Desenvolvimento de comprimidos com atividade antimicrobiana a partir de extrato de Ximenia americana L.

• Ano de defesa: 2016
• Autor(a) principal: Santana, Cleildo Pereira de
• Orientador(a): Medeiros, Ana Claudia Dantas de
• Banca de defesa: Macedo, Rui Oliveira , Gomes, Ana Paula Barreto , Diniz, Paulo Henrique Gonçalves Dias
• Tipo de documento: Dissertação
• Tipo de acesso: Acesso aberto
• Idioma: por
• Instituição de defesa: Universidade Estadual da Paraíba
• Programa de Pós-Graduação: Programa de Pós-Graduação em Ciências Farmacêuticas - PPGCF
• Departamento: Pró-Reitoria de Pós-Graduação e Pesquisa - PRPGP
• País: Brasil
• Palavras-chave em Português: Ximenia americana L.; Plantas medicinais; Atividade antimicrobiana; Fitoterápicos
• Área do conhecimento CNPq: CIENCIAS DA SAUDE::FARMACIA
• Link de acesso: http://tede.bc.uepb.edu.br/tede/jspui/handle/tede/2735

The use of plants for medicinal purposes is a tradition in many cultures around the world, from ancient times. Although knowledge of traditional medicine is not as intensely widespread, the tradition of using medicinal plants persist in the population, which often makes use of herbal medicines, traditional or manufactured drugs. With the increase in the consumption of this type of product, the pharmaceutical industry has shown strong interest in the improvement of herbal production methods in various pharmaceutical forms. Thus, this study aimed to obtain a tablet formulation of Ximenia americana L. nebulized extract, and to evaluate this formulation as its quality parameters. The extract, obtained by drying of a water-alcohol extraction solution was characterized as to its phytochemical composition and compatibility with various pharmaceutical excipients, allowing the selection of excipients that integrated tablet formulations. The formulation that was considered most appropriate was used to obtain a batch of tablets, which was characterized with respect to its quality parameters. The formulations obtained demonstrated excellent flow and was used in the production of tablets with a mean weight of 302.20 mg, average hardness of 45.15 N, friability of 0.34% and average disintegration time of 6 minutes and 8 seconds. Furthermore, the tablets have been shown to be capable of releasing about 70% of its plant extract content by 30 minutes in medium around neutrality. Thus, it was possible to develop a pharmaceutical form to facilitate the medicinal use of this plant by the population, and to evaluate the quality characteristics of the formulation developed in order to establish ways to ensure its quality characteristics, safety and efficacy.