Rela??o da ?rea de gordura visceral com a doen?a hep?tica gordurosa n?o alco?lica
Ano de defesa: | 2021 |
---|---|
Autor(a) principal: | |
Orientador(a): | |
Banca de defesa: | |
Tipo de documento: | Tese |
Tipo de acesso: | Acesso aberto |
Idioma: | por |
Instituição de defesa: |
Pontif?cia Universidade Cat?lica do Rio Grande do Sul
|
Programa de Pós-Graduação: |
Programa de P?s-Gradua??o em Medicina e Ci?ncias da Sa?de
|
Departamento: |
Escola de Medicina
|
País: |
Brasil
|
Palavras-chave em Português: | |
Palavras-chave em Inglês: | |
Área do conhecimento CNPq: | |
Link de acesso: | https://tede2.pucrs.br/tede2/handle/tede/10181 |
Resumo: | Introduction: obesity and non-alcoholic fatty liver disease (NAFLD) cause harm to personal health, interfere with the individual's quality of life and entail high costs for the public health system. Visceral fat is closely related to the development of a myriad of metabolic abnormalities and is associated with NAFLD. Objective: to investigate the association between visceral fat area and non-alcoholic fatty liver disease in patients with obesity. Method: crosssectional study with retrospective data collection. The sample consisted of obese patients, of both sexes, over 18 years old, candidates for bariatric surgery between July 2015 and July 2017 at COM/HSL/PUCRS. Anthropometric data and visceral fat area were evaluated using multi-frequency bioimpedance. Smoking and comorbidity variables were also analysed. NAFLD was evaluated by liver biopsy. The significance level adopted was 5% (p?0.05) and statistical analyses were performed using the SPSS version 21.0 program. The study was approved by the Research Ethics Committee of PUCRS - CAAE 51992321.0.0000.5336. Results: 369 participants were included, mostly women (79.4%), with a mean age of 39.2 ? 10.6 years and mean BMI of 45 ? 7.1 kg/m?. No statistically significant association with NAFLD was found. There was a positive association (p<0.001) between % body fat and visceral fat area. There was a positive correlation (p<0.001) between steatohepatitis and waist circumference. There was an association (p<0.001) between type II diabetes mellitus, metabolic syndrome and systemic arterial hypertension with NAFLD. Conclusion: The association between NAFLD and visceral fat area was not confirmed. The percentage of body fat proved to be an alternative to assess visceral fat. Waist circumference is a risk factor for the evolution of NAFLD. New studies with more robust designs must be carried out to confirm or refute the results of this study. |
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Mottin, Cl?udio Cor?http://lattes.cnpq.br/8827120189677376http://lattes.cnpq.br/2051016899483396Cort?s, Margarita Alexandra Pe?a2022-05-03T17:12:54Z2021-11-27https://tede2.pucrs.br/tede2/handle/tede/10181Introduction: obesity and non-alcoholic fatty liver disease (NAFLD) cause harm to personal health, interfere with the individual's quality of life and entail high costs for the public health system. Visceral fat is closely related to the development of a myriad of metabolic abnormalities and is associated with NAFLD. Objective: to investigate the association between visceral fat area and non-alcoholic fatty liver disease in patients with obesity. Method: crosssectional study with retrospective data collection. The sample consisted of obese patients, of both sexes, over 18 years old, candidates for bariatric surgery between July 2015 and July 2017 at COM/HSL/PUCRS. Anthropometric data and visceral fat area were evaluated using multi-frequency bioimpedance. Smoking and comorbidity variables were also analysed. NAFLD was evaluated by liver biopsy. The significance level adopted was 5% (p?0.05) and statistical analyses were performed using the SPSS version 21.0 program. The study was approved by the Research Ethics Committee of PUCRS - CAAE 51992321.0.0000.5336. Results: 369 participants were included, mostly women (79.4%), with a mean age of 39.2 ? 10.6 years and mean BMI of 45 ? 7.1 kg/m?. No statistically significant association with NAFLD was found. There was a positive association (p<0.001) between % body fat and visceral fat area. There was a positive correlation (p<0.001) between steatohepatitis and waist circumference. There was an association (p<0.001) between type II diabetes mellitus, metabolic syndrome and systemic arterial hypertension with NAFLD. Conclusion: The association between NAFLD and visceral fat area was not confirmed. The percentage of body fat proved to be an alternative to assess visceral fat. Waist circumference is a risk factor for the evolution of NAFLD. New studies with more robust designs must be carried out to confirm or refute the results of this study.Introdu??o: a obesidade e a doen?a hep?tica gordurosa n?o alco?lica (DHGNA) causam preju?zos ? sa?de, interferem na qualidade de vida do indiv?duo e acarretam custos elevados para o sistema p?blico de sa?de. A gordura visceral est? intimamente relacionada ao desenvolvimento de uma mir?ade de anormalidades metab?licas e est? associado ? DHGNA. Objetivo: investigar a associa??o entre a ?rea de gordura visceral e a doen?a hep?tica gordurosa n?o alco?lica em pacientes com obesidade. M?todo: estudo transversal com coleta de dados retrospectiva. A amostra foi composta por pacientes com obesidade, de ambos os sexos, maiores de 18 anos, candidatos ? cirurgia bari?trica entre julho de 2015 a julho de 2017 no COM/HSL/PUCRS. Foram avaliados dados antropom?tricos e a ?rea de gordura visceral atrav?s da bioimped?ncia multi-frequencial. As vari?veis tabagismo e comorbidades tamb?m foram analisadas. A DHGNA foi avaliada por bi?psia hep?tica. O n?vel de signific?ncia adotado foi de 5% (p?0,05) e as an?lises estat?sticas foram realizadas pelo programa SPSS vers?o 21.0. O estudo foi aprovado pelo Comit? de ?tica em Pesquisa da PUCRS sob CAAE 51992321.0.0000.5336. Resultados: Foram inclu?dos 369 participantes, a maioria mulheres (79,4%), com m?dia de idade de 39,2 ? 10,6 anos e IMC m?dio de 45?7,1 kg/m?. N?o foi encontrada associa??o estatisticamente significativa com a DHGNA. Houve associa??o positiva (p<0,001) entre % de gordura corporal e ?rea de gordura visceral. Houve correla??o positiva (p<0,001) entre esteato-hepatite e circunfer?ncia da cintura. Houve associa??o (p<0,001) entre diabetes mellitus tipo II, s?ndrome metab?lica e hipertens?o arterial sist?mica com a DHGNA.Conclus?o: A associa??o entre DHGNA e a ?rea de gordura visceral n?o foi confirmada. O percentual de gordura corporal mostrou ser uma alternativa para avaliar a gordura visceral. A circunfer?ncia da cintura ? um fator de risco para a evolu??o da DHGNA. Novos estudos com delineamentos mais robustos devem ser realizados para confirmar ou refutar os resultados deste estudo.Submitted by PPG Medicina e Ci?ncias da Sa?de (medicina-pg@pucrs.br) on 2022-04-29T19:25:11Z No. of bitstreams: 1 Tese_MargaritaCortes.pdf: 1782451 bytes, checksum: 560f7be4d78c22f091afb7083cd9aab0 (MD5)Approved for entry into archive by Caroline Xavier (caroline.xavier@pucrs.br) on 2022-05-03T17:06:53Z (GMT) No. of bitstreams: 1 Tese_MargaritaCortes.pdf: 1782451 bytes, checksum: 560f7be4d78c22f091afb7083cd9aab0 (MD5)Made available in DSpace on 2022-05-03T17:12:54Z (GMT). No. of bitstreams: 1 Tese_MargaritaCortes.pdf: 1782451 bytes, checksum: 560f7be4d78c22f091afb7083cd9aab0 (MD5) Previous issue date: 2021-11-27application/pdfhttps://tede2.pucrs.br/tede2/retrieve/183830/TES_MARGARITA_ALEXANDRA_PENA_CORTES_CONFIDENCIAL.pdf.jpgporPontif?cia Universidade Cat?lica do Rio Grande do SulPrograma de P?s-Gradua??o em Medicina e Ci?ncias da Sa?dePUCRSBrasilEscola de MedicinaObesidadeEsteatose Hep?ticaDHGNAGordura Intra-abdominalAntropometriaObesityHepatic SteatosisNAFLDIntra-abdominal FatAntropometryCIENCIAS DA SAUDE::MEDICINARela??o da ?rea de gordura visceral com a doen?a hep?tica gordurosa n?o alco?licainfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/doctoralThesisTrabalho ser? publicado como artigo ou livro60 meses03/05/2027-721401722658532398500500500-224747486637135387-969369452308786627info:eu-repo/semantics/openAccessreponame:Biblioteca Digital de Teses e Dissertações da PUC_RSinstname:Pontifícia Universidade Católica do Rio Grande do Sul (PUCRS)instacron:PUC_RSTHUMBNAILTES_MARGARITA_ALEXANDRA_PENA_CORTES_CONFIDENCIAL.pdf.jpgTES_MARGARITA_ALEXANDRA_PENA_CORTES_CONFIDENCIAL.pdf.jpgimage/jpeg4120https://tede2.pucrs.br/tede2/bitstream/tede/10181/4/TES_MARGARITA_ALEXANDRA_PENA_CORTES_CONFIDENCIAL.pdf.jpg3b6eef51c747065d859294bdf96ead2bMD54TEXTTES_MARGARITA_ALEXANDRA_PENA_CORTES_CONFIDENCIAL.pdf.txtTES_MARGARITA_ALEXANDRA_PENA_CORTES_CONFIDENCIAL.pdf.txttext/plain2191https://tede2.pucrs.br/tede2/bitstream/tede/10181/3/TES_MARGARITA_ALEXANDRA_PENA_CORTES_CONFIDENCIAL.pdf.txt17d0be89847fa908e25a208896d0f825MD53ORIGINALTES_MARGARITA_ALEXANDRA_PENA_CORTES_CONFIDENCIAL.pdfTES_MARGARITA_ALEXANDRA_PENA_CORTES_CONFIDENCIAL.pdfapplication/pdf402266https://tede2.pucrs.br/tede2/bitstream/tede/10181/2/TES_MARGARITA_ALEXANDRA_PENA_CORTES_CONFIDENCIAL.pdf9f8e6ce58a78644fe8af0fdf9663bbd2MD52LICENSElicense.txtlicense.txttext/plain; charset=utf-8590https://tede2.pucrs.br/tede2/bitstream/tede/10181/1/license.txt220e11f2d3ba5354f917c7035aadef24MD51tede/101812022-05-03 20:00:21.352oai:tede2.pucrs.br:tede/10181QXV0b3JpemE/P28gcGFyYSBQdWJsaWNhPz9vIEVsZXRyP25pY2E6IENvbSBiYXNlIG5vIGRpc3Bvc3RvIG5hIExlaSBGZWRlcmFsIG4/OS42MTAsIGRlIDE5IGRlIGZldmVyZWlybyBkZSAxOTk4LCBvIGF1dG9yIEFVVE9SSVpBIGEgcHVibGljYT8/byBlbGV0cj9uaWNhIGRhIHByZXNlbnRlIG9icmEgbm8gYWNlcnZvIGRhIEJpYmxpb3RlY2EgRGlnaXRhbCBkYSBQb250aWY/Y2lhIFVuaXZlcnNpZGFkZSBDYXQ/bGljYSBkbyBSaW8gR3JhbmRlIGRvIFN1bCwgc2VkaWFkYSBhIEF2LiBJcGlyYW5nYSA2NjgxLCBQb3J0byBBbGVncmUsIFJpbyBHcmFuZGUgZG8gU3VsLCBjb20gcmVnaXN0cm8gZGUgQ05QSiA4ODYzMDQxMzAwMDItODEgYmVtIGNvbW8gZW0gb3V0cmFzIGJpYmxpb3RlY2FzIGRpZ2l0YWlzLCBuYWNpb25haXMgZSBpbnRlcm5hY2lvbmFpcywgY29ucz9yY2lvcyBlIHJlZGVzID9zIHF1YWlzIGEgYmlibGlvdGVjYSBkYSBQVUNSUyBwb3NzYSBhIHZpciBwYXJ0aWNpcGFyLCBzZW0gP251cyBhbHVzaXZvIGFvcyBkaXJlaXRvcyBhdXRvcmFpcywgYSB0P3R1bG8gZGUgZGl2dWxnYT8/byBkYSBwcm9kdT8/byBjaWVudD9maWNhLgo=Biblioteca Digital de Teses e Dissertaçõeshttp://tede2.pucrs.br/tede2/PRIhttps://tede2.pucrs.br/oai/requestbiblioteca.central@pucrs.br||opendoar:2022-05-03T23:00:21Biblioteca Digital de Teses e Dissertações da PUC_RS - Pontifícia Universidade Católica do Rio Grande do Sul (PUCRS)false |
dc.title.por.fl_str_mv |
Rela??o da ?rea de gordura visceral com a doen?a hep?tica gordurosa n?o alco?lica |
title |
Rela??o da ?rea de gordura visceral com a doen?a hep?tica gordurosa n?o alco?lica |
spellingShingle |
Rela??o da ?rea de gordura visceral com a doen?a hep?tica gordurosa n?o alco?lica Cort?s, Margarita Alexandra Pe?a Obesidade Esteatose Hep?tica DHGNA Gordura Intra-abdominal Antropometria Obesity Hepatic Steatosis NAFLD Intra-abdominal Fat Antropometry CIENCIAS DA SAUDE::MEDICINA |
title_short |
Rela??o da ?rea de gordura visceral com a doen?a hep?tica gordurosa n?o alco?lica |
title_full |
Rela??o da ?rea de gordura visceral com a doen?a hep?tica gordurosa n?o alco?lica |
title_fullStr |
Rela??o da ?rea de gordura visceral com a doen?a hep?tica gordurosa n?o alco?lica |
title_full_unstemmed |
Rela??o da ?rea de gordura visceral com a doen?a hep?tica gordurosa n?o alco?lica |
title_sort |
Rela??o da ?rea de gordura visceral com a doen?a hep?tica gordurosa n?o alco?lica |
author |
Cort?s, Margarita Alexandra Pe?a |
author_facet |
Cort?s, Margarita Alexandra Pe?a |
author_role |
author |
dc.contributor.advisor1.fl_str_mv |
Mottin, Cl?udio Cor? |
dc.contributor.advisor1Lattes.fl_str_mv |
http://lattes.cnpq.br/8827120189677376 |
dc.contributor.authorLattes.fl_str_mv |
http://lattes.cnpq.br/2051016899483396 |
dc.contributor.author.fl_str_mv |
Cort?s, Margarita Alexandra Pe?a |
contributor_str_mv |
Mottin, Cl?udio Cor? |
dc.subject.por.fl_str_mv |
Obesidade Esteatose Hep?tica DHGNA Gordura Intra-abdominal Antropometria |
topic |
Obesidade Esteatose Hep?tica DHGNA Gordura Intra-abdominal Antropometria Obesity Hepatic Steatosis NAFLD Intra-abdominal Fat Antropometry CIENCIAS DA SAUDE::MEDICINA |
dc.subject.eng.fl_str_mv |
Obesity Hepatic Steatosis NAFLD Intra-abdominal Fat Antropometry |
dc.subject.cnpq.fl_str_mv |
CIENCIAS DA SAUDE::MEDICINA |
description |
Introduction: obesity and non-alcoholic fatty liver disease (NAFLD) cause harm to personal health, interfere with the individual's quality of life and entail high costs for the public health system. Visceral fat is closely related to the development of a myriad of metabolic abnormalities and is associated with NAFLD. Objective: to investigate the association between visceral fat area and non-alcoholic fatty liver disease in patients with obesity. Method: crosssectional study with retrospective data collection. The sample consisted of obese patients, of both sexes, over 18 years old, candidates for bariatric surgery between July 2015 and July 2017 at COM/HSL/PUCRS. Anthropometric data and visceral fat area were evaluated using multi-frequency bioimpedance. Smoking and comorbidity variables were also analysed. NAFLD was evaluated by liver biopsy. The significance level adopted was 5% (p?0.05) and statistical analyses were performed using the SPSS version 21.0 program. The study was approved by the Research Ethics Committee of PUCRS - CAAE 51992321.0.0000.5336. Results: 369 participants were included, mostly women (79.4%), with a mean age of 39.2 ? 10.6 years and mean BMI of 45 ? 7.1 kg/m?. No statistically significant association with NAFLD was found. There was a positive association (p<0.001) between % body fat and visceral fat area. There was a positive correlation (p<0.001) between steatohepatitis and waist circumference. There was an association (p<0.001) between type II diabetes mellitus, metabolic syndrome and systemic arterial hypertension with NAFLD. Conclusion: The association between NAFLD and visceral fat area was not confirmed. The percentage of body fat proved to be an alternative to assess visceral fat. Waist circumference is a risk factor for the evolution of NAFLD. New studies with more robust designs must be carried out to confirm or refute the results of this study. |
publishDate |
2021 |
dc.date.issued.fl_str_mv |
2021-11-27 |
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2022-05-03T17:12:54Z |
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https://tede2.pucrs.br/tede2/handle/tede/10181 |
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por |
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por |
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500 500 500 |
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Pontif?cia Universidade Cat?lica do Rio Grande do Sul |
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Programa de P?s-Gradua??o em Medicina e Ci?ncias da Sa?de |
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PUCRS |
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Brasil |
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Escola de Medicina |
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Pontif?cia Universidade Cat?lica do Rio Grande do Sul |
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