Associação entre os polimorfismos genéticos rs15763 e rs1800849 do gene UCP3 e a redução da força da preensão palmar em adultos

• Ano de defesa: 2014
• Autor(a) principal: Cruz, Raphael Silva da
• Orientador(a): Curado, Maria Paula
• Banca de defesa: Cruz, Aparecido Divino da, Minasi, Lysa Bernardes, Gigonzac, Thaís Cidália Vieira, Silva, Cláudio Carlos da
• Tipo de documento: Dissertação
• Tipo de acesso: Acesso aberto
• Idioma: por
• Instituição de defesa: Universidade Federal de Goiás
• Programa de Pós-Graduação: Programa de Pós-graduação em Ciências da Saúde (FM)
• Departamento: Faculdade de Medicina - FM (RG)
• País: Brasil
• Palavras-chave em Português: Sarcopenia; Envelhecimento; Espécies reativas de oxigênio; Proteína mitocondrial de desacoplamento
• Palavras-chave em Inglês: Sarcopenia; Aging; Reactive oxygen species; Mitochondrial uncoupling protein
• Área do conhecimento CNPq: CIENCIAS DA SAUDE::MEDICINA
• Link de acesso: http://repositorio.bc.ufg.br/tede/handle/tede/4333

The increase of the elderly population requires the development of strategies to minimize the negative effects of advancing chronological age in the body. The sarcopenia is one of the main changes observed in aging that causes loss of muscle strength. The assessment of hand grip strength (HGS) is an important variable to estimate the impairment of overall muscular strength of a person and is used as an indicator in several countries. Has been highlighted the genetic susceptibility studies underlying the aging phenomenon. In this context, the objective of this study was to evaluate the possible relationship between the SNPs rs1800849 and rs15763 of UCP3 gene and the HGS in adults. This study was a cross-sectional that included 161 individuals from Goiás population, who underwent an evaluation of HGS, and the collection of biological samples for genotyping by qPCR of polymorphic sites rs15763 and rs1800849 of UCP3 gene. Of the participants, 69.9% were women. The mean age was 50.5 (± 19.9) years and the HGS was 29.7 (± 14.6) kgf. We observed a negative and statistically significant correlation between FPP and age (r = -0.55; p≤0,0001). Regarding the polymorphism CC individuals were stronger than those individuals TT + CT for both SNPs. The maximum of HGS was between 30 to 50 years. The greatest decrease of HGS/ year was associated with genotypes that had the T allele for both SNPs studied. Individuals who presented the T allele in rs18949 had 1,684 times more likely to reduce the HGS in relation to genotype rs15763, the OR was 1.876. The UCP3 appears to be an important variable to modulate muscle strength and therefore may be a useful marker to monitor the aging process. This data from will contribute to the specialized attention to health, especially for the elderly population group.