An??lise do efeito da laserterapia de baixa intensidade na nocicep????o, express??o de mediadores inflamat??rios, neutr??filos e macr??fagos na fase aguda de artrite reumat??ide experimental em ratos
Ano de defesa: | 2016 |
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Autor(a) principal: | |
Orientador(a): | |
Banca de defesa: | , , , , |
Tipo de documento: | Tese |
Tipo de acesso: | Acesso aberto |
Idioma: | por |
Instituição de defesa: |
Universidade Nove de Julho
|
Programa de Pós-Graduação: |
Programa de P??s-Gradua????o em Ci??ncias da Reabilita????o
|
Departamento: |
Sa??de
|
País: |
Brasil
|
Palavras-chave em Português: | |
Palavras-chave em Inglês: | |
Área do conhecimento CNPq: | |
Link de acesso: | http://bibliotecatede.uninove.br/handle/tede/1821 |
Resumo: | Rheumatoid Arthritis (RA) treatment in the last decades has evolved medications with cytokine inhibitors, which though they are today considered the gold standard in RA treatment, still do not guarantee complete remission from the disease or from hyperalgesia, and it is know that the Photobiostimulation (PBM) is also capable of acting on the expression of pro-inflammatory cytokines, being in this way an alternative treatment for RA. This research had as its objective the analysis and comparison of the effects of PBM in the acute phase of experimental RA in terms of nociception, of the number of inflammatory cells (neutrophils, macrophages, lymphocytes), and of the protein expression of inflammatory mediators (TNF-??, IL-6, IL-10), in the lavage and joint cartilage of rats. 49 male Wistar rats were used, with an approximate age of 90 days and a body weight varying from 250 to 300g. The animals were randomly distributed in 3 groups, with 21 animals in each experimental group (Rheumatoid arthritis group ??? RA) and the group treated with PBM (RA-LLLT), and with 7 animals in the control group. Each group was arrranged in three distinct experimental periods according to the time of euthanasia (6 hours, 24 hours, and 48 hours). For the reproduction of the lesion the animals were submitted to two inductions: the first consisted in a subcutaneous infiltration in the dorsal of each animal (in the RA and RA-LLLT groups) using 500 ??g of mBSA diluted in a solution of 100 ??L of complete Adjuvant de Freund (CFA), and 100 ??L of PBS, with this procedure being repeated weekly for 21 days. On the 28th day, an intrajoint induction was carried out with 10 ??g of mBSA diluted in 10??L of PBS, in the joint space of the right hind paw of each animal. After the joint induction, the treatment on the RA-LLLT group began, using a DMC?? brand Photon Laser III, with a wave length of ?? 808 nm, active medium of Gallium Arsenide, and Aluminium (AsGaAI), with a potency of 50 mW (potency density of 1,78 W/cm2) and area of the beam 0,028cm2. The final dose was of 2J, the density of energy of 71,2 J/cm2, and time of 40s by point. At the end of each test period (6 hours, 24 hours, and 48 hours) the animals were submitted to an evaluation of their nociception, followed by the extraction of joint lavage and joint cartilage, which were sent for analysis of the total count and differential cells, and for protein expression of the inflammatory mediators described. The results demonstrate biomodulation in the expression of neutrophils and macrophages amongst the control group and RA, as well as in the cytokines IL-6 and IL-10, contributing daily to the attenuation of hyperalgesia by the PBM. |
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Carvalho, Paulo de Tarso Camillo deCarvalho, Paulo de Tarso Camillo deSerra, Andrey JorgeLeal Junior, Ernesto Cesar PintoBocalini, Rodrigo Leal de PaivaCarvalho, Rodrigo Leal de Paivahttp://lattes.cnpq.br/3219918840040902Alves, Ana Carolina Araruna2018-06-21T15:40:31Z2016-03-29Alves, Ana Carolina Araruna. An??lise do efeito da laserterapia de baixa intensidade na nocicep????o, express??o de mediadores inflamat??rios, neutr??filos e macr??fagos na fase aguda de artrite reumat??ide experimental em ratos. 2016. 85 f. Tese( Programa de P??s-Gradua????o em Ci??ncias da Reabilita????o) - Universidade Nove de Julho, S??o Paulo.http://bibliotecatede.uninove.br/handle/tede/1821Rheumatoid Arthritis (RA) treatment in the last decades has evolved medications with cytokine inhibitors, which though they are today considered the gold standard in RA treatment, still do not guarantee complete remission from the disease or from hyperalgesia, and it is know that the Photobiostimulation (PBM) is also capable of acting on the expression of pro-inflammatory cytokines, being in this way an alternative treatment for RA. This research had as its objective the analysis and comparison of the effects of PBM in the acute phase of experimental RA in terms of nociception, of the number of inflammatory cells (neutrophils, macrophages, lymphocytes), and of the protein expression of inflammatory mediators (TNF-??, IL-6, IL-10), in the lavage and joint cartilage of rats. 49 male Wistar rats were used, with an approximate age of 90 days and a body weight varying from 250 to 300g. The animals were randomly distributed in 3 groups, with 21 animals in each experimental group (Rheumatoid arthritis group ??? RA) and the group treated with PBM (RA-LLLT), and with 7 animals in the control group. Each group was arrranged in three distinct experimental periods according to the time of euthanasia (6 hours, 24 hours, and 48 hours). For the reproduction of the lesion the animals were submitted to two inductions: the first consisted in a subcutaneous infiltration in the dorsal of each animal (in the RA and RA-LLLT groups) using 500 ??g of mBSA diluted in a solution of 100 ??L of complete Adjuvant de Freund (CFA), and 100 ??L of PBS, with this procedure being repeated weekly for 21 days. On the 28th day, an intrajoint induction was carried out with 10 ??g of mBSA diluted in 10??L of PBS, in the joint space of the right hind paw of each animal. After the joint induction, the treatment on the RA-LLLT group began, using a DMC?? brand Photon Laser III, with a wave length of ?? 808 nm, active medium of Gallium Arsenide, and Aluminium (AsGaAI), with a potency of 50 mW (potency density of 1,78 W/cm2) and area of the beam 0,028cm2. The final dose was of 2J, the density of energy of 71,2 J/cm2, and time of 40s by point. At the end of each test period (6 hours, 24 hours, and 48 hours) the animals were submitted to an evaluation of their nociception, followed by the extraction of joint lavage and joint cartilage, which were sent for analysis of the total count and differential cells, and for protein expression of the inflammatory mediators described. The results demonstrate biomodulation in the expression of neutrophils and macrophages amongst the control group and RA, as well as in the cytokines IL-6 and IL-10, contributing daily to the attenuation of hyperalgesia by the PBM.O tratamento para Artrite Reumatoide (AR) com inibidores de citocinas tem sido considerado padr??o-ouro nas ??ltimas d??cadas embora ainda n??o garantam a remiss??o completa da doen??a ou da hiperalgesia, sabe-se que a Laserterapia de Baixa Intensidade (LBI) tamb??m ?? capaz de atuar na express??o das citocinas pr??-inflamat??rias, podendo ser assim, uma alternativa de tratamento para a AR. Este trabalho teve como objetivo analisar os efeitos da LBI na fase aguda de AR experimental sobre a nocicep????o, sobre o n??mero de c??lulas inflamat??rias (neutr??filos, macr??fagos, e linf??citos), e sobre a express??o proteica de mediadores inflamat??rios (TNF-??, IL-6, IL-10) no lavado e cartilagem articular de ratos. Foram utilizados 49 ratos Wistar, machos, com idade aproximada de 90 dias e peso corporal variando de 250 a 300 g. Os animais foram distribu??dos aleatoriamente em 3 grupos, com 21 animais em cada grupo experimental (grupo Artrite Reumatoide - RA e o grupo tratado com laser AR-LBI), e 7 animais no grupo controle. Cada grupo foi composto por 3 tempos experimentais distintos de acordo com o tempo da eutan??sia (6 horas, 24 horas e 48 horas). Para a reprodu????o da les??o os animais foram submetidos a duas indu????es: a primeira consistiu em uma infiltra????o subcut??nea no dorso de cada animal (nos grupos AR e AR-LBI) utilizando-se 500 ??g de mBSA dilu??do em uma solu????o de 100 ??L de Adjuvante completo de Freund (CFA), e 100??L de PBS, esse procedimento foi repetido semanalmente por 21 dias. No 28?? dia, foi realizada uma indu????o intra-articular com 10 ??g de mBSA dilu??do em 10??L PBS, no espa??o articular da pata direita traseira de cada animal. Ap??s a indu????o articular, deu-se in??cio ao tratamento no grupo AR-LBI, por meio do laser da marca DMC?? modelo Photon Laser III, com comprimento de onda de ?? 808 nm, meio ativo de Arsenieto de G??lio e Alum??nio (AsGaAI), com pot??ncia de 50 mW (densidade de pot??ncia de 1,78 W/cm2), ??rea do feixe de 0,028cm2 e aplica????o sob a forma de dois pontos pelo m??todo transcut??neo nos compartimentos medial e lateral da articula????o, dose final foi de 2J, densidade de energia de 71,2 J/cm2, e tempo 40s, por ponto. Ao final de cada per??odo experimental (6 horas, 24 horas e 48 horas) os animais foram submetidos ?? avalia????o da nocicep????o, seguido de extra????o do lavado articular e da cartilagem articular, que foram encaminhados ??s an??lises de contagem total e diferencial de c??lulas, e da express??o proteica dos mediadores inflamat??rios descritos. Os resultados demonstram biomodula????o da LBI principalmente na express??o de neutr??filos e macr??fagos entre os grupos controle e AR, bem como nas citocinas IL-6 e IL-10, contribuindo diretamente para a atenua????o da hiperalgesia.Submitted by Nadir Basilio (nadirsb@uninove.br) on 2018-06-21T15:40:31Z No. of bitstreams: 1 Ana Carolina Araruna Alves.pdf: 1155545 bytes, checksum: 5e9fda24285778105d5ac0d8276f9036 (MD5)Made available in DSpace on 2018-06-21T15:40:31Z (GMT). No. of bitstreams: 1 Ana Carolina Araruna Alves.pdf: 1155545 bytes, checksum: 5e9fda24285778105d5ac0d8276f9036 (MD5) Previous issue date: 2016-03-29application/pdfporUniversidade Nove de JulhoPrograma de P??s-Gradua????o em Ci??ncias da Reabilita????oUNINOVEBrasilSa??deartrite reumatoidelaser de baixa intensidadehiperalgesiacitocinasrheumatoid arthritislow intensity laserhyperalgesiacytokinesCIENCIAS DA SAUDEAn??lise do efeito da laserterapia de baixa intensidade na nocicep????o, express??o de mediadores inflamat??rios, neutr??filos e macr??fagos na fase aguda de artrite reumat??ide experimental em ratosAnalysis of lasertherapy effects on nociception,inflammatory mediators expression, neutrophils and macrophages on acute phasys of experimental rheumatoid arthritis in ratsinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/doctoralThesis8765449414823306929600info:eu-repo/semantics/openAccessreponame:Biblioteca Digital de Teses e Dissertações da Uninoveinstname:Universidade Nove de Julho (UNINOVE)instacron:UNINOVEORIGINALAna Carolina Araruna Alves.pdfAna Carolina Araruna Alves.pdfapplication/pdf1155545http://localhost:8080/tede/bitstream/tede/1821/2/Ana+Carolina+Araruna+Alves.pdf5e9fda24285778105d5ac0d8276f9036MD52LICENSElicense.txtlicense.txttext/plain; charset=utf-82165http://localhost:8080/tede/bitstream/tede/1821/1/license.txtbd3efa91386c1718a7f26a329fdcb468MD51tede/18212018-06-21 12:40:31.538oai:localhost: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Biblioteca Digital de Teses e Dissertaçõeshttp://bibliotecatede.uninove.br/PRIhttp://bibliotecatede.uninove.br/oai/requestbibliotecatede@uninove.br||bibliotecatede@uninove.bropendoar:2018-06-21T15:40:31Biblioteca Digital de Teses e Dissertações da Uninove - Universidade Nove de Julho (UNINOVE)false |
dc.title.por.fl_str_mv |
An??lise do efeito da laserterapia de baixa intensidade na nocicep????o, express??o de mediadores inflamat??rios, neutr??filos e macr??fagos na fase aguda de artrite reumat??ide experimental em ratos |
dc.title.alternative.eng.fl_str_mv |
Analysis of lasertherapy effects on nociception,inflammatory mediators expression, neutrophils and macrophages on acute phasys of experimental rheumatoid arthritis in rats |
title |
An??lise do efeito da laserterapia de baixa intensidade na nocicep????o, express??o de mediadores inflamat??rios, neutr??filos e macr??fagos na fase aguda de artrite reumat??ide experimental em ratos |
spellingShingle |
An??lise do efeito da laserterapia de baixa intensidade na nocicep????o, express??o de mediadores inflamat??rios, neutr??filos e macr??fagos na fase aguda de artrite reumat??ide experimental em ratos Alves, Ana Carolina Araruna artrite reumatoide laser de baixa intensidade hiperalgesia citocinas rheumatoid arthritis low intensity laser hyperalgesia cytokines CIENCIAS DA SAUDE |
title_short |
An??lise do efeito da laserterapia de baixa intensidade na nocicep????o, express??o de mediadores inflamat??rios, neutr??filos e macr??fagos na fase aguda de artrite reumat??ide experimental em ratos |
title_full |
An??lise do efeito da laserterapia de baixa intensidade na nocicep????o, express??o de mediadores inflamat??rios, neutr??filos e macr??fagos na fase aguda de artrite reumat??ide experimental em ratos |
title_fullStr |
An??lise do efeito da laserterapia de baixa intensidade na nocicep????o, express??o de mediadores inflamat??rios, neutr??filos e macr??fagos na fase aguda de artrite reumat??ide experimental em ratos |
title_full_unstemmed |
An??lise do efeito da laserterapia de baixa intensidade na nocicep????o, express??o de mediadores inflamat??rios, neutr??filos e macr??fagos na fase aguda de artrite reumat??ide experimental em ratos |
title_sort |
An??lise do efeito da laserterapia de baixa intensidade na nocicep????o, express??o de mediadores inflamat??rios, neutr??filos e macr??fagos na fase aguda de artrite reumat??ide experimental em ratos |
author |
Alves, Ana Carolina Araruna |
author_facet |
Alves, Ana Carolina Araruna |
author_role |
author |
dc.contributor.advisor1.fl_str_mv |
Carvalho, Paulo de Tarso Camillo de |
dc.contributor.referee1.fl_str_mv |
Carvalho, Paulo de Tarso Camillo de |
dc.contributor.referee2.fl_str_mv |
Serra, Andrey Jorge |
dc.contributor.referee3.fl_str_mv |
Leal Junior, Ernesto Cesar Pinto |
dc.contributor.referee4.fl_str_mv |
Bocalini, Rodrigo Leal de Paiva |
dc.contributor.referee5.fl_str_mv |
Carvalho, Rodrigo Leal de Paiva |
dc.contributor.authorLattes.fl_str_mv |
http://lattes.cnpq.br/3219918840040902 |
dc.contributor.author.fl_str_mv |
Alves, Ana Carolina Araruna |
contributor_str_mv |
Carvalho, Paulo de Tarso Camillo de Carvalho, Paulo de Tarso Camillo de Serra, Andrey Jorge Leal Junior, Ernesto Cesar Pinto Bocalini, Rodrigo Leal de Paiva Carvalho, Rodrigo Leal de Paiva |
dc.subject.por.fl_str_mv |
artrite reumatoide laser de baixa intensidade hiperalgesia citocinas |
topic |
artrite reumatoide laser de baixa intensidade hiperalgesia citocinas rheumatoid arthritis low intensity laser hyperalgesia cytokines CIENCIAS DA SAUDE |
dc.subject.eng.fl_str_mv |
rheumatoid arthritis low intensity laser hyperalgesia cytokines |
dc.subject.cnpq.fl_str_mv |
CIENCIAS DA SAUDE |
description |
Rheumatoid Arthritis (RA) treatment in the last decades has evolved medications with cytokine inhibitors, which though they are today considered the gold standard in RA treatment, still do not guarantee complete remission from the disease or from hyperalgesia, and it is know that the Photobiostimulation (PBM) is also capable of acting on the expression of pro-inflammatory cytokines, being in this way an alternative treatment for RA. This research had as its objective the analysis and comparison of the effects of PBM in the acute phase of experimental RA in terms of nociception, of the number of inflammatory cells (neutrophils, macrophages, lymphocytes), and of the protein expression of inflammatory mediators (TNF-??, IL-6, IL-10), in the lavage and joint cartilage of rats. 49 male Wistar rats were used, with an approximate age of 90 days and a body weight varying from 250 to 300g. The animals were randomly distributed in 3 groups, with 21 animals in each experimental group (Rheumatoid arthritis group ??? RA) and the group treated with PBM (RA-LLLT), and with 7 animals in the control group. Each group was arrranged in three distinct experimental periods according to the time of euthanasia (6 hours, 24 hours, and 48 hours). For the reproduction of the lesion the animals were submitted to two inductions: the first consisted in a subcutaneous infiltration in the dorsal of each animal (in the RA and RA-LLLT groups) using 500 ??g of mBSA diluted in a solution of 100 ??L of complete Adjuvant de Freund (CFA), and 100 ??L of PBS, with this procedure being repeated weekly for 21 days. On the 28th day, an intrajoint induction was carried out with 10 ??g of mBSA diluted in 10??L of PBS, in the joint space of the right hind paw of each animal. After the joint induction, the treatment on the RA-LLLT group began, using a DMC?? brand Photon Laser III, with a wave length of ?? 808 nm, active medium of Gallium Arsenide, and Aluminium (AsGaAI), with a potency of 50 mW (potency density of 1,78 W/cm2) and area of the beam 0,028cm2. The final dose was of 2J, the density of energy of 71,2 J/cm2, and time of 40s by point. At the end of each test period (6 hours, 24 hours, and 48 hours) the animals were submitted to an evaluation of their nociception, followed by the extraction of joint lavage and joint cartilage, which were sent for analysis of the total count and differential cells, and for protein expression of the inflammatory mediators described. The results demonstrate biomodulation in the expression of neutrophils and macrophages amongst the control group and RA, as well as in the cytokines IL-6 and IL-10, contributing daily to the attenuation of hyperalgesia by the PBM. |
publishDate |
2016 |
dc.date.issued.fl_str_mv |
2016-03-29 |
dc.date.accessioned.fl_str_mv |
2018-06-21T15:40:31Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/doctoralThesis |
format |
doctoralThesis |
status_str |
publishedVersion |
dc.identifier.citation.fl_str_mv |
Alves, Ana Carolina Araruna. An??lise do efeito da laserterapia de baixa intensidade na nocicep????o, express??o de mediadores inflamat??rios, neutr??filos e macr??fagos na fase aguda de artrite reumat??ide experimental em ratos. 2016. 85 f. Tese( Programa de P??s-Gradua????o em Ci??ncias da Reabilita????o) - Universidade Nove de Julho, S??o Paulo. |
dc.identifier.uri.fl_str_mv |
http://bibliotecatede.uninove.br/handle/tede/1821 |
identifier_str_mv |
Alves, Ana Carolina Araruna. An??lise do efeito da laserterapia de baixa intensidade na nocicep????o, express??o de mediadores inflamat??rios, neutr??filos e macr??fagos na fase aguda de artrite reumat??ide experimental em ratos. 2016. 85 f. Tese( Programa de P??s-Gradua????o em Ci??ncias da Reabilita????o) - Universidade Nove de Julho, S??o Paulo. |
url |
http://bibliotecatede.uninove.br/handle/tede/1821 |
dc.language.iso.fl_str_mv |
por |
language |
por |
dc.relation.cnpq.fl_str_mv |
8765449414823306929 |
dc.relation.confidence.fl_str_mv |
600 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Universidade Nove de Julho |
dc.publisher.program.fl_str_mv |
Programa de P??s-Gradua????o em Ci??ncias da Reabilita????o |
dc.publisher.initials.fl_str_mv |
UNINOVE |
dc.publisher.country.fl_str_mv |
Brasil |
dc.publisher.department.fl_str_mv |
Sa??de |
publisher.none.fl_str_mv |
Universidade Nove de Julho |
dc.source.none.fl_str_mv |
reponame:Biblioteca Digital de Teses e Dissertações da Uninove instname:Universidade Nove de Julho (UNINOVE) instacron:UNINOVE |
instname_str |
Universidade Nove de Julho (UNINOVE) |
instacron_str |
UNINOVE |
institution |
UNINOVE |
reponame_str |
Biblioteca Digital de Teses e Dissertações da Uninove |
collection |
Biblioteca Digital de Teses e Dissertações da Uninove |
bitstream.url.fl_str_mv |
http://localhost:8080/tede/bitstream/tede/1821/2/Ana+Carolina+Araruna+Alves.pdf http://localhost:8080/tede/bitstream/tede/1821/1/license.txt |
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5e9fda24285778105d5ac0d8276f9036 bd3efa91386c1718a7f26a329fdcb468 |
bitstream.checksumAlgorithm.fl_str_mv |
MD5 MD5 |
repository.name.fl_str_mv |
Biblioteca Digital de Teses e Dissertações da Uninove - Universidade Nove de Julho (UNINOVE) |
repository.mail.fl_str_mv |
bibliotecatede@uninove.br||bibliotecatede@uninove.br |
_version_ |
1797250754859237376 |