Efeito cardiovascular das saponinas extraídas das folhas de Syzygium cumini (L.) Skeels

Detalhes bibliográficos
Ano de defesa: 2019
Autor(a) principal: CAMPOS, Matheus Brandão lattes
Orientador(a): BORGES, Marilene Oliveira da Rocha lattes
Banca de defesa: BORGES, Marilene Oliveira da Rocha lattes, SILVA JÚNIOR, José Ribamar da, BORGES, Antônio Carlos Romão, OLIVEIRA, Rui Miguel Gil da Costa, CARTÁGENES, Maria do Socorro de Sousa
Tipo de documento: Tese
Tipo de acesso: Acesso aberto
Idioma: por
Instituição de defesa: Universidade Federal do Maranhão
Programa de Pós-Graduação: PROGRAMA DE PÓS-GRADUAÇÃO EM BIOTECNOLOGIA - RENORBIO/CCBS
Departamento: DEPARTAMENTO DE CIÊNCIAS FISIOLÓGICAS/CCBS
País: Brasil
Palavras-chave em Português:
Saponinas;
Cardiovascular;
Syzygium cumini;
Vasorrelaxante;
Anti-hipertensivo
Palavras-chave em Inglês:
Saponins;
Cardiovascular;
Syzygium cumini;
Vasorelaxant;
Antihypertensive
Área do conhecimento CNPq:
Farmacologia Clínica
Link de acesso: https://tedebc.ufma.br/jspui/handle/tede/tede/5125
Resumo: Cardiovascular diseases (CVD) are the leading causes of death in the world and the search for new medicines that can ensure the treatment of diseases such as hypertension, for example, are becoming more frequent. Among the compounds investigated are products of plant origin that present classes of metabolites with pharmacological potential on the cardiovascular system. Saponins, class of plant origin, are amphiphilic molecules that have been seen as a prominent source of compounds with beneficial activity to the cardiovascular system. The present study evaluated the pharmacological potential of saponins extracted from leaves of Syzygium cumini (L.) Skeels in the cardiovascular system of spontaneously hypertensive rats (SHR). SHR male were treated for a period of 15 days with a rich fraction of S. cumini (FRS) 10 mg / kg / day / week saponins. and FRS 50 mg / kg / day / v.o. The results demonstrated that FRS was able to reduce blood pressure of SHRs, promote a reduction of arrhythmic events such as atrioventricular block and act on peripheral vascular resistance in resistance arteries, causing the decrease of noradrenaline-induced contraction in treated SHR animals with the highest dose. The vasorelaxation mechanisms were also evaluated in mesenteric artery rings. FRS was able to promote the vasorelaxing effect and block the contraction induced by extracellular calcium. With the results presented, it is concluded that FRS appears to act by blocking the influx of calcium and promoting cardioprotection, being therefore a prominent agent with potential antihypertensive effect and in cardiovascular disorders.
id UFMA_93378595034c359643fc8f2979c46e6a
oai_identifier_str oai:tede2:tede/5125
network_acronym_str UFMA
network_name_str Biblioteca Digital de Teses e Dissertações da UFMA
repository_id_str
spelling BORGES, Marilene Oliveira da Rochahttp://lattes.cnpq.br/3283574594616838RIBEIRO, Rachel MeloBORGES, Marilene Oliveira da Rochahttp://lattes.cnpq.br/3283574594616838SILVA JÚNIOR, José Ribamar daBORGES, Antônio Carlos RomãoOLIVEIRA, Rui Miguel Gil da CostaCARTÁGENES, Maria do Socorro de Sousahttp://lattes.cnpq.br/3035412310091857CAMPOS, Matheus Brandão2024-02-01T19:24:36Z2019-08-08CAMPOS, Matheus Brandão. Efeito cardiovascular das saponinas extraídas das folhas de Syzygium cumini (L.) Skeels. 2019. 92 f. Tese( Programa de Pós-Graduação em Biotecnologia - RENORBIO/CCBS) - Universidade Federal do Maranhão, São Luís, 2019.https://tedebc.ufma.br/jspui/handle/tede/tede/5125Cardiovascular diseases (CVD) are the leading causes of death in the world and the search for new medicines that can ensure the treatment of diseases such as hypertension, for example, are becoming more frequent. Among the compounds investigated are products of plant origin that present classes of metabolites with pharmacological potential on the cardiovascular system. Saponins, class of plant origin, are amphiphilic molecules that have been seen as a prominent source of compounds with beneficial activity to the cardiovascular system. The present study evaluated the pharmacological potential of saponins extracted from leaves of Syzygium cumini (L.) Skeels in the cardiovascular system of spontaneously hypertensive rats (SHR). SHR male were treated for a period of 15 days with a rich fraction of S. cumini (FRS) 10 mg / kg / day / week saponins. and FRS 50 mg / kg / day / v.o. The results demonstrated that FRS was able to reduce blood pressure of SHRs, promote a reduction of arrhythmic events such as atrioventricular block and act on peripheral vascular resistance in resistance arteries, causing the decrease of noradrenaline-induced contraction in treated SHR animals with the highest dose. The vasorelaxation mechanisms were also evaluated in mesenteric artery rings. FRS was able to promote the vasorelaxing effect and block the contraction induced by extracellular calcium. With the results presented, it is concluded that FRS appears to act by blocking the influx of calcium and promoting cardioprotection, being therefore a prominent agent with potential antihypertensive effect and in cardiovascular disorders.As doenças cardiovasculares (DCV) são as principais causas de morte no mundo e, a busca por novos medicamentos que possam assegurar o tratamento de doenças como a hipertensão arterial, por exemplo, são cada vez mais frequentes. Dentre os compostos investigados destacam-se os produtos de origem vegetal que apresentam metabólitos secundários com potencial farmacológico sobre o sistema cardiovascular. As saponinas, classe de metabólitos de origem vegetal, são moléculas anfifílicas que tem sido vistas como uma proeminente fonte de compostos com atividade benéfica ao sistema cardiovascular. O presente estudo avaliou o potencial farmacológico da fração rica em saponinas (FRS) extraída das folhas de Syzygium cumini (L.) Skeels, no sistema cardiovascular de ratos espontaneamente hipertensos (SHR). A FRS foi obtida por processo físico (patente (INPI BR 102014003275-4), e sua composição foi comprovada por análise fitoquímica. A FRS apresentou atividade antioxidante pelo método do DPPH. Para a avaliação farmacológica, SHR machos com 90 dias de idade foram tratados diariamente, pelo período de 15 dias, com a fração rica em saponinas isoladas de S. cumini (FRS), nas doses de 10 e 50 mg/kg/v.o. Os resultados demonstraram que a FRS reduziu a pressão arterial (PA) dos SHR, promoveu uma redução de eventos arrítmicos, tais como bloqueio atrioventricular e diminuiu resistência vascular periférica, causando a diminuição da contração induzida por noradrenalina nos animais SHR tratados com a dose mais alta. Os mecanismos do vasorrelaxamento foram investigados em anéis de artéria mesentérica. A FRS foi capaz de promover o efeito vasorrelaxante e bloquear a contração induzida pelo cálcio extracelular. Com os resultados apresentados conclui-se que a FRS diminui a PA por mecanismo que envolve o bloqueio do influxo de cálcio e, promove cardioproteção em SHR, sendo, portanto, um proeminente agente com potencial efeito anti-hipertensivo e em desordens cardiovasculares.Submitted by Maria Aparecida (cidazen@gmail.com) on 2024-02-01T19:24:36Z No. of bitstreams: 1 Matheus_Brandao_Campos.pdf: 23529103 bytes, checksum: f0f3fe05ac6ab79cc3c016169aefde02 (MD5)Made available in DSpace on 2024-02-01T19:24:36Z (GMT). No. of bitstreams: 1 Matheus_Brandao_Campos.pdf: 23529103 bytes, checksum: f0f3fe05ac6ab79cc3c016169aefde02 (MD5) Previous issue date: 2019-08-08CAPESFAPEMAapplication/pdfporUniversidade Federal do MaranhãoPROGRAMA DE PÓS-GRADUAÇÃO EM BIOTECNOLOGIA - RENORBIO/CCBSUFMABrasilDEPARTAMENTO DE CIÊNCIAS FISIOLÓGICAS/CCBSSaponinas;Cardiovascular;Syzygium cumini;Vasorrelaxante;Anti-hipertensivoSaponins;Cardiovascular;Syzygium cumini;Vasorelaxant;AntihypertensiveFarmacologia ClínicaEfeito cardiovascular das saponinas extraídas das folhas de Syzygium cumini (L.) SkeelsCardiovascular effect of saponins extracted from Syzygium cumini (L.) Skeels leavesinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/doctoralThesisinfo:eu-repo/semantics/openAccessreponame:Biblioteca Digital de Teses e Dissertações da UFMAinstname:Universidade Federal do Maranhão (UFMA)instacron:UFMAORIGINALMatheus_Brandao_Campos.pdfMatheus_Brandao_Campos.pdfapplication/pdf23529103http://tedebc.ufma.br:8080/bitstream/tede/5125/2/Matheus_Brandao_Campos.pdff0f3fe05ac6ab79cc3c016169aefde02MD52LICENSElicense.txtlicense.txttext/plain; charset=utf-82255http://tedebc.ufma.br:8080/bitstream/tede/5125/1/license.txt97eeade1fce43278e63fe063657f8083MD51tede/51252024-02-01 16:24:36.804oai:tede2: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Biblioteca Digital de Teses e Dissertaçõeshttps://tedebc.ufma.br/jspui/PUBhttp://tedebc.ufma.br:8080/oai/requestrepositorio@ufma.br||repositorio@ufma.bropendoar:21312024-02-01T19:24:36Biblioteca Digital de Teses e Dissertações da UFMA - Universidade Federal do Maranhão (UFMA)false
dc.title.por.fl_str_mv Efeito cardiovascular das saponinas extraídas das folhas de Syzygium cumini (L.) Skeels
dc.title.alternative.eng.fl_str_mv Cardiovascular effect of saponins extracted from Syzygium cumini (L.) Skeels leaves
title Efeito cardiovascular das saponinas extraídas das folhas de Syzygium cumini (L.) Skeels
spellingShingle Efeito cardiovascular das saponinas extraídas das folhas de Syzygium cumini (L.) Skeels
CAMPOS, Matheus Brandão
Saponinas;
Cardiovascular;
Syzygium cumini;
Vasorrelaxante;
Anti-hipertensivo
Saponins;
Cardiovascular;
Syzygium cumini;
Vasorelaxant;
Antihypertensive
Farmacologia Clínica
title_short Efeito cardiovascular das saponinas extraídas das folhas de Syzygium cumini (L.) Skeels
title_full Efeito cardiovascular das saponinas extraídas das folhas de Syzygium cumini (L.) Skeels
title_fullStr Efeito cardiovascular das saponinas extraídas das folhas de Syzygium cumini (L.) Skeels
title_full_unstemmed Efeito cardiovascular das saponinas extraídas das folhas de Syzygium cumini (L.) Skeels
title_sort Efeito cardiovascular das saponinas extraídas das folhas de Syzygium cumini (L.) Skeels
author CAMPOS, Matheus Brandão
author_facet CAMPOS, Matheus Brandão
author_role author
dc.contributor.advisor1.fl_str_mv BORGES, Marilene Oliveira da Rocha
dc.contributor.advisor1Lattes.fl_str_mv http://lattes.cnpq.br/3283574594616838
dc.contributor.advisor-co1.fl_str_mv RIBEIRO, Rachel Melo
dc.contributor.referee1.fl_str_mv BORGES, Marilene Oliveira da Rocha
dc.contributor.referee1Lattes.fl_str_mv http://lattes.cnpq.br/3283574594616838
dc.contributor.referee2.fl_str_mv SILVA JÚNIOR, José Ribamar da
dc.contributor.referee3.fl_str_mv BORGES, Antônio Carlos Romão
dc.contributor.referee4.fl_str_mv OLIVEIRA, Rui Miguel Gil da Costa
dc.contributor.referee5.fl_str_mv CARTÁGENES, Maria do Socorro de Sousa
dc.contributor.authorLattes.fl_str_mv http://lattes.cnpq.br/3035412310091857
dc.contributor.author.fl_str_mv CAMPOS, Matheus Brandão
contributor_str_mv BORGES, Marilene Oliveira da Rocha
RIBEIRO, Rachel Melo
BORGES, Marilene Oliveira da Rocha
SILVA JÚNIOR, José Ribamar da
BORGES, Antônio Carlos Romão
OLIVEIRA, Rui Miguel Gil da Costa
CARTÁGENES, Maria do Socorro de Sousa
dc.subject.por.fl_str_mv Saponinas;
Cardiovascular;
Syzygium cumini;
Vasorrelaxante;
Anti-hipertensivo
topic Saponinas;
Cardiovascular;
Syzygium cumini;
Vasorrelaxante;
Anti-hipertensivo
Saponins;
Cardiovascular;
Syzygium cumini;
Vasorelaxant;
Antihypertensive
Farmacologia Clínica
dc.subject.eng.fl_str_mv Saponins;
Cardiovascular;
Syzygium cumini;
Vasorelaxant;
Antihypertensive
dc.subject.cnpq.fl_str_mv Farmacologia Clínica
description Cardiovascular diseases (CVD) are the leading causes of death in the world and the search for new medicines that can ensure the treatment of diseases such as hypertension, for example, are becoming more frequent. Among the compounds investigated are products of plant origin that present classes of metabolites with pharmacological potential on the cardiovascular system. Saponins, class of plant origin, are amphiphilic molecules that have been seen as a prominent source of compounds with beneficial activity to the cardiovascular system. The present study evaluated the pharmacological potential of saponins extracted from leaves of Syzygium cumini (L.) Skeels in the cardiovascular system of spontaneously hypertensive rats (SHR). SHR male were treated for a period of 15 days with a rich fraction of S. cumini (FRS) 10 mg / kg / day / week saponins. and FRS 50 mg / kg / day / v.o. The results demonstrated that FRS was able to reduce blood pressure of SHRs, promote a reduction of arrhythmic events such as atrioventricular block and act on peripheral vascular resistance in resistance arteries, causing the decrease of noradrenaline-induced contraction in treated SHR animals with the highest dose. The vasorelaxation mechanisms were also evaluated in mesenteric artery rings. FRS was able to promote the vasorelaxing effect and block the contraction induced by extracellular calcium. With the results presented, it is concluded that FRS appears to act by blocking the influx of calcium and promoting cardioprotection, being therefore a prominent agent with potential antihypertensive effect and in cardiovascular disorders.
publishDate 2019
dc.date.issued.fl_str_mv 2019-08-08
dc.date.accessioned.fl_str_mv 2024-02-01T19:24:36Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/doctoralThesis
format doctoralThesis
status_str publishedVersion
dc.identifier.citation.fl_str_mv CAMPOS, Matheus Brandão. Efeito cardiovascular das saponinas extraídas das folhas de Syzygium cumini (L.) Skeels. 2019. 92 f. Tese( Programa de Pós-Graduação em Biotecnologia - RENORBIO/CCBS) - Universidade Federal do Maranhão, São Luís, 2019.
dc.identifier.uri.fl_str_mv https://tedebc.ufma.br/jspui/handle/tede/tede/5125
identifier_str_mv CAMPOS, Matheus Brandão. Efeito cardiovascular das saponinas extraídas das folhas de Syzygium cumini (L.) Skeels. 2019. 92 f. Tese( Programa de Pós-Graduação em Biotecnologia - RENORBIO/CCBS) - Universidade Federal do Maranhão, São Luís, 2019.
url https://tedebc.ufma.br/jspui/handle/tede/tede/5125
dc.language.iso.fl_str_mv por
language por
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Universidade Federal do Maranhão
dc.publisher.program.fl_str_mv PROGRAMA DE PÓS-GRADUAÇÃO EM BIOTECNOLOGIA - RENORBIO/CCBS
dc.publisher.initials.fl_str_mv UFMA
dc.publisher.country.fl_str_mv Brasil
dc.publisher.department.fl_str_mv DEPARTAMENTO DE CIÊNCIAS FISIOLÓGICAS/CCBS
publisher.none.fl_str_mv Universidade Federal do Maranhão
dc.source.none.fl_str_mv reponame:Biblioteca Digital de Teses e Dissertações da UFMA
instname:Universidade Federal do Maranhão (UFMA)
instacron:UFMA
instname_str Universidade Federal do Maranhão (UFMA)
instacron_str UFMA
institution UFMA
reponame_str Biblioteca Digital de Teses e Dissertações da UFMA
collection Biblioteca Digital de Teses e Dissertações da UFMA
bitstream.url.fl_str_mv http://tedebc.ufma.br:8080/bitstream/tede/5125/2/Matheus_Brandao_Campos.pdf
http://tedebc.ufma.br:8080/bitstream/tede/5125/1/license.txt
bitstream.checksum.fl_str_mv f0f3fe05ac6ab79cc3c016169aefde02
97eeade1fce43278e63fe063657f8083
bitstream.checksumAlgorithm.fl_str_mv MD5
MD5
repository.name.fl_str_mv Biblioteca Digital de Teses e Dissertações da UFMA - Universidade Federal do Maranhão (UFMA)
repository.mail.fl_str_mv repositorio@ufma.br||repositorio@ufma.br
_version_ 1797055642044727296

Registros relacionados