Associação entre a qualidade de vida e polimorfismos do gene do estrógeno em pacientes com deformidade dentofacial
Ano de defesa: | 2019 |
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Autor(a) principal: | |
Orientador(a): | |
Banca de defesa: | |
Tipo de documento: | Dissertação |
Tipo de acesso: | Acesso aberto |
Idioma: | por |
Instituição de defesa: |
Universidade Positivo
Brasil Pós-Graduação Programa de Pós-Graduação em Odontologia Clínica UP |
Programa de Pós-Graduação: |
Não Informado pela instituição
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Departamento: |
Não Informado pela instituição
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País: |
Não Informado pela instituição
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Palavras-chave em Português: | |
Link de acesso: | https://repositorio.cruzeirodosul.edu.br/handle/123456789/2238 |
Resumo: | Introduction: Qualified quality of life in oral health is the absence of negative impacts of oral conditions on social life and positive feeling of self-confidence. Dentofacial deformity (DDF) is known to alter the perception of QOL of individuals. The estrogen transport genes (ESR1 and ESR2) may be associated with these perceptions and their variations may have a negative impact on quality of life oral health, causing severe functional and psychosocial problems. Objective: To evaluate an association between QOL and oral health and estrogen transport gene polymorphisms in patients with DDF. Materials and methods: The study included 234 adult male and female patients with FDD who underwent orthognathic surgery. To assess the perception of QOL, the oral health used was the Oral Health Impact Profile (OHIP-14); gender, age and facial profile were also applied. In addition, oral mucosa cells were collected for DNA extraction. The estrogen transport genes ESR1 (rs2234693, rs9340799) and ESR2 (rs1256049 and rs4986938) were genotyped by real time PCR technique. The results were submitted to statistical analysis, with a significance level of 0.05. Results: It was observed that age was associated with the perception of QOL. Patients older than 28 years have a worse perception of QOL with overall oral health (p = 0.003). The association between OHIP-14 and sex shown as women with DDF has a worse perception of overall QOL when compared to men (p <0.001). In the analysis between the perception of QoL and the results shown by the DDF, it was observed that Profile II had a worse perception of QoL in the domain of social disability, compared with profile III (p = 0.030). There was an association between the rs9340799 polymorphism and a perception of quality of life in the domain of functional limitation and social disadvantage. Conclusion: Age, sex, facial profile and rs9340799 polymorphism alter the QOL of patients with DDF. Patients over 28 years of age have a worse perception of QOL related to oral health. Women with DDF have a worse perception of QOL. Facial profile II individuals had a worse perception of QOL compared to profile III individuals. |
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Associação entre a qualidade de vida e polimorfismos do gene do estrógeno em pacientes com deformidade dentofacialOdontologiaArcada Osseodentária - AnormalidadesEstrógenosQualidade de vidaCNPQ::CIENCIAS DA SAUDE::ODONTOLOGIAIntroduction: Qualified quality of life in oral health is the absence of negative impacts of oral conditions on social life and positive feeling of self-confidence. Dentofacial deformity (DDF) is known to alter the perception of QOL of individuals. The estrogen transport genes (ESR1 and ESR2) may be associated with these perceptions and their variations may have a negative impact on quality of life oral health, causing severe functional and psychosocial problems. Objective: To evaluate an association between QOL and oral health and estrogen transport gene polymorphisms in patients with DDF. Materials and methods: The study included 234 adult male and female patients with FDD who underwent orthognathic surgery. To assess the perception of QOL, the oral health used was the Oral Health Impact Profile (OHIP-14); gender, age and facial profile were also applied. In addition, oral mucosa cells were collected for DNA extraction. The estrogen transport genes ESR1 (rs2234693, rs9340799) and ESR2 (rs1256049 and rs4986938) were genotyped by real time PCR technique. The results were submitted to statistical analysis, with a significance level of 0.05. Results: It was observed that age was associated with the perception of QOL. Patients older than 28 years have a worse perception of QOL with overall oral health (p = 0.003). The association between OHIP-14 and sex shown as women with DDF has a worse perception of overall QOL when compared to men (p <0.001). In the analysis between the perception of QoL and the results shown by the DDF, it was observed that Profile II had a worse perception of QoL in the domain of social disability, compared with profile III (p = 0.030). There was an association between the rs9340799 polymorphism and a perception of quality of life in the domain of functional limitation and social disadvantage. Conclusion: Age, sex, facial profile and rs9340799 polymorphism alter the QOL of patients with DDF. Patients over 28 years of age have a worse perception of QOL related to oral health. Women with DDF have a worse perception of QOL. Facial profile II individuals had a worse perception of QOL compared to profile III individuals.Introdução:Qualidade de vida relacionada a saúde bucal é a ausência de impactos negativos das condições bucais na vida social e sentimento positivo de autoconfiança.Sabe-se que a deformidade dentofacial (DDF) altera a perceção da QV dos indivíduos. Os genes de transporte do estrógeno(ESR1 e ESR2) podem estar associados a essas percepções e, suas variações, podem ter um impacto negativo sobre a QV relacionada a saúde bucal dos indivíduos, causando problemas funcionais e psicossociais graves. Objetivo: Avaliar a associação entre QV relacionada a saúde bucal e polimorfismos nos genes de transporte do estrógeno em pacientes com DDF. Materiais e métodos: Foram incluídos nesse estudo 234 pacientes adultos, de ambos os sexos, com DDF e que foram submetidos à cirurgia ortognática. Para avaliação da percepção da QV relacionada a saúde bucal foi utilizado o Oral Health Impact Profile (OHIP14), também foram avaliados o sexo, a idade e o perfil facial. Além disso foi realizada coleta de células da mucosa bucal para extração do DNA. Os genes de transporte do estrógeno ESR1 (rs2234693, rs9340799) e ESR2 (rs1256049 e rs4986938) foram genotipados, por técnica de PCR em tempo real. Os resultados obtidos foram submetidos à análise estatística, com nível de significância de 0,05. Resultados: Foi possível observar que a idade foi associada à percepção de QV. Os pacientes com mais de 28 anos possuem uma pior percepção de QV relacionada à saúde bucal em geral (p = 0,003). A associação entre o OHIP-14 com sexo mostrou que as mulheres com DDF possuem uma pior percepção de QV geral quando comparado com os homens (p < 0,001). Na análise entre a percepção de QV e os perfis faciais dos indivíduos com DDF, foi observado que os indivíduos Perfil II tiveram uma pior percepção de QV no domínio de incapacidade social, comparado com os indivíduos Perfil III (p = 0,030). Houve associação entre o polimorfismo rs9340799 e a percepção de qualidade de vida nos domínio de limitação funcional e desvantagem social. Conclusão: A idade, o sexo, o perfil facial e o polimorfismo rs9340799 alteram a QV dos pacientes com DDF. Os pacientes com mais de 28 anos, possuem uma pior percepção da QV relacionada a saúde bucal. As mulheres com DDF possuem pior percepção da QV. Os indivíduos de perfil facial II, tiveram uma pior percepção de QV comparado com os indivíduos perfil III.Universidade PositivoBrasilPós-GraduaçãoPrograma de Pós-Graduação em Odontologia ClínicaUPScariot, Rafaelahttp://lattes.cnpq.br/8726711027143249Machado, Nilza Cristina da Silva2021-05-24T20:47:18Z20192021-05-24T20:47:18Z2019info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/masterThesisapplication/pdfhttps://repositorio.cruzeirodosul.edu.br/handle/123456789/2238porinfo:eu-repo/semantics/openAccessreponame:Repositório do Centro Universitário Braz Cubasinstname:Centro Universitário Braz Cubas (CUB)instacron:CUB2021-08-04T12:38:25Zoai:repositorio.cruzeirodosul.edu.br:123456789/2238Repositório InstitucionalPUBhttps://repositorio.brazcubas.edu.br/oai/requestbibli@brazcubas.edu.bropendoar:2021-08-04T12:38:25Repositório do Centro Universitário Braz Cubas - Centro Universitário Braz Cubas (CUB)false |
dc.title.none.fl_str_mv |
Associação entre a qualidade de vida e polimorfismos do gene do estrógeno em pacientes com deformidade dentofacial |
title |
Associação entre a qualidade de vida e polimorfismos do gene do estrógeno em pacientes com deformidade dentofacial |
spellingShingle |
Associação entre a qualidade de vida e polimorfismos do gene do estrógeno em pacientes com deformidade dentofacial Machado, Nilza Cristina da Silva Odontologia Arcada Osseodentária - Anormalidades Estrógenos Qualidade de vida CNPQ::CIENCIAS DA SAUDE::ODONTOLOGIA |
title_short |
Associação entre a qualidade de vida e polimorfismos do gene do estrógeno em pacientes com deformidade dentofacial |
title_full |
Associação entre a qualidade de vida e polimorfismos do gene do estrógeno em pacientes com deformidade dentofacial |
title_fullStr |
Associação entre a qualidade de vida e polimorfismos do gene do estrógeno em pacientes com deformidade dentofacial |
title_full_unstemmed |
Associação entre a qualidade de vida e polimorfismos do gene do estrógeno em pacientes com deformidade dentofacial |
title_sort |
Associação entre a qualidade de vida e polimorfismos do gene do estrógeno em pacientes com deformidade dentofacial |
author |
Machado, Nilza Cristina da Silva |
author_facet |
Machado, Nilza Cristina da Silva |
author_role |
author |
dc.contributor.none.fl_str_mv |
Scariot, Rafaela http://lattes.cnpq.br/8726711027143249 |
dc.contributor.author.fl_str_mv |
Machado, Nilza Cristina da Silva |
dc.subject.por.fl_str_mv |
Odontologia Arcada Osseodentária - Anormalidades Estrógenos Qualidade de vida CNPQ::CIENCIAS DA SAUDE::ODONTOLOGIA |
topic |
Odontologia Arcada Osseodentária - Anormalidades Estrógenos Qualidade de vida CNPQ::CIENCIAS DA SAUDE::ODONTOLOGIA |
description |
Introduction: Qualified quality of life in oral health is the absence of negative impacts of oral conditions on social life and positive feeling of self-confidence. Dentofacial deformity (DDF) is known to alter the perception of QOL of individuals. The estrogen transport genes (ESR1 and ESR2) may be associated with these perceptions and their variations may have a negative impact on quality of life oral health, causing severe functional and psychosocial problems. Objective: To evaluate an association between QOL and oral health and estrogen transport gene polymorphisms in patients with DDF. Materials and methods: The study included 234 adult male and female patients with FDD who underwent orthognathic surgery. To assess the perception of QOL, the oral health used was the Oral Health Impact Profile (OHIP-14); gender, age and facial profile were also applied. In addition, oral mucosa cells were collected for DNA extraction. The estrogen transport genes ESR1 (rs2234693, rs9340799) and ESR2 (rs1256049 and rs4986938) were genotyped by real time PCR technique. The results were submitted to statistical analysis, with a significance level of 0.05. Results: It was observed that age was associated with the perception of QOL. Patients older than 28 years have a worse perception of QOL with overall oral health (p = 0.003). The association between OHIP-14 and sex shown as women with DDF has a worse perception of overall QOL when compared to men (p <0.001). In the analysis between the perception of QoL and the results shown by the DDF, it was observed that Profile II had a worse perception of QoL in the domain of social disability, compared with profile III (p = 0.030). There was an association between the rs9340799 polymorphism and a perception of quality of life in the domain of functional limitation and social disadvantage. Conclusion: Age, sex, facial profile and rs9340799 polymorphism alter the QOL of patients with DDF. Patients over 28 years of age have a worse perception of QOL related to oral health. Women with DDF have a worse perception of QOL. Facial profile II individuals had a worse perception of QOL compared to profile III individuals. |
publishDate |
2019 |
dc.date.none.fl_str_mv |
2019 2019 2021-05-24T20:47:18Z 2021-05-24T20:47:18Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/masterThesis |
format |
masterThesis |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
https://repositorio.cruzeirodosul.edu.br/handle/123456789/2238 |
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https://repositorio.cruzeirodosul.edu.br/handle/123456789/2238 |
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por |
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por |
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info:eu-repo/semantics/openAccess |
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openAccess |
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application/pdf |
dc.publisher.none.fl_str_mv |
Universidade Positivo Brasil Pós-Graduação Programa de Pós-Graduação em Odontologia Clínica UP |
publisher.none.fl_str_mv |
Universidade Positivo Brasil Pós-Graduação Programa de Pós-Graduação em Odontologia Clínica UP |
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reponame:Repositório do Centro Universitário Braz Cubas instname:Centro Universitário Braz Cubas (CUB) instacron:CUB |
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Centro Universitário Braz Cubas (CUB) |
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CUB |
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CUB |
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Repositório do Centro Universitário Braz Cubas |
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Repositório do Centro Universitário Braz Cubas |
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Repositório do Centro Universitário Braz Cubas - Centro Universitário Braz Cubas (CUB) |
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bibli@brazcubas.edu.br |
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