L??quen escleroso vulvar: fotobiomodula????o e terapia fotodin??mica como alternativas ?? corticoterapia
Ano de defesa: | 2015 |
---|---|
Autor(a) principal: | |
Orientador(a): | |
Banca de defesa: | , , |
Tipo de documento: | Dissertação |
Tipo de acesso: | Acesso aberto |
Idioma: | por |
Instituição de defesa: |
Universidade Nove de Julho
|
Programa de Pós-Graduação: |
Programa de P??s-Gradua????o em Biofot??nica Aplicada ??s Ci??ncias da Sa??de
|
Departamento: |
Sa??de
|
País: |
Brasil
|
Palavras-chave em Português: | |
Palavras-chave em Inglês: | |
Área do conhecimento CNPq: | |
Link de acesso: | http://bibliotecatede.uninove.br/handle/tede/1781 |
Resumo: | Vulvar Lichen Sclerosus (VLS) is a chronic lymphocyte mediated dermatosis with unclear etiopathogenesis and difficult clinical control besides the risk of malignant transformation to squamous cell carcinoma of the vulva. The treatment is based on topical steroids that can cause undesirable side effects, however photonic therapies have been described in autoimmune diseases of the skin which encouraged this study. There were evaluated twenty eight women with histological diagnosis of VLS distributed into three groups: Photodynamic Therapy (PDT), Low Intensity Laser Therapy (LILT) and Topical Steroids and the objective was to compare the clinical effects before and after treatment by measuring pruritus, skin thickness, lesion area and temperature. No significant difference was observed in the intensity of pruritus between the groups. The Steroid therapy group showed significant variation in the longitudinal thickness of the skin in relation to LILT group (p = 0.000) with a reduction of -8.48%, while in LILT increased 24.8% as well as the PDT group with 20.9 %. However the variation of the transverse thickness was not different between the groups. The change in the lesion area showed no difference between groups. The LILT group showed significant temperature increase (3.03%) compared to PDT (-2.29%) and steroid (-1.45%) (p = 0.002) groups. Recurrences were registered in the corticosteroid group in two months, PDT in one and LILT in four months post treatment. The results showed that photonic therapies may be considered as treatment for VLS. |
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Silva, Daniela de F??tima Teixeira daSilva, Daniela de F??tima Teixeira daChavantes, Maria CristinaRibeiro, Martha Sim??eshttp://lattes.cnpq.br/2852522195279294Belotto, Renata Aparecida2018-06-15T14:12:19Z2015-12-14Belotto, Renata Aparecida. L??quen escleroso vulvar: fotobiomodula????o e terapia fotodin??mica como alternativas ?? corticoterapia. 2015. 65 f. Disserta????o( Programa de P??s-Gradua????o em Biofot??nica Aplicada ??s Ci??ncias da Sa??de) - Universidade Nove de Julho, S??o Paulo.http://bibliotecatede.uninove.br/handle/tede/1781Vulvar Lichen Sclerosus (VLS) is a chronic lymphocyte mediated dermatosis with unclear etiopathogenesis and difficult clinical control besides the risk of malignant transformation to squamous cell carcinoma of the vulva. The treatment is based on topical steroids that can cause undesirable side effects, however photonic therapies have been described in autoimmune diseases of the skin which encouraged this study. There were evaluated twenty eight women with histological diagnosis of VLS distributed into three groups: Photodynamic Therapy (PDT), Low Intensity Laser Therapy (LILT) and Topical Steroids and the objective was to compare the clinical effects before and after treatment by measuring pruritus, skin thickness, lesion area and temperature. No significant difference was observed in the intensity of pruritus between the groups. The Steroid therapy group showed significant variation in the longitudinal thickness of the skin in relation to LILT group (p = 0.000) with a reduction of -8.48%, while in LILT increased 24.8% as well as the PDT group with 20.9 %. However the variation of the transverse thickness was not different between the groups. The change in the lesion area showed no difference between groups. The LILT group showed significant temperature increase (3.03%) compared to PDT (-2.29%) and steroid (-1.45%) (p = 0.002) groups. Recurrences were registered in the corticosteroid group in two months, PDT in one and LILT in four months post treatment. The results showed that photonic therapies may be considered as treatment for VLS.O L??quen Escleroso Vulvar (LEV) ?? uma dermatose cr??nica linf??cito mediada com etiopatogenia n??o definida, de dif??cil controle cl??nico al??m de apresentar risco de maligniza????o para o carcinoma escamoso de vulva. O tratamento da doen??a baseia-se no uso de corticosteroides t??picos que podem causar efeitos colaterais indesej??veis, no entanto terapias fot??nicas v??m sendo descritas em processos inflamat??rios autoimunes em pele o que estimulou esse estudo. Foram avaliadas vinte e oito mulheres com diagn??stico histol??gico de LEV que foram distribu??das em tr??s grupos: Terapia Fotodin??mica (TFD), Terapia Laser de baixa intensidade (TLBI) e Corticosteroide t??pico com o objetivo de compara????o dos efeitos cl??nicos pr?? e p??s-tratamento atrav??s da medi????o do prurido, espessura da pele, ??rea da les??o e temperatura. Foi observado que a varia????o da intensidade do prurido entre os grupos n??o demonstrou diferen??a estat??stica significante. O grupo Corticoterapia apresentou varia????o significante na espessura longitudinal da pele em rela????o ao grupo TLBI (p = 0,000) com redu????o de -8,48%, enquanto no TLBI houve aumento de 24,8% e no grupo TFD de 20,9%. No entanto, a varia????o da espessura transversal n??o foi diferente entre os grupos. A varia????o da ??rea da les??o n??o apresentou diferen??a entre os grupos. O grupo TLBI apresentou aumento significante da temperatura (3,03%) em rela????o aos grupos TFD (-2,29%) e Corticoterapia (-1,45%) (p= 0,002). Recorr??ncias foram registradas nos grupos Corticoterapia, em dois meses, TFD, em um m??s e TLBI, em quatro meses. Os resultados favorecem considerar as terapias fot??nicas como possibilidades terap??uticas para o LEV.Submitted by Nadir Basilio (nadirsb@uninove.br) on 2018-06-15T14:12:19Z No. of bitstreams: 1 Renata Aparecida Belotto.pdf: 1572353 bytes, checksum: fbf4acd7b5d75990f32c4e21593fe951 (MD5)Made available in DSpace on 2018-06-15T14:12:19Z (GMT). No. of bitstreams: 1 Renata Aparecida Belotto.pdf: 1572353 bytes, checksum: fbf4acd7b5d75990f32c4e21593fe951 (MD5) Previous issue date: 2015-12-14application/pdfporUniversidade Nove de JulhoPrograma de P??s-Gradua????o em Biofot??nica Aplicada ??s Ci??ncias da Sa??deUNINOVEBrasilSa??dedoen??as da vulvalasersfototerapiacorticosteroidespelevulvar diseaseslasersphototherapyadrenal cortex hormonesskinCIENCIAS DA SAUDEL??quen escleroso vulvar: fotobiomodula????o e terapia fotodin??mica como alternativas ?? corticoterapiaVulvar lichen sclerosus: photobiomodulation and photodynamic therapy as alternatives to topical corticosteroidsinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/masterThesis8765449414823306929600info:eu-repo/semantics/openAccessreponame:Biblioteca Digital de Teses e Dissertações da Uninoveinstname:Universidade Nove de Julho (UNINOVE)instacron:UNINOVEORIGINALRenata Aparecida Belotto.pdfRenata Aparecida Belotto.pdfapplication/pdf1572353http://localhost:8080/tede/bitstream/tede/1781/2/Renata+Aparecida+Belotto.pdffbf4acd7b5d75990f32c4e21593fe951MD52LICENSElicense.txtlicense.txttext/plain; charset=utf-82165http://localhost:8080/tede/bitstream/tede/1781/1/license.txtbd3efa91386c1718a7f26a329fdcb468MD51tede/17812018-06-19 15:54:18.118oai:localhost: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Biblioteca Digital de Teses e Dissertaçõeshttp://bibliotecatede.uninove.br/PRIhttp://bibliotecatede.uninove.br/oai/requestbibliotecatede@uninove.br||bibliotecatede@uninove.bropendoar:2018-06-19T18:54:18Biblioteca Digital de Teses e Dissertações da Uninove - Universidade Nove de Julho (UNINOVE)false |
dc.title.por.fl_str_mv |
L??quen escleroso vulvar: fotobiomodula????o e terapia fotodin??mica como alternativas ?? corticoterapia |
dc.title.alternative.eng.fl_str_mv |
Vulvar lichen sclerosus: photobiomodulation and photodynamic therapy as alternatives to topical corticosteroids |
title |
L??quen escleroso vulvar: fotobiomodula????o e terapia fotodin??mica como alternativas ?? corticoterapia |
spellingShingle |
L??quen escleroso vulvar: fotobiomodula????o e terapia fotodin??mica como alternativas ?? corticoterapia Belotto, Renata Aparecida doen??as da vulva lasers fototerapia corticosteroides pele vulvar diseases lasers phototherapy adrenal cortex hormones skin CIENCIAS DA SAUDE |
title_short |
L??quen escleroso vulvar: fotobiomodula????o e terapia fotodin??mica como alternativas ?? corticoterapia |
title_full |
L??quen escleroso vulvar: fotobiomodula????o e terapia fotodin??mica como alternativas ?? corticoterapia |
title_fullStr |
L??quen escleroso vulvar: fotobiomodula????o e terapia fotodin??mica como alternativas ?? corticoterapia |
title_full_unstemmed |
L??quen escleroso vulvar: fotobiomodula????o e terapia fotodin??mica como alternativas ?? corticoterapia |
title_sort |
L??quen escleroso vulvar: fotobiomodula????o e terapia fotodin??mica como alternativas ?? corticoterapia |
author |
Belotto, Renata Aparecida |
author_facet |
Belotto, Renata Aparecida |
author_role |
author |
dc.contributor.advisor1.fl_str_mv |
Silva, Daniela de F??tima Teixeira da |
dc.contributor.referee1.fl_str_mv |
Silva, Daniela de F??tima Teixeira da |
dc.contributor.referee2.fl_str_mv |
Chavantes, Maria Cristina |
dc.contributor.referee3.fl_str_mv |
Ribeiro, Martha Sim??es |
dc.contributor.authorLattes.fl_str_mv |
http://lattes.cnpq.br/2852522195279294 |
dc.contributor.author.fl_str_mv |
Belotto, Renata Aparecida |
contributor_str_mv |
Silva, Daniela de F??tima Teixeira da Silva, Daniela de F??tima Teixeira da Chavantes, Maria Cristina Ribeiro, Martha Sim??es |
dc.subject.por.fl_str_mv |
doen??as da vulva lasers fototerapia corticosteroides pele |
topic |
doen??as da vulva lasers fototerapia corticosteroides pele vulvar diseases lasers phototherapy adrenal cortex hormones skin CIENCIAS DA SAUDE |
dc.subject.eng.fl_str_mv |
vulvar diseases lasers phototherapy adrenal cortex hormones skin |
dc.subject.cnpq.fl_str_mv |
CIENCIAS DA SAUDE |
description |
Vulvar Lichen Sclerosus (VLS) is a chronic lymphocyte mediated dermatosis with unclear etiopathogenesis and difficult clinical control besides the risk of malignant transformation to squamous cell carcinoma of the vulva. The treatment is based on topical steroids that can cause undesirable side effects, however photonic therapies have been described in autoimmune diseases of the skin which encouraged this study. There were evaluated twenty eight women with histological diagnosis of VLS distributed into three groups: Photodynamic Therapy (PDT), Low Intensity Laser Therapy (LILT) and Topical Steroids and the objective was to compare the clinical effects before and after treatment by measuring pruritus, skin thickness, lesion area and temperature. No significant difference was observed in the intensity of pruritus between the groups. The Steroid therapy group showed significant variation in the longitudinal thickness of the skin in relation to LILT group (p = 0.000) with a reduction of -8.48%, while in LILT increased 24.8% as well as the PDT group with 20.9 %. However the variation of the transverse thickness was not different between the groups. The change in the lesion area showed no difference between groups. The LILT group showed significant temperature increase (3.03%) compared to PDT (-2.29%) and steroid (-1.45%) (p = 0.002) groups. Recurrences were registered in the corticosteroid group in two months, PDT in one and LILT in four months post treatment. The results showed that photonic therapies may be considered as treatment for VLS. |
publishDate |
2015 |
dc.date.issued.fl_str_mv |
2015-12-14 |
dc.date.accessioned.fl_str_mv |
2018-06-15T14:12:19Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/masterThesis |
format |
masterThesis |
status_str |
publishedVersion |
dc.identifier.citation.fl_str_mv |
Belotto, Renata Aparecida. L??quen escleroso vulvar: fotobiomodula????o e terapia fotodin??mica como alternativas ?? corticoterapia. 2015. 65 f. Disserta????o( Programa de P??s-Gradua????o em Biofot??nica Aplicada ??s Ci??ncias da Sa??de) - Universidade Nove de Julho, S??o Paulo. |
dc.identifier.uri.fl_str_mv |
http://bibliotecatede.uninove.br/handle/tede/1781 |
identifier_str_mv |
Belotto, Renata Aparecida. L??quen escleroso vulvar: fotobiomodula????o e terapia fotodin??mica como alternativas ?? corticoterapia. 2015. 65 f. Disserta????o( Programa de P??s-Gradua????o em Biofot??nica Aplicada ??s Ci??ncias da Sa??de) - Universidade Nove de Julho, S??o Paulo. |
url |
http://bibliotecatede.uninove.br/handle/tede/1781 |
dc.language.iso.fl_str_mv |
por |
language |
por |
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8765449414823306929 |
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600 |
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info:eu-repo/semantics/openAccess |
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openAccess |
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application/pdf |
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Universidade Nove de Julho |
dc.publisher.program.fl_str_mv |
Programa de P??s-Gradua????o em Biofot??nica Aplicada ??s Ci??ncias da Sa??de |
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UNINOVE |
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Brasil |
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Sa??de |
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Universidade Nove de Julho |
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