Alterações morfológicas no pênis de ratos hipertensos tratados com sildenafil, enalapril e sua combinação

• Ano de defesa: 2014
• Autor(a) principal: Patrício, Bruno Félix
• Orientador(a): Souza, Diogo Benchimol de
• Banca de defesa: Costa, Waldemar Silva , Sampaio, Marco Aurélio Pereira , Figueiredo, Marcelo Abidu , Gallo, Carla Braga Mano , Carvalho, João Paulo Martins de
• Tipo de documento: Tese
• Tipo de acesso: Acesso aberto
• Idioma: por
• Instituição de defesa: Universidade do Estado do Rio de Janeiro
• Programa de Pós-Graduação: Programa de Pós-Graduação em Fisiopatologia e Ciências Cirúrgicas
• Departamento: Centro Biomédico::Faculdade de Ciências Médicas
• País: BR
• Palavras-chave em Português: Disfunção erétil; Hipertensão; Morfologia; Pênis; Enalapril; Sildenafil; Rato; Hipertensão Complicações; Disfunção erétil Etiologia; Enalapril Farmacocinética; Sildenafil Farmacocinética
• Palavras-chave em Inglês: Erectile dysfunction; Hypertension; Morphology; Penis; Enalapril; Sildenafil; Rato
• Área do conhecimento CNPq: CNPQ::CIENCIAS DA SAUDE
• Link de acesso: http://www.bdtd.uerj.br/handle/1/12322

Erectile dysfunction is frequently associated to systemic arterial hypertension and anti-hypertensive drugs, however the penile morphological aspects on these situations are poorly known. The objective of this study was to evaluate the penile morphology of untreated hypertensive rats and rats treated with enalapril or sildenafil alone or in combination. Fifty male rats were assigned into 5 groups, each with 10 animals: group WKY, with normotensive Wistar Kyoto rats; group H, with untreated spontaneously hypertensive rats (SHR); group HE with enalapril (30mg/Kg/day); group HS with SHR treated with sildenafil (1mg/Kg/day); and group HES, with SHR treated with enalapril and sildenafil. Blood pressure was measured weekly from 90 days of the animals´ age, until the end of the experiment. At the conclusion of the study, with 160 days of age, the rats were submitted to euthanasia and their penises were collected for histomorphometrical analysis. The cross-sectional areas of the penis, tunica albuginea, and corpus cavernosum were measured. The density of the corpus cavernosum structures was quantified. Both groups of SHR rats treated with enalapril became normotensive. Animals from group H showed no difference in penile and cavernosal cross-sectional area compared to WKY rats. However, those rats treated with enalapril or sildenafil alone demonstrated an increase in these parameters. Rats of the group HES showed no cross-sectional area differences compared to normotensive rats. Cavernosal connective tissue density was increased while the sinusoidal spaces were diminished in untreated SHR. All treatments were effective in maintaining connective tissue density in comparison to normotensive animals. Cavernosal smooth muscle density was similar in all groups, with the exception of the combination therapy group, which demonstrated a reduction in smooth muscle. Hypertension promoted structural alterations in the corpus cavernosum that may be related to ED. Enalapril and sildenafil treated animals had preservation of normal corpus cavernosum structure and an increase in penile and cavernosal cross-sectional area. The combination of these drugs showed less benefit than individual use.