Imunoexpressão de CXCL12 e CXCR4 em ceratocistos odontogênicos isolados e associados à Síndrome de Gorlin-Goltz
Ano de defesa: | 2020 |
---|---|
Autor(a) principal: | |
Orientador(a): | |
Banca de defesa: | , |
Tipo de documento: | Dissertação |
Tipo de acesso: | Acesso aberto |
Idioma: | por |
Instituição de defesa: |
Universidade Estadual da Paraíba
|
Programa de Pós-Graduação: |
Programa de Pós-Graduação em Odontologia - PPGO
|
Departamento: |
Pró-Reitoria de Pós-Graduação e Pesquisa - PRPGP
|
País: |
Brasil
|
Palavras-chave em Português: | |
Palavras-chave em Inglês: | |
Área do conhecimento CNPq: | |
Link de acesso: | http://tede.bc.uepb.edu.br/jspui/handle/tede/4145 |
Resumo: | Odontogenic keratocyst (OKC) has infiltrative potential, high recurrence and mutations in the PTCH1 tumor suppressor gene, besides the capacity of association to the Gorlin-Goltz syndrome, where the syndromic OKCs are potentially more aggressive. These characteristics have influenced the search for information on the etiopathogenesis of this injury, through protein and molecular markers that aim to improve the understanding of its biological behavior, but there is still much to be clarified. CXCL12 chemokine (SDF-1) and its CXCR4 primary receptor regulate important events in the pathogenesis of various injuries. This paper was intended to analyze the CXCL12 and CXCR4 immunoexpression in isolated and syndromic OKCs. The sample was composed of 21 cases of isolated OKCs and 21 syndromic OKCs, submitted to morphological and immunohistochemical analysis of the proteins in cells of 10 fields of the epithelial component and 10 fields of the underlying fibrous capsule. We observed CXCL12 immunoexpression in epithelial cells of 20 isolated OKCs and 19 syndromic OKCs, with a statistically significant difference in the positivity index (PI) among injuries (p<0.001), with greater expression in isolated OKCs. We found CXCL12 expression in fibroblasts and endothelial cells of all isolated OKCs and in 20 syndromic OKCs, with a statistically significant difference in PI between groups (p<0.001) and greater expression in isolated OKCs. CXCR4 was expressed in cytoplasm and nucleus of suprabasal epithelial cells of all OKCs, with a statistically significant difference in nuclear PI between isolated and syndromic OKCs (p=0.007). We observed the CXCR4 cytoplasmic expression in fibroblasts and, mainly, in endothelial cells of 90.5% of the syndromic OKCs and in all isolated OKCs. We observed CXCR4 nuclear positivity in fibroblasts and endothelial cells of 20 isolated OKCs and in all syndromic OKCs. According to Spearman’s statistical test, there was a statistically significant correlation only for the epithelial syndromic OKCs between the PI of the CXCR4 cytoplasmic and nuclear expressions (r=0.730; p<0.001). In the CXCL12 and CXCR4 expression in cystic capsule, we noted a statistically significant correlation between nuclear and cytoplasmic PI of CXCR4 in isolated (r=0.698; p> 0.001) and syndromic (r=0.826; p>0.001) OKCs. The results suggest that, in the cystic epithelial component, CXCL12 chemokine and its CXCR4 main receptor seem to play a minor role in relation to the pathogenesis and the biological behavior of OKCs. In the fibrous capsule, it is likely that the evaluated proteins may be implicated in some mechanism associated with pathogenesis and differences in the biological behavior among different types of OKCs, especially in the angiogenic events responsible for injuries. |
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Gordón-Nuñez, Manuel Antônio96866326487Andrade, Emanuel Sávio de Souza49783726404Nonaka, Cassiano Francisco Weege0278193242608690565493Lima, Wliana Pontes de2022-02-22T13:51:44Z2020-07-09LIMA, Wliana Pontes de. Imunoexpressão de CXCL12 e CXCR4 em ceratocistos odontogênicos isolados e associados à Síndrome de Gorlin-Goltz. 2020. 101f. Dissertação (Programa de Pós-Graduação em Odontologia - PPGO) - Universidade Estadual da Paraíba, Campina Grande, 2022.http://tede.bc.uepb.edu.br/jspui/handle/tede/4145Odontogenic keratocyst (OKC) has infiltrative potential, high recurrence and mutations in the PTCH1 tumor suppressor gene, besides the capacity of association to the Gorlin-Goltz syndrome, where the syndromic OKCs are potentially more aggressive. These characteristics have influenced the search for information on the etiopathogenesis of this injury, through protein and molecular markers that aim to improve the understanding of its biological behavior, but there is still much to be clarified. CXCL12 chemokine (SDF-1) and its CXCR4 primary receptor regulate important events in the pathogenesis of various injuries. This paper was intended to analyze the CXCL12 and CXCR4 immunoexpression in isolated and syndromic OKCs. The sample was composed of 21 cases of isolated OKCs and 21 syndromic OKCs, submitted to morphological and immunohistochemical analysis of the proteins in cells of 10 fields of the epithelial component and 10 fields of the underlying fibrous capsule. We observed CXCL12 immunoexpression in epithelial cells of 20 isolated OKCs and 19 syndromic OKCs, with a statistically significant difference in the positivity index (PI) among injuries (p<0.001), with greater expression in isolated OKCs. We found CXCL12 expression in fibroblasts and endothelial cells of all isolated OKCs and in 20 syndromic OKCs, with a statistically significant difference in PI between groups (p<0.001) and greater expression in isolated OKCs. CXCR4 was expressed in cytoplasm and nucleus of suprabasal epithelial cells of all OKCs, with a statistically significant difference in nuclear PI between isolated and syndromic OKCs (p=0.007). We observed the CXCR4 cytoplasmic expression in fibroblasts and, mainly, in endothelial cells of 90.5% of the syndromic OKCs and in all isolated OKCs. We observed CXCR4 nuclear positivity in fibroblasts and endothelial cells of 20 isolated OKCs and in all syndromic OKCs. According to Spearman’s statistical test, there was a statistically significant correlation only for the epithelial syndromic OKCs between the PI of the CXCR4 cytoplasmic and nuclear expressions (r=0.730; p<0.001). In the CXCL12 and CXCR4 expression in cystic capsule, we noted a statistically significant correlation between nuclear and cytoplasmic PI of CXCR4 in isolated (r=0.698; p> 0.001) and syndromic (r=0.826; p>0.001) OKCs. The results suggest that, in the cystic epithelial component, CXCL12 chemokine and its CXCR4 main receptor seem to play a minor role in relation to the pathogenesis and the biological behavior of OKCs. In the fibrous capsule, it is likely that the evaluated proteins may be implicated in some mechanism associated with pathogenesis and differences in the biological behavior among different types of OKCs, especially in the angiogenic events responsible for injuries.O ceratocisto odontogênico (CO) apresenta potencial infiltrativo, elevada recorrência e mutações no gene supressor de tumor PTCH1, além da capacidade de associação à síndrome de Gorlin-Goltz, sendo os COs sindrômicos potencialmente mais agressivos. Tais características tem influenciado a busca de informações sobre a etiopatogênese desta lesão, por meio de marcadores proteicos e moleculares que visem melhorar o entendimento do seu comportamento biológico, porém ainda há muito a ser esclarecido. A quimiocina CXCL12 (SDF-1) e seu receptor principal CXCR4 regulam eventos importantes na patogênese de diversas lesões, desde neoplasias a cistos inflamatórios. Objetivou-se analisar a imunoexpressão de CXCL12 e CXCR4 em COs isolados e sindrômicos. A amostra foi constituída por 21 casos de COs isolados e 21 sindrômicos, submetida à análise morfológica e imunoistoquímica das proteínas em células de 10 campos do componente epitelial e 10 campos da cápsula fibrosa subjacente. Observou-se imunoexpressão de CXCL12 em células epiteliais de 20 COs isolados e 19 sindrômicos, com diferença estatisticamente significativa do IP entre as lesões (p < 0,001), com maior expressão em COs isolados. Foi verificada expressão de CXCL12 em fibroblastos e células endoteliais de todos os COs isolados e em 20 sindrômicos, com diferença estatisticamente significativa do IP entre os grupos (p < 0,001) e maior expressão em COs isolados. CXCR4 foi expresso em citoplasma e núcleo de células suprabasais epiteliais de todos os COs, com diferença estatisticamente significativa do IP nuclear entre COs isolados e sindrômicos (p=0,007). A expressão citoplasmática de CXCR4 foi observada em fibroblastos e principalmente em células endoteliais de 90,5% dos COs sindrômicos e em todos os COs isolados. Observou se positividade nuclear de CXCR4 em fibroblastos e células endoteliais de 20 COs isolados e em todos os COs sindrômicos. De acordo com o teste estatístico de Spearman, houve correlação estatisticamente significativa apenas para os COs sindrômicos em epitélio, entre o IP da expressão citoplasmática e nuclear de CXCR4 (r= 0,730; p < 0,001). Na expressão de CXCL12 e CXCR4 em cápsula fibrosa, notou-se correlação estatisticamente significativa entre o IP nuclear e citoplasmático de CXCR4 nos COs isolados (r = 0,698; p > 0,001) e sindrômicos (r = 0,826; p > 0,001). Os resultados sugerem que no componente epitelial cístico, a quimiocina CXCL12 e seu receptor principal CXCR4 parecem exercer um papel pouco significativo em relação à patogênese e comportamento biológico dos COs. Na cápsula fibrosa, é provável que as proteínas avaliadas possam estar implicadas em algum mecanismo associado à patogenia e diferenças no comportamento biológico entre os diferentes tipos de COs, principalmente nos eventos angiogênicos lesionais.Submitted by Jean Medeiros (jeanletras@uepb.edu.br) on 2022-02-18T13:36:42Z No. of bitstreams: 1 PDF - Wliana Pontes de Lima.pdf: 2119601 bytes, checksum: 31ddb807a50397d09ee165eb6ce5b472 (MD5)Approved for entry into archive by Secta BC (secta.csu.bc@uepb.edu.br) on 2022-02-22T13:51:30Z (GMT) No. of bitstreams: 1 PDF - Wliana Pontes de Lima.pdf: 2119601 bytes, checksum: 31ddb807a50397d09ee165eb6ce5b472 (MD5)Made available in DSpace on 2022-02-22T13:51:44Z (GMT). No. of bitstreams: 1 PDF - Wliana Pontes de Lima.pdf: 2119601 bytes, checksum: 31ddb807a50397d09ee165eb6ce5b472 (MD5) Previous issue date: 2020-07-09application/pdfporUniversidade Estadual da ParaíbaPrograma de Pós-Graduação em Odontologia - PPGOUEPBBrasilPró-Reitoria de Pós-Graduação e Pesquisa - PRPGPCistos odontogênicosCXCL12CXCR4Síndrome do Nevo BasocelularBasal Cell Nevus SyndromeOdontogenic cystsCXCR4CXCL12CIENCIAS DA SAUDE::ODONTOLOGIAImunoexpressão de CXCL12 e CXCR4 em ceratocistos odontogênicos isolados e associados à Síndrome de Gorlin-Goltzinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/masterThesis188746850794111162600600600524871450381110278-2070498469879244349info:eu-repo/semantics/openAccessreponame:Biblioteca Digital de Teses e Dissertações da UEPBinstname:Universidade Estadual da Paraíba (UEPB)instacron:UEPBORIGINALPDF - Wliana Pontes de Lima.pdfPDF - Wliana Pontes de Lima.pdfapplication/pdf2119601http://tede.bc.uepb.edu.br/jspui/bitstream/tede/4145/2/PDF+-+Wliana+Pontes+de+Lima.pdf31ddb807a50397d09ee165eb6ce5b472MD52LICENSElicense.txtlicense.txttext/plain; charset=utf-81960http://tede.bc.uepb.edu.br/jspui/bitstream/tede/4145/1/license.txt6052ae61e77222b2086e666b7ae213ceMD51tede/41452022-02-22 10:51:44.214oai:tede.bc.uepb.edu.br: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Biblioteca Digital de Teses e Dissertaçõeshttp://tede.bc.uepb.edu.br/jspui/PUBhttp://tede.bc.uepb.edu.br/oai/requestbc@uepb.edu.br||opendoar:2022-02-22T13:51:44Biblioteca Digital de Teses e Dissertações da UEPB - Universidade Estadual da Paraíba (UEPB)false |
dc.title.por.fl_str_mv |
Imunoexpressão de CXCL12 e CXCR4 em ceratocistos odontogênicos isolados e associados à Síndrome de Gorlin-Goltz |
title |
Imunoexpressão de CXCL12 e CXCR4 em ceratocistos odontogênicos isolados e associados à Síndrome de Gorlin-Goltz |
spellingShingle |
Imunoexpressão de CXCL12 e CXCR4 em ceratocistos odontogênicos isolados e associados à Síndrome de Gorlin-Goltz Lima, Wliana Pontes de Cistos odontogênicos CXCL12 CXCR4 Síndrome do Nevo Basocelular Basal Cell Nevus Syndrome Odontogenic cysts CXCR4 CXCL12 CIENCIAS DA SAUDE::ODONTOLOGIA |
title_short |
Imunoexpressão de CXCL12 e CXCR4 em ceratocistos odontogênicos isolados e associados à Síndrome de Gorlin-Goltz |
title_full |
Imunoexpressão de CXCL12 e CXCR4 em ceratocistos odontogênicos isolados e associados à Síndrome de Gorlin-Goltz |
title_fullStr |
Imunoexpressão de CXCL12 e CXCR4 em ceratocistos odontogênicos isolados e associados à Síndrome de Gorlin-Goltz |
title_full_unstemmed |
Imunoexpressão de CXCL12 e CXCR4 em ceratocistos odontogênicos isolados e associados à Síndrome de Gorlin-Goltz |
title_sort |
Imunoexpressão de CXCL12 e CXCR4 em ceratocistos odontogênicos isolados e associados à Síndrome de Gorlin-Goltz |
author |
Lima, Wliana Pontes de |
author_facet |
Lima, Wliana Pontes de |
author_role |
author |
dc.contributor.advisor1.fl_str_mv |
Gordón-Nuñez, Manuel Antônio |
dc.contributor.advisor1ID.fl_str_mv |
96866326487 |
dc.contributor.referee1.fl_str_mv |
Andrade, Emanuel Sávio de Souza |
dc.contributor.referee1ID.fl_str_mv |
49783726404 |
dc.contributor.referee2.fl_str_mv |
Nonaka, Cassiano Francisco Weege |
dc.contributor.referee2ID.fl_str_mv |
02781932426 |
dc.contributor.authorID.fl_str_mv |
08690565493 |
dc.contributor.author.fl_str_mv |
Lima, Wliana Pontes de |
contributor_str_mv |
Gordón-Nuñez, Manuel Antônio Andrade, Emanuel Sávio de Souza Nonaka, Cassiano Francisco Weege |
dc.subject.por.fl_str_mv |
Cistos odontogênicos CXCL12 CXCR4 Síndrome do Nevo Basocelular |
topic |
Cistos odontogênicos CXCL12 CXCR4 Síndrome do Nevo Basocelular Basal Cell Nevus Syndrome Odontogenic cysts CXCR4 CXCL12 CIENCIAS DA SAUDE::ODONTOLOGIA |
dc.subject.eng.fl_str_mv |
Basal Cell Nevus Syndrome Odontogenic cysts CXCR4 CXCL12 |
dc.subject.cnpq.fl_str_mv |
CIENCIAS DA SAUDE::ODONTOLOGIA |
description |
Odontogenic keratocyst (OKC) has infiltrative potential, high recurrence and mutations in the PTCH1 tumor suppressor gene, besides the capacity of association to the Gorlin-Goltz syndrome, where the syndromic OKCs are potentially more aggressive. These characteristics have influenced the search for information on the etiopathogenesis of this injury, through protein and molecular markers that aim to improve the understanding of its biological behavior, but there is still much to be clarified. CXCL12 chemokine (SDF-1) and its CXCR4 primary receptor regulate important events in the pathogenesis of various injuries. This paper was intended to analyze the CXCL12 and CXCR4 immunoexpression in isolated and syndromic OKCs. The sample was composed of 21 cases of isolated OKCs and 21 syndromic OKCs, submitted to morphological and immunohistochemical analysis of the proteins in cells of 10 fields of the epithelial component and 10 fields of the underlying fibrous capsule. We observed CXCL12 immunoexpression in epithelial cells of 20 isolated OKCs and 19 syndromic OKCs, with a statistically significant difference in the positivity index (PI) among injuries (p<0.001), with greater expression in isolated OKCs. We found CXCL12 expression in fibroblasts and endothelial cells of all isolated OKCs and in 20 syndromic OKCs, with a statistically significant difference in PI between groups (p<0.001) and greater expression in isolated OKCs. CXCR4 was expressed in cytoplasm and nucleus of suprabasal epithelial cells of all OKCs, with a statistically significant difference in nuclear PI between isolated and syndromic OKCs (p=0.007). We observed the CXCR4 cytoplasmic expression in fibroblasts and, mainly, in endothelial cells of 90.5% of the syndromic OKCs and in all isolated OKCs. We observed CXCR4 nuclear positivity in fibroblasts and endothelial cells of 20 isolated OKCs and in all syndromic OKCs. According to Spearman’s statistical test, there was a statistically significant correlation only for the epithelial syndromic OKCs between the PI of the CXCR4 cytoplasmic and nuclear expressions (r=0.730; p<0.001). In the CXCL12 and CXCR4 expression in cystic capsule, we noted a statistically significant correlation between nuclear and cytoplasmic PI of CXCR4 in isolated (r=0.698; p> 0.001) and syndromic (r=0.826; p>0.001) OKCs. The results suggest that, in the cystic epithelial component, CXCL12 chemokine and its CXCR4 main receptor seem to play a minor role in relation to the pathogenesis and the biological behavior of OKCs. In the fibrous capsule, it is likely that the evaluated proteins may be implicated in some mechanism associated with pathogenesis and differences in the biological behavior among different types of OKCs, especially in the angiogenic events responsible for injuries. |
publishDate |
2020 |
dc.date.issued.fl_str_mv |
2020-07-09 |
dc.date.accessioned.fl_str_mv |
2022-02-22T13:51:44Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/masterThesis |
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masterThesis |
status_str |
publishedVersion |
dc.identifier.citation.fl_str_mv |
LIMA, Wliana Pontes de. Imunoexpressão de CXCL12 e CXCR4 em ceratocistos odontogênicos isolados e associados à Síndrome de Gorlin-Goltz. 2020. 101f. Dissertação (Programa de Pós-Graduação em Odontologia - PPGO) - Universidade Estadual da Paraíba, Campina Grande, 2022. |
dc.identifier.uri.fl_str_mv |
http://tede.bc.uepb.edu.br/jspui/handle/tede/4145 |
identifier_str_mv |
LIMA, Wliana Pontes de. Imunoexpressão de CXCL12 e CXCR4 em ceratocistos odontogênicos isolados e associados à Síndrome de Gorlin-Goltz. 2020. 101f. Dissertação (Programa de Pós-Graduação em Odontologia - PPGO) - Universidade Estadual da Paraíba, Campina Grande, 2022. |
url |
http://tede.bc.uepb.edu.br/jspui/handle/tede/4145 |
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por |
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por |
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600 600 600 |
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info:eu-repo/semantics/openAccess |
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openAccess |
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Universidade Estadual da Paraíba |
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Programa de Pós-Graduação em Odontologia - PPGO |
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UEPB |
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Brasil |
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Pró-Reitoria de Pós-Graduação e Pesquisa - PRPGP |
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Universidade Estadual da Paraíba |
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