Influência do treinamento resistido na atividade fagocítica de monócitos e neutrófilos em mulheres idosas
Ano de defesa: | 2018 |
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Autor(a) principal: | |
Orientador(a): | |
Banca de defesa: | |
Tipo de documento: | Tese |
Tipo de acesso: | Acesso aberto |
Idioma: | por |
Instituição de defesa: |
Universidade Católica de Brasília
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Programa de Pós-Graduação: |
Programa Stricto Sensu em Educação Física
|
Departamento: |
Escola de Saúde e Medicina
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País: |
Brasil
|
Palavras-chave em Português: | |
Área do conhecimento CNPq: | |
Resumo em Inglês: | Projections of the increase in absolute and relative numbers of elderly represent new challenges for public health. Aging is accompanied by gradual decline of physiological functions, immune function and muscle strength. In this way, the elderly is more susceptible to sarcopenia, osteoporosis, cancer and cardiovascular, metabolic and neurodegenerative diseases. Resistance Training (RT) has been shown to be an important intervention for increased muscle strength and decreased chronic inflammation in the elderly. However, little is known about the influence of RT on the functional response of cells that constitute the first line of defense during immunosenescence. In this sense, the present study aimed to investigate an association between RT adaptations induced by a program and a functional response of circulating phagocytes in elderly. The present cross-sectional study was composed of 54 elderly women, 71.3 ± 6.3 years, apparently healthy, non-institutionalized and divided into two distinct groups: Trained (n = 28) and Sedentary (n = 26). The elderly of the Trained group were participants of a RT program for 8.6 ± 0.3 months and performed a training consisting of 12 exercises, 3 sessions weekly, with intensity of 70% of a maximum repetition, while the Sedentary group did not participate of any physical activity program during the same period. Body mass, height, body mass index, waisthip ratio, fat free mass and fat mass were evaluated. The total energy intake and macronutrients in the usual diet were assessed. TNF-a, IL-6 and IGF-1 analyzes, total and differential leukocyte count, monocyte or neutrophil phagocytosis test, phagocytosis index (IF) and microbicidal activity of phagocytes were performed. Data analysis was performed using the Statistical Package for the Social Sciences (SPSS) program and considered statistically significant P <0.05 for two-tailed tests. The results show that the IF of neutrophils (but not of monocytes) in the Trained group was significantly higher (! <0.001, effect size, (") = 0.90, 95% CI: [0.75-1.04]) compared to that in Sedentary group. In contrast, the microbicidal activity of phagocytic cells was not significantly influenced by RT. Also, total energy and carbohydrate intake, as well as serum levels of IL-6, had a significant influence on the phagocytic activity of neutrophils (! = 0.04), being considered in the model. Multivariate regression identified the physical condition of the subject (β = 0.425; ! = 0.01) as a significant predictor of the IF. In conclusion, the circulating neutrophils of elderly women who had TR showed higher phagocytic activity, whereas microbicidal activity did not present a statistically significant difference between groups, demonstrating a positive effect of RT in the first line of defense of the organism. |
Link de acesso: | https://bdtd.ucb.br:8443/jspui/handle/tede/2428 |
Resumo: | Projections of the increase in absolute and relative numbers of elderly represent new challenges for public health. Aging is accompanied by gradual decline of physiological functions, immune function and muscle strength. In this way, the elderly is more susceptible to sarcopenia, osteoporosis, cancer and cardiovascular, metabolic and neurodegenerative diseases. Resistance Training (RT) has been shown to be an important intervention for increased muscle strength and decreased chronic inflammation in the elderly. However, little is known about the influence of RT on the functional response of cells that constitute the first line of defense during immunosenescence. In this sense, the present study aimed to investigate an association between RT adaptations induced by a program and a functional response of circulating phagocytes in elderly. The present cross-sectional study was composed of 54 elderly women, 71.3 ± 6.3 years, apparently healthy, non-institutionalized and divided into two distinct groups: Trained (n = 28) and Sedentary (n = 26). The elderly of the Trained group were participants of a RT program for 8.6 ± 0.3 months and performed a training consisting of 12 exercises, 3 sessions weekly, with intensity of 70% of a maximum repetition, while the Sedentary group did not participate of any physical activity program during the same period. Body mass, height, body mass index, waisthip ratio, fat free mass and fat mass were evaluated. The total energy intake and macronutrients in the usual diet were assessed. TNF-a, IL-6 and IGF-1 analyzes, total and differential leukocyte count, monocyte or neutrophil phagocytosis test, phagocytosis index (IF) and microbicidal activity of phagocytes were performed. Data analysis was performed using the Statistical Package for the Social Sciences (SPSS) program and considered statistically significant P <0.05 for two-tailed tests. The results show that the IF of neutrophils (but not of monocytes) in the Trained group was significantly higher (! <0.001, effect size, (") = 0.90, 95% CI: [0.75-1.04]) compared to that in Sedentary group. In contrast, the microbicidal activity of phagocytic cells was not significantly influenced by RT. Also, total energy and carbohydrate intake, as well as serum levels of IL-6, had a significant influence on the phagocytic activity of neutrophils (! = 0.04), being considered in the model. Multivariate regression identified the physical condition of the subject (β = 0.425; ! = 0.01) as a significant predictor of the IF. In conclusion, the circulating neutrophils of elderly women who had TR showed higher phagocytic activity, whereas microbicidal activity did not present a statistically significant difference between groups, demonstrating a positive effect of RT in the first line of defense of the organism. |
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UCB_ef74fc6e96317cfaac66528d42d22bda |
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oai_identifier_str |
oai:bdtd.ucb.br:tede/2428 |
network_acronym_str |
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network_name_str |
Biblioteca Digital de Teses e Dissertações da UCB |
spelling |
Vieira, Elaine Cristinahttp://lattes.cnpq.br/2660003401901914http://lattes.cnpq.br/6005476151104879Bartholomeu Neto, João2018-07-27T15:19:43Z2018-06-14BARTHOLOMEU NETO, João. Influência do treinamento resistido na atividade fagocítica de monócitos e neutrófilos em mulheres idosas. 2018. 54 f. Tese (Programa Stricto Sensu em Educação Física) - Universidade Católica de Brasília, Brasília, 2018.https://bdtd.ucb.br:8443/jspui/handle/tede/2428Projections of the increase in absolute and relative numbers of elderly represent new challenges for public health. Aging is accompanied by gradual decline of physiological functions, immune function and muscle strength. In this way, the elderly is more susceptible to sarcopenia, osteoporosis, cancer and cardiovascular, metabolic and neurodegenerative diseases. Resistance Training (RT) has been shown to be an important intervention for increased muscle strength and decreased chronic inflammation in the elderly. However, little is known about the influence of RT on the functional response of cells that constitute the first line of defense during immunosenescence. In this sense, the present study aimed to investigate an association between RT adaptations induced by a program and a functional response of circulating phagocytes in elderly. The present cross-sectional study was composed of 54 elderly women, 71.3 ± 6.3 years, apparently healthy, non-institutionalized and divided into two distinct groups: Trained (n = 28) and Sedentary (n = 26). The elderly of the Trained group were participants of a RT program for 8.6 ± 0.3 months and performed a training consisting of 12 exercises, 3 sessions weekly, with intensity of 70% of a maximum repetition, while the Sedentary group did not participate of any physical activity program during the same period. Body mass, height, body mass index, waisthip ratio, fat free mass and fat mass were evaluated. The total energy intake and macronutrients in the usual diet were assessed. TNF-a, IL-6 and IGF-1 analyzes, total and differential leukocyte count, monocyte or neutrophil phagocytosis test, phagocytosis index (IF) and microbicidal activity of phagocytes were performed. Data analysis was performed using the Statistical Package for the Social Sciences (SPSS) program and considered statistically significant P <0.05 for two-tailed tests. The results show that the IF of neutrophils (but not of monocytes) in the Trained group was significantly higher (! <0.001, effect size, (") = 0.90, 95% CI: [0.75-1.04]) compared to that in Sedentary group. In contrast, the microbicidal activity of phagocytic cells was not significantly influenced by RT. Also, total energy and carbohydrate intake, as well as serum levels of IL-6, had a significant influence on the phagocytic activity of neutrophils (! = 0.04), being considered in the model. Multivariate regression identified the physical condition of the subject (β = 0.425; ! = 0.01) as a significant predictor of the IF. In conclusion, the circulating neutrophils of elderly women who had TR showed higher phagocytic activity, whereas microbicidal activity did not present a statistically significant difference between groups, demonstrating a positive effect of RT in the first line of defense of the organism.As projeções do aumento nos números absoluto e relativo de idosos representa novos desafios para a saúde pública. O envelhecimento vem acompanhado declínio gradual das funções fisiológicas, da função imunológica e da força muscular. Dessa forma, idosos são mais susceptíveis a sarcopenia, osteoporose, câncer e doenças cardiovasculares, metabólicas e neurodegenerativas. O Treinamento Resistido (TR) tem se mostrado importante intervenção para aumento da força muscular e diminuição da inflamação crônica em idosos. No entanto, pouco se conhece a respeito da influência do TR na resposta funcional de células que constituem a primeira linha de defesa durante a imunossenescência. Nesse sentido, o presente estudo buscou investigar a associação entre adaptações induzidas por um programa de TR e a resposta funcional de fagócitos circulantes em idosas. O presente estudo de caráter transversal, foi composto por 54 idosas com idade 71.3 ± 6.3 anos, aparentemente saudáveis, não institucionalizadas e divididas em dois grupos distintos: Treinadas (n=28) e Sedentárias (n=26). As idosas do grupo Treinadas eram participantes de um programa de TR há 8,6 ± 0,3 meses e realizaram um treino composto por 12 exercícios, 3 sessões semanais, com intensidade de 70% de uma repetição máxima, enquanto o grupo Sedentárias não participou de nenhum programa de atividades físicas durante o mesmo período. Avaliou-se a massa corporal, estatura, índice de massa corporal, relação cintura-quadril, massa livre de gordura e massa gorda. Foi avaliado o consumo de energia total e de macronutrientes na dieta habitual. Foram realizadas análises de fator de necrose tumoral alfa (TNF-α), interleucina 6 (IL-6) e Fator de crescimento semelhante à insulina (IGF-1), contagem total e diferencial de leucócitos, teste de fagocitose por monócitos ou neutrófilos, índice de fagocitose (IF) e atividade microbicida de fagócitos. A análise dos dados foi realizada por meio do programa Statistical Package for the Social Sciences (SPSS) e considerado P < 0.05 estatisticamente significante para testes bicaudais. Os resultados demonstram que o IF de neutrófilos, mas não de monócitos, no grupo Treinadas foi significativamente maior (! <0,001; tamanho do efeito, (") = 0,90, IC 95%: [0,75–1,04]) em comparação com o grupo Sedentárias. Em contraste, a atividade microbicida das células fagocítica não foi influenciada significativamente pelo TR. Além disso, a ingestão total de energia e carboidratos, bem como os níveis séricos de IL-6, tiveram influência significativa na atividade fagocítica dos neutrófilos (! = 0,04), sendo considerados no modelo. Em conclusão, os neutrófilos circulantes de mulheres idosas que praticaram TR expressaram maior atividade fagocitária, enquanto atividade microbicida não apresentou diferença estatisticamente significante entre grupos, demonstrando efeito positivo do TR na primeira linha de defesa do organismo.Submitted by Sara Ribeiro (sara.ribeiro@ucb.br) on 2018-07-27T15:19:25Z No. of bitstreams: 1 JoãoBartholomeuNetoTese2018.pdf: 1992204 bytes, checksum: c127f6e78b3371ee05b0b87f14163392 (MD5)Approved for entry into archive by Sara Ribeiro (sara.ribeiro@ucb.br) on 2018-07-27T15:19:43Z (GMT) No. of bitstreams: 1 JoãoBartholomeuNetoTese2018.pdf: 1992204 bytes, checksum: c127f6e78b3371ee05b0b87f14163392 (MD5)Made available in DSpace on 2018-07-27T15:19:43Z (GMT). No. of bitstreams: 1 JoãoBartholomeuNetoTese2018.pdf: 1992204 bytes, checksum: c127f6e78b3371ee05b0b87f14163392 (MD5) Previous issue date: 2018-06-14application/pdfhttps://bdtd.ucb.br:8443/jspui/retrieve/5773/Jo%c3%a3oBartholomeuNetoTese2018.pdf.jpgporUniversidade Católica de BrasíliaPrograma Stricto Sensu em Educação FísicaUCBBrasilEscola de Saúde e MedicinaFagocitoseImunologiaMusculaçãoEnvelhecimentoTreinamento de forçaResistance trainingStrength trainingPhagocytosisImmunologyAgingCNPQ::CIENCIAS DA SAUDE::EDUCACAO FISICAInfluência do treinamento resistido na atividade fagocítica de monócitos e neutrófilos em mulheres idosasinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/doctoralThesisinfo:eu-repo/semantics/openAccessreponame:Biblioteca Digital de Teses e Dissertações da UCBinstname:Universidade Católica de Brasíliainstacron:UCBTHUMBNAILJoãoBartholomeuNetoTese2018.pdf.jpgJoãoBartholomeuNetoTese2018.pdf.jpgimage/jpeg5016https://bdtd.ucb.br:8443/jspui/bitstream/tede/2428/4/Jo%C3%A3oBartholomeuNetoTese2018.pdf.jpgb40a9f44f3d8746d9ea840d72951e70eMD54TEXTJoãoBartholomeuNetoTese2018.pdf.txtJoãoBartholomeuNetoTese2018.pdf.txttext/plain170248https://bdtd.ucb.br:8443/jspui/bitstream/tede/2428/3/Jo%C3%A3oBartholomeuNetoTese2018.pdf.txt9ff82460838932bc8f45801f33872bd5MD53ORIGINALJoãoBartholomeuNetoTese2018.pdfJoãoBartholomeuNetoTese2018.pdfapplication/pdf1992204https://bdtd.ucb.br:8443/jspui/bitstream/tede/2428/2/Jo%C3%A3oBartholomeuNetoTese2018.pdfc127f6e78b3371ee05b0b87f14163392MD52LICENSElicense.txtlicense.txttext/plain; charset=utf-81905https://bdtd.ucb.br:8443/jspui/bitstream/tede/2428/1/license.txt75558dcf859532757239878b42f1c2c7MD51tede/2428oai:bdtd.ucb.br:tede/24282018-07-28 01:06:05.188Biblioteca Digital de Dissertações da Universidade Católica de Brasília - UCBsdi@ucb.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 |
dc.title.por.fl_str_mv |
Influência do treinamento resistido na atividade fagocítica de monócitos e neutrófilos em mulheres idosas |
title |
Influência do treinamento resistido na atividade fagocítica de monócitos e neutrófilos em mulheres idosas |
spellingShingle |
Influência do treinamento resistido na atividade fagocítica de monócitos e neutrófilos em mulheres idosas Bartholomeu Neto, João Fagocitose Imunologia Musculação Envelhecimento Treinamento de força Resistance training Strength training Phagocytosis Immunology Aging CNPQ::CIENCIAS DA SAUDE::EDUCACAO FISICA |
title_short |
Influência do treinamento resistido na atividade fagocítica de monócitos e neutrófilos em mulheres idosas |
title_full |
Influência do treinamento resistido na atividade fagocítica de monócitos e neutrófilos em mulheres idosas |
title_fullStr |
Influência do treinamento resistido na atividade fagocítica de monócitos e neutrófilos em mulheres idosas |
title_full_unstemmed |
Influência do treinamento resistido na atividade fagocítica de monócitos e neutrófilos em mulheres idosas |
title_sort |
Influência do treinamento resistido na atividade fagocítica de monócitos e neutrófilos em mulheres idosas |
author |
Bartholomeu Neto, João |
author_facet |
Bartholomeu Neto, João |
author_role |
author |
dc.contributor.advisor1.fl_str_mv |
Vieira, Elaine Cristina |
dc.contributor.advisor1Lattes.fl_str_mv |
http://lattes.cnpq.br/2660003401901914 |
dc.contributor.authorLattes.fl_str_mv |
http://lattes.cnpq.br/6005476151104879 |
dc.contributor.author.fl_str_mv |
Bartholomeu Neto, João |
contributor_str_mv |
Vieira, Elaine Cristina |
dc.subject.por.fl_str_mv |
Fagocitose Imunologia Musculação Envelhecimento Treinamento de força Resistance training Strength training Phagocytosis Immunology Aging |
topic |
Fagocitose Imunologia Musculação Envelhecimento Treinamento de força Resistance training Strength training Phagocytosis Immunology Aging CNPQ::CIENCIAS DA SAUDE::EDUCACAO FISICA |
dc.subject.cnpq.fl_str_mv |
CNPQ::CIENCIAS DA SAUDE::EDUCACAO FISICA |
dc.description.abstract.eng.fl_txt_mv |
Projections of the increase in absolute and relative numbers of elderly represent new challenges for public health. Aging is accompanied by gradual decline of physiological functions, immune function and muscle strength. In this way, the elderly is more susceptible to sarcopenia, osteoporosis, cancer and cardiovascular, metabolic and neurodegenerative diseases. Resistance Training (RT) has been shown to be an important intervention for increased muscle strength and decreased chronic inflammation in the elderly. However, little is known about the influence of RT on the functional response of cells that constitute the first line of defense during immunosenescence. In this sense, the present study aimed to investigate an association between RT adaptations induced by a program and a functional response of circulating phagocytes in elderly. The present cross-sectional study was composed of 54 elderly women, 71.3 ± 6.3 years, apparently healthy, non-institutionalized and divided into two distinct groups: Trained (n = 28) and Sedentary (n = 26). The elderly of the Trained group were participants of a RT program for 8.6 ± 0.3 months and performed a training consisting of 12 exercises, 3 sessions weekly, with intensity of 70% of a maximum repetition, while the Sedentary group did not participate of any physical activity program during the same period. Body mass, height, body mass index, waisthip ratio, fat free mass and fat mass were evaluated. The total energy intake and macronutrients in the usual diet were assessed. TNF-a, IL-6 and IGF-1 analyzes, total and differential leukocyte count, monocyte or neutrophil phagocytosis test, phagocytosis index (IF) and microbicidal activity of phagocytes were performed. Data analysis was performed using the Statistical Package for the Social Sciences (SPSS) program and considered statistically significant P <0.05 for two-tailed tests. The results show that the IF of neutrophils (but not of monocytes) in the Trained group was significantly higher (! <0.001, effect size, (") = 0.90, 95% CI: [0.75-1.04]) compared to that in Sedentary group. In contrast, the microbicidal activity of phagocytic cells was not significantly influenced by RT. Also, total energy and carbohydrate intake, as well as serum levels of IL-6, had a significant influence on the phagocytic activity of neutrophils (! = 0.04), being considered in the model. Multivariate regression identified the physical condition of the subject (β = 0.425; ! = 0.01) as a significant predictor of the IF. In conclusion, the circulating neutrophils of elderly women who had TR showed higher phagocytic activity, whereas microbicidal activity did not present a statistically significant difference between groups, demonstrating a positive effect of RT in the first line of defense of the organism. |
dc.description.abstract.por.fl_txt_mv |
As projeções do aumento nos números absoluto e relativo de idosos representa novos desafios para a saúde pública. O envelhecimento vem acompanhado declínio gradual das funções fisiológicas, da função imunológica e da força muscular. Dessa forma, idosos são mais susceptíveis a sarcopenia, osteoporose, câncer e doenças cardiovasculares, metabólicas e neurodegenerativas. O Treinamento Resistido (TR) tem se mostrado importante intervenção para aumento da força muscular e diminuição da inflamação crônica em idosos. No entanto, pouco se conhece a respeito da influência do TR na resposta funcional de células que constituem a primeira linha de defesa durante a imunossenescência. Nesse sentido, o presente estudo buscou investigar a associação entre adaptações induzidas por um programa de TR e a resposta funcional de fagócitos circulantes em idosas. O presente estudo de caráter transversal, foi composto por 54 idosas com idade 71.3 ± 6.3 anos, aparentemente saudáveis, não institucionalizadas e divididas em dois grupos distintos: Treinadas (n=28) e Sedentárias (n=26). As idosas do grupo Treinadas eram participantes de um programa de TR há 8,6 ± 0,3 meses e realizaram um treino composto por 12 exercícios, 3 sessões semanais, com intensidade de 70% de uma repetição máxima, enquanto o grupo Sedentárias não participou de nenhum programa de atividades físicas durante o mesmo período. Avaliou-se a massa corporal, estatura, índice de massa corporal, relação cintura-quadril, massa livre de gordura e massa gorda. Foi avaliado o consumo de energia total e de macronutrientes na dieta habitual. Foram realizadas análises de fator de necrose tumoral alfa (TNF-α), interleucina 6 (IL-6) e Fator de crescimento semelhante à insulina (IGF-1), contagem total e diferencial de leucócitos, teste de fagocitose por monócitos ou neutrófilos, índice de fagocitose (IF) e atividade microbicida de fagócitos. A análise dos dados foi realizada por meio do programa Statistical Package for the Social Sciences (SPSS) e considerado P < 0.05 estatisticamente significante para testes bicaudais. Os resultados demonstram que o IF de neutrófilos, mas não de monócitos, no grupo Treinadas foi significativamente maior (! <0,001; tamanho do efeito, (") = 0,90, IC 95%: [0,75–1,04]) em comparação com o grupo Sedentárias. Em contraste, a atividade microbicida das células fagocítica não foi influenciada significativamente pelo TR. Além disso, a ingestão total de energia e carboidratos, bem como os níveis séricos de IL-6, tiveram influência significativa na atividade fagocítica dos neutrófilos (! = 0,04), sendo considerados no modelo. Em conclusão, os neutrófilos circulantes de mulheres idosas que praticaram TR expressaram maior atividade fagocitária, enquanto atividade microbicida não apresentou diferença estatisticamente significante entre grupos, demonstrando efeito positivo do TR na primeira linha de defesa do organismo. |
description |
Projections of the increase in absolute and relative numbers of elderly represent new challenges for public health. Aging is accompanied by gradual decline of physiological functions, immune function and muscle strength. In this way, the elderly is more susceptible to sarcopenia, osteoporosis, cancer and cardiovascular, metabolic and neurodegenerative diseases. Resistance Training (RT) has been shown to be an important intervention for increased muscle strength and decreased chronic inflammation in the elderly. However, little is known about the influence of RT on the functional response of cells that constitute the first line of defense during immunosenescence. In this sense, the present study aimed to investigate an association between RT adaptations induced by a program and a functional response of circulating phagocytes in elderly. The present cross-sectional study was composed of 54 elderly women, 71.3 ± 6.3 years, apparently healthy, non-institutionalized and divided into two distinct groups: Trained (n = 28) and Sedentary (n = 26). The elderly of the Trained group were participants of a RT program for 8.6 ± 0.3 months and performed a training consisting of 12 exercises, 3 sessions weekly, with intensity of 70% of a maximum repetition, while the Sedentary group did not participate of any physical activity program during the same period. Body mass, height, body mass index, waisthip ratio, fat free mass and fat mass were evaluated. The total energy intake and macronutrients in the usual diet were assessed. TNF-a, IL-6 and IGF-1 analyzes, total and differential leukocyte count, monocyte or neutrophil phagocytosis test, phagocytosis index (IF) and microbicidal activity of phagocytes were performed. Data analysis was performed using the Statistical Package for the Social Sciences (SPSS) program and considered statistically significant P <0.05 for two-tailed tests. The results show that the IF of neutrophils (but not of monocytes) in the Trained group was significantly higher (! <0.001, effect size, (") = 0.90, 95% CI: [0.75-1.04]) compared to that in Sedentary group. In contrast, the microbicidal activity of phagocytic cells was not significantly influenced by RT. Also, total energy and carbohydrate intake, as well as serum levels of IL-6, had a significant influence on the phagocytic activity of neutrophils (! = 0.04), being considered in the model. Multivariate regression identified the physical condition of the subject (β = 0.425; ! = 0.01) as a significant predictor of the IF. In conclusion, the circulating neutrophils of elderly women who had TR showed higher phagocytic activity, whereas microbicidal activity did not present a statistically significant difference between groups, demonstrating a positive effect of RT in the first line of defense of the organism. |
publishDate |
2018 |
dc.date.accessioned.fl_str_mv |
2018-07-27T15:19:43Z |
dc.date.issued.fl_str_mv |
2018-06-14 |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
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info:eu-repo/semantics/doctoralThesis |
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dc.identifier.citation.fl_str_mv |
BARTHOLOMEU NETO, João. Influência do treinamento resistido na atividade fagocítica de monócitos e neutrófilos em mulheres idosas. 2018. 54 f. Tese (Programa Stricto Sensu em Educação Física) - Universidade Católica de Brasília, Brasília, 2018. |
dc.identifier.uri.fl_str_mv |
https://bdtd.ucb.br:8443/jspui/handle/tede/2428 |
identifier_str_mv |
BARTHOLOMEU NETO, João. Influência do treinamento resistido na atividade fagocítica de monócitos e neutrófilos em mulheres idosas. 2018. 54 f. Tese (Programa Stricto Sensu em Educação Física) - Universidade Católica de Brasília, Brasília, 2018. |
url |
https://bdtd.ucb.br:8443/jspui/handle/tede/2428 |
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por |
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por |
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info:eu-repo/semantics/openAccess |
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openAccess |
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application/pdf |
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Universidade Católica de Brasília |
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Programa Stricto Sensu em Educação Física |
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UCB |
dc.publisher.country.fl_str_mv |
Brasil |
dc.publisher.department.fl_str_mv |
Escola de Saúde e Medicina |
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Universidade Católica de Brasília |
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