Influência da obesidade sobre as morfologias de onda da pressão intracraniana e cerebral: um estudo prospectivo
Ano de defesa: | 2021 |
---|---|
Autor(a) principal: | |
Orientador(a): | |
Banca de defesa: | |
Tipo de documento: | Tese |
Tipo de acesso: | Acesso aberto |
Idioma: | por |
Instituição de defesa: |
Universidade Federal de São Carlos
Câmpus São Carlos |
Programa de Pós-Graduação: |
Programa Interinstitucional de Pós-Graduação em Ciências Fisiológicas - PIPGCF
|
Departamento: |
Não Informado pela instituição
|
País: |
Não Informado pela instituição
|
Palavras-chave em Português: | |
Palavras-chave em Inglês: | |
Área do conhecimento CNPq: | |
Link de acesso: | https://repositorio.ufscar.br/handle/ufscar/14456 |
Resumo: | Introduction: Obesity is a low-grade inflammatory disease, which can lead to the development of other pathologies, such as diabetes mellitus, dyslipidemias and arterial hypertension (AH). Compare the relationship between blood pressure (BP) and intracranial pressure (ICP), given by the cerebral perfusion pressure, AH can cause an increase in ICP. The increase in ICP is related to stroke, migraines, ocular hypertension, among other pathologies. Thus, the aim of this study was to analyze the behavior of the ICP wave morphology in the face of obesity, to analyze the non-invasive form and to prospect for information about AH, ICP, inflammatory and metabolic aspects, and cerebral morphology in Wistar rats. Materials and methods: Two parallel studies were carried out, with a 24-week treatment of a high-fat diet, to induce obesity, after a previous adaptation of 60 days, with a standard diet. In study 1, 16 rats were divided into the Obese (OB, n = 9) and Non-Obese (NOB, n = 7) groups. All animals were adopted every 4 weeks, being: Fat percentage (% g), Body mass (BM), Fat free mass (FFM), Bone mineral content (BMC), BP, Heart rate (HR) and ICP. In study 2, 61 animals were divided into the groups, high-fat diet (HFD) and chow diet (CD) and subdivided by weeks in which they were sacrificed, over the 24 weeks (W0, W8, W16, W24). Group OB and W-HFD were fed with HFD and NOB and W-CD with CD. The evaluations of the non-invasive variables were carried out in study 2 every 8 weeks, and part of the animals being sacrificed. Also extracted were: brain weight, brain lipid content, number of cells in the primary motor area (M1), the thickness of the gray matter in this area, in addition to blood glucose, lipid profile, and inflammatory profile. Euthanasia took place every 8 weeks in study 2, and in study 1 at the end of 24 weeks. Results: Study 1 statistical difference in the area under the ICP curve, between OB and NOB, with a reduction in the NOB group, remaining below OB during treatment. In study 2, there was no difference between the groups, only was a probability of an increase in the W24-HFD group. Regarding BP, no statistical difference was found in both studies. However, HR was statistically different in study 1, being higher in OB, and the probability of increase in study 2. BM,%fat, FFM, and BMC were higher in the OB and W24-HFD groups, compared to the control. There is no difference in brain lipid content or relative brain weight at the end of treatment. There was a probability of a decrease in brain weight in the HFD groups, and also a decrease in the total number of M1 cells, in addition to an increase in the thickness of the gray matter of this same area in the HFD group. Discovery of decreased brain-derived neurotrophic factor (BDNF), and increased leptin at the end of treatment in the W24-HFD group. Conclusion: The HFD developed obesity in rats, but did not promote dyslipidemia or chronic inflammation. The increase in blood glucose in the OB group demonstrates possible insulin resistance. Variations in ICP are due to the better cerebral compliance of the NOB group. An increased likelihood of leptin, gray matter thickness, loss of cell number and reduction of circulating BDNF levels may indicate loss of neural plasticity, glial cells, and increased fluid in the brain parenchyma. This scenario may be the beginning of a greater damage to the brain, potentially leading to an increase in the PIC. |
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Marine, Diego AdornaDuarte, Ana Cláudia Garcia de Oliveirahttp://lattes.cnpq.br/1996950253264696http://lattes.cnpq.br/26751796411488382021-06-29T11:53:56Z2021-06-29T11:53:56Z2021-05-13MARINE, Diego Adorna. Influência da obesidade sobre as morfologias de onda da pressão intracraniana e cerebral: um estudo prospectivo. 2021. Tese (Doutorado em Ciências Fisiológicas) – Universidade Federal de São Carlos, São Carlos, 2021. Disponível em: https://repositorio.ufscar.br/handle/ufscar/14456.https://repositorio.ufscar.br/handle/ufscar/14456Introduction: Obesity is a low-grade inflammatory disease, which can lead to the development of other pathologies, such as diabetes mellitus, dyslipidemias and arterial hypertension (AH). Compare the relationship between blood pressure (BP) and intracranial pressure (ICP), given by the cerebral perfusion pressure, AH can cause an increase in ICP. The increase in ICP is related to stroke, migraines, ocular hypertension, among other pathologies. Thus, the aim of this study was to analyze the behavior of the ICP wave morphology in the face of obesity, to analyze the non-invasive form and to prospect for information about AH, ICP, inflammatory and metabolic aspects, and cerebral morphology in Wistar rats. Materials and methods: Two parallel studies were carried out, with a 24-week treatment of a high-fat diet, to induce obesity, after a previous adaptation of 60 days, with a standard diet. In study 1, 16 rats were divided into the Obese (OB, n = 9) and Non-Obese (NOB, n = 7) groups. All animals were adopted every 4 weeks, being: Fat percentage (% g), Body mass (BM), Fat free mass (FFM), Bone mineral content (BMC), BP, Heart rate (HR) and ICP. In study 2, 61 animals were divided into the groups, high-fat diet (HFD) and chow diet (CD) and subdivided by weeks in which they were sacrificed, over the 24 weeks (W0, W8, W16, W24). Group OB and W-HFD were fed with HFD and NOB and W-CD with CD. The evaluations of the non-invasive variables were carried out in study 2 every 8 weeks, and part of the animals being sacrificed. Also extracted were: brain weight, brain lipid content, number of cells in the primary motor area (M1), the thickness of the gray matter in this area, in addition to blood glucose, lipid profile, and inflammatory profile. Euthanasia took place every 8 weeks in study 2, and in study 1 at the end of 24 weeks. Results: Study 1 statistical difference in the area under the ICP curve, between OB and NOB, with a reduction in the NOB group, remaining below OB during treatment. In study 2, there was no difference between the groups, only was a probability of an increase in the W24-HFD group. Regarding BP, no statistical difference was found in both studies. However, HR was statistically different in study 1, being higher in OB, and the probability of increase in study 2. BM,%fat, FFM, and BMC were higher in the OB and W24-HFD groups, compared to the control. There is no difference in brain lipid content or relative brain weight at the end of treatment. There was a probability of a decrease in brain weight in the HFD groups, and also a decrease in the total number of M1 cells, in addition to an increase in the thickness of the gray matter of this same area in the HFD group. Discovery of decreased brain-derived neurotrophic factor (BDNF), and increased leptin at the end of treatment in the W24-HFD group. Conclusion: The HFD developed obesity in rats, but did not promote dyslipidemia or chronic inflammation. The increase in blood glucose in the OB group demonstrates possible insulin resistance. Variations in ICP are due to the better cerebral compliance of the NOB group. An increased likelihood of leptin, gray matter thickness, loss of cell number and reduction of circulating BDNF levels may indicate loss of neural plasticity, glial cells, and increased fluid in the brain parenchyma. This scenario may be the beginning of a greater damage to the brain, potentially leading to an increase in the PIC.Introdução: A obesidade é uma doença inflamatória de baixo grau, que pode levar ao desenvolvimento de outras patologias, como diabetes mellitus, dislipidemias e hipertensão arterial (HA). Considerando a relação entre a pressão arterial (PA) e a Pressão Intracraniana (PIC), dando-se através da pressão de perfusão cerebral, a HA pode ocasionar o aumento da PIC. O aumento da PIC relaciona-se ao Acidente Vascular Cerebral (AVC), enxaquecas, hipertensão ocular, entre outras patologias. Desta forma, o objetivo deste estudo foi analisar o comportamento da morfologia de onda da PIC frente à obesidade, analisada de forma não invasiva, e prospectar informações a respeito da HA, PIC, aspectos inflamatórios e metabólicos, e morfologia cerebral, em ratos Wistar. Materiais e métodos: Foram realizados dois estudos paralelos, com tratamento de 24 semanas de dieta hiperlipídica, para indução da obesidade, após uma adaptação prévia de 60 dias, com dieta padrão. No estudo 1, 16 ratos foram divididos nos grupos Obeso (OB, n=9) e Não Obeso (NOB, n=7). Todos os animais foram avaliados a cada 4 semanas, sendo: Percentual de gordura (%g), Massa corporal total (MT), Massa livre de gordura (MLG), Conteúdo mineral ósseo (CMO), PA, Frequência Cardíaca (FC) e PIC. No estudo 2, 61 animais foram divididos nos grupos, dieta hiperlipídica (DH) e dieta padrão (DP) e subdivididos por semanas em que foram sacrificados, ao longo das 24 semanas(S0, S8, S16, S24). Grupo OB e S-DH foram alimentados com DH e NOB e S-DP com DP. As avaliações das variáveis não invasivas foram realizadas no estudo 2 a cada 8 semanas, e parte dos animais sendo sacrificada. Avaliamos também: peso cerebral, conteúdo de lipídeos cerebrais, número de células da área motora primária (M1), a espessura da matéria cinza desta área, além de glicemia, perfil lipídico, e perfil inflamatório. A eutanásia aconteceu a cada 8 semanas no estudo 2, e no estudo 1 ao final das 24 semanas. Resultados: O estudo 1 demonstrou diferença estatística da área sob a curva da PIC, entre OB e NOB, com redução no grupo NOB, permanecendo abaixo de OB durante o tratamento. No estudo 2 não houve diferença entre grupos, apenas probabilidade de aumento do grupo S24-DH. Sobre a PA, não encontramos diferença estatística em ambos estudos. Entretanto, a FC foi diferente estatisticamente no estudo 1 sendo maior em OB, e probabilidade de aumento no estudo 2. MT, %g, MLG, e CMO foi maior nos grupos OB e S24-DH, em relação ao controle. Não ouve diferença do conteúdo de lipídeos cerebrais ou do peso relativo cerebral ao final do tratamento. Houve probabilidade de diminuição do peso cerebral nos grupos DH, e também de diminuição do número total de células da M1, além de aumento da espessura da matéria cinza desta mesma área no grupo DH. Encontramos probabilidade de diminuição do fator neurotrófico derivado do cérebro (BDNF), e de aumento de Leptina ao final do tratamento em S24-DH. Conclusão: A DH desenvolveu a obesidade em ratos, mas não promoveu dislipidemias ou inflamação crônica. O aumento da glicemia no grupo OB demonstra possível resistência à insulina. Variações na PIC deve-se a melhor complacência cerebral do grupo NOB. A probabilidade de aumento da leptina, da espessura da matéria cinza, da perda do número de células e redução dos níveis circulantes de BDNF podem indicar a perda da plasticidade neural, de células gliais, e aumento de líquido no parênquima cerebral. Este cenário pode ser o início de um prejuízo maior para o cérebro, podendo potencialmente levar ao aumento da PIC.Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)FAPESP: 2016/09602-4porUniversidade Federal de São CarlosCâmpus São CarlosPrograma Interinstitucional de Pós-Graduação em Ciências Fisiológicas - PIPGCFUFSCarAttribution-NonCommercial-NoDerivs 3.0 Brazilhttp://creativecommons.org/licenses/by-nc-nd/3.0/br/info:eu-repo/semantics/openAccessPressão intracranianaHipertensãoObesidadeInflamaçãoIntracranial pressureHypertensionObesityInflammationCIENCIAS BIOLOGICAS::FISIOLOGIA::FISIOLOGIA GERALInfluência da obesidade sobre as morfologias de onda da pressão intracraniana e cerebral: um estudo prospectivoInfluence of obesity on the pressure wave morphologies intracranial and brain: a prospective studyinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/doctoralThesisreponame:Repositório Institucional da UFSCARinstname:Universidade Federal de São Carlos (UFSCAR)instacron:UFSCARORIGINALTese final Diego Adorna Marine assinada 2021.pdfTese final Diego Adorna Marine assinada 2021.pdfTese final de doutoradoapplication/pdf10040852https://{{ getenv "DSPACE_HOST" "repositorio.ufscar.br" }}/bitstream/ufscar/14456/1/Tese%20final%20Diego%20Adorna%20Marine%20%20assinada%202021.pdf78ef6d02d2598d26c03beb9db42771e8MD51Novo modelo carta comprovante - entrega versão final da tese Diego Adorna Marine 2021.pdfNovo modelo carta comprovante - entrega versão final da tese Diego Adorna Marine 2021.pdfCarta comprovante de entrega de tese finalapplication/pdf101772https://{{ getenv "DSPACE_HOST" "repositorio.ufscar.br" }}/bitstream/ufscar/14456/2/Novo%20modelo%20carta%20comprovante%20-%20entrega%20vers%c3%a3o%20final%20da%20tese%20Diego%20Adorna%20Marine%202021.pdfe46f205b2b0be4d9d24ef18b21c81de7MD52CC-LICENSElicense_rdflicense_rdfapplication/rdf+xml; charset=utf-8811https://{{ getenv "DSPACE_HOST" "repositorio.ufscar.br" }}/bitstream/ufscar/14456/4/license_rdfe39d27027a6cc9cb039ad269a5db8e34MD54TEXTTese final Diego Adorna Marine assinada 2021.pdf.txtTese final Diego Adorna Marine assinada 2021.pdf.txtExtracted texttext/plain120537https://{{ getenv "DSPACE_HOST" "repositorio.ufscar.br" }}/bitstream/ufscar/14456/5/Tese%20final%20Diego%20Adorna%20Marine%20%20assinada%202021.pdf.txt1cfbafdf051a603c21c9ac14be8acf90MD55Novo modelo carta comprovante - entrega versão final da tese Diego Adorna Marine 2021.pdf.txtNovo modelo carta comprovante - entrega versão final da tese Diego Adorna Marine 2021.pdf.txtExtracted texttext/plain1807https://{{ getenv "DSPACE_HOST" "repositorio.ufscar.br" }}/bitstream/ufscar/14456/7/Novo%20modelo%20carta%20comprovante%20-%20entrega%20vers%c3%a3o%20final%20da%20tese%20Diego%20Adorna%20Marine%202021.pdf.txt8f800335c812961ef543c43cefac8b04MD57THUMBNAILTese final Diego Adorna Marine assinada 2021.pdf.jpgTese final Diego Adorna Marine assinada 2021.pdf.jpgIM Thumbnailimage/jpeg7083https://{{ getenv "DSPACE_HOST" "repositorio.ufscar.br" }}/bitstream/ufscar/14456/6/Tese%20final%20Diego%20Adorna%20Marine%20%20assinada%202021.pdf.jpg9e22e5983970f79375a204a69f954513MD56Novo modelo carta comprovante - entrega versão final da tese Diego Adorna Marine 2021.pdf.jpgNovo modelo carta comprovante - entrega versão final da tese Diego Adorna Marine 2021.pdf.jpgIM Thumbnailimage/jpeg6204https://{{ getenv "DSPACE_HOST" "repositorio.ufscar.br" }}/bitstream/ufscar/14456/8/Novo%20modelo%20carta%20comprovante%20-%20entrega%20vers%c3%a3o%20final%20da%20tese%20Diego%20Adorna%20Marine%202021.pdf.jpga9f759fe289156ecab388d2995bb04a0MD58ufscar/144562021-06-30 03:13:46.374oai:repositorio.ufscar.br:ufscar/14456Repositório InstitucionalPUBhttps://repositorio.ufscar.br/oai/requestopendoar:43222023-05-25T13:01:34.164441Repositório Institucional da UFSCAR - Universidade Federal de São Carlos (UFSCAR)false |
dc.title.por.fl_str_mv |
Influência da obesidade sobre as morfologias de onda da pressão intracraniana e cerebral: um estudo prospectivo |
dc.title.alternative.eng.fl_str_mv |
Influence of obesity on the pressure wave morphologies intracranial and brain: a prospective study |
title |
Influência da obesidade sobre as morfologias de onda da pressão intracraniana e cerebral: um estudo prospectivo |
spellingShingle |
Influência da obesidade sobre as morfologias de onda da pressão intracraniana e cerebral: um estudo prospectivo Marine, Diego Adorna Pressão intracraniana Hipertensão Obesidade Inflamação Intracranial pressure Hypertension Obesity Inflammation CIENCIAS BIOLOGICAS::FISIOLOGIA::FISIOLOGIA GERAL |
title_short |
Influência da obesidade sobre as morfologias de onda da pressão intracraniana e cerebral: um estudo prospectivo |
title_full |
Influência da obesidade sobre as morfologias de onda da pressão intracraniana e cerebral: um estudo prospectivo |
title_fullStr |
Influência da obesidade sobre as morfologias de onda da pressão intracraniana e cerebral: um estudo prospectivo |
title_full_unstemmed |
Influência da obesidade sobre as morfologias de onda da pressão intracraniana e cerebral: um estudo prospectivo |
title_sort |
Influência da obesidade sobre as morfologias de onda da pressão intracraniana e cerebral: um estudo prospectivo |
author |
Marine, Diego Adorna |
author_facet |
Marine, Diego Adorna |
author_role |
author |
dc.contributor.authorlattes.por.fl_str_mv |
http://lattes.cnpq.br/2675179641148838 |
dc.contributor.author.fl_str_mv |
Marine, Diego Adorna |
dc.contributor.advisor1.fl_str_mv |
Duarte, Ana Cláudia Garcia de Oliveira |
dc.contributor.advisor1Lattes.fl_str_mv |
http://lattes.cnpq.br/1996950253264696 |
contributor_str_mv |
Duarte, Ana Cláudia Garcia de Oliveira |
dc.subject.por.fl_str_mv |
Pressão intracraniana Hipertensão Obesidade Inflamação |
topic |
Pressão intracraniana Hipertensão Obesidade Inflamação Intracranial pressure Hypertension Obesity Inflammation CIENCIAS BIOLOGICAS::FISIOLOGIA::FISIOLOGIA GERAL |
dc.subject.eng.fl_str_mv |
Intracranial pressure Hypertension Obesity Inflammation |
dc.subject.cnpq.fl_str_mv |
CIENCIAS BIOLOGICAS::FISIOLOGIA::FISIOLOGIA GERAL |
description |
Introduction: Obesity is a low-grade inflammatory disease, which can lead to the development of other pathologies, such as diabetes mellitus, dyslipidemias and arterial hypertension (AH). Compare the relationship between blood pressure (BP) and intracranial pressure (ICP), given by the cerebral perfusion pressure, AH can cause an increase in ICP. The increase in ICP is related to stroke, migraines, ocular hypertension, among other pathologies. Thus, the aim of this study was to analyze the behavior of the ICP wave morphology in the face of obesity, to analyze the non-invasive form and to prospect for information about AH, ICP, inflammatory and metabolic aspects, and cerebral morphology in Wistar rats. Materials and methods: Two parallel studies were carried out, with a 24-week treatment of a high-fat diet, to induce obesity, after a previous adaptation of 60 days, with a standard diet. In study 1, 16 rats were divided into the Obese (OB, n = 9) and Non-Obese (NOB, n = 7) groups. All animals were adopted every 4 weeks, being: Fat percentage (% g), Body mass (BM), Fat free mass (FFM), Bone mineral content (BMC), BP, Heart rate (HR) and ICP. In study 2, 61 animals were divided into the groups, high-fat diet (HFD) and chow diet (CD) and subdivided by weeks in which they were sacrificed, over the 24 weeks (W0, W8, W16, W24). Group OB and W-HFD were fed with HFD and NOB and W-CD with CD. The evaluations of the non-invasive variables were carried out in study 2 every 8 weeks, and part of the animals being sacrificed. Also extracted were: brain weight, brain lipid content, number of cells in the primary motor area (M1), the thickness of the gray matter in this area, in addition to blood glucose, lipid profile, and inflammatory profile. Euthanasia took place every 8 weeks in study 2, and in study 1 at the end of 24 weeks. Results: Study 1 statistical difference in the area under the ICP curve, between OB and NOB, with a reduction in the NOB group, remaining below OB during treatment. In study 2, there was no difference between the groups, only was a probability of an increase in the W24-HFD group. Regarding BP, no statistical difference was found in both studies. However, HR was statistically different in study 1, being higher in OB, and the probability of increase in study 2. BM,%fat, FFM, and BMC were higher in the OB and W24-HFD groups, compared to the control. There is no difference in brain lipid content or relative brain weight at the end of treatment. There was a probability of a decrease in brain weight in the HFD groups, and also a decrease in the total number of M1 cells, in addition to an increase in the thickness of the gray matter of this same area in the HFD group. Discovery of decreased brain-derived neurotrophic factor (BDNF), and increased leptin at the end of treatment in the W24-HFD group. Conclusion: The HFD developed obesity in rats, but did not promote dyslipidemia or chronic inflammation. The increase in blood glucose in the OB group demonstrates possible insulin resistance. Variations in ICP are due to the better cerebral compliance of the NOB group. An increased likelihood of leptin, gray matter thickness, loss of cell number and reduction of circulating BDNF levels may indicate loss of neural plasticity, glial cells, and increased fluid in the brain parenchyma. This scenario may be the beginning of a greater damage to the brain, potentially leading to an increase in the PIC. |
publishDate |
2021 |
dc.date.accessioned.fl_str_mv |
2021-06-29T11:53:56Z |
dc.date.available.fl_str_mv |
2021-06-29T11:53:56Z |
dc.date.issued.fl_str_mv |
2021-05-13 |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/doctoralThesis |
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doctoralThesis |
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publishedVersion |
dc.identifier.citation.fl_str_mv |
MARINE, Diego Adorna. Influência da obesidade sobre as morfologias de onda da pressão intracraniana e cerebral: um estudo prospectivo. 2021. Tese (Doutorado em Ciências Fisiológicas) – Universidade Federal de São Carlos, São Carlos, 2021. Disponível em: https://repositorio.ufscar.br/handle/ufscar/14456. |
dc.identifier.uri.fl_str_mv |
https://repositorio.ufscar.br/handle/ufscar/14456 |
identifier_str_mv |
MARINE, Diego Adorna. Influência da obesidade sobre as morfologias de onda da pressão intracraniana e cerebral: um estudo prospectivo. 2021. Tese (Doutorado em Ciências Fisiológicas) – Universidade Federal de São Carlos, São Carlos, 2021. Disponível em: https://repositorio.ufscar.br/handle/ufscar/14456. |
url |
https://repositorio.ufscar.br/handle/ufscar/14456 |
dc.language.iso.fl_str_mv |
por |
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por |
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Attribution-NonCommercial-NoDerivs 3.0 Brazil http://creativecommons.org/licenses/by-nc-nd/3.0/br/ info:eu-repo/semantics/openAccess |
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Attribution-NonCommercial-NoDerivs 3.0 Brazil http://creativecommons.org/licenses/by-nc-nd/3.0/br/ |
eu_rights_str_mv |
openAccess |
dc.publisher.none.fl_str_mv |
Universidade Federal de São Carlos Câmpus São Carlos |
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Programa Interinstitucional de Pós-Graduação em Ciências Fisiológicas - PIPGCF |
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UFSCar |
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Universidade Federal de São Carlos Câmpus São Carlos |
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