A associa??o entre a obesidade e o desenvolvimento do adenoma, um precursor do c?ncer colorretal
Ano de defesa: | 2019 |
---|---|
Autor(a) principal: | |
Orientador(a): | |
Banca de defesa: | |
Tipo de documento: | Tese |
Tipo de acesso: | Acesso aberto |
Idioma: | por |
Instituição de defesa: |
Pontif?cia Universidade Cat?lica do Rio Grande do Sul
|
Programa de Pós-Graduação: |
Programa de P?s-Gradua??o em Medicina e Ci?ncias da Sa?de
|
Departamento: |
Escola de Medicina
|
País: |
Brasil
|
Palavras-chave em Português: | |
Palavras-chave em Inglês: | |
Área do conhecimento CNPq: | |
Link de acesso: | http://tede2.pucrs.br/tede2/handle/tede/8910 |
Resumo: | INTRODUCTION: One of the most important concerns on health is the increased rates of obesity in population and the speed in which this number is increasing. This growing increasing in the obese population translates a serious public health problem, since it also increases the risk of several other pathologies associated with obesity and it results in a significant morbidity and mortality. Among these, it seems to be several neoplasms, such as colorectal carcinoma (CRC). OBJECTIVE: This study aims to evaluate the relationship of obesity as a risk factor for CRC through the detection of adenoma, and to discuss the mechanisms that could establish a link between obesity and neoplasm. METHODS: Patients who underwent colonoscopy at the Proctology Service of the S?o Lucas Hospital of PUCRS between the years 2017 and 2018 were included. Personal and anthropometric data, clinical history, and results of the tests were analyzed in order to verify the correlation of BMI and the presence of adenomatous polyps. RESULTS: A total of 142 patients were studied, whith a mean age of 62 years. Of the patients, 74 (52.1%) were men and 68 (47.9%) were. Obesity was identified in 16.2% of the patients. Polyps were found in 61 patients (42.9%), mostly smaller than 1 cm. Obese individuals were 1.29 times more likely to present colorectal adenoma than patients with normal weight. CONCLUSIONS: This study, although showing the greater presence of colorectal adenomas in obese individuals, did not show a significant difference in the occurrence of premalignant lesions. |
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Padoin, Alexandre Vontobelhttp://lattes.cnpq.br/0241056171343649http://lattes.cnpq.br/7551527423519691Freitas, Bianca Astrogildo de2019-10-02T13:35:47Z2019-08-29http://tede2.pucrs.br/tede2/handle/tede/8910INTRODUCTION: One of the most important concerns on health is the increased rates of obesity in population and the speed in which this number is increasing. This growing increasing in the obese population translates a serious public health problem, since it also increases the risk of several other pathologies associated with obesity and it results in a significant morbidity and mortality. Among these, it seems to be several neoplasms, such as colorectal carcinoma (CRC). OBJECTIVE: This study aims to evaluate the relationship of obesity as a risk factor for CRC through the detection of adenoma, and to discuss the mechanisms that could establish a link between obesity and neoplasm. METHODS: Patients who underwent colonoscopy at the Proctology Service of the S?o Lucas Hospital of PUCRS between the years 2017 and 2018 were included. Personal and anthropometric data, clinical history, and results of the tests were analyzed in order to verify the correlation of BMI and the presence of adenomatous polyps. RESULTS: A total of 142 patients were studied, whith a mean age of 62 years. Of the patients, 74 (52.1%) were men and 68 (47.9%) were. Obesity was identified in 16.2% of the patients. Polyps were found in 61 patients (42.9%), mostly smaller than 1 cm. Obese individuals were 1.29 times more likely to present colorectal adenoma than patients with normal weight. CONCLUSIONS: This study, although showing the greater presence of colorectal adenomas in obese individuals, did not show a significant difference in the occurrence of premalignant lesions.INTRODU??O: Uma das grandes preocupa??es no ?mbito da sa?de ? o crescente ?ndice de obesidade na popula??o e a velocidade com que esse n?mero vem aumentando. Esse crescente aumento da popula??o obesa constitui um grave problema de sa?de p?blica, uma vez que aumenta tamb?m o risco de in?meras patologias associadas a obesidade e que resultam em morbimortalidade significativa, como o c?ncer colorretal (CCR). OBJETIVO: O objetivo deste trabalho consiste em avaliar a rela??o da obesidade como fator de risco para o CCR, atrav?s da detec??o de p?lipos adenomatosos, e discutir os mecanismos que podem estabelecer uma liga??o entre esta neoplasia e a obesidade. M?TODOS: Foram inclu?dos pacientes submetidos ao exame de colonoscopia no Servi?o de Proctologia do Hospital S?o Lucas da PUCRS entre os anos de 2017 e 2018. Dados pessoais e antropom?tricos, antecedentes cl?nicos e laudos dos exames foram analisados, a fim de verificar a correla??o do IMC e a presen?a de p?lipos adenomatosos. RESULTADOS: Foram estudados 142 pacientes, 74 (52,1%) homens e 68 (47,9%) mulheres, com m?dia de 62 anos. A obesidade foi identificada em 16,2% dos pacientes. P?lipos foram encontrados em 61 pacientes (42,9%), sendo em sua maioria menores do que 1 cm. Obesos tiveram probabilidade 1,29 vez maior de apresentar adenoma colorretal que pacientes com peso normal. CONCLUS?ES: Este estudo, apesar de mostrar a maior presen?a de adenomas colorretais em indiv?duos obesos, n?o mostrou uma diferen?a estatisticamente significativa na ocorr?ncia de les?es pr?-malignas.Submitted by PPG Medicina e Ci?ncias da Sa?de (medicina-pg@pucrs.br) on 2019-09-26T17:52:38Z No. of bitstreams: 1 dissertacao bianca.pdf: 1826290 bytes, checksum: a8ddd6d3988f8a0b67eb531b3c57558e (MD5)Approved for entry into archive by Sheila Dias (sheila.dias@pucrs.br) on 2019-10-02T13:28:57Z (GMT) No. of bitstreams: 1 dissertacao bianca.pdf: 1826290 bytes, checksum: a8ddd6d3988f8a0b67eb531b3c57558e (MD5)Made available in DSpace on 2019-10-02T13:35:47Z (GMT). No. of bitstreams: 1 dissertacao bianca.pdf: 1826290 bytes, checksum: a8ddd6d3988f8a0b67eb531b3c57558e (MD5) Previous issue date: 2019-08-29application/pdfhttp://tede2.pucrs.br:80/tede2/retrieve/176565/TES_BIANCA_ASTROGILDO_DE_FREITAS_CONFIDENCIAL.pdf.jpgporPontif?cia Universidade Cat?lica do Rio Grande do SulPrograma de P?s-Gradua??o em Medicina e Ci?ncias da Sa?dePUCRSBrasilEscola de MedicinaAdenomaColonoscopiaNeoplasias ColorretaisObesidadeAdenomaColonoscopyColorectal NeoplasmsObesityCIENCIAS DA SAUDE::MEDICINAA associa??o entre a obesidade e o desenvolvimento do adenoma, um precursor do c?ncer colorretalinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/doctoralThesisTrabalho ser? publicado como artigo ou livro60 meses02/10/2024-721401722658532398500500500-224747486637135387-969369452308786627info:eu-repo/semantics/openAccessreponame:Biblioteca Digital de Teses e Dissertações da PUC_RSinstname:Pontifícia Universidade Católica do Rio Grande do Sul (PUCRS)instacron:PUC_RSTHUMBNAILTES_BIANCA_ASTROGILDO_DE_FREITAS_CONFIDENCIAL.pdf.jpgTES_BIANCA_ASTROGILDO_DE_FREITAS_CONFIDENCIAL.pdf.jpgimage/jpeg4080http://tede2.pucrs.br/tede2/bitstream/tede/8910/4/TES_BIANCA_ASTROGILDO_DE_FREITAS_CONFIDENCIAL.pdf.jpgba24fe794b53a178365ff0138f969108MD54TEXTTES_BIANCA_ASTROGILDO_DE_FREITAS_CONFIDENCIAL.pdf.txtTES_BIANCA_ASTROGILDO_DE_FREITAS_CONFIDENCIAL.pdf.txttext/plain1259http://tede2.pucrs.br/tede2/bitstream/tede/8910/3/TES_BIANCA_ASTROGILDO_DE_FREITAS_CONFIDENCIAL.pdf.txt3242dfc923303d24f6b2929aed22accbMD53ORIGINALTES_BIANCA_ASTROGILDO_DE_FREITAS_CONFIDENCIAL.pdfTES_BIANCA_ASTROGILDO_DE_FREITAS_CONFIDENCIAL.pdfapplication/pdf534429http://tede2.pucrs.br/tede2/bitstream/tede/8910/2/TES_BIANCA_ASTROGILDO_DE_FREITAS_CONFIDENCIAL.pdf15a96e3831de1af81f77c8dd61771f3fMD52LICENSElicense.txtlicense.txttext/plain; charset=utf-8590http://tede2.pucrs.br/tede2/bitstream/tede/8910/1/license.txt220e11f2d3ba5354f917c7035aadef24MD51tede/89102019-10-02 12:00:35.515oai:tede2.pucrs.br:tede/8910QXV0b3JpemE/P28gcGFyYSBQdWJsaWNhPz9vIEVsZXRyP25pY2E6IENvbSBiYXNlIG5vIGRpc3Bvc3RvIG5hIExlaSBGZWRlcmFsIG4/OS42MTAsIGRlIDE5IGRlIGZldmVyZWlybyBkZSAxOTk4LCBvIGF1dG9yIEFVVE9SSVpBIGEgcHVibGljYT8/byBlbGV0cj9uaWNhIGRhIHByZXNlbnRlIG9icmEgbm8gYWNlcnZvIGRhIEJpYmxpb3RlY2EgRGlnaXRhbCBkYSBQb250aWY/Y2lhIFVuaXZlcnNpZGFkZSBDYXQ/bGljYSBkbyBSaW8gR3JhbmRlIGRvIFN1bCwgc2VkaWFkYSBhIEF2LiBJcGlyYW5nYSA2NjgxLCBQb3J0byBBbGVncmUsIFJpbyBHcmFuZGUgZG8gU3VsLCBjb20gcmVnaXN0cm8gZGUgQ05QSiA4ODYzMDQxMzAwMDItODEgYmVtIGNvbW8gZW0gb3V0cmFzIGJpYmxpb3RlY2FzIGRpZ2l0YWlzLCBuYWNpb25haXMgZSBpbnRlcm5hY2lvbmFpcywgY29ucz9yY2lvcyBlIHJlZGVzID9zIHF1YWlzIGEgYmlibGlvdGVjYSBkYSBQVUNSUyBwb3NzYSBhIHZpciBwYXJ0aWNpcGFyLCBzZW0gP251cyBhbHVzaXZvIGFvcyBkaXJlaXRvcyBhdXRvcmFpcywgYSB0P3R1bG8gZGUgZGl2dWxnYT8/byBkYSBwcm9kdT8/byBjaWVudD9maWNhLgo=Biblioteca Digital de Teses e Dissertaçõeshttp://tede2.pucrs.br/tede2/PRIhttps://tede2.pucrs.br/oai/requestbiblioteca.central@pucrs.br||opendoar:2019-10-02T15:00:35Biblioteca Digital de Teses e Dissertações da PUC_RS - Pontifícia Universidade Católica do Rio Grande do Sul (PUCRS)false |
dc.title.por.fl_str_mv |
A associa??o entre a obesidade e o desenvolvimento do adenoma, um precursor do c?ncer colorretal |
title |
A associa??o entre a obesidade e o desenvolvimento do adenoma, um precursor do c?ncer colorretal |
spellingShingle |
A associa??o entre a obesidade e o desenvolvimento do adenoma, um precursor do c?ncer colorretal Freitas, Bianca Astrogildo de Adenoma Colonoscopia Neoplasias Colorretais Obesidade Adenoma Colonoscopy Colorectal Neoplasms Obesity CIENCIAS DA SAUDE::MEDICINA |
title_short |
A associa??o entre a obesidade e o desenvolvimento do adenoma, um precursor do c?ncer colorretal |
title_full |
A associa??o entre a obesidade e o desenvolvimento do adenoma, um precursor do c?ncer colorretal |
title_fullStr |
A associa??o entre a obesidade e o desenvolvimento do adenoma, um precursor do c?ncer colorretal |
title_full_unstemmed |
A associa??o entre a obesidade e o desenvolvimento do adenoma, um precursor do c?ncer colorretal |
title_sort |
A associa??o entre a obesidade e o desenvolvimento do adenoma, um precursor do c?ncer colorretal |
author |
Freitas, Bianca Astrogildo de |
author_facet |
Freitas, Bianca Astrogildo de |
author_role |
author |
dc.contributor.advisor1.fl_str_mv |
Padoin, Alexandre Vontobel |
dc.contributor.advisor1Lattes.fl_str_mv |
http://lattes.cnpq.br/0241056171343649 |
dc.contributor.authorLattes.fl_str_mv |
http://lattes.cnpq.br/7551527423519691 |
dc.contributor.author.fl_str_mv |
Freitas, Bianca Astrogildo de |
contributor_str_mv |
Padoin, Alexandre Vontobel |
dc.subject.por.fl_str_mv |
Adenoma Colonoscopia Neoplasias Colorretais Obesidade |
topic |
Adenoma Colonoscopia Neoplasias Colorretais Obesidade Adenoma Colonoscopy Colorectal Neoplasms Obesity CIENCIAS DA SAUDE::MEDICINA |
dc.subject.eng.fl_str_mv |
Adenoma Colonoscopy Colorectal Neoplasms Obesity |
dc.subject.cnpq.fl_str_mv |
CIENCIAS DA SAUDE::MEDICINA |
description |
INTRODUCTION: One of the most important concerns on health is the increased rates of obesity in population and the speed in which this number is increasing. This growing increasing in the obese population translates a serious public health problem, since it also increases the risk of several other pathologies associated with obesity and it results in a significant morbidity and mortality. Among these, it seems to be several neoplasms, such as colorectal carcinoma (CRC). OBJECTIVE: This study aims to evaluate the relationship of obesity as a risk factor for CRC through the detection of adenoma, and to discuss the mechanisms that could establish a link between obesity and neoplasm. METHODS: Patients who underwent colonoscopy at the Proctology Service of the S?o Lucas Hospital of PUCRS between the years 2017 and 2018 were included. Personal and anthropometric data, clinical history, and results of the tests were analyzed in order to verify the correlation of BMI and the presence of adenomatous polyps. RESULTS: A total of 142 patients were studied, whith a mean age of 62 years. Of the patients, 74 (52.1%) were men and 68 (47.9%) were. Obesity was identified in 16.2% of the patients. Polyps were found in 61 patients (42.9%), mostly smaller than 1 cm. Obese individuals were 1.29 times more likely to present colorectal adenoma than patients with normal weight. CONCLUSIONS: This study, although showing the greater presence of colorectal adenomas in obese individuals, did not show a significant difference in the occurrence of premalignant lesions. |
publishDate |
2019 |
dc.date.accessioned.fl_str_mv |
2019-10-02T13:35:47Z |
dc.date.issued.fl_str_mv |
2019-08-29 |
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http://tede2.pucrs.br/tede2/handle/tede/8910 |
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http://tede2.pucrs.br/tede2/handle/tede/8910 |
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Pontif?cia Universidade Cat?lica do Rio Grande do Sul |
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Programa de P?s-Gradua??o em Medicina e Ci?ncias da Sa?de |
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PUCRS |
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Brasil |
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Pontif?cia Universidade Cat?lica do Rio Grande do Sul |
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