An?lise computacional de sintases da quitina de fungos basidiomicetos

Detalhes bibliográficos
Ano de defesa: 2010
Autor(a) principal: Diniz, Marcelo Vera Cruz lattes
Orientador(a): G?es-Neto, Arist?teles
Banca de defesa: Não Informado pela instituição
Tipo de documento: Dissertação
Tipo de acesso: Acesso aberto
Idioma: por
Instituição de defesa: Universidade Estadual de Feira de Santana
Programa de Pós-Graduação: Mestrado Acad?mico em Biotecnologia
Departamento: DEPARTAMENTO DE CI?NCIAS BIOL?GICAS
País: Brasil
Palavras-chave em Português:
sintase da quitina
Basidiomycota
filogenia
redes complexas
biotecnologia
Palavras-chave em Inglês:
chitin synthase
phylogeny
complex networks
biotechnology
Área do conhecimento CNPq:
CIENCIAS BIOLOGICAS
Link de acesso: http://tede2.uefs.br:8080/handle/tede/1186
Resumo: One of the main components of the fungal cell wall is the polysaccharide chitin, which is synthesized by the enzyme chitin synthase. Our work aimed to carry out an integrated in silico study of protein sequences of basidiomycotan chitin synthases using methods of comparative analysis of profiles and patterns, phylogenetic analyses, and complex network approach. Initially, we construct a relational database The following products were generated at the end of the project: (I) a relational database containing all complete or partial protein sequences of chitin syntases of Basidiomycota, constructed and validated; (II) identification and characterization of conserved domains of protein sequences; (III) phylogenetic trees of protein sequences; and (IV) complex networks protein sequences of basidiomycotan chitin synthases. The results will subsidize the development, by molecular modelling, of new compounds or chemical modifications of pr?-existent compounds, addressed to the inhibition of the chitin synthesis in the cell wall of phytopathogenic Basidiomycota.
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spelling G?es-Neto, Arist?teles5443488252079563058534http://lattes.cnpq.br/4162291555771478Diniz, Marcelo Vera Cruz2020-06-22T19:52:13Z2010-05-26DINIZ, Marcelo Vera Cruz. An?lise computacional de sintases da quitina de fungos basidiomicetos. 2010. 125 f. Disserta??o (Mestrado Acad?mico em Biotecnologia)- Universidade Estadual de Feira de Santana, Feira de Santana, 2010.http://tede2.uefs.br:8080/handle/tede/1186One of the main components of the fungal cell wall is the polysaccharide chitin, which is synthesized by the enzyme chitin synthase. Our work aimed to carry out an integrated in silico study of protein sequences of basidiomycotan chitin synthases using methods of comparative analysis of profiles and patterns, phylogenetic analyses, and complex network approach. Initially, we construct a relational database The following products were generated at the end of the project: (I) a relational database containing all complete or partial protein sequences of chitin syntases of Basidiomycota, constructed and validated; (II) identification and characterization of conserved domains of protein sequences; (III) phylogenetic trees of protein sequences; and (IV) complex networks protein sequences of basidiomycotan chitin synthases. The results will subsidize the development, by molecular modelling, of new compounds or chemical modifications of pr?-existent compounds, addressed to the inhibition of the chitin synthesis in the cell wall of phytopathogenic Basidiomycota.Um dos principais componentes da parede celular f?ngica ? o polissacar?deo quitina que ? sintetizado a partir da atividade da enzima sintase da quitina. Este projeto teve como objetivo realizar um estudo integrado in silico de sequ?ncias aminoac?dicas de sintases da quitina de fungos basidiomicetos atrav?s de m?todos de an?lise comparativa de perfis e padr?es, an?lise filogen?tica e constru??o de redes complexas. Os seguintes produtos ser?o gerados ao final do projeto: (I) um banco de dados relacional contendo todas as sequ?ncias prot?icas, completas ou parciais, de sintases da quitina de Basidiomycota constru?do e validado; (II) identifica??o e caracteriza??o dos dom?nios conservados das sequ?ncias prot?icas; (III) ?rvores filogen?ticas das sequ?ncias prot?icas; e (IV) redes complexas das sequ?ncias prot?icas de sintases da quitina de Basidiomycota. Os resultados subsidiar?o o desenvolvimento, atrav?s de modelagem molecular, de novos compostos ou de modifica??es qu?micas de compostos pr?-existentes, direcionados ? inibi??o da s?ntese da quitina na parede celular de fungos basidiomicetos fitopat?genos.Submitted by Bruno Matos Nascimento (brunomatos@uefs.br) on 2020-06-22T19:52:13Z No. of bitstreams: 1 Dissertacao-Marcelo-Versao-Final.pdf: 2821664 bytes, checksum: 0a138918ff43e875f6bbe41103062de3 (MD5)Made available in DSpace on 2020-06-22T19:52:13Z (GMT). No. of bitstreams: 1 Dissertacao-Marcelo-Versao-Final.pdf: 2821664 bytes, checksum: 0a138918ff43e875f6bbe41103062de3 (MD5) Previous issue date: 2010-05-26application/pdfporUniversidade Estadual de Feira de SantanaMestrado Acad?mico em BiotecnologiaUEFSBrasilDEPARTAMENTO DE CI?NCIAS BIOL?GICASsintase da quitinaBasidiomycotafilogeniaredes complexasbiotecnologiachitin synthasephylogenycomplex networksbiotechnologyCIENCIAS BIOLOGICASAn?lise computacional de sintases da quitina de fungos basidiomicetosinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/masterThesis-54735432730516527826006006005026123383450589282-3439178843068202161info:eu-repo/semantics/openAccessreponame:Biblioteca Digital de Teses e Dissertações da UEFSinstname:Universidade Estadual de Feira de Santana (UEFS)instacron:UEFSORIGINALDissertacao-Marcelo-Versao-Final.pdfDissertacao-Marcelo-Versao-Final.pdfapplication/pdf2821664http://tede2.uefs.br:8080/bitstream/tede/1186/2/Dissertacao-Marcelo-Versao-Final.pdf0a138918ff43e875f6bbe41103062de3MD52LICENSElicense.txtlicense.txttext/plain; charset=utf-82089http://tede2.uefs.br:8080/bitstream/tede/1186/1/license.txt7b5ba3d2445355f386edab96125d42b7MD51tede/11862020-06-22 16:52:13.795oai:tede2.uefs.br:8080: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Biblioteca Digital de Teses e Dissertaçõeshttp://tede2.uefs.br:8080/PUBhttp://tede2.uefs.br:8080/oai/requestbcuefs@uefs.br|| bcref@uefs.br||bcuefs@uefs.bropendoar:2020-06-22T19:52:13Biblioteca Digital de Teses e Dissertações da UEFS - Universidade Estadual de Feira de Santana (UEFS)false
dc.title.por.fl_str_mv An?lise computacional de sintases da quitina de fungos basidiomicetos
title An?lise computacional de sintases da quitina de fungos basidiomicetos
spellingShingle An?lise computacional de sintases da quitina de fungos basidiomicetos
Diniz, Marcelo Vera Cruz
sintase da quitina
Basidiomycota
filogenia
redes complexas
biotecnologia
chitin synthase
phylogeny
complex networks
biotechnology
CIENCIAS BIOLOGICAS
title_short An?lise computacional de sintases da quitina de fungos basidiomicetos
title_full An?lise computacional de sintases da quitina de fungos basidiomicetos
title_fullStr An?lise computacional de sintases da quitina de fungos basidiomicetos
title_full_unstemmed An?lise computacional de sintases da quitina de fungos basidiomicetos
title_sort An?lise computacional de sintases da quitina de fungos basidiomicetos
author Diniz, Marcelo Vera Cruz
author_facet Diniz, Marcelo Vera Cruz
author_role author
dc.contributor.advisor1.fl_str_mv G?es-Neto, Arist?teles
dc.contributor.advisor1ID.fl_str_mv 54434882520
dc.contributor.authorID.fl_str_mv 79563058534
dc.contributor.authorLattes.fl_str_mv http://lattes.cnpq.br/4162291555771478
dc.contributor.author.fl_str_mv Diniz, Marcelo Vera Cruz
contributor_str_mv G?es-Neto, Arist?teles
dc.subject.por.fl_str_mv sintase da quitina
Basidiomycota
filogenia
redes complexas
biotecnologia
topic sintase da quitina
Basidiomycota
filogenia
redes complexas
biotecnologia
chitin synthase
phylogeny
complex networks
biotechnology
CIENCIAS BIOLOGICAS
dc.subject.eng.fl_str_mv chitin synthase
phylogeny
complex networks
biotechnology
dc.subject.cnpq.fl_str_mv CIENCIAS BIOLOGICAS
description One of the main components of the fungal cell wall is the polysaccharide chitin, which is synthesized by the enzyme chitin synthase. Our work aimed to carry out an integrated in silico study of protein sequences of basidiomycotan chitin synthases using methods of comparative analysis of profiles and patterns, phylogenetic analyses, and complex network approach. Initially, we construct a relational database The following products were generated at the end of the project: (I) a relational database containing all complete or partial protein sequences of chitin syntases of Basidiomycota, constructed and validated; (II) identification and characterization of conserved domains of protein sequences; (III) phylogenetic trees of protein sequences; and (IV) complex networks protein sequences of basidiomycotan chitin synthases. The results will subsidize the development, by molecular modelling, of new compounds or chemical modifications of pr?-existent compounds, addressed to the inhibition of the chitin synthesis in the cell wall of phytopathogenic Basidiomycota.
publishDate 2010
dc.date.issued.fl_str_mv 2010-05-26
dc.date.accessioned.fl_str_mv 2020-06-22T19:52:13Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/masterThesis
format masterThesis
status_str publishedVersion
dc.identifier.citation.fl_str_mv DINIZ, Marcelo Vera Cruz. An?lise computacional de sintases da quitina de fungos basidiomicetos. 2010. 125 f. Disserta??o (Mestrado Acad?mico em Biotecnologia)- Universidade Estadual de Feira de Santana, Feira de Santana, 2010.
dc.identifier.uri.fl_str_mv http://tede2.uefs.br:8080/handle/tede/1186
identifier_str_mv DINIZ, Marcelo Vera Cruz. An?lise computacional de sintases da quitina de fungos basidiomicetos. 2010. 125 f. Disserta??o (Mestrado Acad?mico em Biotecnologia)- Universidade Estadual de Feira de Santana, Feira de Santana, 2010.
url http://tede2.uefs.br:8080/handle/tede/1186
dc.language.iso.fl_str_mv por
language por
dc.relation.program.fl_str_mv -5473543273051652782
dc.relation.confidence.fl_str_mv 600
600
600
dc.relation.department.fl_str_mv 5026123383450589282
dc.relation.cnpq.fl_str_mv -3439178843068202161
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Universidade Estadual de Feira de Santana
dc.publisher.program.fl_str_mv Mestrado Acad?mico em Biotecnologia
dc.publisher.initials.fl_str_mv UEFS
dc.publisher.country.fl_str_mv Brasil
dc.publisher.department.fl_str_mv DEPARTAMENTO DE CI?NCIAS BIOL?GICAS
publisher.none.fl_str_mv Universidade Estadual de Feira de Santana
dc.source.none.fl_str_mv reponame:Biblioteca Digital de Teses e Dissertações da UEFS
instname:Universidade Estadual de Feira de Santana (UEFS)
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reponame_str Biblioteca Digital de Teses e Dissertações da UEFS
collection Biblioteca Digital de Teses e Dissertações da UEFS
bitstream.url.fl_str_mv http://tede2.uefs.br:8080/bitstream/tede/1186/2/Dissertacao-Marcelo-Versao-Final.pdf
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