Avaliação do comportamento metabólico de cisticercos de Taenia crassiceps cultivados in vitro e expostos a condições estressantes
Ano de defesa: | 2013 |
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Autor(a) principal: | |
Orientador(a): | |
Banca de defesa: | , , |
Tipo de documento: | Dissertação |
Tipo de acesso: | Acesso aberto |
Idioma: | por |
Instituição de defesa: |
Universidade Federal de Goiás
|
Programa de Pós-Graduação: |
Programa de Pós-graduação em Biologia das Interações PH (IPTSP)
|
Departamento: |
Instituto de Patologia Tropical e Saúde Pública - IPTSP (RG)
|
País: |
Brasil
|
Palavras-chave em Português: | |
Palavras-chave em Inglês: | |
Área do conhecimento CNPq: | |
Link de acesso: | http://repositorio.bc.ufg.br/tede/handle/tede/5874 |
Resumo: | Taenia crassiceps cysticerci possess antigenic similarities to T. solium cysticerci and because of this and added to the relative easiness in its maintainance in laboratory they are used as an experimental model to T. solium studies. The objective of this study was to analyze the in vitro influence of glucose and insulin on the energetic and respiratory metabolism of T. crassiceps cysticerci exposed to low dosages of anti-helminthic drugs, albendazol and praziquantel, and also to different concentrations of glucose and insulin. Glucose is the main energy source to these parasites in their larval and adult stages and glycogen is their main energetic reserve. Glycogen may be converted into glucose in case of low glucose uptake and is stored in the cysticerci tegument. The cysticerci were collected from the peritoneal cavity of BALB/c female mice experimentally infected and maintained in the animal facilities of IPTSP/UFG. After 24hours of culture in RPMI culture medium supplemented and with glucose, glargine insulin (LANTUS®, Sanofi Aventis), albendazol and praziquantel, the cysticerci were removed and the medium was frozen in liquid nitrogen as to allow the metabolix stasis. Afterwards this culture medium was analyzes through HPLC as to permit the quantification of the following organic acids related to the carbohydrates metabolism: lactate and pyruvate, intermediary metabolism: citrate, α-ketoglutarate, succinate, fumarate, malate and oxaloacetate, fatty acids metabolism: β-hydroxibutyrate and propionate. It was possible to detect propionate and β-hydroxibutyrate secreted by T. crassiceps cysticerci which indicates the fatty acids oxidation as an alternative energy xv source used by the initial stage cysticerci which are in rapid growth. Also the detection of organic acids from the citric acid cycle indicates the in vitro aerobiosis performed by the initial stage cysticerci. |
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Vinaud, Marina Clarehttp://lattes.cnpq.br/1921551651088660Vinaud, Marina ClareCosta, Tatiane LuizaCastro, Ana Maria dehttp://lattes.cnpq.br/9080165922658124Andrade, Lilian Cristina Morais de2016-08-09T12:19:51Z2013-09-06ANDRADE, L. C. M. Avaliação do comportamento metabólico de cisticercos de Taenia crassiceps cultivados in vitro e expostos a condições estressantes. 2013. 62 f. Dissertação (Mestrado em Biologia da Relação Parasito-Hospedeiro) - Universidade Federal de Goiás, Goiânia, 2013.http://repositorio.bc.ufg.br/tede/handle/tede/5874Taenia crassiceps cysticerci possess antigenic similarities to T. solium cysticerci and because of this and added to the relative easiness in its maintainance in laboratory they are used as an experimental model to T. solium studies. The objective of this study was to analyze the in vitro influence of glucose and insulin on the energetic and respiratory metabolism of T. crassiceps cysticerci exposed to low dosages of anti-helminthic drugs, albendazol and praziquantel, and also to different concentrations of glucose and insulin. Glucose is the main energy source to these parasites in their larval and adult stages and glycogen is their main energetic reserve. Glycogen may be converted into glucose in case of low glucose uptake and is stored in the cysticerci tegument. The cysticerci were collected from the peritoneal cavity of BALB/c female mice experimentally infected and maintained in the animal facilities of IPTSP/UFG. After 24hours of culture in RPMI culture medium supplemented and with glucose, glargine insulin (LANTUS®, Sanofi Aventis), albendazol and praziquantel, the cysticerci were removed and the medium was frozen in liquid nitrogen as to allow the metabolix stasis. Afterwards this culture medium was analyzes through HPLC as to permit the quantification of the following organic acids related to the carbohydrates metabolism: lactate and pyruvate, intermediary metabolism: citrate, α-ketoglutarate, succinate, fumarate, malate and oxaloacetate, fatty acids metabolism: β-hydroxibutyrate and propionate. It was possible to detect propionate and β-hydroxibutyrate secreted by T. crassiceps cysticerci which indicates the fatty acids oxidation as an alternative energy xv source used by the initial stage cysticerci which are in rapid growth. Also the detection of organic acids from the citric acid cycle indicates the in vitro aerobiosis performed by the initial stage cysticerci.Os cisticercos de Taenia crassiceps possuem similaridades antigênicas com cisticercos de Taenia solium e por este motivo, associado ao fato de uma relativa facilidade de sua manutenção em animais de laboratório, são utilizados como modelo experimental para estudos da cisticercose por T. solium. O objetivo deste trabalho foi analisar in vitro a influência da glicose e da insulina no metabolismo energético e respiratório de cisticercos de T. crassiceps expostos aos fármacos anti-helmínticos albendazol e praziquantel em baixas doses, e diferentes concentrações de glicose e insulina. A glicose é a principal fonte de energia para estes parasitos tanto na fase larval quanto adultos e o glicogênio, que pode ser novamente convertido em glicose, é fonte de reserva energética, sendo encontrado armazenado em suas membranas. Os cisticercos foram provenientes da cavidade peritoneal de camundongos fêmeas Balb/c infectados experimentalmente e mantidos no biotério do IPTSP/UFG. Após 24 horas de cultivo em meio RPMI® suplementado e adicionado de glicose, insulina glargina (LANTUS®, Sanofi Aventis), albendazol e praziquantel, foram retirados da placa e o meio foi congelado em nitrogênio líquido para ocorrer estase metabólica. Posteriormente o meio de cultura passou por um processo de extração sendo analisado em Cromatografia Líquida de Alta Performance com detector UV (CLAE) dos seguintes ácidos orgânicos oriundos do metabolismo de carboidratos (lactato, piruvato), metabolismo intermediário (citrato, α-cetoglutarato succinato, fumarato, malato, oxaloacetato) e metabolismo de ácidos graxos (β-hidroxibutirato e propionato). Foram detectados propionato e β-hidroxibutirato secretados por cisticercos de T. crassiceps indicando a oxidação de ácidos graxos como fonte de energia alternativa, utilizada em especial nos estádios de crescimento e também em situações de baixas concentrações de substancias energéticas provenientes do hospedeiro. Em adição, a detecção de xiv ácidos orgânicos do ciclo do ácido cítrico nos cisticercos analisados confirma a aerobiose in vitro do estádio evolutivos inicial dos cisticercos.Submitted by Luciana Ferreira (lucgeral@gmail.com) on 2016-08-09T12:17:35Z No. of bitstreams: 2 Dissertação - Lilian Cristina Morais de Andrade - 2013.pdf: 1070622 bytes, checksum: c44e7d6decc4c88ffa0d3bbacd190bc6 (MD5) license_rdf: 0 bytes, checksum: d41d8cd98f00b204e9800998ecf8427e (MD5)Approved for entry into archive by Luciana Ferreira (lucgeral@gmail.com) on 2016-08-09T12:19:51Z (GMT) No. of bitstreams: 2 Dissertação - Lilian Cristina Morais de Andrade - 2013.pdf: 1070622 bytes, checksum: c44e7d6decc4c88ffa0d3bbacd190bc6 (MD5) license_rdf: 0 bytes, checksum: d41d8cd98f00b204e9800998ecf8427e (MD5)Made available in DSpace on 2016-08-09T12:19:51Z (GMT). No. of bitstreams: 2 Dissertação - Lilian Cristina Morais de Andrade - 2013.pdf: 1070622 bytes, checksum: c44e7d6decc4c88ffa0d3bbacd190bc6 (MD5) license_rdf: 0 bytes, checksum: d41d8cd98f00b204e9800998ecf8427e (MD5) Previous issue date: 2013-09-06application/pdfporUniversidade Federal de GoiásPrograma de Pós-graduação em Biologia das Interações PH (IPTSP)UFGBrasilInstituto de Patologia Tropical e Saúde Pública - IPTSP (RG)http://creativecommons.org/licenses/by-nc-nd/4.0/info:eu-repo/semantics/openAccessTaenia crassicepsPraziquantelAlbendazolCLAEMetabolismoAvaliação in vitroInsulinaGlicoseÁcidos orgânicosTaenia crassicepsAlbendazolePraziquantelMetabolismIn vitro evaluationIinsulinGlucoseOrganic acidsHPLCCIENCIAS BIOLOGICAS::PARASITOLOGIAAvaliação do comportamento metabólico de cisticercos de Taenia crassiceps cultivados in vitro e expostos a condições estressantesinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/masterThesis6367159433410056917600600600-7769011444564556288-4544576747271574306reponame:Repositório Institucional da UFGinstname:Universidade Federal de Goiás (UFG)instacron:UFGLICENSElicense.txtlicense.txttext/plain; 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dc.title.por.fl_str_mv |
Avaliação do comportamento metabólico de cisticercos de Taenia crassiceps cultivados in vitro e expostos a condições estressantes |
title |
Avaliação do comportamento metabólico de cisticercos de Taenia crassiceps cultivados in vitro e expostos a condições estressantes |
spellingShingle |
Avaliação do comportamento metabólico de cisticercos de Taenia crassiceps cultivados in vitro e expostos a condições estressantes Andrade, Lilian Cristina Morais de Taenia crassiceps Praziquantel Albendazol CLAE Metabolismo Avaliação in vitro Insulina Glicose Ácidos orgânicos Taenia crassiceps Albendazole Praziquantel Metabolism In vitro evaluation Iinsulin Glucose Organic acids HPLC CIENCIAS BIOLOGICAS::PARASITOLOGIA |
title_short |
Avaliação do comportamento metabólico de cisticercos de Taenia crassiceps cultivados in vitro e expostos a condições estressantes |
title_full |
Avaliação do comportamento metabólico de cisticercos de Taenia crassiceps cultivados in vitro e expostos a condições estressantes |
title_fullStr |
Avaliação do comportamento metabólico de cisticercos de Taenia crassiceps cultivados in vitro e expostos a condições estressantes |
title_full_unstemmed |
Avaliação do comportamento metabólico de cisticercos de Taenia crassiceps cultivados in vitro e expostos a condições estressantes |
title_sort |
Avaliação do comportamento metabólico de cisticercos de Taenia crassiceps cultivados in vitro e expostos a condições estressantes |
author |
Andrade, Lilian Cristina Morais de |
author_facet |
Andrade, Lilian Cristina Morais de |
author_role |
author |
dc.contributor.advisor1.fl_str_mv |
Vinaud, Marina Clare |
dc.contributor.advisor1Lattes.fl_str_mv |
http://lattes.cnpq.br/1921551651088660 |
dc.contributor.referee1.fl_str_mv |
Vinaud, Marina Clare |
dc.contributor.referee2.fl_str_mv |
Costa, Tatiane Luiza |
dc.contributor.referee3.fl_str_mv |
Castro, Ana Maria de |
dc.contributor.authorLattes.fl_str_mv |
http://lattes.cnpq.br/9080165922658124 |
dc.contributor.author.fl_str_mv |
Andrade, Lilian Cristina Morais de |
contributor_str_mv |
Vinaud, Marina Clare Vinaud, Marina Clare Costa, Tatiane Luiza Castro, Ana Maria de |
dc.subject.por.fl_str_mv |
Taenia crassiceps Praziquantel Albendazol CLAE Metabolismo Avaliação in vitro Insulina Glicose Ácidos orgânicos |
topic |
Taenia crassiceps Praziquantel Albendazol CLAE Metabolismo Avaliação in vitro Insulina Glicose Ácidos orgânicos Taenia crassiceps Albendazole Praziquantel Metabolism In vitro evaluation Iinsulin Glucose Organic acids HPLC CIENCIAS BIOLOGICAS::PARASITOLOGIA |
dc.subject.eng.fl_str_mv |
Taenia crassiceps Albendazole Praziquantel Metabolism In vitro evaluation Iinsulin Glucose Organic acids HPLC |
dc.subject.cnpq.fl_str_mv |
CIENCIAS BIOLOGICAS::PARASITOLOGIA |
description |
Taenia crassiceps cysticerci possess antigenic similarities to T. solium cysticerci and because of this and added to the relative easiness in its maintainance in laboratory they are used as an experimental model to T. solium studies. The objective of this study was to analyze the in vitro influence of glucose and insulin on the energetic and respiratory metabolism of T. crassiceps cysticerci exposed to low dosages of anti-helminthic drugs, albendazol and praziquantel, and also to different concentrations of glucose and insulin. Glucose is the main energy source to these parasites in their larval and adult stages and glycogen is their main energetic reserve. Glycogen may be converted into glucose in case of low glucose uptake and is stored in the cysticerci tegument. The cysticerci were collected from the peritoneal cavity of BALB/c female mice experimentally infected and maintained in the animal facilities of IPTSP/UFG. After 24hours of culture in RPMI culture medium supplemented and with glucose, glargine insulin (LANTUS®, Sanofi Aventis), albendazol and praziquantel, the cysticerci were removed and the medium was frozen in liquid nitrogen as to allow the metabolix stasis. Afterwards this culture medium was analyzes through HPLC as to permit the quantification of the following organic acids related to the carbohydrates metabolism: lactate and pyruvate, intermediary metabolism: citrate, α-ketoglutarate, succinate, fumarate, malate and oxaloacetate, fatty acids metabolism: β-hydroxibutyrate and propionate. It was possible to detect propionate and β-hydroxibutyrate secreted by T. crassiceps cysticerci which indicates the fatty acids oxidation as an alternative energy xv source used by the initial stage cysticerci which are in rapid growth. Also the detection of organic acids from the citric acid cycle indicates the in vitro aerobiosis performed by the initial stage cysticerci. |
publishDate |
2013 |
dc.date.issued.fl_str_mv |
2013-09-06 |
dc.date.accessioned.fl_str_mv |
2016-08-09T12:19:51Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/masterThesis |
format |
masterThesis |
status_str |
publishedVersion |
dc.identifier.citation.fl_str_mv |
ANDRADE, L. C. M. Avaliação do comportamento metabólico de cisticercos de Taenia crassiceps cultivados in vitro e expostos a condições estressantes. 2013. 62 f. Dissertação (Mestrado em Biologia da Relação Parasito-Hospedeiro) - Universidade Federal de Goiás, Goiânia, 2013. |
dc.identifier.uri.fl_str_mv |
http://repositorio.bc.ufg.br/tede/handle/tede/5874 |
identifier_str_mv |
ANDRADE, L. C. M. Avaliação do comportamento metabólico de cisticercos de Taenia crassiceps cultivados in vitro e expostos a condições estressantes. 2013. 62 f. Dissertação (Mestrado em Biologia da Relação Parasito-Hospedeiro) - Universidade Federal de Goiás, Goiânia, 2013. |
url |
http://repositorio.bc.ufg.br/tede/handle/tede/5874 |
dc.language.iso.fl_str_mv |
por |
language |
por |
dc.relation.program.fl_str_mv |
6367159433410056917 |
dc.relation.confidence.fl_str_mv |
600 600 600 |
dc.relation.department.fl_str_mv |
-7769011444564556288 |
dc.relation.cnpq.fl_str_mv |
-4544576747271574306 |
dc.rights.driver.fl_str_mv |
http://creativecommons.org/licenses/by-nc-nd/4.0/ info:eu-repo/semantics/openAccess |
rights_invalid_str_mv |
http://creativecommons.org/licenses/by-nc-nd/4.0/ |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Universidade Federal de Goiás |
dc.publisher.program.fl_str_mv |
Programa de Pós-graduação em Biologia das Interações PH (IPTSP) |
dc.publisher.initials.fl_str_mv |
UFG |
dc.publisher.country.fl_str_mv |
Brasil |
dc.publisher.department.fl_str_mv |
Instituto de Patologia Tropical e Saúde Pública - IPTSP (RG) |
publisher.none.fl_str_mv |
Universidade Federal de Goiás |
dc.source.none.fl_str_mv |
reponame:Repositório Institucional da UFG instname:Universidade Federal de Goiás (UFG) instacron:UFG |
instname_str |
Universidade Federal de Goiás (UFG) |
instacron_str |
UFG |
institution |
UFG |
reponame_str |
Repositório Institucional da UFG |
collection |
Repositório Institucional da UFG |
bitstream.url.fl_str_mv |
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bitstream.checksum.fl_str_mv |
bd3efa91386c1718a7f26a329fdcb468 4afdbb8c545fd630ea7db775da747b2f d41d8cd98f00b204e9800998ecf8427e d41d8cd98f00b204e9800998ecf8427e c44e7d6decc4c88ffa0d3bbacd190bc6 |
bitstream.checksumAlgorithm.fl_str_mv |
MD5 MD5 MD5 MD5 MD5 |
repository.name.fl_str_mv |
Repositório Institucional da UFG - Universidade Federal de Goiás (UFG) |
repository.mail.fl_str_mv |
tasesdissertacoes.bc@ufg.br |
_version_ |
1793965706037952512 |