Avaliação das ações de rastreamento do câncer de colo uterino no Parque Indígena do Xingu

Detalhes bibliográficos
Ano de defesa: 2019
Autor(a) principal: Scopin, Ana Carolina Carvalho [UNIFESP]
Orientador(a): Não Informado pela instituição
Banca de defesa: Não Informado pela instituição
Tipo de documento: Dissertação
Tipo de acesso: Acesso aberto
Idioma: por
Instituição de defesa: Universidade Federal de São Paulo (UNIFESP)
Programa de Pós-Graduação: Não Informado pela instituição
Departamento: Não Informado pela instituição
País: Não Informado pela instituição
Palavras-chave em Português:
HPV
Link de acesso: https://sucupira.capes.gov.br/sucupira/public/consultas/coleta/trabalhoConclusao/viewTrabalhoConclusao.jsf?popup=true&id_trabalho=8006103
https://repositorio.unifesp.br/handle/11600/59707
Resumo: Introduction: There are few epidemiological studies on Human Papillomavirus (HPV) infection and cervical cancer in indigenous populations. Because it is a specific population with habits and rituals of its own, HPV infection and its onco genesis could not present the same evolution in Relation to the populations commonly studied. Through the data over time analysis, it was possible to determine the most appropriate form of follow-up, aiming the diagnosis of cervical lesions, reduction of care costs and lower morbidity. Objective: To evaluate 13 years of cervical cancer screening actions and assistance in the Xingu Indigenous Park, through cytological alterations analysis, correlating age and DNA-HPV test. Methods: This is an observational, transversal and retrospective study conducted by data analysis of screening and control actions of uterine cervical cancer in the scope of the Xingu project of the Universidade Federal de São Paulo (UNIFESP). The population studied consiste do find igenous, sexually active women, aged 11 years or older, belonging to sixteen ethnic groups residing in the middle, lower and east Xingu regions. The study was developed with the analysis of the result sobtained by convencional cervical screening test (Pap smear). Results: The population coverage of cytological examination in the period averaged 89.4%. In all actions, there was a higher percentage of normal cytological results. In 2005 and 2010 years, occurred the largest number of cytological alterations, with high-grade squamous intra epithelial lesion (HSIL) and low-grade squamous intraepithelial lesion (LSIL) respectively. Only 3 cases of cervical cancer were documented over the 13 years of follow-up. The HPV positivite rate was 24.5% and latency 22.9%. Conclusion: It was observed that the high coverage of the population was valuable in maintaining the quality of screening because of the large number of normal exams and rare cases of cancer compared to the national incidence. The extremes of the ages showed a higher percentage of LSIL and HSIL respectively. The basic DNA-HPV test, without genotyping, confirmed a higher percentage of positivity in those who had HSIL.
id UFSP_008b3634861ee72b109af0399d2a9a76
oai_identifier_str oai:repositorio.unifesp.br/:11600/59707
network_acronym_str UFSP
network_name_str Repositório Institucional da UNIFESP
repository_id_str
spelling Avaliação das ações de rastreamento do câncer de colo uterino no Parque Indígena do XinguCervical cancerIndigenousHPVCâncer de colo uterinoIndígenaHPVIntroduction: There are few epidemiological studies on Human Papillomavirus (HPV) infection and cervical cancer in indigenous populations. Because it is a specific population with habits and rituals of its own, HPV infection and its onco genesis could not present the same evolution in Relation to the populations commonly studied. Through the data over time analysis, it was possible to determine the most appropriate form of follow-up, aiming the diagnosis of cervical lesions, reduction of care costs and lower morbidity. Objective: To evaluate 13 years of cervical cancer screening actions and assistance in the Xingu Indigenous Park, through cytological alterations analysis, correlating age and DNA-HPV test. Methods: This is an observational, transversal and retrospective study conducted by data analysis of screening and control actions of uterine cervical cancer in the scope of the Xingu project of the Universidade Federal de São Paulo (UNIFESP). The population studied consiste do find igenous, sexually active women, aged 11 years or older, belonging to sixteen ethnic groups residing in the middle, lower and east Xingu regions. The study was developed with the analysis of the result sobtained by convencional cervical screening test (Pap smear). Results: The population coverage of cytological examination in the period averaged 89.4%. In all actions, there was a higher percentage of normal cytological results. In 2005 and 2010 years, occurred the largest number of cytological alterations, with high-grade squamous intra epithelial lesion (HSIL) and low-grade squamous intraepithelial lesion (LSIL) respectively. Only 3 cases of cervical cancer were documented over the 13 years of follow-up. The HPV positivite rate was 24.5% and latency 22.9%. Conclusion: It was observed that the high coverage of the population was valuable in maintaining the quality of screening because of the large number of normal exams and rare cases of cancer compared to the national incidence. The extremes of the ages showed a higher percentage of LSIL and HSIL respectively. The basic DNA-HPV test, without genotyping, confirmed a higher percentage of positivity in those who had HSIL.Introdução: Existem poucos estudos epidemiológicos sobre câncer de colo de útero e infecção por Papilomavirus humano (HPV) nas populações indígenas. Por se tratar de uma população específica com hábitos e rituais próprios, a infecção pelo HPV e sua oncogênese poderiam não apresentar a mesma evolução em relação às populações comumente estudadas. Por meio da análise de dados ao longo do tempo, foi possível determinar a forma de seguimento mais adequada, visando diagnóstico das lesões cervicais, redução de custos na assistência e menor morbidade. Objetivo: Avaliar as ações de rastreamento do câncer de colo uterino no Parque Indígena do Xingu em 13 anos de assistência, por meio da análise das alterações citológicas, correlacionando a idade e teste de DNA HPV. Métodos: Trata-se de estudo observacional, transversal e retrospectivo realizado por meio da análise de dados das ações de prevenção e de controle do câncer do colo do útero no âmbito do Projeto Xingu da Universidade Federal de São Paulo (UNIFESP). A população estudada foi composta por mulheres indígenas, sexualmente ativas, com idade igual ou superior a 11 anos, pertencentes a dezesseis etnias que residem nas regiões do Médio, Baixo e Leste Xingu. O estudo foi desenvolvido com a análise dos resultados obtidos pelo exame de citologia oncótica cérvico-vaginal convencional (Papanicolaou). Resultados: A cobertura populacional do exame citológico no Xingu no período foi em média 89,4%. Em todas as ações verificou-se maior percentual de resultados citológicos dentro da normalidade. Nos anos de 2005 e 2010 ocorreu o maior número de alterações citológicas, com os achados de lesão intraepitelial de alto grau (LAG) e lesão intra epitelial de baixo grau (LBG), respectivamente. Apenas 3 casos de câncer de colo uterino foram documentados ao longo dos 13 anos de seguimento. A taxa de positividade do HPV foi de 24,5% e latência de 22,9%. Conclusão: Observou-se que a alta cobertura populacional foi quesito precioso na manutenção da qualidade do rastreamento pela grande quantidade de exames normais e raros casos de câncer em comparação com a incidência nacional. Os extremos das idades evidenciaram maior percentual de LBG e LAG, respectivamente. O teste de DNA-HPV básico, sem genotipagem, confirmou maior percentual de positividade naquelas que apresentaram LAG.Dados abertos - Sucupira - Teses e dissertações (2019)Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)Universidade Federal de São Paulo (UNIFESP)Speck, Neila Maria de Gois [UNIFESP]Tso, Fernanda Kesselring [UNIFESP]http://lattes.cnpq.br/4640267129189904http://lattes.cnpq.br/8169544398769371http://lattes.cnpq.br/3181443805404423São PauloUniversidade Federal de São Paulo (UNIFESP)Scopin, Ana Carolina Carvalho [UNIFESP]2021-01-19T16:35:20Z2021-01-19T16:35:20Z2019-03-28info:eu-repo/semantics/masterThesisinfo:eu-repo/semantics/publishedVersion57 f.application/pdfhttps://sucupira.capes.gov.br/sucupira/public/consultas/coleta/trabalhoConclusao/viewTrabalhoConclusao.jsf?popup=true&id_trabalho=8006103ANA CAROLINA CARVALHO SCOPIN.pdfhttps://repositorio.unifesp.br/handle/11600/59707porinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UNIFESPinstname:Universidade Federal de São Paulo (UNIFESP)instacron:UNIFESP2024-08-11T05:12:27Zoai:repositorio.unifesp.br/:11600/59707Repositório InstitucionalPUBhttp://www.repositorio.unifesp.br/oai/requestbiblioteca.csp@unifesp.bropendoar:34652024-08-11T05:12:27Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP)false
dc.title.none.fl_str_mv Avaliação das ações de rastreamento do câncer de colo uterino no Parque Indígena do Xingu
title Avaliação das ações de rastreamento do câncer de colo uterino no Parque Indígena do Xingu
spellingShingle Avaliação das ações de rastreamento do câncer de colo uterino no Parque Indígena do Xingu
Scopin, Ana Carolina Carvalho [UNIFESP]
Cervical cancer
Indigenous
HPV
Câncer de colo uterino
Indígena
HPV
title_short Avaliação das ações de rastreamento do câncer de colo uterino no Parque Indígena do Xingu
title_full Avaliação das ações de rastreamento do câncer de colo uterino no Parque Indígena do Xingu
title_fullStr Avaliação das ações de rastreamento do câncer de colo uterino no Parque Indígena do Xingu
title_full_unstemmed Avaliação das ações de rastreamento do câncer de colo uterino no Parque Indígena do Xingu
title_sort Avaliação das ações de rastreamento do câncer de colo uterino no Parque Indígena do Xingu
author Scopin, Ana Carolina Carvalho [UNIFESP]
author_facet Scopin, Ana Carolina Carvalho [UNIFESP]
author_role author
dc.contributor.none.fl_str_mv Speck, Neila Maria de Gois [UNIFESP]
Tso, Fernanda Kesselring [UNIFESP]
http://lattes.cnpq.br/4640267129189904
http://lattes.cnpq.br/8169544398769371
http://lattes.cnpq.br/3181443805404423
São Paulo
Universidade Federal de São Paulo (UNIFESP)
dc.contributor.author.fl_str_mv Scopin, Ana Carolina Carvalho [UNIFESP]
dc.subject.por.fl_str_mv Cervical cancer
Indigenous
HPV
Câncer de colo uterino
Indígena
HPV
topic Cervical cancer
Indigenous
HPV
Câncer de colo uterino
Indígena
HPV
description Introduction: There are few epidemiological studies on Human Papillomavirus (HPV) infection and cervical cancer in indigenous populations. Because it is a specific population with habits and rituals of its own, HPV infection and its onco genesis could not present the same evolution in Relation to the populations commonly studied. Through the data over time analysis, it was possible to determine the most appropriate form of follow-up, aiming the diagnosis of cervical lesions, reduction of care costs and lower morbidity. Objective: To evaluate 13 years of cervical cancer screening actions and assistance in the Xingu Indigenous Park, through cytological alterations analysis, correlating age and DNA-HPV test. Methods: This is an observational, transversal and retrospective study conducted by data analysis of screening and control actions of uterine cervical cancer in the scope of the Xingu project of the Universidade Federal de São Paulo (UNIFESP). The population studied consiste do find igenous, sexually active women, aged 11 years or older, belonging to sixteen ethnic groups residing in the middle, lower and east Xingu regions. The study was developed with the analysis of the result sobtained by convencional cervical screening test (Pap smear). Results: The population coverage of cytological examination in the period averaged 89.4%. In all actions, there was a higher percentage of normal cytological results. In 2005 and 2010 years, occurred the largest number of cytological alterations, with high-grade squamous intra epithelial lesion (HSIL) and low-grade squamous intraepithelial lesion (LSIL) respectively. Only 3 cases of cervical cancer were documented over the 13 years of follow-up. The HPV positivite rate was 24.5% and latency 22.9%. Conclusion: It was observed that the high coverage of the population was valuable in maintaining the quality of screening because of the large number of normal exams and rare cases of cancer compared to the national incidence. The extremes of the ages showed a higher percentage of LSIL and HSIL respectively. The basic DNA-HPV test, without genotyping, confirmed a higher percentage of positivity in those who had HSIL.
publishDate 2019
dc.date.none.fl_str_mv 2019-03-28
2021-01-19T16:35:20Z
2021-01-19T16:35:20Z
dc.type.driver.fl_str_mv info:eu-repo/semantics/masterThesis
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format masterThesis
status_str publishedVersion
dc.identifier.uri.fl_str_mv https://sucupira.capes.gov.br/sucupira/public/consultas/coleta/trabalhoConclusao/viewTrabalhoConclusao.jsf?popup=true&id_trabalho=8006103
ANA CAROLINA CARVALHO SCOPIN.pdf
https://repositorio.unifesp.br/handle/11600/59707
url https://sucupira.capes.gov.br/sucupira/public/consultas/coleta/trabalhoConclusao/viewTrabalhoConclusao.jsf?popup=true&id_trabalho=8006103
https://repositorio.unifesp.br/handle/11600/59707
identifier_str_mv ANA CAROLINA CARVALHO SCOPIN.pdf
dc.language.iso.fl_str_mv por
language por
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 57 f.
application/pdf
dc.publisher.none.fl_str_mv Universidade Federal de São Paulo (UNIFESP)
publisher.none.fl_str_mv Universidade Federal de São Paulo (UNIFESP)
dc.source.none.fl_str_mv reponame:Repositório Institucional da UNIFESP
instname:Universidade Federal de São Paulo (UNIFESP)
instacron:UNIFESP
instname_str Universidade Federal de São Paulo (UNIFESP)
instacron_str UNIFESP
institution UNIFESP
reponame_str Repositório Institucional da UNIFESP
collection Repositório Institucional da UNIFESP
repository.name.fl_str_mv Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP)
repository.mail.fl_str_mv biblioteca.csp@unifesp.br
_version_ 1814268850603032576