Efeitos da administração do extrato de cranberry (vaccinium macrocarpon) por 30 dias sobre parâmetros metabólicos e hormonais em ratos Wistar obesos

• Ano de defesa: 2016
• Autor(a) principal: Peixoto, Thamara Cherem
• Orientador(a): Silva, Patrícia Cristina Lisbôa da
• Banca de defesa: Daleprane, Júlio Beltrame , Lopes, Gustavo Casimiro , Ferreira, Andrea Claudia Freitas
• Tipo de documento: Dissertação
• Tipo de acesso: Acesso aberto
• Idioma: por
• Instituição de defesa: Universidade do Estado do Rio de Janeiro
• Programa de Pós-Graduação: Programa de Pós-Graduação em Fisiopatologia Clínica e Experimental
• Departamento: Centro Biomédico::Faculdade de Ciências Médicas
• País: BR
• Palavras-chave em Português: Obesidade; Dieta rica em gordura; Extrato de cranberry; Corticosterona; Lipídios; Estresse oxidativo; Obesidade - Aspectos nutricionais; Dieta hiperlipídica; Cranberries - Uso terepêutico; Corticosterona - Metabolismo; Lipídios - Metabolismo; Ratos como animais de laboratório
• Palavras-chave em Inglês: Obesity; High fat diet; Cranberry extract; Corticosterone; Lipids; Oxidative stress
• Área do conhecimento CNPq: CNPQ::CIENCIAS BIOLOGICAS::FISIOLOGIA::FISIOLOGIA DE ORGAOS E SISTEMAS::FISIOLOGIA ENDOCRINA
• Link de acesso: http://www.bdtd.uerj.br/handle/1/12725

Obese individuals have higher production of reactive oxygen species, which leads to oxidative damage. We hypothesize that cranberry extract can improve this dysfunction in HFD induced obese rats, since it has an important antioxidant activity. Here, we evaluated the effects of cranberry extract in food intake, adiposity, biochemical and hormonal parameters, lipogenic and adipogenic factors and oxidative balance in a HFD model. At postnatal day 120 (PN120), Wistar male rats were assigned into two groups: 1) SD (n=36) fed with a standard diet and 2) HFD (n=36), fed with a diet containing 44, 5% (35.2% from lard) energy from fat. At PN150, 12 animals of SD and HFD groups were euthanized while the others were subdivided into 4 groups (n=12/group): animals that received 200 mg/kg cranberry extract (SD CE, HFD CE) gavage/daily/30 days or water (SD, HFD). At PN180, animals were killed. HFD group showed higher body weight and visceral fat, hypercorticosteronemia, higher liver glucocorticoid sensitivity, cholesterol and triglyceridecontents. Also, HFD group had higher lipid peroxidation (plasma and tissues) and higher protein carbonylation (liver and adipose tissue) compared to SD group. HFD CE group showed lower body weight gain, hypotrygliceridemia, hypocorticosteronemia, and lower hepatic cholesterol and fatty acid synthase contents. Besides, HFD CE group displayed lower lipid peroxidation and protein carbonylation (liver and adipose tissue) compared to HFD group. Thus, although does not decrease adiposity, cranberry extract improves metabolic profile and reduces oxidative damage in HFD induced obese rats, which suggest a promising role of cranberry extract to help the management of obesity-related disorders.