Caracterização farmacognóstica e atividade gastroprotetora do extrato aquoso das folhas de Celtis Iguanaea (Jacq.) Sargent

• Ano de defesa: 2009
• Autor(a) principal: PAULA, Marcio André de
• Orientador(a): COSTA, Elson Alves
• Tipo de documento: Dissertação
• Tipo de acesso: Acesso aberto
• Idioma: por
• Instituição de defesa: Universidade Federal de Goiás
• Programa de Pós-Graduação: Mestrado em Ciências Farmacêuticas
• Departamento: Ciências da Saúde - Farmácia
• País: BR
• Palavras-chave em Português: Plantas medicinais, Celtis, cumarinas, flavonóides, mucilagens, gastroproteção
• Palavras-chave em Inglês: Medicinal plants, Celtis, coumarins, flavonoids, mucilages, gastro protection
• Área do conhecimento CNPq: CNPQ::CIENCIAS DA SAUDE::FARMACIA
• Link de acesso: http://repositorio.bc.ufg.br/tede/handle/tde/2133

Celtis iguanaea (Jacq.) Sargent is a small postage plant belonging to the Ulmaceae family, it has very flexible branches, usually in a crossed and overcoated form armed with spines. The leaves are short-petioled, ovals and have sizes that vary from 5-13 cm long and 3-7 cm wide. The tea obtained through it leaves is popularly used for body pain, rheumatism, chest pain, asthma, cramps, poor digestion, and as diuretic. Samples were collected in Campestre-GO, a exsiccates identified and deposited in the Herbarium of UFG under number 40110. It was performed macro and microscopic analysis and part of the botanical material was dried and ground to testing for moisture, total ash and acid insoluble ash, phytochemical screening and obtaining the aqueous extract of leaves of esporão-de-galo (EAEG). The EAEG was obtained by infusion of 3% of the powder of the leaves. Swiss mice (male adult, weighing between 25 to 35 g) were pre-treated orally with EAEG (70, 200 and 600 mg / kg), vehicle (water filtered 10 mL / kg) and ranitidine (50 mg / kg) before induction of gastric lesions by indomethacin (30 mg / kg sc), ethanol 75% (v / v) and by restraint stress and hypothermia. The effects of the extract on the volume, pH and total acidity of gastric secretion were evaluated by the method of pyloric ligation, and the treatments were performed by intraduodenal administration (id). It also assessed the influence of intestinal transit EAEG in animals with previous treatments made orally.. In macroscopic analysis were confirmed common characteristics of the species. In the microscopic analysis it was observed structures, such as: short and long trichomes, unicellular and pluricellular, epidermal cells of various sizes, cells containing druses, prismatic crystals and cystoliths. In phytochemical prospecting was detected the presence of mucilage and secondary metabolites as coumarins and flavonoids. The efficiency of the extraction process was 20%. In models of ulcers induced by different agents: indomethacin, ethanol and stress in doses of 70, 200 and 600 mg/kg, there was reduction in the number of injuries caused by these agents. When the EAEG was administered by intraduodenal route, there was reduction in the volume of total and free acidity of gastric secretion in mice with ligation of pylorus. In assessing the influence of EAEG on intestinal transit was observed increase only with the dose increased to 600 mg/kg. The results suggest that the EAEG contains active ingredients gastro protectors that do not reduce intestinal motility and may justify the popular use of the plant to gastritis and ulcers