O impacto da obesidade na s?ndrome respirat?ria aguda grave causada pelo novo coronav?rus (SARS-COV-2)
Ano de defesa: | 2022 |
---|---|
Autor(a) principal: | |
Orientador(a): | |
Banca de defesa: | |
Tipo de documento: | Dissertação |
Tipo de acesso: | Acesso aberto |
Idioma: | por |
Instituição de defesa: |
Pontif?cia Universidade Cat?lica do Rio Grande do Sul
|
Programa de Pós-Graduação: |
Programa de P?s-Gradua??o em Medicina e Ci?ncias da Sa?de
|
Departamento: |
Escola de Medicina
|
País: |
Brasil
|
Palavras-chave em Português: | |
Palavras-chave em Inglês: | |
Área do conhecimento CNPq: | |
Link de acesso: | https://tede2.pucrs.br/tede2/handle/tede/10498 |
Resumo: | COVID-19 is an infection caused by a new type of Coronavirus, which was identified in China at the end of 2019. In late March the World Health Organization declared a pandemic and by January 2022, there were more than 336 million people infected. Clinical manifestations of COVID-19 include asymptomatic carrier status, acute respiratory disease, and pneumonia. Most infected people will have mild to moderate symptoms, but approximately 5% will require intensive treatment. Laboratory diagnosis of the disease is performed through real-time RT-PCR and partial or total sequencing of the viral genome, collected through Nasopharynx Swab or Oropharynx. According to the Brazilian Ministry of Health, adults over 60 years of age with cardiovascular diseases, diabetes or obesity may be at higher risk for complications. The primary aim of was to verify if mortality among patients with obesity hospitalized in intensive care units (ICU) por COVID-19 and severe acute respiratory syndrome (RS) was higher than among non-obese. The secondary aim was to verify if obesity is associated with the need for invasive mechanical ventilation, renal replacement therapy and tracheostomy. A Historical Cohort study was conducted between March 2020 and January 2021. Patients with a confirmed diagnosis of Covid-19 and who were hospitalized in ICUs at S?o Lucas Hospital at PUC-RS and Ernesto Dornelles Hospital in the city of Porto Alegre were included in the study. Data from the medical records of the selected patients were reviewed. Patients with and without obesity were compared using logistic regression to estimate the risk of mechanical ventilation, renal replacement therapy, tracheostomy, and death. Of the 257 patients with COVID-19 and SRAG hospitalized in the ICU, 42% were obese. The mean age of obese patients was 12 years younger than that of non-obese. We found an association with age ? 70 years with mortality (OR 6.38 95%CI 3.48-11.69). Crude analysis showed reduced risk of death for obese patients (OR 0.41 95%CI 0.24-0.68). After adjusting for age, sex and comorbidities, obesity was not associated with mortality, mechanical ventilation, renal replacement therapy, and tracheostomy. In conclusion, we did not find in a higher mortality among obese patients admitted to a intensive care unit with COVID-19 and SRAG when compared to non-obese patients. In our study, obesity was not associated with invasive mechanical ventilation, renal replacement therapy and tracheostomy. |
id |
P_RS_b34bdb176864280a41997322ad9a757f |
---|---|
oai_identifier_str |
oai:tede2.pucrs.br:tede/10498 |
network_acronym_str |
P_RS |
network_name_str |
Biblioteca Digital de Teses e Dissertações da PUC_RS |
repository_id_str |
|
spelling |
Padoin, Alexandre Vontobelhttp://lattes.cnpq.br/0241056171343649http://lattes.cnpq.br/9289159395059075Susin, Karine Sabrina Bonamigo2022-09-30T15:07:38Z2022-03-24https://tede2.pucrs.br/tede2/handle/tede/10498COVID-19 is an infection caused by a new type of Coronavirus, which was identified in China at the end of 2019. In late March the World Health Organization declared a pandemic and by January 2022, there were more than 336 million people infected. Clinical manifestations of COVID-19 include asymptomatic carrier status, acute respiratory disease, and pneumonia. Most infected people will have mild to moderate symptoms, but approximately 5% will require intensive treatment. Laboratory diagnosis of the disease is performed through real-time RT-PCR and partial or total sequencing of the viral genome, collected through Nasopharynx Swab or Oropharynx. According to the Brazilian Ministry of Health, adults over 60 years of age with cardiovascular diseases, diabetes or obesity may be at higher risk for complications. The primary aim of was to verify if mortality among patients with obesity hospitalized in intensive care units (ICU) por COVID-19 and severe acute respiratory syndrome (RS) was higher than among non-obese. The secondary aim was to verify if obesity is associated with the need for invasive mechanical ventilation, renal replacement therapy and tracheostomy. A Historical Cohort study was conducted between March 2020 and January 2021. Patients with a confirmed diagnosis of Covid-19 and who were hospitalized in ICUs at S?o Lucas Hospital at PUC-RS and Ernesto Dornelles Hospital in the city of Porto Alegre were included in the study. Data from the medical records of the selected patients were reviewed. Patients with and without obesity were compared using logistic regression to estimate the risk of mechanical ventilation, renal replacement therapy, tracheostomy, and death. Of the 257 patients with COVID-19 and SRAG hospitalized in the ICU, 42% were obese. The mean age of obese patients was 12 years younger than that of non-obese. We found an association with age ? 70 years with mortality (OR 6.38 95%CI 3.48-11.69). Crude analysis showed reduced risk of death for obese patients (OR 0.41 95%CI 0.24-0.68). After adjusting for age, sex and comorbidities, obesity was not associated with mortality, mechanical ventilation, renal replacement therapy, and tracheostomy. In conclusion, we did not find in a higher mortality among obese patients admitted to a intensive care unit with COVID-19 and SRAG when compared to non-obese patients. In our study, obesity was not associated with invasive mechanical ventilation, renal replacement therapy and tracheostomy.A doen?a COVID-19 ? uma infec??o causada por um novo tipo de Coronav?rus, que foi identificado na China, no final de 2019. Em final de mar?o a Organiza??o Mundial da Sa?de declarou pandemia e em janeiro de 2022, havia mais de 336 milh?es de pessoas infectadas. As manifesta??es cl?nicas da COVID-19 incluem o estado de portador assintom?tico, doen?a respirat?ria aguda e pneumonia. A maioria das pessoas infectadas ter? sintomas leves a moderados, mas aproximadamente 5% necessitar?o de tratamento intensivo. O diagn?stico laboratorial da doen?a ? realizado atrav?s do RT-PCR em tempo real e sequenciamento parcial ou total do genoma viral, coletados atrav?s de Swab da Nasofaringe ou Orofaringe. Segundo o Minist?rio da Sa?de do Brasil, adultos com mais de 60 anos, com doen?as cardiovasculares, diabetes ou obesidade podem apresentar maior risco para complica??es da S?ndrome Gripal. O objetivo prim?rio deste estudo foi verificar se a mortalidade entre pacientes obesos internados em unidades de tratamento intensivo (UTI) por COVID-19 e s?ndrome respirat?ria aguda grave (SRAG) ? maior do que entre os pacientes n?oobesos. O objetivo secund?rio foi verificar se a obesidade se relaciona com ventila??o mec?nica invasiva, terapia de substitui??o renal e realiza??o de traqueostomia. Foi realizado um estudo de Coorte Hist?rica entre os meses mar?o de 2020 e janeiro de 2021. Os pacientes com diagn?stico confirmado de Covid-19 e que estiveram internados em UTI nos hospitais S?o Lucas da PUC-RS e Hospital Ernesto Dornelles, na cidade de Porto Alegre entre mar?o de 2020 e janeiro de 2021 foram inclu?dos no estudo. Foi feita a revis?o dos dados dos prontu?rios dos pacientes selecionados. Pacientes com e sem obesidade foram comparados usando regress?o log?stica para estimar o risco de ventila??o mec?nica, terapia de substitui??o renal, traqueostomia e morte. Dos 257 pacientes internados na UTI com COVID-19 e SRAG, 42% eram obesos. A m?dia de idade dos obesos era 12 anos a menos que a dos n?o-obesos. N?s encontramos associa??o com idade ? 70 anos com mortalidade (OR 6,38 IC 95% 3,48-11,69). A an?lise bruta mostrou risco reduzido de morte para os pacientes obesos (OR 0,41 IC95% 0,24-0,68). Ap?s o ajuste para idade, sexo e comorbidades, a obesidade n?o foi associada com mortalidade, ventila??o mec?nica, terapia de substitui??o renal e traqueostomia. Concluindo, n?o encontramos no nosso estudo uma maior mortalidade entre pacientes obesos internados na UTI com COVID-19 e SRAG quando comparados a pacientes n?o-obesos. No nosso estudo, a obesidade n?o foi associada ? necessidade de ventila??o mec?nica invasiva, terapia de substitui??o renal e traqueostomia.Submitted by PPG Medicina e Ci?ncias da Sa?de (medicina-pg@pucrs.br) on 2022-09-26T14:40:39Z No. of bitstreams: 1 Disserta??o final aluna Karine Sabrina Bonamigo Susin.pdf: 6146601 bytes, checksum: 3153ef1b07d3b32101e068f859c5eb69 (MD5)Approved for entry into archive by Sheila Dias (sheila.dias@pucrs.br) on 2022-09-30T14:54:57Z (GMT) No. of bitstreams: 1 Disserta??o final aluna Karine Sabrina Bonamigo Susin.pdf: 6146601 bytes, checksum: 3153ef1b07d3b32101e068f859c5eb69 (MD5)Made available in DSpace on 2022-09-30T15:07:38Z (GMT). No. of bitstreams: 1 Disserta??o final aluna Karine Sabrina Bonamigo Susin.pdf: 6146601 bytes, checksum: 3153ef1b07d3b32101e068f859c5eb69 (MD5) Previous issue date: 2022-03-24Coordena??o de Aperfei?oamento de Pessoal de N?vel Superior - CAPESapplication/pdfhttps://tede2.pucrs.br/tede2/retrieve/185605/DIS_KARINE_SABRINA_BONAMIGO_SUSIN_CONFIDENCIAL.pdf.jpgporPontif?cia Universidade Cat?lica do Rio Grande do SulPrograma de P?s-Gradua??o em Medicina e Ci?ncias da Sa?dePUCRSBrasilEscola de MedicinaCovid-19CoronavirusObesidadeUTISARS-CoV-2ICUObesityHistorical CohortCIENCIAS DA SAUDE::MEDICINAO impacto da obesidade na s?ndrome respirat?ria aguda grave causada pelo novo coronav?rus (SARS-COV-2)info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/masterThesisTrabalho ser? publicado como artigo ou livro60 meses30/09/2027-721401722658532398500500500600-224747486637135387-9693694523087866273590462550136975366info:eu-repo/semantics/openAccessreponame:Biblioteca Digital de Teses e Dissertações da PUC_RSinstname:Pontifícia Universidade Católica do Rio Grande do Sul (PUCRS)instacron:PUC_RSTHUMBNAILDIS_KARINE_SABRINA_BONAMIGO_SUSIN_CONFIDENCIAL.pdf.jpgDIS_KARINE_SABRINA_BONAMIGO_SUSIN_CONFIDENCIAL.pdf.jpgimage/jpeg4127https://tede2.pucrs.br/tede2/bitstream/tede/10498/4/DIS_KARINE_SABRINA_BONAMIGO_SUSIN_CONFIDENCIAL.pdf.jpg8ad6213a37c259fdb94b87adbfde1bbfMD54TEXTDIS_KARINE_SABRINA_BONAMIGO_SUSIN_CONFIDENCIAL.pdf.txtDIS_KARINE_SABRINA_BONAMIGO_SUSIN_CONFIDENCIAL.pdf.txttext/plain1596https://tede2.pucrs.br/tede2/bitstream/tede/10498/3/DIS_KARINE_SABRINA_BONAMIGO_SUSIN_CONFIDENCIAL.pdf.txt08e7ee690b5484635d45eaabdb25f90aMD53ORIGINALDIS_KARINE_SABRINA_BONAMIGO_SUSIN_CONFIDENCIAL.pdfDIS_KARINE_SABRINA_BONAMIGO_SUSIN_CONFIDENCIAL.pdfapplication/pdf926579https://tede2.pucrs.br/tede2/bitstream/tede/10498/2/DIS_KARINE_SABRINA_BONAMIGO_SUSIN_CONFIDENCIAL.pdf3a453e8eb34f30f80c2f9b3a67284fc3MD52LICENSElicense.txtlicense.txttext/plain; charset=utf-8590https://tede2.pucrs.br/tede2/bitstream/tede/10498/1/license.txt220e11f2d3ba5354f917c7035aadef24MD51tede/104982022-09-30 20:00:14.431oai:tede2.pucrs.br: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Biblioteca Digital de Teses e Dissertaçõeshttp://tede2.pucrs.br/tede2/PRIhttps://tede2.pucrs.br/oai/requestbiblioteca.central@pucrs.br||opendoar:2022-09-30T23:00:14Biblioteca Digital de Teses e Dissertações da PUC_RS - Pontifícia Universidade Católica do Rio Grande do Sul (PUCRS)false |
dc.title.por.fl_str_mv |
O impacto da obesidade na s?ndrome respirat?ria aguda grave causada pelo novo coronav?rus (SARS-COV-2) |
title |
O impacto da obesidade na s?ndrome respirat?ria aguda grave causada pelo novo coronav?rus (SARS-COV-2) |
spellingShingle |
O impacto da obesidade na s?ndrome respirat?ria aguda grave causada pelo novo coronav?rus (SARS-COV-2) Susin, Karine Sabrina Bonamigo Covid-19 Coronavirus Obesidade UTI SARS-CoV-2 ICU Obesity Historical Cohort CIENCIAS DA SAUDE::MEDICINA |
title_short |
O impacto da obesidade na s?ndrome respirat?ria aguda grave causada pelo novo coronav?rus (SARS-COV-2) |
title_full |
O impacto da obesidade na s?ndrome respirat?ria aguda grave causada pelo novo coronav?rus (SARS-COV-2) |
title_fullStr |
O impacto da obesidade na s?ndrome respirat?ria aguda grave causada pelo novo coronav?rus (SARS-COV-2) |
title_full_unstemmed |
O impacto da obesidade na s?ndrome respirat?ria aguda grave causada pelo novo coronav?rus (SARS-COV-2) |
title_sort |
O impacto da obesidade na s?ndrome respirat?ria aguda grave causada pelo novo coronav?rus (SARS-COV-2) |
author |
Susin, Karine Sabrina Bonamigo |
author_facet |
Susin, Karine Sabrina Bonamigo |
author_role |
author |
dc.contributor.advisor1.fl_str_mv |
Padoin, Alexandre Vontobel |
dc.contributor.advisor1Lattes.fl_str_mv |
http://lattes.cnpq.br/0241056171343649 |
dc.contributor.authorLattes.fl_str_mv |
http://lattes.cnpq.br/9289159395059075 |
dc.contributor.author.fl_str_mv |
Susin, Karine Sabrina Bonamigo |
contributor_str_mv |
Padoin, Alexandre Vontobel |
dc.subject.por.fl_str_mv |
Covid-19 Coronavirus Obesidade UTI |
topic |
Covid-19 Coronavirus Obesidade UTI SARS-CoV-2 ICU Obesity Historical Cohort CIENCIAS DA SAUDE::MEDICINA |
dc.subject.eng.fl_str_mv |
SARS-CoV-2 ICU Obesity Historical Cohort |
dc.subject.cnpq.fl_str_mv |
CIENCIAS DA SAUDE::MEDICINA |
description |
COVID-19 is an infection caused by a new type of Coronavirus, which was identified in China at the end of 2019. In late March the World Health Organization declared a pandemic and by January 2022, there were more than 336 million people infected. Clinical manifestations of COVID-19 include asymptomatic carrier status, acute respiratory disease, and pneumonia. Most infected people will have mild to moderate symptoms, but approximately 5% will require intensive treatment. Laboratory diagnosis of the disease is performed through real-time RT-PCR and partial or total sequencing of the viral genome, collected through Nasopharynx Swab or Oropharynx. According to the Brazilian Ministry of Health, adults over 60 years of age with cardiovascular diseases, diabetes or obesity may be at higher risk for complications. The primary aim of was to verify if mortality among patients with obesity hospitalized in intensive care units (ICU) por COVID-19 and severe acute respiratory syndrome (RS) was higher than among non-obese. The secondary aim was to verify if obesity is associated with the need for invasive mechanical ventilation, renal replacement therapy and tracheostomy. A Historical Cohort study was conducted between March 2020 and January 2021. Patients with a confirmed diagnosis of Covid-19 and who were hospitalized in ICUs at S?o Lucas Hospital at PUC-RS and Ernesto Dornelles Hospital in the city of Porto Alegre were included in the study. Data from the medical records of the selected patients were reviewed. Patients with and without obesity were compared using logistic regression to estimate the risk of mechanical ventilation, renal replacement therapy, tracheostomy, and death. Of the 257 patients with COVID-19 and SRAG hospitalized in the ICU, 42% were obese. The mean age of obese patients was 12 years younger than that of non-obese. We found an association with age ? 70 years with mortality (OR 6.38 95%CI 3.48-11.69). Crude analysis showed reduced risk of death for obese patients (OR 0.41 95%CI 0.24-0.68). After adjusting for age, sex and comorbidities, obesity was not associated with mortality, mechanical ventilation, renal replacement therapy, and tracheostomy. In conclusion, we did not find in a higher mortality among obese patients admitted to a intensive care unit with COVID-19 and SRAG when compared to non-obese patients. In our study, obesity was not associated with invasive mechanical ventilation, renal replacement therapy and tracheostomy. |
publishDate |
2022 |
dc.date.accessioned.fl_str_mv |
2022-09-30T15:07:38Z |
dc.date.issued.fl_str_mv |
2022-03-24 |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/masterThesis |
format |
masterThesis |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
https://tede2.pucrs.br/tede2/handle/tede/10498 |
url |
https://tede2.pucrs.br/tede2/handle/tede/10498 |
dc.language.iso.fl_str_mv |
por |
language |
por |
dc.relation.program.fl_str_mv |
-721401722658532398 |
dc.relation.confidence.fl_str_mv |
500 500 500 600 |
dc.relation.department.fl_str_mv |
-224747486637135387 |
dc.relation.cnpq.fl_str_mv |
-969369452308786627 |
dc.relation.sponsorship.fl_str_mv |
3590462550136975366 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Pontif?cia Universidade Cat?lica do Rio Grande do Sul |
dc.publisher.program.fl_str_mv |
Programa de P?s-Gradua??o em Medicina e Ci?ncias da Sa?de |
dc.publisher.initials.fl_str_mv |
PUCRS |
dc.publisher.country.fl_str_mv |
Brasil |
dc.publisher.department.fl_str_mv |
Escola de Medicina |
publisher.none.fl_str_mv |
Pontif?cia Universidade Cat?lica do Rio Grande do Sul |
dc.source.none.fl_str_mv |
reponame:Biblioteca Digital de Teses e Dissertações da PUC_RS instname:Pontifícia Universidade Católica do Rio Grande do Sul (PUCRS) instacron:PUC_RS |
instname_str |
Pontifícia Universidade Católica do Rio Grande do Sul (PUCRS) |
instacron_str |
PUC_RS |
institution |
PUC_RS |
reponame_str |
Biblioteca Digital de Teses e Dissertações da PUC_RS |
collection |
Biblioteca Digital de Teses e Dissertações da PUC_RS |
bitstream.url.fl_str_mv |
https://tede2.pucrs.br/tede2/bitstream/tede/10498/4/DIS_KARINE_SABRINA_BONAMIGO_SUSIN_CONFIDENCIAL.pdf.jpg https://tede2.pucrs.br/tede2/bitstream/tede/10498/3/DIS_KARINE_SABRINA_BONAMIGO_SUSIN_CONFIDENCIAL.pdf.txt https://tede2.pucrs.br/tede2/bitstream/tede/10498/2/DIS_KARINE_SABRINA_BONAMIGO_SUSIN_CONFIDENCIAL.pdf https://tede2.pucrs.br/tede2/bitstream/tede/10498/1/license.txt |
bitstream.checksum.fl_str_mv |
8ad6213a37c259fdb94b87adbfde1bbf 08e7ee690b5484635d45eaabdb25f90a 3a453e8eb34f30f80c2f9b3a67284fc3 220e11f2d3ba5354f917c7035aadef24 |
bitstream.checksumAlgorithm.fl_str_mv |
MD5 MD5 MD5 MD5 |
repository.name.fl_str_mv |
Biblioteca Digital de Teses e Dissertações da PUC_RS - Pontifícia Universidade Católica do Rio Grande do Sul (PUCRS) |
repository.mail.fl_str_mv |
biblioteca.central@pucrs.br|| |
_version_ |
1796793257507684352 |