Efeito da dextrina de trigo na sensibilidade à insulina e estado nutricional de indivíduos com Diabetes Mellitus tipo 2
Ano de defesa: | 2012 |
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Autor(a) principal: | |
Orientador(a): | |
Banca de defesa: | |
Tipo de documento: | Tese |
Tipo de acesso: | Acesso aberto |
Idioma: | por |
Instituição de defesa: |
Universidade Federal de Goiás
|
Programa de Pós-Graduação: |
Doutorado em Ciencias da Saude
|
Departamento: |
Ciencias da Saude
|
País: |
BR
|
Palavras-chave em Português: | |
Palavras-chave em Inglês: | |
Área do conhecimento CNPq: | |
Link de acesso: | http://repositorio.bc.ufg.br/tede/handle/tde/1531 |
Resumo: | Introduction: The dietary fiber, particularly soluble, are assigned the physiological effects that are important for the treatment of patients with type 2 diabetes mellitus. Objective: To evaluate the effect of supplementing wheat dextrin in insulin sensitivity, glycemic control and lipid, and nutritional status of patients with type 2 diabetes mellitus. Methodology: This is a trial blind, randomized, lasting 12 weeks.The sample consisted of 27 type 2 diabetic subjects of both sexes with a BMI ≥ 25.00 kg/m2 and sedentary. These subjects were randomized into two groups, test (n = 14) and placebo (n = 13). The test group was supplemented daily with 200 ml of orange flavor beverage without the addition of sugar and added 10 g of wheat dextrin, 30 minutes before the lunch. The control group received the same drink daily, but without the addition of fiber. Participants were instructed to maintain their lifestyle (diet and physical activity). Fasting plasma glucose, glycated hemoglobin (A1c), insulin sensitivity, lipid profile, the level of physical activity, intestinal function, food intake, and anthropometric indicators were assessed at baseline, 45 and 90 days intervention. Results: The A1c, fasting glucose and lipid profile showed no significant differences within and between groups. There was an increase in the values of HOMA-IR (p = 0.0163) and fasting insulin (p = 0.0406) at 45 days in the placebo group, with significant difference. The increase in HOMA-IR and fasting insulin resulted in decreased insulin sensitivity in the placebo group. In the test group showed no changes in insulin sensitivity. The test group showed improvement in bowel function. The fiber intake was below the recommendation for the diabetic.Food intake, body weight, BMI and waist circumference (WC) also showed no significant change. The percentage of body fat increased in the placebo group at 45 days (p = 0.0342) and decreased in the test group compared to placebo (p = 0.0216 and 0.0285). The basal metabolic rate (BMR) increased in the test group and decreased in placebo (p = 0.0198 and 0.005). Conclusion: Wheat dextrin in 10g/dia dosage did not improve insulin sensitivity, glycemic control and lipid, did not reduce body weight and WC and does not cause changes in the consumption of energy and macronutrients. There was increased consumption of fiber for the minimum of the recommendation, regulate bowel function, reduced body fat and increased the BMR. |
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SILVA, Maria Sebastianahttp://lattes.cnpq.br/1329422634395496http://lattes.cnpq.br/7870040293814328CARVALHO, Ana Clara Martins e Silva2014-07-29T15:25:18Z2012-04-232012-02-27CARVALHO, Ana Clara Martins e Silva. Effect of wheat dextrin in insulin sensitivity and nutritional status of individuals with type 2 diabetes mellitus. 2012. 137 f. Tese (Doutorado em Ciencias da Saude) - Universidade Federal de Goiás, Goiânia, 2012.http://repositorio.bc.ufg.br/tede/handle/tde/1531Introduction: The dietary fiber, particularly soluble, are assigned the physiological effects that are important for the treatment of patients with type 2 diabetes mellitus. Objective: To evaluate the effect of supplementing wheat dextrin in insulin sensitivity, glycemic control and lipid, and nutritional status of patients with type 2 diabetes mellitus. Methodology: This is a trial blind, randomized, lasting 12 weeks.The sample consisted of 27 type 2 diabetic subjects of both sexes with a BMI ≥ 25.00 kg/m2 and sedentary. These subjects were randomized into two groups, test (n = 14) and placebo (n = 13). The test group was supplemented daily with 200 ml of orange flavor beverage without the addition of sugar and added 10 g of wheat dextrin, 30 minutes before the lunch. The control group received the same drink daily, but without the addition of fiber. Participants were instructed to maintain their lifestyle (diet and physical activity). Fasting plasma glucose, glycated hemoglobin (A1c), insulin sensitivity, lipid profile, the level of physical activity, intestinal function, food intake, and anthropometric indicators were assessed at baseline, 45 and 90 days intervention. Results: The A1c, fasting glucose and lipid profile showed no significant differences within and between groups. There was an increase in the values of HOMA-IR (p = 0.0163) and fasting insulin (p = 0.0406) at 45 days in the placebo group, with significant difference. The increase in HOMA-IR and fasting insulin resulted in decreased insulin sensitivity in the placebo group. In the test group showed no changes in insulin sensitivity. The test group showed improvement in bowel function. The fiber intake was below the recommendation for the diabetic.Food intake, body weight, BMI and waist circumference (WC) also showed no significant change. The percentage of body fat increased in the placebo group at 45 days (p = 0.0342) and decreased in the test group compared to placebo (p = 0.0216 and 0.0285). The basal metabolic rate (BMR) increased in the test group and decreased in placebo (p = 0.0198 and 0.005). Conclusion: Wheat dextrin in 10g/dia dosage did not improve insulin sensitivity, glycemic control and lipid, did not reduce body weight and WC and does not cause changes in the consumption of energy and macronutrients. There was increased consumption of fiber for the minimum of the recommendation, regulate bowel function, reduced body fat and increased the BMR.Introdução: À fibra dietética, especialmente a fibra solúvel, são atribuídos efeitos fisiológicos que são importantes para o tratamento do paciente com diabetes mellitus tipo 2. Objetivo: Avaliar o efeito da suplementação de dextrina de trigo na sensibilidade à insulina, controle glicêmico e lipídico, e estado nutricional de portadores de diabetes mellitus tipo 2. Metodologia: Trata-se de um ensaio clínico cego, randomizado com duração de 12 semanas. A amostra foi composta por 27 indivíduos diabéticos tipo 2 de ambos os sexos, com IMC ≥ 25,00 kg/m2 e sedentários. Estes indivíduos foram randomizados em dois grupos, teste (n=14) e placebo (n=13). O grupo teste foi suplementado diariamente com 200 ml de bebida sabor laranja sem adição de açúcar e adicionada de 10 g de dextrina de trigo, 30 minutos antes do almoço. O grupo placebo recebeu diariamente a mesma bebida, mas sem adição de fibra. Os participantes foram orientados a manter seu estilo de vida (hábitos alimentares e de atividade física). A glicemia de jejum, a hemoglobina glicada (A1c), a sensibilidade à insulina, o perfil lipídico, o nível de atividade física, o funcionamento intestinal, o consumo alimentar, e os indicadores antropométricos foram avaliados no início, aos 45 e aos 90 dias de intervenção. Resultados: A A1c, a glicemia de jejum e o perfil lipídico não apresentaram diferenças significativas intra e entre grupos. Houve aumento nos valores de HOMA-IR (p=0,0163) e insulina de jejum (p=0,0406) aos 45 dias no grupo placebo, com diferença significativa. O aumento de HOMA-IR e insulina de jejum resultou em diminuição da sensibilidade à insulina do grupo placebo. No grupo teste não apresentou mudanças na sensibilidade à insulina. O grupo teste apresentou melhora no funcionamento intestinal. O consumo de fibras foi inferior a recomendação para o diabético. O consumo alimentar, o peso corporal, o IMC e a circunferência de cintura (CC) também não apresentaram mudanças significativas. A porcentagem de gordura corporal aumentou no grupo placebo aos 45 dias (p=0,0342) e diminuiu no grupo teste quando comparado ao grupo placebo (p=0,0216 e 0,0285). A Taxa de Metabolismo Basal (TMB) aumentou no grupo teste e diminuiu no placebo (p=0,0198 e 0,005). Conclusão: A dextrina de trigo na dosagem de 10g/dia não promoveu melhora na sensibilidade à insulina, no controle glicêmico e lipídico; não reduziu o peso corporal e CC e, não gerou mudanças no consumo de energia e de macronutrientes. Houve aumentou do consumo de fibra, para o mínimo da recomendação; regularização do funcionamento intestinal, redução da gordura corporal e aumento da TMB.Made available in DSpace on 2014-07-29T15:25:18Z (GMT). No. of bitstreams: 1 Tese Ana Clara M e S Carvalho - Patologia Clinica.pdf: 1557137 bytes, checksum: 899de7fc14fbe34def669ae52588c5f8 (MD5) Previous issue date: 2012-02-27application/pdfhttp://repositorio.bc.ufg.br/TEDE/retrieve/4384/Tese%20Ana%20Clara%20M%20e%20S%20Carvalho%20-%20Patologia%20Clinica.pdf.jpgporUniversidade Federal de GoiásDoutorado em Ciencias da SaudeUFGBRCiencias da Saudediabetes mellitus tipo 2fibra alimentarresistência à insulinaconsumo alimentarcomposição corporaltype 2 diabetes mellitusdietary fiberinsulin resistancefood consumptionbody compositionCNPQ::CIENCIAS DA SAUDE::MEDICINA::CLINICA MEDICAEfeito da dextrina de trigo na sensibilidade à insulina e estado nutricional de indivíduos com Diabetes Mellitus tipo 2Effect of wheat dextrin in insulin sensitivity and nutritional status of individuals with type 2 diabetes mellitusinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/doctoralThesisinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UFGinstname:Universidade Federal de Goiás (UFG)instacron:UFGORIGINALTese Ana Clara M e S Carvalho - Patologia Clinica.pdfapplication/pdf1557137http://repositorio.bc.ufg.br/tede/bitstreams/4c8cedd5-2829-411a-a508-11b74d1e08e9/download899de7fc14fbe34def669ae52588c5f8MD51THUMBNAILTese Ana Clara M e S Carvalho - Patologia Clinica.pdf.jpgTese Ana Clara M e S Carvalho - Patologia Clinica.pdf.jpgGenerated Thumbnailimage/jpeg3734http://repositorio.bc.ufg.br/tede/bitstreams/380f217e-465c-4a56-8c44-6d015cf2d08f/downloadbf86f7c8016ce62a0f1f77446473699eMD52tde/15312014-07-30 03:13:43.67open.accessoai:repositorio.bc.ufg.br:tde/1531http://repositorio.bc.ufg.br/tedeRepositório InstitucionalPUBhttp://repositorio.bc.ufg.br/oai/requesttasesdissertacoes.bc@ufg.bropendoar:2014-07-30T06:13:43Repositório Institucional da UFG - Universidade Federal de Goiás (UFG)false |
dc.title.por.fl_str_mv |
Efeito da dextrina de trigo na sensibilidade à insulina e estado nutricional de indivíduos com Diabetes Mellitus tipo 2 |
dc.title.alternative.eng.fl_str_mv |
Effect of wheat dextrin in insulin sensitivity and nutritional status of individuals with type 2 diabetes mellitus |
title |
Efeito da dextrina de trigo na sensibilidade à insulina e estado nutricional de indivíduos com Diabetes Mellitus tipo 2 |
spellingShingle |
Efeito da dextrina de trigo na sensibilidade à insulina e estado nutricional de indivíduos com Diabetes Mellitus tipo 2 CARVALHO, Ana Clara Martins e Silva diabetes mellitus tipo 2 fibra alimentar resistência à insulina consumo alimentar composição corporal type 2 diabetes mellitus dietary fiber insulin resistance food consumption body composition CNPQ::CIENCIAS DA SAUDE::MEDICINA::CLINICA MEDICA |
title_short |
Efeito da dextrina de trigo na sensibilidade à insulina e estado nutricional de indivíduos com Diabetes Mellitus tipo 2 |
title_full |
Efeito da dextrina de trigo na sensibilidade à insulina e estado nutricional de indivíduos com Diabetes Mellitus tipo 2 |
title_fullStr |
Efeito da dextrina de trigo na sensibilidade à insulina e estado nutricional de indivíduos com Diabetes Mellitus tipo 2 |
title_full_unstemmed |
Efeito da dextrina de trigo na sensibilidade à insulina e estado nutricional de indivíduos com Diabetes Mellitus tipo 2 |
title_sort |
Efeito da dextrina de trigo na sensibilidade à insulina e estado nutricional de indivíduos com Diabetes Mellitus tipo 2 |
author |
CARVALHO, Ana Clara Martins e Silva |
author_facet |
CARVALHO, Ana Clara Martins e Silva |
author_role |
author |
dc.contributor.advisor1.fl_str_mv |
SILVA, Maria Sebastiana |
dc.contributor.advisor1Lattes.fl_str_mv |
http://lattes.cnpq.br/1329422634395496 |
dc.contributor.authorLattes.fl_str_mv |
http://lattes.cnpq.br/7870040293814328 |
dc.contributor.author.fl_str_mv |
CARVALHO, Ana Clara Martins e Silva |
contributor_str_mv |
SILVA, Maria Sebastiana |
dc.subject.por.fl_str_mv |
diabetes mellitus tipo 2 fibra alimentar resistência à insulina consumo alimentar composição corporal |
topic |
diabetes mellitus tipo 2 fibra alimentar resistência à insulina consumo alimentar composição corporal type 2 diabetes mellitus dietary fiber insulin resistance food consumption body composition CNPQ::CIENCIAS DA SAUDE::MEDICINA::CLINICA MEDICA |
dc.subject.eng.fl_str_mv |
type 2 diabetes mellitus dietary fiber insulin resistance food consumption body composition |
dc.subject.cnpq.fl_str_mv |
CNPQ::CIENCIAS DA SAUDE::MEDICINA::CLINICA MEDICA |
description |
Introduction: The dietary fiber, particularly soluble, are assigned the physiological effects that are important for the treatment of patients with type 2 diabetes mellitus. Objective: To evaluate the effect of supplementing wheat dextrin in insulin sensitivity, glycemic control and lipid, and nutritional status of patients with type 2 diabetes mellitus. Methodology: This is a trial blind, randomized, lasting 12 weeks.The sample consisted of 27 type 2 diabetic subjects of both sexes with a BMI ≥ 25.00 kg/m2 and sedentary. These subjects were randomized into two groups, test (n = 14) and placebo (n = 13). The test group was supplemented daily with 200 ml of orange flavor beverage without the addition of sugar and added 10 g of wheat dextrin, 30 minutes before the lunch. The control group received the same drink daily, but without the addition of fiber. Participants were instructed to maintain their lifestyle (diet and physical activity). Fasting plasma glucose, glycated hemoglobin (A1c), insulin sensitivity, lipid profile, the level of physical activity, intestinal function, food intake, and anthropometric indicators were assessed at baseline, 45 and 90 days intervention. Results: The A1c, fasting glucose and lipid profile showed no significant differences within and between groups. There was an increase in the values of HOMA-IR (p = 0.0163) and fasting insulin (p = 0.0406) at 45 days in the placebo group, with significant difference. The increase in HOMA-IR and fasting insulin resulted in decreased insulin sensitivity in the placebo group. In the test group showed no changes in insulin sensitivity. The test group showed improvement in bowel function. The fiber intake was below the recommendation for the diabetic.Food intake, body weight, BMI and waist circumference (WC) also showed no significant change. The percentage of body fat increased in the placebo group at 45 days (p = 0.0342) and decreased in the test group compared to placebo (p = 0.0216 and 0.0285). The basal metabolic rate (BMR) increased in the test group and decreased in placebo (p = 0.0198 and 0.005). Conclusion: Wheat dextrin in 10g/dia dosage did not improve insulin sensitivity, glycemic control and lipid, did not reduce body weight and WC and does not cause changes in the consumption of energy and macronutrients. There was increased consumption of fiber for the minimum of the recommendation, regulate bowel function, reduced body fat and increased the BMR. |
publishDate |
2012 |
dc.date.available.fl_str_mv |
2012-04-23 |
dc.date.issued.fl_str_mv |
2012-02-27 |
dc.date.accessioned.fl_str_mv |
2014-07-29T15:25:18Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/doctoralThesis |
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doctoralThesis |
status_str |
publishedVersion |
dc.identifier.citation.fl_str_mv |
CARVALHO, Ana Clara Martins e Silva. Effect of wheat dextrin in insulin sensitivity and nutritional status of individuals with type 2 diabetes mellitus. 2012. 137 f. Tese (Doutorado em Ciencias da Saude) - Universidade Federal de Goiás, Goiânia, 2012. |
dc.identifier.uri.fl_str_mv |
http://repositorio.bc.ufg.br/tede/handle/tde/1531 |
identifier_str_mv |
CARVALHO, Ana Clara Martins e Silva. Effect of wheat dextrin in insulin sensitivity and nutritional status of individuals with type 2 diabetes mellitus. 2012. 137 f. Tese (Doutorado em Ciencias da Saude) - Universidade Federal de Goiás, Goiânia, 2012. |
url |
http://repositorio.bc.ufg.br/tede/handle/tde/1531 |
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por |
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Universidade Federal de Goiás |
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UFG |
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Ciencias da Saude |
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Universidade Federal de Goiás |
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