Efeitos da fase do ciclo menstrual na massa muscular

• Ano de defesa: 2023
• Autor(a) principal: Dias, Nathalia Fernanda
• Orientador(a): Libardi, Cleiton Augusto
• Tipo de documento: Dissertação
• Tipo de acesso: Acesso aberto
• Idioma: por
• Instituição de defesa: Universidade Federal de São Carlos; Câmpus São Carlos
• Programa de Pós-Graduação: Programa Interinstitucional de Pós-Graduação em Ciências Fisiológicas - PIPGCF
• Palavras-chave em Português: Hormônios; Estradiol; Progesterona; Músculo esquelético
• Palavras-chave em Inglês: Hormones; Estradiol; Progesterone; Skeletal muscle
• Área do conhecimento CNPq: CIENCIAS DA SAUDE::EDUCACAO FISICA
• Link de acesso: https://repositorio.ufscar.br/handle/ufscar/17708

Introduction: Eumenorrheic women are naturally exposed to hormonal fluctuations of estradiol (E2), progesterone (P4), luteinizing hormone, and follicle-stimulating hormone during the menstrual cycle (MC). However, these hormonal oscillations during MC in muscle mass are little known. The aim of the study was to investigate the possible changes in the muscle thickness (MT) and muscular cross-sectional area (MCSA) of the vastus lateralis, during the phases of two CM. As a secondary objective, we sought to investigate changes in muscle parameters throughout the CM, from an individual approach. Methods: Thirty-five healthy young women aged between 18 and 35 years and with a regular MC of 21 to 35 days participated in the study. Muscle evaluations by ultrasound and evaluations of E2 and P4 hormones by salivary samples were performed in the phases of the MC (follicular phase [FOL], ovulatory phase [OVU], and luteal phase [LUT]), for two consecutive cycles. A mixed-model analysis was performed to compare E2 and P4 levels, MT, and MCSA in different phases of MC. In case of significant F, Tukey's adjustment was performed for multiple comparisons. Additionally, a subsample (n=13) was analyzed, including only those participants who met the criteria of increased E2 in OVU in relation to FOL. In this subsample, the same mixed model analysis was performed, as well as a Person correlation analysis between all muscle and hormonal parameters investigated in each of the MC phases. Finally, from an individual analysis, we analyzed how many participants had true changes in MT and MCSA between MC phases. Results: P4 concentrations were significantly higher in first cycle LUT and second cycle LUT compared to first cycle FOL (p = 0.017 and p = 0.039, respectively), first cycle OVU (p = 0.0008 and p = 0.008, respectively), second cycle FOL (p = 0.012 and p = 0.0007, respectively) and second cycle OVU (p = 0.008 and p = 0.006, respectively). However, no significant differences were observed between the phases of the two MC for E2 concentrations. MT and MCSA also did not vary over the cycles. When analyzing a subsample, E2 concentrations were significantly higher in OVU than in FOL (p = 0.001), and P4 concentrations were significantly higher in LUT than in FOL (p = 0.017) and OVU (p = 0.0009). As observed in the complete sample, MT and MCSA were also unchanged. No significant correlation was observed between the muscular and hormonal parameters analyzed either. Finally, regarding the individual analyses, we observed that MT and MCSA showed changes for some participants over the MC. Conclusion: Hormonal variations resulting from the MC do not affect MT and the MCSA. However, changes in this tissue can be observed at the individual level in the different phases of MC, but without associations with the hormones E2 and P4.