Estudo do sono, fun????o pulmonar, for??a muscular ventilat??ria e valida????o de dois instrumentos de evolu????o cl??nica de pacientes com miastenia gravis: Quantitative myasthenia gravis score e MG Composite Scale

• Ano de defesa: 2017
• Autor(a) principal: Oliveira, Ezequiel Fernandes de
• Orientador(a): Oliveira, Claudia Santos
• Banca de defesa: Oliveira, Claudia Santos, Jorge, Luciana Maria Malos?? Sampaio, Palma, Renata Kelly da, Alves, Vera Lucia dos Santos, Nacif, Sergio Roberto
• Tipo de documento: Tese
• Tipo de acesso: Acesso aberto
• Idioma: por
• Instituição de defesa: Universidade Nove de Julho
• Programa de Pós-Graduação: Programa de P??s-Gradua????o em Ci??ncias da Reabilita????o
• Departamento: Sa??de
• País: Brasil
• Palavras-chave em Português: miastenia gravis; sono; fun????o pulmonar; qualidade de vida; valida????o de escalas
• Palavras-chave em Inglês: myasthenia gravis; sleep; pulmonary function; quality of life; validation of scales
• Área do conhecimento CNPq: CIENCIAS DA SAUDE
• Link de acesso: http://bibliotecatede.uninove.br/handle/tede/1903

Introduction: Our hypothesis is that patients with MG present a poor sleep due to the presence of respiratory disorders, compromised by the weakness of the ventilatory muscles, causing worsening of the clinical condition and quality of life. Objectives: To investigate the physiological pattern of sleep through polysomnography, to verify pulmonary function and ventilatory muscle strength through spirometry and manovacuometry, and to perform the translation, cultural adaptation and validation of two specific scales to evaluate the clinical evolution of patients with MG, denominated "Quantitative Test for Myasthenia Gravis" and "Composite Scale for Myasthenia Gravis". Material and methods: This is a cross-sectional study involving patients with MG. Clinical evaluations were performed at the UNINOVE Sleep Laboratory, at the Neuromuscular Diseases Research Unit at UNIFESP, at the Santa Casa de S??o Paulo Department of Neurology and at the Department of Neurology at the Hospital do Servidor P??blico Estadual of S??o Paulo. Results: The results of this thesis are separated into three studies. Study I: article entitled "Sleep, lung function and quality of life in patients with Myasthenia gravis: A cross-sectional study" published in the journal Neuromuscular Disorders. Study II: entitled "Brazilian- Portuguese translation, cross-cultural adaptation and validation of the Myasthenia Gravis Composite scale. A multicentric study." published in the journal Arquivos de Neuropsiquiatria. Study III: entitled "Quantitative Myasthenia gravis Score: a Brazilian multicenter study for translation, cultural adaptation and validation", published in the journal Arquivos de Neuropsiquiatria. Conclusion: Patients with MG presented a considerable presence of DRS with worsening quality of life. They presented reduced values in the maximum ventilatory pressures associated with normal values of pulmonary function. The translation and validation of the scales were performed successfully and we believe that the use of our Portuguese version from Brazil will assist in the care of patients with MG, including a more accurate monitoring of the clinical rehabilitation process.