SÍNTESE DE ANÁLOGOS DE PEPTÍDEOS INCORPORADOS A MATERIAIS NANOPARTICULADOS DE CARBONO FUNCIONALIZADOS VIA REAÇÃO MULTICOMPONENTES
Ano de defesa: | 2018 |
---|---|
Autor(a) principal: | |
Orientador(a): | |
Banca de defesa: | , , , |
Tipo de documento: | Tese |
Tipo de acesso: | Acesso aberto |
Idioma: | por |
Instituição de defesa: |
Universidade Franciscana
|
Programa de Pós-Graduação: |
Programa de Pós-Graduação em Nanociências
|
Departamento: |
Biociências e Nanomateriais
|
País: |
Brasil
|
Palavras-chave em Português: | |
Palavras-chave em Inglês: | |
Área do conhecimento CNPq: | |
Link de acesso: | http://www.tede.universidadefranciscana.edu.br:8080/handle/UFN-BDTD/734 |
Resumo: | Every material has a potential for a determined purpose according to its intrinsic properties. However, these properties manifest as we already known them in a zone of limited size. When the size of this material is smaller than this zone, its properties turns differentiated. Thus, nanoscience and anotechnology (10-9) carry us into a realm of new possibilities. Considering the potential of carbon nanotubes in nanomedicine, it becomes necessary to increase the understanding of their behavior in applications such as drug or gene delivery, or specific treatment of cancer phototherapy for instance. However, controversial results, regarding the distribution, clearance, and toxicity were reported when the carbon nanotubes with different surface properties, and different concentrations, purity, and agglomeration state were studied. In order to contribute to their understanding, in vivo studies sought to acquire more knowledge about possible passageways and agglomeration that may provide greater subsidies regarding toxicity and real possibilities of their application as effective carriers of drugs. Recently has been reported that GO could be used as a strong oxidant to effectively oxidize Fe2+ in Fe3O4 nanoparticles that are deposited simultaneously on the surface of GO. Nanoparticles of graphene oxide (GO.Fe3O4) present magnetic and electrochemical behavior useful for potential energy storage applications, catalytic, biomedical applications, as well as for oxidation of metallic or non-metallic ions. Materials with antimicrobial and metallic absorption have been the object of research for biotechnological application in the development of materials with high efficiency and low toxicity. Multicomponent reactions (MCRs), established themselves as an important tool in organic synthesis studies, in the total synthesis of molecules either with defined activity or in combinatorial chemistry, providing high structural and functional diversity of molecules, for screening for the search of potentially active compounds. A variant of MCRs, the Ugi 4 component reaction (Ugi-4CR), have been successfully explored, and remain as a main study object in different research groups. In this framework, four chemical functionalities: an amine, a carbonyl group, an isocyanide and a carboxylic acid reacted simultaneously providing an peptide derivative, in good yields and furnishing only water as a byproduct. In this work, an easy and fast methodology to obtain the magnetic graphene oxide (GO.Fe3O4) was develop without the need of hydrothermal methods and using smaller amounts of FeCl2. Analyzes confirmed the lower amount of ferrite incorporated with maintenance of the magnetic activity of the material. Thus, allowing the application in the removal of contaminants through adsorption assays. The synthesis of carbon nanomaterials peptide derivatives was carried out employing Ugi-4CR in systems containing ferrite decorated graphene oxide and previously carboxylate carbon nanotubes (CNTs). Despite of established methods, the peptide or derivative is not linked into the nanostructures, but "grow" from them, allowing a greater structural diversity according to the substituent of the other functionalities involved in the reaction. |
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Mortari, Sérgio RobertoSilva, Ivana Zanella daJauris, Carolina Ferreira de MatosJahn, Sérgio LuizVieira, Sylvio Andre GarciaGomes, PatríciaRHODEN, Cristiano Rodrigo Bohn2019-04-23T20:26:39Z2018-08-30RHODEN, Cristiano Rodrigo Bohn. SÍNTESE DE ANÁLOGOS DE PEPTÍDEOS INCORPORADOS A MATERIAIS NANOPARTICULADOS DE CARBONO FUNCIONALIZADOS VIA REAÇÃO MULTICOMPONENTES. 2018. 106f. Tese( Programa de Pós-Graduação em Nanociências) - Universidade Franciscana, Santa Maria - RS .http://www.tede.universidadefranciscana.edu.br:8080/handle/UFN-BDTD/734Every material has a potential for a determined purpose according to its intrinsic properties. However, these properties manifest as we already known them in a zone of limited size. When the size of this material is smaller than this zone, its properties turns differentiated. Thus, nanoscience and anotechnology (10-9) carry us into a realm of new possibilities. Considering the potential of carbon nanotubes in nanomedicine, it becomes necessary to increase the understanding of their behavior in applications such as drug or gene delivery, or specific treatment of cancer phototherapy for instance. However, controversial results, regarding the distribution, clearance, and toxicity were reported when the carbon nanotubes with different surface properties, and different concentrations, purity, and agglomeration state were studied. In order to contribute to their understanding, in vivo studies sought to acquire more knowledge about possible passageways and agglomeration that may provide greater subsidies regarding toxicity and real possibilities of their application as effective carriers of drugs. Recently has been reported that GO could be used as a strong oxidant to effectively oxidize Fe2+ in Fe3O4 nanoparticles that are deposited simultaneously on the surface of GO. Nanoparticles of graphene oxide (GO.Fe3O4) present magnetic and electrochemical behavior useful for potential energy storage applications, catalytic, biomedical applications, as well as for oxidation of metallic or non-metallic ions. Materials with antimicrobial and metallic absorption have been the object of research for biotechnological application in the development of materials with high efficiency and low toxicity. Multicomponent reactions (MCRs), established themselves as an important tool in organic synthesis studies, in the total synthesis of molecules either with defined activity or in combinatorial chemistry, providing high structural and functional diversity of molecules, for screening for the search of potentially active compounds. A variant of MCRs, the Ugi 4 component reaction (Ugi-4CR), have been successfully explored, and remain as a main study object in different research groups. In this framework, four chemical functionalities: an amine, a carbonyl group, an isocyanide and a carboxylic acid reacted simultaneously providing an peptide derivative, in good yields and furnishing only water as a byproduct. In this work, an easy and fast methodology to obtain the magnetic graphene oxide (GO.Fe3O4) was develop without the need of hydrothermal methods and using smaller amounts of FeCl2. Analyzes confirmed the lower amount of ferrite incorporated with maintenance of the magnetic activity of the material. Thus, allowing the application in the removal of contaminants through adsorption assays. The synthesis of carbon nanomaterials peptide derivatives was carried out employing Ugi-4CR in systems containing ferrite decorated graphene oxide and previously carboxylate carbon nanotubes (CNTs). Despite of established methods, the peptide or derivative is not linked into the nanostructures, but "grow" from them, allowing a greater structural diversity according to the substituent of the other functionalities involved in the reaction.De acordo com suas propriedades toda a matéria tem potencial para uma dada finalidade. No entanto, essas propriedades se manifestam da forma que conhecemos numa faixa de tamanho limitada. Quando o tamanho deste material se apresenta menor que esta faixa, suas propriedades se tornam diferenciadas. Assim, a Nanociência e a Nanotecnologia nos transportam para uma esfera de novas possibilidades, para a utilização de materiais. Devido ao potencial dos materiais nanoestruturados de carbono na nanomedicina, tornou-se necessário aumentar a compreensão do seu comportamento in vivo, em aplicações como entrega de fármacos, genes, ou tratamento de câncer com fototerapia específica. Entretanto, resultados controversos quanto à distribuição, estado do material, e toxicidade foram relatados quando diferentes propriedades de superfície, e, diferentes concentrações, pureza, e estado de aglomeração destes nanomateriais foram estudados. Para contribuir à sua compreensão, busca-se, através de estudos in vivo, adquirir maiores conhecimentos sobre as eventuais vias de passagem e aglomeração que poderão fornecer maiores subsidios em relação à toxicidade e reais possibilidades de sua aplicação como efetivos carreadores de fármacos. Recentemente, foi reportado que óxido de grafeno pode ser empregado como oxidante para oxidar Fe2+ em nanopartículas de ferrita (Fe3O4), depositadas simultaneamente na superfície do óxido de grafeno. Nanopartículas de óxido de grafeno e ferro combinadas (GO.Fe3O4) apresentam comportamento magnético e eletroquímico em aplicações no armazenamento de energia, aplicações catalíticas, biomédicas, assim como para a oxidação de íons metálicos ou não metálicos. Materiais com absorção antimicrobiana e metálica tem sido objeto de pesquisa para aplicação biotecnológica no desenvolvimento de materiais com alta eficiência e baixa toxicidade. Reações Multicomponentes (MCRs), ao longo dos anos, estabeleceram-se como uma importante ferramenta em estudos de síntese orgânica, tanto na síntese total de moléculas com atividade definida, quanto em química combinatória, fornecendo alta diversidade estrutural e funcional em moléculas para estudos de triagem, na busca por compostos potencialmente ativos. Uma das variantes em MCRs, a reação de Ugi 4 componentes (Ugi-4CR), tem sido com êxito explorada, sendo objeto de investigação em diferentes grupos de pesquisa. Nesta variante, 4 funcionalidades químicas: uma amina, um grupamento carbonílico, um isocianeto e um ácido carboxílico reagem simultaneamente, fornecendo um derivado amino peptídico, com bons rendimentos e tendo apenas água como subproduto. Neste trabalho, desenvolveu-se uma metodologia fácil e rápida de obtenção do óxido de grafeno magnético (GO.Fe3O4), sem a necessidade de métodos hidrotermais e empregando menores quantidades de FeCl2. Análises confirmaram a menor quantidade de ferrita incorporada com manutenção da atividade magnética do material possibilitando seu emprego na remoção de contaminantes através de ensaios de adsorção. Ainda, foi realizada, neste trabalho, a síntese de derivados peptídicos, através da reação de Ugi-4CR, em sistemas contendo Óxido de Grafeno decorado com ferrita e nanotubos de carbono (CNTs) previamente carboxilados, obtendo-se, desta forma, derivados de peptídeos incorporados a nanomateriais de carbono. Diferentemente de metodologias já existentes, neste trabalho, os peptídeos ou seus derivados não são incorporados aos nanomaterias de carbono, mas sim, “crescem” a partir deste, possibilitando uma maior diversidade estrutural de acordo com os substituintes das demais funcionalidades envolvidas na reação.Submitted by MARCIA ROVADOSCHI (marciar@unifra.br) on 2019-04-23T20:26:39Z No. of bitstreams: 2 Tese_CristianoRodrigoBohnRhoden.pdf: 4040379 bytes, checksum: 2e5919723a2a2b47af2352501f941aa3 (MD5) license_rdf: 0 bytes, checksum: d41d8cd98f00b204e9800998ecf8427e (MD5)Made available in DSpace on 2019-04-23T20:26:39Z (GMT). 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dc.title.por.fl_str_mv |
SÍNTESE DE ANÁLOGOS DE PEPTÍDEOS INCORPORADOS A MATERIAIS NANOPARTICULADOS DE CARBONO FUNCIONALIZADOS VIA REAÇÃO MULTICOMPONENTES |
title |
SÍNTESE DE ANÁLOGOS DE PEPTÍDEOS INCORPORADOS A MATERIAIS NANOPARTICULADOS DE CARBONO FUNCIONALIZADOS VIA REAÇÃO MULTICOMPONENTES |
spellingShingle |
SÍNTESE DE ANÁLOGOS DE PEPTÍDEOS INCORPORADOS A MATERIAIS NANOPARTICULADOS DE CARBONO FUNCIONALIZADOS VIA REAÇÃO MULTICOMPONENTES RHODEN, Cristiano Rodrigo Bohn Nanomateriais de carbono, ferrita, reações multicomponentes Carbon nanomaterials, multicomponent reactions, ferrite Nanociências |
title_short |
SÍNTESE DE ANÁLOGOS DE PEPTÍDEOS INCORPORADOS A MATERIAIS NANOPARTICULADOS DE CARBONO FUNCIONALIZADOS VIA REAÇÃO MULTICOMPONENTES |
title_full |
SÍNTESE DE ANÁLOGOS DE PEPTÍDEOS INCORPORADOS A MATERIAIS NANOPARTICULADOS DE CARBONO FUNCIONALIZADOS VIA REAÇÃO MULTICOMPONENTES |
title_fullStr |
SÍNTESE DE ANÁLOGOS DE PEPTÍDEOS INCORPORADOS A MATERIAIS NANOPARTICULADOS DE CARBONO FUNCIONALIZADOS VIA REAÇÃO MULTICOMPONENTES |
title_full_unstemmed |
SÍNTESE DE ANÁLOGOS DE PEPTÍDEOS INCORPORADOS A MATERIAIS NANOPARTICULADOS DE CARBONO FUNCIONALIZADOS VIA REAÇÃO MULTICOMPONENTES |
title_sort |
SÍNTESE DE ANÁLOGOS DE PEPTÍDEOS INCORPORADOS A MATERIAIS NANOPARTICULADOS DE CARBONO FUNCIONALIZADOS VIA REAÇÃO MULTICOMPONENTES |
author |
RHODEN, Cristiano Rodrigo Bohn |
author_facet |
RHODEN, Cristiano Rodrigo Bohn |
author_role |
author |
dc.contributor.advisor1.fl_str_mv |
Mortari, Sérgio Roberto |
dc.contributor.advisor-co1.fl_str_mv |
Silva, Ivana Zanella da |
dc.contributor.referee1.fl_str_mv |
Jauris, Carolina Ferreira de Matos |
dc.contributor.referee2.fl_str_mv |
Jahn, Sérgio Luiz |
dc.contributor.referee3.fl_str_mv |
Vieira, Sylvio Andre Garcia |
dc.contributor.referee4.fl_str_mv |
Gomes, Patrícia |
dc.contributor.author.fl_str_mv |
RHODEN, Cristiano Rodrigo Bohn |
contributor_str_mv |
Mortari, Sérgio Roberto Silva, Ivana Zanella da Jauris, Carolina Ferreira de Matos Jahn, Sérgio Luiz Vieira, Sylvio Andre Garcia Gomes, Patrícia |
dc.subject.por.fl_str_mv |
Nanomateriais de carbono, ferrita, reações multicomponentes |
topic |
Nanomateriais de carbono, ferrita, reações multicomponentes Carbon nanomaterials, multicomponent reactions, ferrite Nanociências |
dc.subject.eng.fl_str_mv |
Carbon nanomaterials, multicomponent reactions, ferrite |
dc.subject.cnpq.fl_str_mv |
Nanociências |
description |
Every material has a potential for a determined purpose according to its intrinsic properties. However, these properties manifest as we already known them in a zone of limited size. When the size of this material is smaller than this zone, its properties turns differentiated. Thus, nanoscience and anotechnology (10-9) carry us into a realm of new possibilities. Considering the potential of carbon nanotubes in nanomedicine, it becomes necessary to increase the understanding of their behavior in applications such as drug or gene delivery, or specific treatment of cancer phototherapy for instance. However, controversial results, regarding the distribution, clearance, and toxicity were reported when the carbon nanotubes with different surface properties, and different concentrations, purity, and agglomeration state were studied. In order to contribute to their understanding, in vivo studies sought to acquire more knowledge about possible passageways and agglomeration that may provide greater subsidies regarding toxicity and real possibilities of their application as effective carriers of drugs. Recently has been reported that GO could be used as a strong oxidant to effectively oxidize Fe2+ in Fe3O4 nanoparticles that are deposited simultaneously on the surface of GO. Nanoparticles of graphene oxide (GO.Fe3O4) present magnetic and electrochemical behavior useful for potential energy storage applications, catalytic, biomedical applications, as well as for oxidation of metallic or non-metallic ions. Materials with antimicrobial and metallic absorption have been the object of research for biotechnological application in the development of materials with high efficiency and low toxicity. Multicomponent reactions (MCRs), established themselves as an important tool in organic synthesis studies, in the total synthesis of molecules either with defined activity or in combinatorial chemistry, providing high structural and functional diversity of molecules, for screening for the search of potentially active compounds. A variant of MCRs, the Ugi 4 component reaction (Ugi-4CR), have been successfully explored, and remain as a main study object in different research groups. In this framework, four chemical functionalities: an amine, a carbonyl group, an isocyanide and a carboxylic acid reacted simultaneously providing an peptide derivative, in good yields and furnishing only water as a byproduct. In this work, an easy and fast methodology to obtain the magnetic graphene oxide (GO.Fe3O4) was develop without the need of hydrothermal methods and using smaller amounts of FeCl2. Analyzes confirmed the lower amount of ferrite incorporated with maintenance of the magnetic activity of the material. Thus, allowing the application in the removal of contaminants through adsorption assays. The synthesis of carbon nanomaterials peptide derivatives was carried out employing Ugi-4CR in systems containing ferrite decorated graphene oxide and previously carboxylate carbon nanotubes (CNTs). Despite of established methods, the peptide or derivative is not linked into the nanostructures, but "grow" from them, allowing a greater structural diversity according to the substituent of the other functionalities involved in the reaction. |
publishDate |
2018 |
dc.date.issued.fl_str_mv |
2018-08-30 |
dc.date.accessioned.fl_str_mv |
2019-04-23T20:26:39Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/doctoralThesis |
format |
doctoralThesis |
status_str |
publishedVersion |
dc.identifier.citation.fl_str_mv |
RHODEN, Cristiano Rodrigo Bohn. SÍNTESE DE ANÁLOGOS DE PEPTÍDEOS INCORPORADOS A MATERIAIS NANOPARTICULADOS DE CARBONO FUNCIONALIZADOS VIA REAÇÃO MULTICOMPONENTES. 2018. 106f. Tese( Programa de Pós-Graduação em Nanociências) - Universidade Franciscana, Santa Maria - RS . |
dc.identifier.uri.fl_str_mv |
http://www.tede.universidadefranciscana.edu.br:8080/handle/UFN-BDTD/734 |
identifier_str_mv |
RHODEN, Cristiano Rodrigo Bohn. SÍNTESE DE ANÁLOGOS DE PEPTÍDEOS INCORPORADOS A MATERIAIS NANOPARTICULADOS DE CARBONO FUNCIONALIZADOS VIA REAÇÃO MULTICOMPONENTES. 2018. 106f. Tese( Programa de Pós-Graduação em Nanociências) - Universidade Franciscana, Santa Maria - RS . |
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http://www.tede.universidadefranciscana.edu.br:8080/handle/UFN-BDTD/734 |
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por |
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Universidade Franciscana |
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Programa de Pós-Graduação em Nanociências |
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Brasil |
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Biociências e Nanomateriais |
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Universidade Franciscana |
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