Prospecção química, atividade antioxidante e antimicrobiana das folhas e caules de Croton adamantinus Müll. Arg. (EUPHORBIACEAE)
Ano de defesa: | 2022 |
---|---|
Autor(a) principal: | |
Orientador(a): | |
Banca de defesa: | , |
Tipo de documento: | Dissertação |
Tipo de acesso: | Acesso embargado |
Idioma: | por |
Instituição de defesa: |
Universidade Estadual da Paraíba
|
Programa de Pós-Graduação: |
Programa de Pós-Graduação em Química - PPGQ
|
Departamento: |
Pró-Reitoria de Pós-Graduação e Pesquisa - PRPGP
|
País: |
Brasil
|
Palavras-chave em Português: | |
Palavras-chave em Inglês: | |
Área do conhecimento CNPq: | |
Link de acesso: | http://tede.bc.uepb.edu.br/jspui/handle/tede/4585 |
Resumo: | Croton adamantinus MÜLL. ARG, also known as “carrasco” and “velame-bravo”, it is a plant used by Brazilian traditional medicine to improve the healing process and treat digestive and liver problems, however there is no study about its chemical composition neither biological activity using extract of leaves or stems. Thus, this research aimed to carry out a C. adamantinus phytochemical study and investigation on its antimicrobial and antioxidant activity. The stems and leaves’ ethanolic extracts (EEF-CA e EEC-CA) and the fractions (EEF-F2, EEF-F3, EEFF4 e EEF-F5) and (EEC-F2, EEC-F3, EEC-F4 e EEC-F5) were submitted to phytochemical screening and phytochemical analysis by Liquid chromatography coupled to Eletrospray Ionization Mass Spectrometry with “Time of Fly” type analyzer (CL-EM-ESI-TOF). The antimicrobial activity evaluation was carried out by the agar diffusion method. And the antioxidant activity was evaluated by through UV-Vis spectrophotometer by DPPH and metal chelation methods. Based on the analysis of the phytochemical screening, the presence of flavonoids, alkaloids and others was determined. This result was reaffirmed in the CL-EM-ESITOF analysis, which showed the presence of flavonoids, allowing the identification of possible compounds: isomers of apigenin 7-O-glucoside or luteolin-8-C-rhamnoside, isovitexin (apigenin 6- c-glucoside), hydroxyphenylethyl-caffeoyl glucopyranoside, nagylactone E, among others. In the in vitro study of antimicrobial activity by agar diffusion, the EEF-F1, EEFF3, EEC-F2 and EEC-F3 fractions showed zones of inhibition against S. aureus (9±0,00; 9±0,00; 9±0,00 and 9±0,00 mm) respectively, and the EEF-F2 and EEF-F3 fractions showed inhibition against E.coli (9±0,00 e 10 ±0,00 mm). As for fungal strain C.tropicali, the EEF-F1, EEF-F2 and EEC-F2 fractions were active with an inhibition of 6±0,00; 966±0,57 e 9,66±0,57 mm. Both the extracts and the polar fractions showed antioxidant potential with the tested methods. Therefore, this is the first study that reports the identification of chemical constituents for extracts of the species C. adamantinus, and it shows the importance of the dereplication method in the identification of known compounds. |
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Torres, Maria da Conceição de Menezeshttp://lattes.cnpq.br/7638517746936259Teles, Yanna Carolina Ferreirahttp://lattes.cnpq.br/7253814806654553Cole, Thiciana Silva Sousahttp://lattes.cnpq.br/7841081684013324http://lattes.cnpq.br/3753981521187448Sousa, Raiane de Brito2023-04-19T20:54:51Z2999-12-312022-12-20SOUSA, Raiane de Brito. Prospecção química, atividade antioxidante e antimicrobiana das folhas e caules de Croton adamantinus MÜLL. ARG. (EUPHORBIACEAE). 2022. 105f. Dissertação (Programa de Pós-Graduação em Química - PPGQ) - Universidade Estadual da Paraíba, Campina Grande, 2023.http://tede.bc.uepb.edu.br/jspui/handle/tede/4585Croton adamantinus MÜLL. ARG, also known as “carrasco” and “velame-bravo”, it is a plant used by Brazilian traditional medicine to improve the healing process and treat digestive and liver problems, however there is no study about its chemical composition neither biological activity using extract of leaves or stems. Thus, this research aimed to carry out a C. adamantinus phytochemical study and investigation on its antimicrobial and antioxidant activity. The stems and leaves’ ethanolic extracts (EEF-CA e EEC-CA) and the fractions (EEF-F2, EEF-F3, EEFF4 e EEF-F5) and (EEC-F2, EEC-F3, EEC-F4 e EEC-F5) were submitted to phytochemical screening and phytochemical analysis by Liquid chromatography coupled to Eletrospray Ionization Mass Spectrometry with “Time of Fly” type analyzer (CL-EM-ESI-TOF). The antimicrobial activity evaluation was carried out by the agar diffusion method. And the antioxidant activity was evaluated by through UV-Vis spectrophotometer by DPPH and metal chelation methods. Based on the analysis of the phytochemical screening, the presence of flavonoids, alkaloids and others was determined. This result was reaffirmed in the CL-EM-ESITOF analysis, which showed the presence of flavonoids, allowing the identification of possible compounds: isomers of apigenin 7-O-glucoside or luteolin-8-C-rhamnoside, isovitexin (apigenin 6- c-glucoside), hydroxyphenylethyl-caffeoyl glucopyranoside, nagylactone E, among others. In the in vitro study of antimicrobial activity by agar diffusion, the EEF-F1, EEFF3, EEC-F2 and EEC-F3 fractions showed zones of inhibition against S. aureus (9±0,00; 9±0,00; 9±0,00 and 9±0,00 mm) respectively, and the EEF-F2 and EEF-F3 fractions showed inhibition against E.coli (9±0,00 e 10 ±0,00 mm). As for fungal strain C.tropicali, the EEF-F1, EEF-F2 and EEC-F2 fractions were active with an inhibition of 6±0,00; 966±0,57 e 9,66±0,57 mm. Both the extracts and the polar fractions showed antioxidant potential with the tested methods. Therefore, this is the first study that reports the identification of chemical constituents for extracts of the species C. adamantinus, and it shows the importance of the dereplication method in the identification of known compounds.Croton adamantinus MÜLL. ARG, conhecida popularmente como carrasco e velame-bravo, é usada na medicina tradicional para cicatrização, problemas gastrointestinais e hepáticos, no entanto, não há estudos na literatura sobre sua composição química, nem atividade biológica realizada com o extrato das folhas e caules. Assim, teve-se como objetivo realizar o estudo fitoquímico e investigar a atividade antimicrobiana e antioxidante de C. adamantinus. Os extratos etanólicos das folhas e caules (EEF-CA e EEC-CA) e as frações (EEF-F2, EEF-F3, EEF-F4 e EEF-F5) e (EEC-F2, EEC-F3, EEC-F4 e EEC-F5) foram submetidas ao screening fitoquímico, e a análise fitoquímica qualitativa por Cromatografia líquida acoplada a Espectrometria de Massas por Ionização por Eletrospray com Analisador do tipo "Time of Fly" (CL-EM-ESI-TOF). A avaliação da atividade antimicrobiana foi realizada pelo método difusão em ágar. E a avaliação da atividade antioxidante foi realizada através de espectrofotômetro UVVis, sendo utilizado os métodos DPPH e quelação de metais. A partir da análise do screening fitoquímico determinou-se a presença de flavonoides, alcaloides e outros. Esse resultado foi corroborado na análise do CL-EM-ESI-TOF que mostrou a presença de flavonoides, permitindo a identificação dos possíveis compostos: isômeros de apigenina 7-O-glucosídeo ou luteolina-8- C-ramnosídeo, isovitexina (apigenina 6-c-glucosídeo), hidroxifeniletil-cafeoilglucopiranosídeo, nagilactona E, entre outros. No estudo in vitro da atividade antimicrobiana pela difusão em ágar as frações EEF-F1, EEF-F3, EEC-F2 e EEC-F3 apresentaram zonas de inibição contra S. aureus (9±0,00; 9±0,00; 9±0,00 e 9±0,00 mm) respectivamente, e as frações EEF-F2 e EEF-F3 apresentaram inibição contra E. coli (9±0,00 e 10 ±0,00 mm). Já para a cepa fúngica C. tropicali as frações EEF-F1, EEF-F2 e EEC-F2 mostraram-se ativas com inibição de 6±0,00; 9,66±0,57 e 9,66±0,57 mm. Tanto os extratos como as frações polares exibiram potencial antioxidante frente aos métodos testados. Portanto, este é o primeiro estudo que relata a identificação de constituintes químicos para extratos da espécie C. adamantinus, e mostra a importância do método de desreplicação na identificação de compostos conhecidos.Submitted by raiane.sousa@aluno.uepb.edu.br (raiane.sousa@aluno.uepb.edu.br) on 2023-03-14T14:05:05Z No. of bitstreams: 2 DS-Raiane de Brito Sousa.pdf: 4293347 bytes, checksum: b5d6efa9f39af8b6dbe3d3ac4b45a482 (MD5) Termo de depósito BDTD..pdf: 1358454 bytes, checksum: ed2f278400bdfb8f526b9189c43036f8 (MD5)Approved for entry into archive by Jean Medeiros (jeanletras@uepb.edu.br) on 2023-03-14T16:28:48Z (GMT) No. of bitstreams: 2 DS-Raiane de Brito Sousa.pdf: 4293347 bytes, checksum: b5d6efa9f39af8b6dbe3d3ac4b45a482 (MD5) Termo de depósito BDTD..pdf: 1358454 bytes, checksum: ed2f278400bdfb8f526b9189c43036f8 (MD5)Made available in DSpace on 2023-04-19T20:54:51Z (GMT). No. of bitstreams: 2 DS-Raiane de Brito Sousa.pdf: 4293347 bytes, checksum: b5d6efa9f39af8b6dbe3d3ac4b45a482 (MD5) Termo de depósito BDTD..pdf: 1358454 bytes, checksum: ed2f278400bdfb8f526b9189c43036f8 (MD5) Previous issue date: 2022-12-20Fundação de Apoio à Pesquisa do Estado da Paraíba - FAPESQapplication/pdfporUniversidade Estadual da ParaíbaPrograma de Pós-Graduação em Química - PPGQUEPBBrasilPró-Reitoria de Pós-Graduação e Pesquisa - PRPGPCrotonFlavonoidesAtividade antioxidanteAtividade antimicrobianaCrotonAntioxidant ActivityFlavonoidsAntimicrobial activityQUIMICA ORGANICA::QUIMICA DOS PRODUTOS NATURAISProspecção química, atividade antioxidante e antimicrobiana das folhas e caules de Croton adamantinus Müll. Arg. (EUPHORBIACEAE)Chemical prospection, antioxidant and antimicrobial activity of leaves and stems of Croton adamantinus MÜLL. ARG. (EUPHORBIACEAE)info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/masterThesis-79317878423444719666006006005248714503811102784801670629162214816info:eu-repo/semantics/embargoedAccessreponame:Biblioteca Digital de Teses e Dissertações da UEPBinstname:Universidade Estadual da Paraíba (UEPB)instacron:UEPBORIGINALDS-Raiane de Brito Sousa.pdfDS-Raiane de Brito Sousa.pdfapplication/pdf4293347http://tede.bc.uepb.edu.br/jspui/bitstream/tede/4585/2/DS-Raiane+de+Brito+Sousa.pdfb5d6efa9f39af8b6dbe3d3ac4b45a482MD52Termo de depósito BDTD..pdfTermo de depósito BDTD..pdfapplication/pdf1358454http://tede.bc.uepb.edu.br/jspui/bitstream/tede/4585/3/Termo+de+dep%C3%B3sito+BDTD..pdfed2f278400bdfb8f526b9189c43036f8MD53LICENSElicense.txtlicense.txttext/plain; charset=utf-81960http://tede.bc.uepb.edu.br/jspui/bitstream/tede/4585/1/license.txt6052ae61e77222b2086e666b7ae213ceMD51tede/45852023-04-19 17:54:51.768oai:tede.bc.uepb.edu.br: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Biblioteca Digital de Teses e Dissertaçõeshttp://tede.bc.uepb.edu.br/jspui/PUBhttp://tede.bc.uepb.edu.br/oai/requestbc@uepb.edu.br||opendoar:2023-04-19T20:54:51Biblioteca Digital de Teses e Dissertações da UEPB - Universidade Estadual da Paraíba (UEPB)false |
dc.title.por.fl_str_mv |
Prospecção química, atividade antioxidante e antimicrobiana das folhas e caules de Croton adamantinus Müll. Arg. (EUPHORBIACEAE) |
dc.title.alternative.eng.fl_str_mv |
Chemical prospection, antioxidant and antimicrobial activity of leaves and stems of Croton adamantinus MÜLL. ARG. (EUPHORBIACEAE) |
title |
Prospecção química, atividade antioxidante e antimicrobiana das folhas e caules de Croton adamantinus Müll. Arg. (EUPHORBIACEAE) |
spellingShingle |
Prospecção química, atividade antioxidante e antimicrobiana das folhas e caules de Croton adamantinus Müll. Arg. (EUPHORBIACEAE) Sousa, Raiane de Brito Croton Flavonoides Atividade antioxidante Atividade antimicrobiana Croton Antioxidant Activity Flavonoids Antimicrobial activity QUIMICA ORGANICA::QUIMICA DOS PRODUTOS NATURAIS |
title_short |
Prospecção química, atividade antioxidante e antimicrobiana das folhas e caules de Croton adamantinus Müll. Arg. (EUPHORBIACEAE) |
title_full |
Prospecção química, atividade antioxidante e antimicrobiana das folhas e caules de Croton adamantinus Müll. Arg. (EUPHORBIACEAE) |
title_fullStr |
Prospecção química, atividade antioxidante e antimicrobiana das folhas e caules de Croton adamantinus Müll. Arg. (EUPHORBIACEAE) |
title_full_unstemmed |
Prospecção química, atividade antioxidante e antimicrobiana das folhas e caules de Croton adamantinus Müll. Arg. (EUPHORBIACEAE) |
title_sort |
Prospecção química, atividade antioxidante e antimicrobiana das folhas e caules de Croton adamantinus Müll. Arg. (EUPHORBIACEAE) |
author |
Sousa, Raiane de Brito |
author_facet |
Sousa, Raiane de Brito |
author_role |
author |
dc.contributor.advisor1.fl_str_mv |
Torres, Maria da Conceição de Menezes |
dc.contributor.advisor1Lattes.fl_str_mv |
http://lattes.cnpq.br/7638517746936259 |
dc.contributor.referee1.fl_str_mv |
Teles, Yanna Carolina Ferreira |
dc.contributor.referee1Lattes.fl_str_mv |
http://lattes.cnpq.br/7253814806654553 |
dc.contributor.referee2.fl_str_mv |
Cole, Thiciana Silva Sousa |
dc.contributor.referee2Lattes.fl_str_mv |
http://lattes.cnpq.br/7841081684013324 |
dc.contributor.authorLattes.fl_str_mv |
http://lattes.cnpq.br/3753981521187448 |
dc.contributor.author.fl_str_mv |
Sousa, Raiane de Brito |
contributor_str_mv |
Torres, Maria da Conceição de Menezes Teles, Yanna Carolina Ferreira Cole, Thiciana Silva Sousa |
dc.subject.por.fl_str_mv |
Croton Flavonoides Atividade antioxidante Atividade antimicrobiana |
topic |
Croton Flavonoides Atividade antioxidante Atividade antimicrobiana Croton Antioxidant Activity Flavonoids Antimicrobial activity QUIMICA ORGANICA::QUIMICA DOS PRODUTOS NATURAIS |
dc.subject.eng.fl_str_mv |
Croton Antioxidant Activity Flavonoids Antimicrobial activity |
dc.subject.cnpq.fl_str_mv |
QUIMICA ORGANICA::QUIMICA DOS PRODUTOS NATURAIS |
description |
Croton adamantinus MÜLL. ARG, also known as “carrasco” and “velame-bravo”, it is a plant used by Brazilian traditional medicine to improve the healing process and treat digestive and liver problems, however there is no study about its chemical composition neither biological activity using extract of leaves or stems. Thus, this research aimed to carry out a C. adamantinus phytochemical study and investigation on its antimicrobial and antioxidant activity. The stems and leaves’ ethanolic extracts (EEF-CA e EEC-CA) and the fractions (EEF-F2, EEF-F3, EEFF4 e EEF-F5) and (EEC-F2, EEC-F3, EEC-F4 e EEC-F5) were submitted to phytochemical screening and phytochemical analysis by Liquid chromatography coupled to Eletrospray Ionization Mass Spectrometry with “Time of Fly” type analyzer (CL-EM-ESI-TOF). The antimicrobial activity evaluation was carried out by the agar diffusion method. And the antioxidant activity was evaluated by through UV-Vis spectrophotometer by DPPH and metal chelation methods. Based on the analysis of the phytochemical screening, the presence of flavonoids, alkaloids and others was determined. This result was reaffirmed in the CL-EM-ESITOF analysis, which showed the presence of flavonoids, allowing the identification of possible compounds: isomers of apigenin 7-O-glucoside or luteolin-8-C-rhamnoside, isovitexin (apigenin 6- c-glucoside), hydroxyphenylethyl-caffeoyl glucopyranoside, nagylactone E, among others. In the in vitro study of antimicrobial activity by agar diffusion, the EEF-F1, EEFF3, EEC-F2 and EEC-F3 fractions showed zones of inhibition against S. aureus (9±0,00; 9±0,00; 9±0,00 and 9±0,00 mm) respectively, and the EEF-F2 and EEF-F3 fractions showed inhibition against E.coli (9±0,00 e 10 ±0,00 mm). As for fungal strain C.tropicali, the EEF-F1, EEF-F2 and EEC-F2 fractions were active with an inhibition of 6±0,00; 966±0,57 e 9,66±0,57 mm. Both the extracts and the polar fractions showed antioxidant potential with the tested methods. Therefore, this is the first study that reports the identification of chemical constituents for extracts of the species C. adamantinus, and it shows the importance of the dereplication method in the identification of known compounds. |
publishDate |
2022 |
dc.date.issued.fl_str_mv |
2022-12-20 |
dc.date.accessioned.fl_str_mv |
2023-04-19T20:54:51Z |
dc.date.available.fl_str_mv |
2999-12-31 |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/masterThesis |
format |
masterThesis |
status_str |
publishedVersion |
dc.identifier.citation.fl_str_mv |
SOUSA, Raiane de Brito. Prospecção química, atividade antioxidante e antimicrobiana das folhas e caules de Croton adamantinus MÜLL. ARG. (EUPHORBIACEAE). 2022. 105f. Dissertação (Programa de Pós-Graduação em Química - PPGQ) - Universidade Estadual da Paraíba, Campina Grande, 2023. |
dc.identifier.uri.fl_str_mv |
http://tede.bc.uepb.edu.br/jspui/handle/tede/4585 |
identifier_str_mv |
SOUSA, Raiane de Brito. Prospecção química, atividade antioxidante e antimicrobiana das folhas e caules de Croton adamantinus MÜLL. ARG. (EUPHORBIACEAE). 2022. 105f. Dissertação (Programa de Pós-Graduação em Química - PPGQ) - Universidade Estadual da Paraíba, Campina Grande, 2023. |
url |
http://tede.bc.uepb.edu.br/jspui/handle/tede/4585 |
dc.language.iso.fl_str_mv |
por |
language |
por |
dc.relation.program.fl_str_mv |
-7931787842344471966 |
dc.relation.confidence.fl_str_mv |
600 600 600 |
dc.relation.department.fl_str_mv |
524871450381110278 |
dc.relation.cnpq.fl_str_mv |
4801670629162214816 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/embargoedAccess |
eu_rights_str_mv |
embargoedAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Universidade Estadual da Paraíba |
dc.publisher.program.fl_str_mv |
Programa de Pós-Graduação em Química - PPGQ |
dc.publisher.initials.fl_str_mv |
UEPB |
dc.publisher.country.fl_str_mv |
Brasil |
dc.publisher.department.fl_str_mv |
Pró-Reitoria de Pós-Graduação e Pesquisa - PRPGP |
publisher.none.fl_str_mv |
Universidade Estadual da Paraíba |
dc.source.none.fl_str_mv |
reponame:Biblioteca Digital de Teses e Dissertações da UEPB instname:Universidade Estadual da Paraíba (UEPB) instacron:UEPB |
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Universidade Estadual da Paraíba (UEPB) |
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UEPB |
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UEPB |
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Biblioteca Digital de Teses e Dissertações da UEPB |
collection |
Biblioteca Digital de Teses e Dissertações da UEPB |
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http://tede.bc.uepb.edu.br/jspui/bitstream/tede/4585/2/DS-Raiane+de+Brito+Sousa.pdf http://tede.bc.uepb.edu.br/jspui/bitstream/tede/4585/3/Termo+de+dep%C3%B3sito+BDTD..pdf http://tede.bc.uepb.edu.br/jspui/bitstream/tede/4585/1/license.txt |
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MD5 MD5 MD5 |
repository.name.fl_str_mv |
Biblioteca Digital de Teses e Dissertações da UEPB - Universidade Estadual da Paraíba (UEPB) |
repository.mail.fl_str_mv |
bc@uepb.edu.br|| |
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1797038572636733440 |