NANOEMULSÕES CONTENDO DIOSGENINA: PRODUÇÃO E ESTUDO DE ESTABILIDADE

• Ano de defesa: 2019
• Autor(a) principal: Esimann, Priscila
• Orientador(a): Gomes, Patrícia
• Banca de defesa: Wingert , Nathalie Ribeiro, Rhoden, Cristiano Rodrigo Bohn
• Tipo de documento: Dissertação
• Tipo de acesso: Acesso aberto
• Idioma: por
• Instituição de defesa: Universidade Franciscana
• Programa de Pós-Graduação: Programa de Pós-Graduação em Nanociências
• Departamento: Biociências e Nanomateriais
• País: Brasil
• Palavras-chave em Português: Nanocarreadores, Hormônio Esteroide, Estabilidade, Nanotecnologia
• Palavras-chave em Inglês: Nanocarriers, Steroid Hormone , Stability, Nanotechnology
• Área do conhecimento CNPq: Nanociências
• Link de acesso: http://www.tede.universidadefranciscana.edu.br:8080/handle/UFN-BDTD/789

Nanotechnology is an interdisciplinary scientific field where it is possible to manipulate, alter and develop new materials at the nanoscale, changing their properties. It finds applications in the sectors of energy, electronics, pharmacy medicine and cosmetology. In the pharmaceutical and cosmetic areas there is the production of nanocarriers for pharmaceuticals, which can protect, encapsulate and release pharmacologically active compounds. In our study we chose the nanoemulsion as carrier, since it is widely used as a vehicle for drugs, by the cosmetic and pharmaceutical industry. The nanoemulsion has better sensory characteristics maintaining a non-oily texture. The drug used was diosgenin. Diosgenin is a steroidal sapogenin found in roots of wild yam (Dioscorea villosa). Diosgenin has a structure similar to progesterone and estradiol and is used as a chemical precursor in the industrial preparation of oral contraceptive pills and steroid hormones. The general objective was to produce and evaluate diosgenin containing nanoemulsions, aiming at the choice of a stable formulation. Nanoemulsions at concentrations 1 mg/mL, 3 mg/mL and 5 mg/mL were produced using the high energy emulsification method. A spectrophotometric method was co-validated in the visible region to identify Diosgenin in nanoemulsions. The physico-chemical characterization and the stability study at different temperatures allowed to evaluate formulations of diosgenin nanoemulsions at concentration 1mg / mL and white nanocapsules for 90 days. The characterization of the diosgenin containing nanoemulsions showed a nanometric and homogeneous particle diameter, with negative zeta potential, low polydispersity index and slightly acidic pH, which guarantees the quality and stability of the diosgenin nanoemulsion, compatibility for topical use and the possibility reaching the deepest layers of the skin, potentializing the effects of diosgenin. The best condition for storage of nanoemulsions without losing their physico-chemical characteristics during the 90-day period was under refrigeration.