Estudo das alterações microcirculatórias na população idosa comparadas com adultos jovens

• Ano de defesa: 2011
• Autor(a) principal: Lopes, Flávia Gomes
• Orientador(a): Bottino, Daniel Alexandre
• Banca de defesa: Veras, Renato Peixoto , Villela, Nivaldo Ribeiro , Clapauch, Ruth
• Tipo de documento: Dissertação
• Tipo de acesso: Acesso aberto
• Idioma: por
• Instituição de defesa: Universidade do Estado do Rio de Janeiro
• Programa de Pós-Graduação: Programa de Pós-Graduação em Fisiopatologia Clínica e Experimental
• Departamento: Centro Biomédico::Faculdade de Ciências Médicas
• País: BR
• Palavras-chave em Português: Envelhecimento; Capilaroscopia do leito periungueal; Pletismografia de oclusão venosa; Microcirculação
• Palavras-chave em Inglês: Aging; Nailfold videocapillaroscopy; Venous occlusion plethysmography; Microcirculation
• Área do conhecimento CNPq: CNPQ::CIENCIAS DA SAUDE::MEDICINA
• Link de acesso: http://www.bdtd.uerj.br/handle/1/12730

Population aging is a worldwide phenomenon, as well as the prevalence of deaths from cardiovascular diseases. Studies show that aging brings increased vascular stiffness and altered vascular reactivity. The present study compared the microcirculation of elderly people to young adults by venous occlusion plethysmography (POV) and nailfold videocapillaroscopy (NVC). For this, we developed a cross-sectional study with two groups: those aged between 18 and 30 years (n = 16) and another group aged over 60 years (n = 21), and the subdivision of this group into three subgroups: healthy elderly (n = 8), elderly women being treated for hypertension (IDHAS, n = 6) and older in the treatment of dyslipidemia (IDDIS, n = 6). Clinical, anthropometric, biochemical and microcirculatory parameters were evaluated. As results, NVC showed an increase of afferent, apical and efferent capillary diameters and a lower ratio maximum red blood cell velocity/ baseline red blood cell velocity for the older group and all subgroups. POV showed decreased endothelium-dependent vasodilation in all groups and the endothelium-independent vasodilation was altered only in IDHAS and IDDIS. In conclusion, in the aging, there were structural and functional changes of microcirculation as well as reduced endothelium-dependent vasodilation. The endothelium-independent vasodilation remained unchanged, indicating that smooth muscle cells of the vascular wall remains preserved, but show changes in the groups IDHAS and IDDIS.