Avaliação do efeito do chá verde sobre a pressão arterial, função endotelial, perfil metabólico, atividade inflamatória e adiposidade corporal em mulheres pré-hipertensas obesas

• Ano de defesa: 2013
• Autor(a) principal: Nogueira, Lívia de Paula
• Orientador(a): Sanjuliani, Antonio Felipe
• Banca de defesa: Neves, Mário Fritsch Toros , Klein, Márcia Regina Simas Torres , Rosa, Glorimar , Coutinho, Walmir Ferreira
• Tipo de documento: Tese
• Tipo de acesso: Acesso aberto
• Idioma: por
• Instituição de defesa: Universidade do Estado do Rio de Janeiro
• Programa de Pós-Graduação: Programa de Pós-Graduação em Fisiopatologia Clínica e Experimental
• Departamento: Centro Biomédico::Faculdade de Ciências Médicas
• País: BR
• Palavras-chave em Português: Pressão arterial; Função endotelial; Chá Verde; Flavonóides; Chá verde; Camellia sinensis; Adiposidade; Endotélio
• Palavras-chave em Inglês: Blood pressure; Endothelial function; Green tea; Flavonoids
• Área do conhecimento CNPq: CNPQ::CIENCIAS DA SAUDE::NUTRICAO
• Link de acesso: http://www.bdtd.uerj.br/handle/1/12652

Cardiovascular diseases are the leading cause of mortality in Western countries. Some studies have suggested that green tea has beneficial effects on different cardiovascular risk factors. However, others have failed to show such an association. Objective to evaluate the effects of green tea on blood pressure, endothelial function, metabolic profile, inflammatory activity and body adiposity in obese pre-hypertensive women. Study clinical, randomized, crossover, double-blinded, placebo-controlled. During 4 weeks women were instructed to ingest 3 capsules of green tea extract per day (500mg green tea extract/capsule), after 2 weeks of washout and then ingested placebo for 4 weeks. The women who began the study with placebo later have used green tea. That is, all patients received placebo and green tea for the same period. At the beginning and end of each treatment the variables were analyzed. Study of 20 women with pre-hypertension, obesity grade I and II, aged between 25 and 59 years. Study site in Laboratory of the Discipline of Clinical and Experimental Pathophysiological Clinex. Rio de Janeiro State University. Variables studied was blood pressure, reactive hyperemia index (evaluated with Endo-PAT2000®), C-reactive protein, interleukin 6, tumor necrosis factor alpha, vascular cell adhesion molecule, intercellular adhesion molecule, plasminogen activator inhibitor-1, vascular endothelial growth factor, E-selectin, adiponectin, total cholesterol, low density lipoprotein-cholesterol, high density lipoprotein-cholesterol, triglycerides, blood glucose, insulin, HOMA, body mass index, waist circumference, hip circumference, waist-to-hip ratio and body fat. As results, in the assessment of blood pressure by ambulatory blood pressure monitoring was observed significant reduction in 24 hours systolic blood pressure (pre 130.3±1.7 mmHg vs. post 127.0±2.0 mmHg; p= 0.02), daytime systolic blood pressure (pre 134.0±1.7 mmHg vs. post 130.7±2.0 mmHg; p= 0.04) and nighttime systolic blood pressure (pre 122.2±1.8 mmHg vs. post 118.4±2.2 mmHg; p= 0.02), after consumption of green tea compared with placebo. After consumption of green tea, there was an increase, although not statistically significant, in reactive hyperemia index (pre 1.98±0.10 vs. post 2.22±0.14), besides expressive reduction in the concentration of intercellular adhesion molecule (pre 91.8±8.0 ng/ml vs. post 85.8±5.6 ng/ml) and vascular endothelial growth factor (pre 195.8±46.2 pg/ml vs. post 158.6±38.7 pg/ml), however without statistical significance. The other variables evaluated did not change significantly after consumption of green tea. A strong correlation was observed between reduction in 24 hours systolic blood pressure and 24 hours diastolic blood pressure, assessed by ambulatory blood pressure monitoring, and the increase of reactive hyperthermia index (r= -0.47; r= -0.50, respectively). The results of this study suggest that green tea has a beneficial effect on blood pressure and possibly on endothelial function.