 1970. WOODS, J.; RIGBY, S.; BRINSKO, S.; STEPHENS, R.; VARNER, D.; BLANCHARD, T. Effect of intrauterine treatment with prostaglandin E2 prior to inseminantion of mares in the uterine horn or body. 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dc.title.por.fl_str_mv Avalia??o de par?metros reprodutivos com o uso de gonadotrofina cori?nica humana (hCG) e deslorelina em um programa de transfer?ncia de embri?o equino
dc.title.alternative.eng.fl_str_mv Evaluation of reproductive parameters with human chorionic gonadotropin (hCG) and Deslorelin in an equine embryo transfer program
title Avalia??o de par?metros reprodutivos com o uso de gonadotrofina cori?nica humana (hCG) e deslorelina em um programa de transfer?ncia de embri?o equino
spellingShingle Avalia??o de par?metros reprodutivos com o uso de gonadotrofina cori?nica humana (hCG) e deslorelina em um programa de transfer?ncia de embri?o equino
Silva, Paula Cardoso de Almeida
mares
ovulation
ovulation inducers.
?gua
ovula??o
agentes indutores
Medicina Veterin?ria
title_short Avalia??o de par?metros reprodutivos com o uso de gonadotrofina cori?nica humana (hCG) e deslorelina em um programa de transfer?ncia de embri?o equino
title_full Avalia??o de par?metros reprodutivos com o uso de gonadotrofina cori?nica humana (hCG) e deslorelina em um programa de transfer?ncia de embri?o equino
title_fullStr Avalia??o de par?metros reprodutivos com o uso de gonadotrofina cori?nica humana (hCG) e deslorelina em um programa de transfer?ncia de embri?o equino
title_full_unstemmed Avalia??o de par?metros reprodutivos com o uso de gonadotrofina cori?nica humana (hCG) e deslorelina em um programa de transfer?ncia de embri?o equino
title_sort Avalia??o de par?metros reprodutivos com o uso de gonadotrofina cori?nica humana (hCG) e deslorelina em um programa de transfer?ncia de embri?o equino
author Silva, Paula Cardoso de Almeida
author_facet Silva, Paula Cardoso de Almeida
author_role author
dc.contributor.advisor1.fl_str_mv Jacob, Julio Cesar Ferraz
dc.contributor.advisor1Lattes.fl_str_mv http://lattes.cnpq.br/4105470945179000
dc.contributor.referee1.fl_str_mv Dell' Aqua Junior, Jos? Antonio
dc.contributor.referee2.fl_str_mv Mello, Marco Roberto Bourg de
dc.contributor.authorID.fl_str_mv 214.823.838-88
dc.contributor.authorLattes.fl_str_mv http://lattes.cnpq.br/0492292333569676
dc.contributor.author.fl_str_mv Silva, Paula Cardoso de Almeida
contributor_str_mv Jacob, Julio Cesar Ferraz
Dell' Aqua Junior, Jos? Antonio
Mello, Marco Roberto Bourg de
dc.subject.eng.fl_str_mv mares
ovulation
ovulation inducers.
topic mares
ovulation
ovulation inducers.
?gua
ovula??o
agentes indutores
Medicina Veterin?ria
dc.subject.por.fl_str_mv ?gua
ovula??o
agentes indutores
dc.subject.cnpq.fl_str_mv Medicina Veterin?ria
description Embryo transfer (ET) is one of the most prominent techniques in the expansion of horse breeding, enabling the production of more products of a single mare per year, thus increasing the number of animals with high genetic value. The hormonal control of ovulation can be used as a tool to optimize the reproductive parameters and reduce the costs in an ET program. This study compared the effectiveness of lower doses than those traditionally used of Deslorelin and hCG, evaluating the time between ovulation and induction, the recovery rates and embryo attachment. The study was conducted at the Department of Animal Reproduction and Evaluation of UFRRJ. We conducted follow-up of 85 estrous cycles of Breton Postier and Mangalarga Marchador mares, when the mares presenting an ovarian follicle ? 35 mm, they were divided randomly into one of three treatments: G1 (n = 32) - treatment with 1000 IU (1.0 ml iv) of hCG (Chorulon ? - Intervet Schering-Plough Animal Health), G2 (n = 28) - treatment with 0.75 mg (0.75 ml iv) Deslorelin (Botupharma) and G3 (n = 28) - Treatment with 1.0 ml saline iv. Twenty four hours after application, ultrasound evaluation of ovarian was held every six hours up to ovulation. The donors were inseminated the day after induction and embryo collection took place in nine days after ovulation. The recovered embryos were immediately transferred to recipients previously synchronized, these pregnancy diagnosis was performed at 15 and 30 days old embryo. Data regarding the time between ovulation and induction and characteristics of follicular development were analyzed using analysis of variance (ANOVA), and the averages of these data were analyzed when needed by the Tukey test. The data regarding the percentage of mares ovulated in different periods, were analyzed using the Qui-quadrado (?2) 5%. In the case of embryo recovery rate, the data were analyzed using the Fisher exact test, however in relation to pregnancy rate was not possible to perform statistical analysis due to low sample size. The percentage of ovulation in up to 36 hours for G1, G2 and G3 were 34.4%, 13.3% and 8.7%, between 36 and 42 hours were 62.5%, 56.7% and 8.7%, from 42 to 48 hours were 0%, 20% and 13%, more than 48 hours were 3.1%, 10% and 69.6% respectively. Having thus a significant difference between treated and control groups (p <0.05). The embryo recovery rate was 75% (6/8) in G1 and G2, and 44.4% (4/9) in group G3, there was no significant difference between groups (p> 0.05). The rate of pregnancy at fifteen days old embryo was 69.2% (9/13). Thus the lower doses commonly used with inducing agents in question, were effective in promoting ovulation within 48 hours, but the use of these didn't result in significant improvement in the rates of embryo recovery.
publishDate 2012
dc.date.issued.fl_str_mv 2012-01-25
dc.date.accessioned.fl_str_mv 2016-09-12T18:07:34Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/masterThesis
format masterThesis
status_str publishedVersion
dc.identifier.citation.fl_str_mv SILVA, Paula Cardoso de Almeida. Avalia??o de par?metros reprodutivos com o uso de gonadotrofina cori?nica humana (hCG) e deslorelina em um programa de transfer?ncia de embri?o equino. 2012. 63 f. Disserta??o (Mestrado em Medicina Veterin?ria, Patologia e Ci?ncias Cl?nicas) - Instituto de Veterin?ria, Universidade Federal Rural do Rio de Janeiro, Serop?dica, 2012.
dc.identifier.uri.fl_str_mv https://tede.ufrrj.br/jspui/handle/jspui/1198
identifier_str_mv SILVA, Paula Cardoso de Almeida. Avalia??o de par?metros reprodutivos com o uso de gonadotrofina cori?nica humana (hCG) e deslorelina em um programa de transfer?ncia de embri?o equino. 2012. 63 f. Disserta??o (Mestrado em Medicina Veterin?ria, Patologia e Ci?ncias Cl?nicas) - Instituto de Veterin?ria, Universidade Federal Rural do Rio de Janeiro, Serop?dica, 2012.
url https://tede.ufrrj.br/jspui/handle/jspui/1198
dc.language.iso.fl_str_mv por
language por
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