Efeito do ácido fólico nos principais parâmetros do espermograma de homens subférteis

• Ano de defesa: 2012
• Autor(a) principal: SILVA, Tatiana Moreira da
• Orientador(a): APPROBATO, Mario Silva
• Tipo de documento: Dissertação
• Tipo de acesso: Acesso aberto
• Idioma: por
• Instituição de defesa: Universidade Federal de Goiás
• Programa de Pós-Graduação: Mestrado em Ciências da Saúde
• Departamento: Ciências da Saúde - Medicina
• País: BR
• Palavras-chave em Português: infertilidade masculina; suplementos antioxidantes; ácido fólico, espermograma; estresse oxidativo
• Palavras-chave em Inglês: male infertility; antioxidants supplements; folic acid; semen analysis; oxidative stress
• Área do conhecimento CNPq: CNPQ::CIENCIAS DA SAUDE
• Link de acesso: http://repositorio.bc.ufg.br/tede/handle/tde/1754

Research shows that oral supplementation with antioxidants can reduce the damage caused by reactive oxygen species and increase the fertilizing capacity of sperm due to improvement in semen parameters. Semen analysis was assessed according to the criteria of the World Health Organization (1999), subfertile men who received folic acid at a dose of 5 mg/day or placebo, comparing results before and after treatment. A total of 49 patients aged 23-56 years (mean 35.3 years) and diagnosis of subfertility were randomized into two groups. The treated group (n= 23) receiving folic acid and the control group (n= 26) received placebo, each for 3 months. Before the intervention, the mean sperm concentration (x106/mL) in the treated group was 25.91 and 26.08 after treatment. In the control group was: 20.85 pre-treatment and 20.04 after treatment (p= 0.92). Means of progressive motile sperm obtained from the treated and placebo groups before treatment were, respectively: 46.48% and 49.23%. After the intervention, the mean values found were 48.26% in the treated group and 49.65% in the control group (p= 0.99). The mean normal sperm morphology was 23.26% in the treated group pre-intervention, and later was 23.91%. The control group had an average of 22.3% and 24.23%, respectively (p= 0.83). Mean vitality found in the treated group was 66.73% before the treatment and 69.56% after the treatment with folic acid. In the control group was 65.77% after pre-treatment and 65.38% was not significant (p= 0.95). Numerous studies have evaluated the use of antioxidants for improving sperm quality and thus fertility. These substances are used individually or in combination, and differ in the type, the target population, dosage and duration of therapy. This study showed that folic acid at a concentration of 5 mg / day did not improve sperm parameters in subfertile men compared to the control group.