Síntese, cristaloquímica e atividade biológica de complexos de paládio (II), cobre (II) e níquel (II) com benzofenonas hidroxiladas

Detalhes bibliográficos
Ano de defesa: 2012
Autor(a) principal: Rosa, Iara Maria Landre lattes
Orientador(a): Doriguetto, Antônio Carlos lattes
Banca de defesa: Almeida, Eduardo Tonon De, Pinheiro, Carlos Basílio
Tipo de documento: Dissertação
Tipo de acesso: Acesso aberto
Idioma: por
Instituição de defesa: Universidade Federal de Alfenas
Programa de Pós-Graduação: Programa de Pós-Graduação em Química
Departamento: Instituto de Química
País: Brasil
Palavras-chave em Português:
Paládio
Cobre
Níquel
Difração de Raios X
Área do conhecimento CNPq:
QUIMICA::FISICO-QUIMICA
Link de acesso: https://repositorio.unifal-mg.edu.br/handle/123456789/401
Resumo: The study of metallic complexes for therapeutic purposes has been growing steadily in recent years due to the elucidation of their mechanisms of human body action and interaction with biomolecules. Several advances in compounds characterization techniques and molecular modeling have provided a significant increase of research related to this subject. This work aimed to the synthesis and characterization of new complexes of copper (II), nickel (II) and palladium (II) with the ligands hydroxybenzophenone, and the evaluation of their anti-inflammatory, antimicrobial and anti-tumor activities. The first step was the synthesis of complex planning, starting from two synthetic hydroxybenzophenone (ligands), the 2-hydroxybenzophenone and 2,2 '-dihydroxybenzophenone, and three metals, copper (II), nickel (II) and palladium (II). The products of the reactions were characterized by vibrational spectroscopy in the infrared and elemental analysis. The structures of the complexes were determined unambiguously by single crystal X-ray diffraction. Finally, the antimicrobial and anti-inflammatory activities of the compounds were tested showing promising results for the complex trans-bis(2,2'- hydroxybenzophenonate-O,O')copper (II), which has potential anti-inflammatory and anti-microbial.
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spelling Rosa, Iara Maria Landrehttp://lattes.cnpq.br/2484520844365957Almeida, Eduardo Tonon DePinheiro, Carlos BasílioDoriguetto, Antônio Carloshttp://lattes.cnpq.br/24845208443659572015-06-16T19:55:05Z2012-02-14ROSA, Iara Maria Landre. Síntese, cristaloquímica e atividade biológica de complexos de paládio (II), cobre (II) e níquel (II) com benzofenonas hidroxiladas. 2012. 118 f. Dissertação (Metrado em Química) - Universidade Federal de Alfenas, Alfenas, MG, 2012.https://repositorio.unifal-mg.edu.br/handle/123456789/401The study of metallic complexes for therapeutic purposes has been growing steadily in recent years due to the elucidation of their mechanisms of human body action and interaction with biomolecules. Several advances in compounds characterization techniques and molecular modeling have provided a significant increase of research related to this subject. This work aimed to the synthesis and characterization of new complexes of copper (II), nickel (II) and palladium (II) with the ligands hydroxybenzophenone, and the evaluation of their anti-inflammatory, antimicrobial and anti-tumor activities. The first step was the synthesis of complex planning, starting from two synthetic hydroxybenzophenone (ligands), the 2-hydroxybenzophenone and 2,2 '-dihydroxybenzophenone, and three metals, copper (II), nickel (II) and palladium (II). The products of the reactions were characterized by vibrational spectroscopy in the infrared and elemental analysis. The structures of the complexes were determined unambiguously by single crystal X-ray diffraction. Finally, the antimicrobial and anti-inflammatory activities of the compounds were tested showing promising results for the complex trans-bis(2,2'- hydroxybenzophenonate-O,O')copper (II), which has potential anti-inflammatory and anti-microbial.O estudo de complexos metálicos para fins terapêuticos vem crescendo continuamente nos últimos anos, devido à elucidação de seus mecanismos de ação no organismo humano e interação com biomoléculas. O avanço nas técnicas de caracterização de compostos e modelagem molecular tem proporcionado de forma significativa o aumento de pesquisas relacionadas a este assunto. Esse trabalho teve como objetivo a síntese e a caracterização de novos complexos de cobre (II), níquel (II) e paládio (II), tendo como ligantes hidroxibenzofenonas e a avaliação de suas atividades anti-inflamatória, anti-tumoral e antimicrobiana. A primeira estratégia do projeto foi o planejamento de síntese dos complexos, partindo de duas hidroxibenzofenonas sintéticas (ligantes), a 2-hidroxibenzofenona e a 2,2´-di-hidroxibenzofenona, e três metais, cobre (II), níquel (II) e paládio (II). Os produtos das reações foram caracterizados por espectroscopia vibracional na região do infravermelho e análise elementar. As estruturas dos complexos foram inambiguamente determinadas por meio de difração de raios X de monocristal. Finalmente, a atividade anti-microbiana e anti-inflamatória dos complexos foram testadas mostrando resultados promissores para o complexo trans-bis-(2,2’-hidroxibenzofenonato-O,O’)cobre(II), o qual possui elevado potencial anti-inflamatório anti-microbiano.Coordenação de Aperfeiçoamento de Pessoal de Nível Superior - CAPESapplication/pdfporUniversidade Federal de AlfenasPrograma de Pós-Graduação em QuímicaUNIFAL-MGBrasilInstituto de Químicainfo:eu-repo/semantics/openAccesshttp://creativecommons.org/licenses/by-nc-nd/4.0/PaládioCobreNíquelDifração de Raios XQUIMICA::FISICO-QUIMICASíntese, cristaloquímica e atividade biológica de complexos de paládio (II), cobre (II) e níquel (II) com benzofenonas hidroxiladasinfo:eu-repo/semantics/masterThesisinfo:eu-repo/semantics/publishedVersion1328253078826782306600600600-67940694632270714842075167498588264571reponame:Repositório Institucional da Universidade Federal de Alfenas - RiUnifalinstname:Universidade Federal de Alfenas (UNIFAL)instacron:UNIFALRosa, Iara Maria LandreLICENSElicense.txtlicense.txttext/plain; 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dc.title.pt-BR.fl_str_mv Síntese, cristaloquímica e atividade biológica de complexos de paládio (II), cobre (II) e níquel (II) com benzofenonas hidroxiladas
title Síntese, cristaloquímica e atividade biológica de complexos de paládio (II), cobre (II) e níquel (II) com benzofenonas hidroxiladas
spellingShingle Síntese, cristaloquímica e atividade biológica de complexos de paládio (II), cobre (II) e níquel (II) com benzofenonas hidroxiladas
Rosa, Iara Maria Landre
Paládio
Cobre
Níquel
Difração de Raios X
QUIMICA::FISICO-QUIMICA
title_short Síntese, cristaloquímica e atividade biológica de complexos de paládio (II), cobre (II) e níquel (II) com benzofenonas hidroxiladas
title_full Síntese, cristaloquímica e atividade biológica de complexos de paládio (II), cobre (II) e níquel (II) com benzofenonas hidroxiladas
title_fullStr Síntese, cristaloquímica e atividade biológica de complexos de paládio (II), cobre (II) e níquel (II) com benzofenonas hidroxiladas
title_full_unstemmed Síntese, cristaloquímica e atividade biológica de complexos de paládio (II), cobre (II) e níquel (II) com benzofenonas hidroxiladas
title_sort Síntese, cristaloquímica e atividade biológica de complexos de paládio (II), cobre (II) e níquel (II) com benzofenonas hidroxiladas
author Rosa, Iara Maria Landre
author_facet Rosa, Iara Maria Landre
author_role author
dc.contributor.author.fl_str_mv Rosa, Iara Maria Landre
dc.contributor.advisor1Lattes.fl_str_mv http://lattes.cnpq.br/2484520844365957
dc.contributor.referee1.fl_str_mv Almeida, Eduardo Tonon De
dc.contributor.referee2.fl_str_mv Pinheiro, Carlos Basílio
dc.contributor.advisor1.fl_str_mv Doriguetto, Antônio Carlos
dc.contributor.authorLattes.fl_str_mv http://lattes.cnpq.br/2484520844365957
contributor_str_mv Almeida, Eduardo Tonon De
Pinheiro, Carlos Basílio
Doriguetto, Antônio Carlos
dc.subject.por.fl_str_mv Paládio
Cobre
Níquel
Difração de Raios X
topic Paládio
Cobre
Níquel
Difração de Raios X
QUIMICA::FISICO-QUIMICA
dc.subject.cnpq.fl_str_mv QUIMICA::FISICO-QUIMICA
description The study of metallic complexes for therapeutic purposes has been growing steadily in recent years due to the elucidation of their mechanisms of human body action and interaction with biomolecules. Several advances in compounds characterization techniques and molecular modeling have provided a significant increase of research related to this subject. This work aimed to the synthesis and characterization of new complexes of copper (II), nickel (II) and palladium (II) with the ligands hydroxybenzophenone, and the evaluation of their anti-inflammatory, antimicrobial and anti-tumor activities. The first step was the synthesis of complex planning, starting from two synthetic hydroxybenzophenone (ligands), the 2-hydroxybenzophenone and 2,2 '-dihydroxybenzophenone, and three metals, copper (II), nickel (II) and palladium (II). The products of the reactions were characterized by vibrational spectroscopy in the infrared and elemental analysis. The structures of the complexes were determined unambiguously by single crystal X-ray diffraction. Finally, the antimicrobial and anti-inflammatory activities of the compounds were tested showing promising results for the complex trans-bis(2,2'- hydroxybenzophenonate-O,O')copper (II), which has potential anti-inflammatory and anti-microbial.
publishDate 2012
dc.date.issued.fl_str_mv 2012-02-14
dc.date.accessioned.fl_str_mv 2015-06-16T19:55:05Z
dc.type.driver.fl_str_mv info:eu-repo/semantics/masterThesis
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
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dc.identifier.citation.fl_str_mv ROSA, Iara Maria Landre. Síntese, cristaloquímica e atividade biológica de complexos de paládio (II), cobre (II) e níquel (II) com benzofenonas hidroxiladas. 2012. 118 f. Dissertação (Metrado em Química) - Universidade Federal de Alfenas, Alfenas, MG, 2012.
dc.identifier.uri.fl_str_mv https://repositorio.unifal-mg.edu.br/handle/123456789/401
identifier_str_mv ROSA, Iara Maria Landre. Síntese, cristaloquímica e atividade biológica de complexos de paládio (II), cobre (II) e níquel (II) com benzofenonas hidroxiladas. 2012. 118 f. Dissertação (Metrado em Química) - Universidade Federal de Alfenas, Alfenas, MG, 2012.
url https://repositorio.unifal-mg.edu.br/handle/123456789/401
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