Estudo clínico-laboratorial do uso de fenobarbital como anticonvulsivante entre pacientes do Hospital Universitário Alcides Carneiro (HUAC)

• Ano de defesa: 2014
• Autor(a) principal: Medeiros, Palas Atenéia Dantas de
• Orientador(a): Fook, Sayonara Maria Lia
• Banca de defesa: Belém, Lindomar de Farias , Mariz, Saulo Rios
• Tipo de documento: Dissertação
• Tipo de acesso: Acesso aberto
• Idioma: por
• Instituição de defesa: Universidade Estadual da Paraíba
• Programa de Pós-Graduação: Programa de Pós-Graduação em Saúde Pública - PPGSP
• Departamento: Pró-Reitoria de Pós-Graduação e Pesquisa - PRPGP
• País: Brasil
• Palavras-chave em Português: Fenobarbital; Anticonvulsionante; Epilepsia; Monitoramento de medicamentos
• Palavras-chave em Inglês: Phenobarbital; Drug monitoring; Epilepsy; Anticonvulsants
• Área do conhecimento CNPq: SAUDE COLETIVA::SAUDE PUBLICA
• Link de acesso: http://tede.bc.uepb.edu.br/tede/jspui/handle/tede/2606

Introduction: This study characterized the profile of patients treated at the “Alcides Carneiro” University Hospital (HUAC), users of phenobarbital in order to support actions of therapeutic drug monitoring. Methods: Fifty patients were interviewed using a standardized questionnaire. Results: It was observed that 50% of patients have been using the drug for a long time (7.68 years on average). About 74% of respondents are under monotherapy and 59.5% of these have their seizures controlled. The patients under monotherapy have more chance of success in controlling seizures. The main anticonvulsant drug combination observed was phenobarbital with carbamazepine (66% of patients). Sedation and dizziness are among the main adverse effects, reported by 34% of patients. Monotherapy seems to be a protective factor only for adverse effect dizziness (OR=3.1). Conclusions: The analysis of these and other results presented in this paper may be useful in promoting rational use of anticonvulsants at the HUAC.