Detec??o de les?es de esclerose m?ltipla em imagens de resson?ncia magn?tica do tipo Fluid Attenuated Inversion Recovery (FLAIR)
Ano de defesa: | 2016 |
---|---|
Autor(a) principal: | |
Orientador(a): | |
Banca de defesa: | |
Tipo de documento: | Dissertação |
Tipo de acesso: | Acesso aberto |
Idioma: | por |
Instituição de defesa: |
Pontif?cia Universidade Cat?lica do Rio Grande do Sul
|
Programa de Pós-Graduação: |
Programa de P?s-Gradua??o em Ci?ncia da Computa??o
|
Departamento: |
Faculdade de Inform?tica
|
País: |
Brasil
|
Palavras-chave em Português: | |
Área do conhecimento CNPq: | |
Link de acesso: | http://tede2.pucrs.br/tede2/handle/tede/6780 |
Resumo: | The white matter lesion detection is an important procedure for the diagnostic of Multiple Sclerosis in patients. As important as the detection, monitoring the progression of the disease, by calculating the volumes of the lesions, also shows itself necessary. In clinical practice, this procedure is done manually by a professional or, in many cases, only a qualitative analysis is made. The manual nature of this procedure implies in a series of deficiencies on the procedure, such as variations between diagnoses from different experts on the same subject and variation between diagnostics from the same expert to the same subject at distinct moments. Yet, the manual procedure shows itself time consuming, due the large amount of slices acquired by exam and the need for a careful analysis from the expert to quantify the lesions. In order to avoid these problems, automatic approaches for Multiple Sclerosis lesion detection and quantification using computer aided diagnostic systems are proposed. These methods, mostly, demand for the acquisition of an extra modality of magnetic resonance images, where the anatomy of the brain is evidenced, thus allowing the white matter lesion identification. This additional exam goes beyond the scope of the traditional clinical practice, which implies in additional costs and prevents the method of being applied to old exams, for monitoring the disease progression. This work proposes a method for automatic detection and segmentation of Multiple Sclerosis Lesions that uses only the modality of magnetic resonance exam adopted for clinical practice, using probabilistic atlases spatially aligned to the patient?s exams for identifying the brain structures. The results obtained through the usage of the method into a set of 24 patients and 6 healthy controls of different ages, showed that the developed method is capable of detecting white matter lesions with some precision. However, the quantification of these lesions was impaired mostly due divergences between the white matter probabilistic atlas and the real white matter region of the exams. |
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Pinho, M?rcio Sarroglia486.600.860-15http://buscatextual.cnpq.br/buscatextual/visualizacv.do?id=K4785689J2Franco, Alexandre Rosahttp://buscatextual.cnpq.br/buscatextual/visualizacv.do?id=K4706482A5009.505.910-50http://buscatextual.cnpq.br/buscatextual/visualizacv.do?id=K8751559D4Klein, Pedro Costa2016-06-22T19:31:46Z2016-03-29http://tede2.pucrs.br/tede2/handle/tede/6780The white matter lesion detection is an important procedure for the diagnostic of Multiple Sclerosis in patients. As important as the detection, monitoring the progression of the disease, by calculating the volumes of the lesions, also shows itself necessary. In clinical practice, this procedure is done manually by a professional or, in many cases, only a qualitative analysis is made. The manual nature of this procedure implies in a series of deficiencies on the procedure, such as variations between diagnoses from different experts on the same subject and variation between diagnostics from the same expert to the same subject at distinct moments. Yet, the manual procedure shows itself time consuming, due the large amount of slices acquired by exam and the need for a careful analysis from the expert to quantify the lesions. In order to avoid these problems, automatic approaches for Multiple Sclerosis lesion detection and quantification using computer aided diagnostic systems are proposed. These methods, mostly, demand for the acquisition of an extra modality of magnetic resonance images, where the anatomy of the brain is evidenced, thus allowing the white matter lesion identification. This additional exam goes beyond the scope of the traditional clinical practice, which implies in additional costs and prevents the method of being applied to old exams, for monitoring the disease progression. This work proposes a method for automatic detection and segmentation of Multiple Sclerosis Lesions that uses only the modality of magnetic resonance exam adopted for clinical practice, using probabilistic atlases spatially aligned to the patient?s exams for identifying the brain structures. The results obtained through the usage of the method into a set of 24 patients and 6 healthy controls of different ages, showed that the developed method is capable of detecting white matter lesions with some precision. However, the quantification of these lesions was impaired mostly due divergences between the white matter probabilistic atlas and the real white matter region of the exams.A detec??o de les?es de subst?ncia branca ? um procedimento importante para o diagn?stico da Esclerose M?ltipla em pacientes. T?o importante quanto a detec??o, o acompanhamento da progress?o da doen?a, por meio do c?lculo da volumetria destas les?es, tamb?m se mostra necess?rio. Na pr?tica cl?nica, este procedimento ? realizado manualmente por um profissional, ou em muitas vezes ? somente realizada uma an?lise qualitativa. O car?ter manual deste procedimento implica em uma s?rie de defici?ncias no procedimento como varia??es entre diagn?sticos de diferentes especialistas para um mesmo paciente e varia??es entre diagn?sticos de um mesmo especialista para um mesmo paciente em momentos distintos. Ainda, a tarefa manual mostra-se muito custosa em tempo, devido ao grande n?mero de fatias adquiridas por exame e a necessidade de uma an?lise cuidadosa do especialista para a quantifica??o das les?es. Com o intuito de evitar estes problemas, abordagens autom?ticas para detec??o e quantifica??o de les?es de Esclerose M?ltipla atrav?s do uso de sistemas de diagn?stico auxiliado por computador v?m sendo propostas. Estes m?todos autom?ticos, em sua maioria, demandam a aquisi??o de uma modalidade adicional de imagem de resson?ncia magn?tica, na qual ficam evidenciadas as estruturas anat?micas do c?rebro, permitindo assim a identifica??o de les?es em subst?ncia branca. Este exame adicional foge ao escopo tradicional da pr?tica cl?nica, o que implica em custos adicionais e impede que estes m?todos sejam aplicados em exames antigos, para acompanhamento da progress?o da doen?a. Este trabalho prop?e um m?todo para detec??o e segmenta??o autom?tica de les?es de Esclerose M?ltipla que utiliza apenas a modalidade de exame de resson?ncia magn?tica utilizada na pr?tica cl?nica, utilizando para identifica??o das estruturas cerebrais atlas probabil?sticos alinhados ao espa?o do paciente. Os resultados obtidos atrav?s do emprego do m?todo em um conjunto de 24 pacientes e 6 controles de diferentes faixas et?rias, mostram que o m?todo desenvolvido ? capaz de detectar les?es de subst?ncia branca com certa precis?o. Entretanto a quantifica??o destas les?es mostrou-se prejudicada principalmente por diverg?ncias entre o atlas probabil?stico de subst?ncia branca e a regi?o real de subst?ncia branca nos exames.Submitted by Setor de Tratamento da Informa??o - BC/PUCRS (tede2@pucrs.br) on 2016-06-22T19:31:46Z No. of bitstreams: 1 DIS_PEDRO_COSTA_KLEIN_COMPLETO.pdf: 6980963 bytes, checksum: a6ac65c82ee1febce8c50b5771036f44 (MD5)Made available in DSpace on 2016-06-22T19:31:46Z (GMT). No. of bitstreams: 1 DIS_PEDRO_COSTA_KLEIN_COMPLETO.pdf: 6980963 bytes, checksum: a6ac65c82ee1febce8c50b5771036f44 (MD5) Previous issue date: 2016-03-29Coordena??o de Aperfei?oamento de Pessoal de N?vel Superior - CAPESapplication/pdfhttp://tede2.pucrs.br:80/tede2/retrieve/165438/DIS_PEDRO_COSTA_KLEIN_COMPLETO.pdf.jpgporPontif?cia Universidade Cat?lica do Rio Grande do SulPrograma de P?s-Gradua??o em Ci?ncia da Computa??oPUCRSBrasilFaculdade de Inform?ticaESPECTROSCOPIA DE RESSON?NCIA MAGN?TICAESCLEROSE M?LTIPLADIAGN?STICO POR IMAGEMPROCESSAMENTO DE IMAGENSINFORM?TICACIENCIAS EXATAS E DA TERRA::CIENCIA DA COMPUTACAODetec??o de les?es de esclerose m?ltipla em imagens de resson?ncia magn?tica do tipo Fluid Attenuated Inversion Recovery (FLAIR)Multiple sclerosis lesion detection in fluis attenuated inversion recovery (FLAIR) magnetic resonance imagesinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/masterThesis1974996533081274470600600600600-300854251040114914436717112058112045092075167498588264571info:eu-repo/semantics/openAccessreponame:Biblioteca Digital de Teses e Dissertações da PUC_RSinstname:Pontifícia Universidade Católica do Rio Grande do Sul (PUCRS)instacron:PUC_RSTHUMBNAILDIS_PEDRO_COSTA_KLEIN_COMPLETO.pdf.jpgDIS_PEDRO_COSTA_KLEIN_COMPLETO.pdf.jpgimage/jpeg4285http://tede2.pucrs.br/tede2/bitstream/tede/6780/5/DIS_PEDRO_COSTA_KLEIN_COMPLETO.pdf.jpg2210ef2f9f394ad77f625c7515d2dfc6MD55TEXTDIS_PEDRO_COSTA_KLEIN_COMPLETO.pdf.txtDIS_PEDRO_COSTA_KLEIN_COMPLETO.pdf.txttext/plain176586http://tede2.pucrs.br/tede2/bitstream/tede/6780/4/DIS_PEDRO_COSTA_KLEIN_COMPLETO.pdf.txta307d17b33403cfcd89ec33c114ff152MD54LICENSElicense.txtlicense.txttext/plain; charset=utf-8610http://tede2.pucrs.br/tede2/bitstream/tede/6780/3/license.txt5a9d6006225b368ef605ba16b4f6d1beMD53ORIGINALDIS_PEDRO_COSTA_KLEIN_COMPLETO.pdfDIS_PEDRO_COSTA_KLEIN_COMPLETO.pdfapplication/pdf6980963http://tede2.pucrs.br/tede2/bitstream/tede/6780/2/DIS_PEDRO_COSTA_KLEIN_COMPLETO.pdfa6ac65c82ee1febce8c50b5771036f44MD52tede/67802016-06-22 20:00:21.505oai:tede2.pucrs.br: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Biblioteca Digital de Teses e Dissertaçõeshttp://tede2.pucrs.br/tede2/PRIhttps://tede2.pucrs.br/oai/requestbiblioteca.central@pucrs.br||opendoar:2016-06-22T23:00:21Biblioteca Digital de Teses e Dissertações da PUC_RS - Pontifícia Universidade Católica do Rio Grande do Sul (PUCRS)false |
dc.title.por.fl_str_mv |
Detec??o de les?es de esclerose m?ltipla em imagens de resson?ncia magn?tica do tipo Fluid Attenuated Inversion Recovery (FLAIR) |
dc.title.alternative.eng.fl_str_mv |
Multiple sclerosis lesion detection in fluis attenuated inversion recovery (FLAIR) magnetic resonance images |
title |
Detec??o de les?es de esclerose m?ltipla em imagens de resson?ncia magn?tica do tipo Fluid Attenuated Inversion Recovery (FLAIR) |
spellingShingle |
Detec??o de les?es de esclerose m?ltipla em imagens de resson?ncia magn?tica do tipo Fluid Attenuated Inversion Recovery (FLAIR) Klein, Pedro Costa ESPECTROSCOPIA DE RESSON?NCIA MAGN?TICA ESCLEROSE M?LTIPLA DIAGN?STICO POR IMAGEM PROCESSAMENTO DE IMAGENS INFORM?TICA CIENCIAS EXATAS E DA TERRA::CIENCIA DA COMPUTACAO |
title_short |
Detec??o de les?es de esclerose m?ltipla em imagens de resson?ncia magn?tica do tipo Fluid Attenuated Inversion Recovery (FLAIR) |
title_full |
Detec??o de les?es de esclerose m?ltipla em imagens de resson?ncia magn?tica do tipo Fluid Attenuated Inversion Recovery (FLAIR) |
title_fullStr |
Detec??o de les?es de esclerose m?ltipla em imagens de resson?ncia magn?tica do tipo Fluid Attenuated Inversion Recovery (FLAIR) |
title_full_unstemmed |
Detec??o de les?es de esclerose m?ltipla em imagens de resson?ncia magn?tica do tipo Fluid Attenuated Inversion Recovery (FLAIR) |
title_sort |
Detec??o de les?es de esclerose m?ltipla em imagens de resson?ncia magn?tica do tipo Fluid Attenuated Inversion Recovery (FLAIR) |
author |
Klein, Pedro Costa |
author_facet |
Klein, Pedro Costa |
author_role |
author |
dc.contributor.advisor1.fl_str_mv |
Pinho, M?rcio Sarroglia |
dc.contributor.advisor1ID.fl_str_mv |
486.600.860-15 |
dc.contributor.advisor1Lattes.fl_str_mv |
http://buscatextual.cnpq.br/buscatextual/visualizacv.do?id=K4785689J2 |
dc.contributor.advisor-co1.fl_str_mv |
Franco, Alexandre Rosa |
dc.contributor.advisor-co1Lattes.fl_str_mv |
http://buscatextual.cnpq.br/buscatextual/visualizacv.do?id=K4706482A5 |
dc.contributor.authorID.fl_str_mv |
009.505.910-50 |
dc.contributor.authorLattes.fl_str_mv |
http://buscatextual.cnpq.br/buscatextual/visualizacv.do?id=K8751559D4 |
dc.contributor.author.fl_str_mv |
Klein, Pedro Costa |
contributor_str_mv |
Pinho, M?rcio Sarroglia Franco, Alexandre Rosa |
dc.subject.por.fl_str_mv |
ESPECTROSCOPIA DE RESSON?NCIA MAGN?TICA ESCLEROSE M?LTIPLA DIAGN?STICO POR IMAGEM PROCESSAMENTO DE IMAGENS INFORM?TICA |
topic |
ESPECTROSCOPIA DE RESSON?NCIA MAGN?TICA ESCLEROSE M?LTIPLA DIAGN?STICO POR IMAGEM PROCESSAMENTO DE IMAGENS INFORM?TICA CIENCIAS EXATAS E DA TERRA::CIENCIA DA COMPUTACAO |
dc.subject.cnpq.fl_str_mv |
CIENCIAS EXATAS E DA TERRA::CIENCIA DA COMPUTACAO |
description |
The white matter lesion detection is an important procedure for the diagnostic of Multiple Sclerosis in patients. As important as the detection, monitoring the progression of the disease, by calculating the volumes of the lesions, also shows itself necessary. In clinical practice, this procedure is done manually by a professional or, in many cases, only a qualitative analysis is made. The manual nature of this procedure implies in a series of deficiencies on the procedure, such as variations between diagnoses from different experts on the same subject and variation between diagnostics from the same expert to the same subject at distinct moments. Yet, the manual procedure shows itself time consuming, due the large amount of slices acquired by exam and the need for a careful analysis from the expert to quantify the lesions. In order to avoid these problems, automatic approaches for Multiple Sclerosis lesion detection and quantification using computer aided diagnostic systems are proposed. These methods, mostly, demand for the acquisition of an extra modality of magnetic resonance images, where the anatomy of the brain is evidenced, thus allowing the white matter lesion identification. This additional exam goes beyond the scope of the traditional clinical practice, which implies in additional costs and prevents the method of being applied to old exams, for monitoring the disease progression. This work proposes a method for automatic detection and segmentation of Multiple Sclerosis Lesions that uses only the modality of magnetic resonance exam adopted for clinical practice, using probabilistic atlases spatially aligned to the patient?s exams for identifying the brain structures. The results obtained through the usage of the method into a set of 24 patients and 6 healthy controls of different ages, showed that the developed method is capable of detecting white matter lesions with some precision. However, the quantification of these lesions was impaired mostly due divergences between the white matter probabilistic atlas and the real white matter region of the exams. |
publishDate |
2016 |
dc.date.accessioned.fl_str_mv |
2016-06-22T19:31:46Z |
dc.date.issued.fl_str_mv |
2016-03-29 |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
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info:eu-repo/semantics/masterThesis |
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masterThesis |
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publishedVersion |
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http://tede2.pucrs.br/tede2/handle/tede/6780 |
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http://tede2.pucrs.br/tede2/handle/tede/6780 |
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por |
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por |
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1974996533081274470 |
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600 600 600 600 |
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Pontif?cia Universidade Cat?lica do Rio Grande do Sul |
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Programa de P?s-Gradua??o em Ci?ncia da Computa??o |
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PUCRS |
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Pontif?cia Universidade Cat?lica do Rio Grande do Sul |
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