Surto de Circovirose (S?ndrome Definhante Multissist?mica de Su?nos Desmamados) no Estado do Rio de Janeiro

Detalhes bibliográficos
Ano de defesa: 2004
Autor(a) principal: Fran?a, Ticiana do Nascimento lattes
Orientador(a): Peixoto, Paulo Fernando de Vargas lattes
Banca de defesa: Tokarnia , Carlos M. A. Hubinger, Brito, Marilene de Farias, Dobereiner, Jurguen, Pitombo, Cicero Ara?jo
Tipo de documento: Tese
Tipo de acesso: Acesso aberto
Idioma: por
Instituição de defesa: Universidade Federal Rural do Rio de Janeiro
Programa de Pós-Graduação: Programa de P?s-Gradua??o em Ci?ncias Veterin?rias
Departamento: Instituto de Veterin?ria
País: Brasil
Palavras-chave em Português:
Circov?rus porcino tipo 2
histopatologia
imunohistoqu?mica
Palavras-chave em Inglês:
Porcine circovirus type 2
histopathology
immunohistochemestry
Área do conhecimento CNPq:
Medicina Veterin?ria
Link de acesso: https://tede.ufrrj.br/jspui/handle/jspui/3888
Resumo: The first outbreak of swine circoviruse infection which occurred in the State of Rio de Janeiro was described. The disease which affects mainly weaned pigs, about 4 months old, caused the death of at least 14 animals. The property where the outbreak occurred, had inadequate sanitary and management conditions. Clinically the disease was characterized by wasting, poor development, coughing, tachypnoea, dispnoea, ataxia , tremors after simulation, decubitus and convulsions. The course of the disease was acute to subacute. The most important post-mortem findings were paleness of the body, enlarged lymphnodes, non-colapsed lungs, with consolidated ?reas mainly in the cranial lobes. Histological lesions consisted mainly of lymphohistiocytic infiltration with multinucleate giant cells cells in lymph nodes, spleen, Peyer?s patches, kidney, lungs and liver, depletion and/or lymphoid hyperplasia, as well as lymphohistiocytic intersticial pneumonia and areas of secondary broncopneumonia. The diagnosis was established through observations of the symptoms and typical lesions of Postweaning Multisystemic Wasting Syndrome (PMWS), and was confirmed by immunohistochemical examination and PCR. The objective of this study was to characterize the epidemiological and clinical-pathological aspects of na outbreak of PMWS in Rio de Janeiro, because of its severe direct or indirect economical losses to the world pig industry.
id UFRRJ-1_638d1e704bd12d88c005964bfb6c9b6d
oai_identifier_str oai:localhost:jspui/3888
network_acronym_str UFRRJ-1
network_name_str Biblioteca Digital de Teses e Dissertações da UFRRJ
repository_id_str
spelling Peixoto, Paulo Fernando de Vargashttp://lattes.cnpq.br/3002512195318611Tokarnia , Carlos M. A. HubingerBrito, Marilene de FariasDobereiner, JurguenPitombo, Cicero Ara?johttp://lattes.cnpq.br/3545873525091315Fran?a, Ticiana do Nascimento2020-09-15T19:30:29Z2004-07-08FRAN?A, Ticiana do Nascimento. Surto de Circovirose (S?ndrome definhante multissist?mica de su?nos desmamados) no Estado do Rio de Janeiro. 2004. 110 f. Tese (Doutorado em Ci?ncias Veterin?rias) - Instituto de Veterin?ria, Universidade Federal Rural do Rio de Janeiro, Serop?dica - RJ, 2004.https://tede.ufrrj.br/jspui/handle/jspui/3888The first outbreak of swine circoviruse infection which occurred in the State of Rio de Janeiro was described. The disease which affects mainly weaned pigs, about 4 months old, caused the death of at least 14 animals. The property where the outbreak occurred, had inadequate sanitary and management conditions. Clinically the disease was characterized by wasting, poor development, coughing, tachypnoea, dispnoea, ataxia , tremors after simulation, decubitus and convulsions. The course of the disease was acute to subacute. The most important post-mortem findings were paleness of the body, enlarged lymphnodes, non-colapsed lungs, with consolidated ?reas mainly in the cranial lobes. Histological lesions consisted mainly of lymphohistiocytic infiltration with multinucleate giant cells cells in lymph nodes, spleen, Peyer?s patches, kidney, lungs and liver, depletion and/or lymphoid hyperplasia, as well as lymphohistiocytic intersticial pneumonia and areas of secondary broncopneumonia. The diagnosis was established through observations of the symptoms and typical lesions of Postweaning Multisystemic Wasting Syndrome (PMWS), and was confirmed by immunohistochemical examination and PCR. The objective of this study was to characterize the epidemiological and clinical-pathological aspects of na outbreak of PMWS in Rio de Janeiro, because of its severe direct or indirect economical losses to the world pig industry.Descreve-se o primeiro surto de infec??o por Circovirus Porcino Tipo 2 (PCV-2) em su?nos no Estado do Rio de Janeiro. A enfermidade que afetou, principalmente, su?nos desmamados com idade em torno de 4 meses, levou a ?bito pelo menos 14 animais. A granja onde o surto ocorreu tinha p?ssimas condi??es sanit?rias e de manejo. Clinicamente, a doen?a caracterizou-se por m? condi??o corporal, pouco desenvolvimento, tosse, taquipn?ia, dispn?ia, diarr?ia, ataxia, tremores ap?s est?mulo, dec?bito e convuls?es, com evolu??o aguda ? subaguda. ? necropsia, os achados mais importantes foram palidez da carca?a, aumento de linfonodos e pulm?es n?o-colapsados, com ?reas consolidadas, principalmente nos lobos craniais e por??o anterior dos lobos m?dios. O exame histol?gico revelou , com maior freq??ncia, infiltra??o linfo-histioc?tica com c?lulas sinciciais em linfonodos, ba?o, placas de Peyer, rim, pulm?o e f?gado, deple??o e/ou hiperplasia linfon?ide, bem como pneumonia bronco-interstical linfo-histiocit?ria e ?reas de broncopneumonia secund?ria. O diagn?stico firmou-se pela observa??o dos sintomas e les?es histol?gicas t?picas da S?ndrome Definhante Multissist?mica de Su?nos Desmamados (SDMSD) e foi confirmado por exame imunohistoqu?mico e PCR. Esse estudo teve por objetivo caracterizar os aspectos epidemiol?gico e cl?nico-patol?gico desse surto no Estado do Rio de Janeiro, j? que amesma tem causado grandes perdas econ?micas diretas ou indiretas, ? suinocultura mundial.Submitted by Sandra Pereira (srpereira@ufrrj.br) on 2020-09-15T19:30:28Z No. of bitstreams: 1 2004 - Ticiana do Nascimento Fran?a.pdf: 6130574 bytes, checksum: 7549a4231418e8c91806e49066b30e13 (MD5)Made available in DSpace on 2020-09-15T19:30:29Z (GMT). No. of bitstreams: 1 2004 - Ticiana do Nascimento Fran?a.pdf: 6130574 bytes, checksum: 7549a4231418e8c91806e49066b30e13 (MD5) Previous issue date: 2004-07-08CAPES - Coordena??o de Aperfei?oamento de Pessoal de N?vel Superior,application/pdfhttps://tede.ufrrj.br/retrieve/61941/2004%20-%20Ticiana%20do%20Nascimento%20Fran%c3%a7a.pdf.jpghttps://tede.ufrrj.br/retrieve/74785/2004%20-%20Ticiana%20do%20Nascimento%20Fran%c3%a7a%20.pdf.jpgporUniversidade Federal Rural do Rio de JaneiroPrograma de P?s-Gradua??o em Ci?ncias Veterin?riasUFRRJBrasilInstituto de Veterin?riaADAIR, B.; McNEILLY, F.; McCONELL, C.D.; TODD, D.; NELSON, R.T.; McNULTY, M.S. Effects of chicken anemia agent on lymphokine production and lymphocyte transformation in experimentally infected chickens. Avian Diseases, v.35, p.783-792, 1991 (apude LUKERT & ALLAN, 1999). ALBINA, E.; TRUONG, C.; HUTET, E.; BLANCHARD, P.; CARIOLES, R.; L?HOSPITALIER, R.; MAH?, D.; ALL?E, C.; MORVAN, H.; AMENNA, N.; Le DIMNA, M.; MADEC, F.; JESTIN, A. Na experimental model for post-weaning multisystemic wasting syndrome (PMWS) in growing piglets. Journal of Comparative Pathology, v.123, p.292-303, 2001. ALLAN, G.M.; MACKIE, D.P.; Mc NAIR, J.; ADAIR, B.M.; McNULTY, M.S. Production, preliminary characterization and applications of monoclonal antibodies to porcine circovirus. Veterinary Immunology and Immunopathology, v.43, p.357-371, 1994a. ALLAN, G.M.; McNELLY, F.; FOSTER, J.C.; ADAIR, B.M. Infection of leucocyte cell cultures from different species with porcine circovirus. Veterinary Microbiology, n.41, p.267-279, 1994b. ALLAN, G.M.; PHENIX, K.V.; TODD, D.; McNULTY, M.S. Some biological and physico-chemical properties of porcine circovirus. Journal of Veterinary Medicine, n.41, p.17-26, 1994c. ALLAN, G.M.; McNEILLY, F.; CASSIDY, J.P.; REILLY, G.A.C.; ADAIR, B.; ELLIS, W.A.; McNULTY, M.S. Pathogenesis of porcine circovirus: experimental infections of colostrum deprived piglets and examination of pig foetal material. Veterinary Microbiology, n.44, p.49-64, 1995. ALLAN, G.M.; McNEILLY, F.; KENNEDY, S.; DAFT, B.; CLARKE, E.G.; ELLIS, J.A.; HAINES, D.M.; MEEHAN, B.M.; ADAIR, B.M. Isolation of porcine circovirus-like viruses from pigs with a wasting disease in the USA and Europe. Jourrnal of Veterinary Diagnostic Investigation, v.10, p.3-10, 1998. ALLAN, G.M.; KENNEDY, S.; McNEILLY, F., FOSTER, J.C.; ELLIS, J.A.; KRAKOWKA, S.J.; MEEHAN, B.M.; ADAIR, B.M. Experimental reproduction of severe wasting disease by co-infection of pigs with porcine circovirus and porcine parvovirus. Journal of Comparative Pathology, v. 121, p. 1-11, 1999a. ALLAN, G.M.; McNEILLY, F.M.; MEEHAN, B.M.; KENNEDY, S.; MACKIE, D.P.; ELLIS, J.A.; CLARK, E.G.; ESPUNA, E.; SAUBI, N.; RIERA, P.; BOETNER, A.; CHARREYRE, C.E. Isolation and characterization of circoviruses from pigs with wasting syndromes in Spain, Denmark and Northern Ireland. Veterinary Microbiology, v. 66, p. 115-123, 1999b. ALLAN, G.M.; ELLIS, J. Porcine circovirus: A review. Journal of Veterinary Diagnostic Investigation, v.12,p.3-14, 2000. ALLAN, G.M.; McNEILLY, F.; ELLIS, J.; KRAKOWKA, S.; MEEHAN, B.; McNAIR, I.; WALKER, I.; KENNEDY, S. Experimental infections of colostrum deprived with porcine circovirus 2 (PCV2) and porcine reproductive and respiratory syndrome v?rus (PRRSV) potentiates PCV2 replication. Archives of Virology, v.145, p.2421-2429, 2000a. ALLAN, G.M.; McNEILLY, F.; McNAIR, I.; CURRAN, M.D.; WALKER, I.; ELLIS, J.; KONOBY, C.; KENNEDY, S.; MEEHAN, B. Absence of evidence for porcine circovirus types 2 in cattle and humans, and lack of seroconversion or lesions in experimentally infected sheep. Archives of Virology, v.145, n.4, p.853-857, 2000b. ALLAN, G.M.; McNEILLY, F.; MEEHAN, B.; KENNEDY, S.; JOHNSTON, D.; ELLIS, J.; KRAKOWKA, S.; FOSSUM, C.; WATTRANG, E.; WALLGREN, P. Reproduction of PMWS with a 1993 Swedish isolate of PCV-2. Veterinary Record, Letters, p.225-256, 2002. BALASCH, M.; SEGAL?S, J.; ROSELI, C.; DOMINGO, M.; MANKERTZ, A.; URNIZA, A.; PLANA-DUR?N, J. Experimental inoculation of conventional pigs with tissue homogenates from pigs with post-weaning multisystemic wasting syndrome Journal of Comparative Pathology, v. 124, p.139-159, 1999. BARKER, I. K.; VAN DREUMEL, A.A.; PALMER, N. The alimentary system IN: JUBB, K.V.F.; KENNEDY, P.C.; PALMER, N. Pathology of domestic animals, 4th Ed., vol.2, San Diego: Academic Press, 1993. P.1-318. BASSAMI, M.R.; YPELLAR, I.; BERRYMAN, D.; WILCOW, G.E.; RAIDAL, S.R. Genetic diversity of beak and feather disease v?rus detected in pisittacine species in Australia. Virology, v.279, n 2, p.392-400, 2001. BENFIELD, D.A.; COLLINS, J.E.; DEE, S.A.; HALBUR, P.G.; JOO, H.S.; LAGER, K.M.; MENGELING, W.L.; MURTAUGH, M.P.; ROSSOW, K.D.; STEVENSON, G.W.; ZIMMERMAN, J.J. Porcine Reproductive and Respiratory Syndrome, In: STRAW, B.E.S.,; D?ALLAIRE, S.; MENGELING, W.L.; TAYLOR, D.J. (Eds). DISEASES of Swine, 8th Ed, Iowa State: University Press, 1999, p.201-276. BIAGINI, P. Human circoviruses. Veterinary Microbiology, v.98, p.95-101, 2004. BAGDAN, J.; WEST, K.; CLARK, E.; KONOBY, C.; HAINES, D.; ALLAN, G.M.; McNEILLY, F.; MEEHAN, B.; KRAKOWKA, S.; ELLIS, J.A. Association of porcine circovirus 2 with reproductive failure in pigs: a retrospective study. Canadian Veterinary Journal, v.42, n.7, p.548-550, 2001. BOLIN, S.R.; STOFREGEN, W.C.; NAYAR, G.P.; HAMEL, A.L. Postweaning multisystemic wasting syndrome induced after experimental inoculation of cesarean-derived, colostrum-deprived piglets with type 2 porcine circovirus. Journal of Veterinary Diagnostic Investigation, v.13, p.185-194, 2001 (apud SEGAL?S, 2003). BUKI, H.J.; TISCHER, I.; KOCH, M.A. Cloning and sequencing of the porcine circovirus PCV genome. Zentralbl. Fur Bakteriol. Mikrobiol. Hyg. Se. A, v. 260, p.465, 1985 (apud ALLAN ET AL., 1999). BUKH, H.J.; BLAD, I.; TISCHER, I. Replication of negative strand DNA of single-stranded porcine circovirus genome. In: Abstr. Joint Meeting of Sektion virologie and Virus Group of Soc. Gen. Microbiol., p.54., 1988 (apud LUKERT; ALLAN, 1999). CALSAMIGLIA, M.; SEGAL?S, J.; ROSELL, C.; DOMINGO, M. Detection of porcine circovirus types 1 and 2 in serum and tissue samples of pigs with and without postweaning wasting syndrome. Journal of Clinical Microbiology, v.40, n.5, p.1848-1850, 2002. CARIOLET, R.; BLANCHARD, P. LeDIMMA, M.; MAH?, D.; JOLLY, J.P.; BOISS?SSION, C.; TRUONG, C.; ECOBICHON, P.; MADEC, F.; JESTIN. A. Experimental infection of pregnant SPF sows with PCV2 through tracheal and muscular routes. In: Proceedings of the European Society on Veterinary Virology, PMWS, 2001a, p. 128 (apud SEGAL?S ET AL., 2004). CARIOLET, R. BLANCHARD, P.; LeDIMMA, M.; MAH?, D.; KERANFLEC?H, A.; JULOU, P.; BEAUREPAIRE, B.; DE BOISS?SON, C.; TRUONG, C.; JESTIN, A. Consequences of PCV2 experimental infection of non immune SPF sows using the intra uterine route. In: Proceedings of the European Society on Veteerinary Virology, PMWS, 2001b, p. 129. (apud SEGAL?S ET AL., 2004). CASTRO, A.M.M.G,; RUIZ, V.L.A.; CASTRO Jr, F.G.; BERSANO, J.G., MORENO, A.M., CORTEZ, A. Detec??o e diferencia??o de circov?rus su?no tipo 1 e 2 (PCV-1 e PCV-2) em su?nos nas fases de creche e crescimento/termina??o em diferentes Estados brasileiros e em su?nos do Estado de S?o Paulo. In: Congresso Brasileiro de Veterin?rios Especialistas em su?nos, 11, 2003, Goi?nia, GO. Anais... Conc?rdia: Embrapa Su?nos e Aves, 2003, p. 107-108. CELERA, V.Jr.; CARASOVA, P. First evidence of porcine circov?rus type 2 (PCV-2) infection of pigs in the Czech Republic by semi-nested PCR. Journal of Veterinary Medicine B, Infectious Disease and Veterinary Public Health, v.49, n.3, p.155-159, 2002. CHIANINI, F.; MAJ?, N.; SEGAL?S, J.; DOM?NGUEZ, M.; DOMINGO, M. Immunohistochemical characterization of PCV2 associate lesions in lymphoid and non-lymphoid tissues of pigs with natural postweaning multisystemic wasting syndrome (PMWS). Veterinary Immunology and Immunopathology, v.94, p.63-75, 2003. CHOI, C.; CHAE, C.; CLARK, E.G. Porcine postweaning multisystemic wasting syndrome in Korean pig: detection of porcine circovirus 2 infection by immunohistochemistry and polymerase chain reaction. Journal of Veterinary Diagnostic Investigation, v. 12, p. 151-153, 2000. CHOI, C.; KIM, J.; KANG, I.J.; CHAE, C. Concurrent outbreak of PMWS and PDNS in a herdo f pigs in Korea. Veterinary Record, v.151, p.484-485, 2002a. CHOI, J.; STEVENSON, G.W.; KIUPEL, M.; HARRACH, B.; ANOTHAYANONTHA, L.; KANITZ, C.L.; MITTAL, S.K. Sequence analysis of old and new strains of porcine circov?rus associated with congenital tremors in pigs and their comparison with strains involved with postweaning multisystemic wasting syndrome. Canadian Journal of Veterinary Research, v.66, p.217-224, 2002b. CLARK, E.G. Post-weaning multisystemic wasting syndrome. Proceedings of the American Association of Swine Practitioners, v.28, p.499-501, 1997. COLES, E.H. Patologia Cl?nica Veterin?ria. Editora Manole, 3a ed., S?o Paulo, Brasil, 1984, p.566. CRAWFORD, G.R. Circoviridae: new viruses of pigs, parrots and chickens. Correspondence. Australian Veterinary Journal, v.71, n.10, p.351, 1994. DARWICH, L.; SEGAL?S, J.; DOMINGO, M.; MATEU, E. Changes in CD4, CD8, CD4, CD*, and immunoglobulin M-Positive peripheral blood mononuclear cells of postweaning multisystemic wasting syndrome-affected pigs and age-matched uninfected wasted and healthy pigs correlate with lesions and Porcine Circov?rus Type 2 load in lymphoid tissues. Clin. Diag. Lab. Immunol, v.9, n.2, p.236-242, 2002. DARWICH, L.; BALASCH, M.; PLANA-DUR?N, J.; SEGAL?S, J.; DOMINGO, M.; MATEU, E. Cytokine profiles of peripheral blood mononuclear cells of pigs suffering from postweaning multisystemic wasting syndrome in response to mitogen, superantingen or recall viral antigens. Journal of General Virology, v.84, p. 3453-3457, 2003a. DARWICH, L.; PIE, S.; ROVIRA, A.; SEGAL?S, J.; DOMINGO, M.; OSWALD, I.P., MATEU, E. Cytokine mRNA expression profiles in lymphoid tissues of pigs naturally affected by postweaning multisystemic wasting syndrome. Journal of General Virology, v.84, p. 2117-2125, 2003b. DARWICH, L.; SEGAL?S, J.; MATEU, E. Pathogenesis of postweaning multisystemic wasting syndrome caused by porcine circov?rus 2: na Immune riddle. Archives of Virology, v.149, n.5, p.857-874, 2004. DAVIDSON, F.; MacDONALD, D.; MOKILI, J.L.; PRESCOTT, L.E.; GRAHAM, S.; SIMMONDS, P. Early acquisition of TT virsus (TTV) in na ?rea endermic for TTV infection. Journal of Infectious Disease, v. 179, p.1070-1076, 1999. DEGUCHI, E.; AKUZAWA, M. Effects of fighting after grouping on plasma cortisol concentration and lymphocytes blastogenesis of peripheral blood mononuclear cells induced by mitogens in piglets. Journal of Veterinary Medical Science, v.60, p.149-153, 1998. DROLET, R.; THIBAULT, S.; D?ALLAIRE, S.; THOMPSON, J.; DONE, S. Porcine dermatitis and nephropathy syndrome (PDNS): na overview of the disease. Swine Health Production, v. 6, p.283-285, 1999. DROLET, R.; D?ALLAIRE, S.; LAROCHELLE, R.; MAGAR, R.; RIBOTTA, M.; HIGGINS, R. ET AL. Infectious agents identified in pigs with multifocal intersticial nephritis at slaughter. Veterinary Record, v.150, n. 5, p.139-143, 2002. DROLET, R.; LAROCHELLE, R.; MORIN, M.; DELISLE, B.; MAGAR, R. Detection rates of porcine reproductive and respiratory syndrome v?rus, Porcine Circov?rus Type 2, and Swine Influenza V?rus in porcine proliferative and necrotizing pneumonia. Veterinary Pathology, v.40, p.143-148, 2003. DULAC, G.C.; AFSHAR, A. Porcine circovirus antigens in PK-15 cell line (ATCC CCL-33) and evidence of antibodies to circovirus in Canadian pigs. Canadian Journal of Veterinary Research., v.53, p.431-433, 1989. DUNGWORTH, D.L. The respiratory system. In: JUBB, K.V.F.; KENNEDY, P.C.; PALMER, N.(eds). Pathology of domestic animals, 4th ed, vol.2, San Diego: Academic Press, 1993, p.539-699. DURAN, C.O.; RAMOS-VARA, J.; RENDER, J.A. Porcine dermatitis and nephropathy syndrome: a new condition to include in the differential diagnosis list for skin discolouration in swine. Swine Health Production, v.5, n.6, p.241-244, 1997 (apud HARDING, 2004). EASTERDAY, B.C.; VAN REETH, K. Swine Influenza. In: STRAW B.E.; D?ALLAIRE S., MENGELING W.L., TAYLOR D.J (eds). Disease of Swine, 8th ed., Iowa State:University Press, 1999, p.277-290. EDWARDS, S.; SANDS. J.J. Evidence of circovirus infection in British pigs. Veterinary Record., v.134, p.680-681, 1994. EDWARDS, M.J.; MULLEY, R.C. Genetic, developmental and neoplastic diseases. In: STRAW, B.E., D?LLAIRE, S., MENGELING, W,L., TAYLOR, DJ. (eds.), Diseases of Swine, 8th ed, Iowa State: University Press, 1999, p.695-721 (apud SEGAL?S ET AL., 2004). ELLIS, J.A.; HASSARD, L.; CLARK, E.; HARDING, J.; ALLAN, G.M.; WILLSON, P.; STROKAPPE, J.; MARTIN, K.; McNEILLY, F.; MEEHAN, B.; TODD, D.; HAINES, D. Isolation of circovirus from lesions of pigs with postweaning multisystemic wasting syndrome. Canadian Veterinary Journal, v.39, n.1, p.44-51, 1998. ELLIS, J.A.; KONOBY, C.; WEST, K.H.; ALLAN, G.M.; KRAKOWKA, S.; McNEILLY, F.; MEEHAN, B.; WALKER, I. Lack of antibodies to porcine circovirus type 2 virus in beef and dairy cattle and horses in western Canada. Canadian Veterinary Journal, v.42, n.6, p.461-464, 2001. FARNHAM, M.W.; CHOI, Y.K.; GOYAL, S.M.; JOO, H.S. Isolation and characterization of porcine circovirus type 2 from ser? of stillborn fetuses. Canadian Journal of Veterinary Research, v. 67, p.108-113, 2003. FENAUX, M.; HALBUR, P.G.; GILL, M.; TOTH, T.E.; MENG, X,J. Genetic characterization of type 2 porcine circovirus (PCV-2) from pigs with postweaning multisystemic wasting syndrome in different geographic regions of North America and development of a differential PCR-restriction fragment Length polymorphism assay to detect and differentiate between infections with PCV-1 and PCV-2. Journal of Clinical Microbiology, v. 38, n.7, p.2494-2503, 2000. FENAUX, M.; HALBUR, P.G.; HAQSHENAS, G.; ROYER, R.; THOMAS, P.; NAWAGITGUL, P.; GILL, M.; TOTH, T.E.; MENG, X.J. Cloned genomic DNA of type 2 porcine circovirus is infectious when injected directly into the liver and lymph nodes of pigs: characterization of clinical disease, v?rus distribution, and pathologic lesions. Journal of Virology, v.76, n.2, P.541-551, 2002. FERNANDES, L.T.; CIACCI-ZANELLA, J.R.; SCHIOCHET, M.F.; TROMBETTA, C. Estudo da permissibilidade de linhagens de cultivo celular ? infec??o por circovirus su?no tipo 1(PCV2). In: Congresso Brasileiro de Veterin?rios Especialistas em Su?nos, 11, 2003?, Goi?nia, GO. Anais... Conc?rdia: Embrapa Su?nos e Aves, 2003a, p.91-92. FERNANDES, L.T.; CIACCI-ZANELLA, J.R.; TROMBETTA, C.; SCHIOCHET, M.F.; KRAMER, B. Estudo da transmiss?o horizontal de circov?rus su?no tipo 2 (PCV2) entre su?nos. In: Congresso Brasileiro de Veterin?rios Especialistas em Su?nos, 11, 2003b, Goi?nia, GO. Anais... Conc?rdia: Embrapa Su?nos e Aves, 2003b, p. 93-94. FERNANDES, L.T.; CIACCI-ZANELLA, J.R.; TROMBETTA, C.; SOBESTIANSKY, J.; OLIVEIRA, S.; BRITO, L.A.B. Avalia??o da patogenicidade do circov?rus su?no tipo 2 (PCV2) isolado no Estado de Santa Catarina atrav?s de coinfec??o experimental com parvov?rus su?no. In: Congresso Brasileiro de Veterin?rios Especialistas em su?nos, 11, 2003c, Goi?nia, GO. Anais... Conc?rdia: Embrapa de Su?nos e Aves, 2003c, p. 89-90. GALLIAN, P.; BIAGINI, P.; ATTOUI, H.; CANTALOUBE, J.F.; DUSSOL, B.; BERLAND, Y.; MICCO, P.; LAMBALLERIE, X. High genetic diversity revealed by the study of TLMV infection in French hemodialysis patiente. Journal of Medical Virology, v.67, n.4, p.630-635, 2002. GILPIN, D.F.; STEVENSON, L.S.; McCULLOUGH, K.; KRAKOWKA, S.; MEEHAN, B.M.; McNEILLY, F.; FOSTER, J.C.; ADAIR, B.; WELSH, M.; ALLAN, G.M. Studies on the in vitro in vivo effect of porcine circovirus type 2 infection of porcine monocytic cells. In: Proc. ssDNA viruses of plants, birds, pigs and primates, 2001, Saint-Malo, ZOOPOLE developpement (ISPAIA), Frances, 2001, p.97. GILPIN, D.F.; McCULH, K.; MEEHAN, B.M.; McNELLY, F.; McNAIR, I.; STEVENSON, L.S.; FOSTER, J.D.; ELLIS, J.A.; KRAKOWKA, S.; ADAIR, B.M.; ALLAN, G.M. In vitro studies on the infection and replication of porcine circov?rus type 2 in cells of the porcine immune system. Veterinary Immunology and Immunopathology, v.94, p.149-161, 2003. GIRARD, C.; MORIN, M.; ELAZHARY, Y. Experimentally induced porcine proliferative and necrotizing pneumonia. Veterinary Record, v.130, p.206-207, 1992 (apud HARDING, 2004). GRESHAM, A.; GILES, N.; WEAVER, J. PMWS and porcine dermatitis nephropathy syndrome in Great Britain. Veterinary Record., v. 147, p.115, 2000 (apud HARDDING, 2004). HAMEL, A.L.; LIN, L.L.; NAYAR, G.P.S. Nucleotide Sequence of Porcine Circov?rus associated with postweaning multisystemic wasting syndrome in pigs. Journal of Virology, v.6, n.72, p.5262-5267, 1998. HARDING, J.C.S. Post-weaning multisystemic wasting syndrome (PMWS): preliminary epidemiology and clinical presentation. Proceedings of the American Association of Swine Practitioners, 28th Annual MEETING, 1997, Quebec City, Canada, 1997, p.503. HARDING, J.C.S.; CLARK, E.G.; STROKAPPE. J.H.; WILLSON, P.I.; ELLIS, J.A. Postweaning multisystemic wasting syndrome: Epidemiological and clinical presentation. Swine Health Production, v.6, p.249-254, 1998. HARDING, J.C.S. The clinical expression and emergence of porcine circov?rus 2. Veterinary Microbiology, v. 98, n.2, p.131-135, 2004. HARMS, P.A.; SORDEN, S.D. Porcine circovirus-associated pneumonia. In: Proceedings of the 16th IPVS on PMWS: a new emerging disease of swine, 2000, p.33-37 (apud SEGAL?S et al., 2004). HARMS, P.A.; SORDEN, S.D.; HALBUR, P.G.; BOLIN, S.R. LAGER, K.M.; MOROZOV, I.; PAUL, P.S. Experimental reproduction of severe disease in CD/CD pigs concurrently infected with type 2 porcine circov?rus and porcine reproductive and respiratory syndrome v?rus. Veterinary Pathology, v.38, n.5, p.528-539, 2001. HINES, R.K. Porcine circov?rus as a cause of congenital tremors Type A-II proved by fulfilling Koch?s postulates. Ph.D. diss., Univ. Georgia, 1994 (apud LUKERT & ALLAN, 1999). HINES, R.K.; LUKERT, P.D. Porcine circov?rus as a cause congenital tremors in newbom pigs. In: Proceedings American Association of Swine Practitioners, 1994, Chicago, USA, 1994, p.344-345. HINES, R.K.; LUKERT, P.D. Porcine circov?rus: A serological survey of swine in the United States. Swine Health and Production, v.3, n.2, p.71-73, 1995. HINES, R.K.; LUKERT, P.D.; DAU, D.; CASE, D. Some effects of porcine circov?rus on performance. Swine Health and Production, v.3, n.6, p.251-255, 1995. HIRAI, T.; NUNOYA, T.; IHARA, T.; KUSANAGI, K.; SHIBUYA, K. Dual infection with PCV-2 and porcine epidemic diarrhea v?rus in neonatal piglets. Veterinary Record, v. 148, p.482-484, 2001. HORNER, G.W. Pig circovirus antibodies present in New Zealand pigs. Surveillance Wellington, v.18, n.5, p.23, 1991. ISSO, K.; SUZUKI, Y.; TAKAYAMA, M. Mother-to-infant transmission of TT v?rus in Japan. Int. J. Gynaecol. Obstet., v.75, p.11-19, 2001. JANKE, B. Case report: porcine circov?rus as a cause of reproductive problems. In: Proceedings of the Iowa Veterinary Medicine Association, 2000, Iowa, USA, 2000, p.101 (apud HARDING, 2004). JOLIE, R.; RUNNELS, P.; McGAVIN, D. Post-weaning multisystemic wasting syndrome in a group of caesarian derived colostrums deprived pigs. In Proceedings of the 16th International Pig Veterinary Society Congress, 2000. KENNEDY, S.; SEGAL?S, J.; ROVIRA, A.; SCHOLES, S.; DOMINGO, M.; MOFFETT, D.; MEEHAN, B.; O?NEILL, R.; McNEILLY, F.; ALLAN, G.M. Absence of evidence of porcine circov?rus infection in piglets with congenital tremors. Journal of Veterinary Diagnostic Investigation, v.15, n.2, p.151-156, 2003. KIATIPATTANASAKUL-BANLUNARA, W.; TANTILERTCHAROEN, R; SUZUKI, K.; ALBARENQUE, S.M.; THANAWONGNUWECH, R.; NAKAYAMA, H.; DOI, K. Detection of porcine circov?rus 2 (PCV-2) DNA by nested PCR from formalina-fixed tissues of post-weaning multisystemic wasting syndrome (PMWS) pigs in Thailand. Journal of Veterinary Medical Science, v.64, n.5, p.449-452, 2002. KIM, J; HAN, D.U.; CHOI, C.; CHAE, C. Differentiation of porcine circov?rus PCV-1 and PCV-2 in boar s?men using a multiplex nested polymerase chain reaction. Journal of Virological Methods, v.98, n.1, p.25-32, 2001. KIM, J.; CHAE, C. Simultaneos detection of porcine circov?rus 2 and porcine parvov?rus in naturally and experimentally coinfected pigs by Double in situ hybridization. Journal of Veterinary Diagnostic Investigation, v.14, n..3, p.236-240, 2002. KIM, J.; CHUNG, H.K.; JUNG, T.; CHO, W.S.; CHOI, C.; CHAE, C.; Postweaning multisystemic wasting syndrome of pigs in Korea: prevalence, microscopic lesions and coexisting microorganisms. Journal of Veterinary Medical Science, v.64, n.1, p.57-62, 2002. KIM, J.; CHAE, C. A comparison of the lymphocyte subpopulations of pigs experimentally infected with porcine circov?rus 2 and or parvov?rus. Veterinary Journal, v.165, p.325-329, 2003a. KIM, J.CHAE, C. Expression of monocyte chemoattactan protein-1 but not interleukin-8 in granulomatous lesions in lymph nodes from pigs with naturally occurring postweaning multisystemic wasting syndrome. Veterinary Pathology, v.40, p.181-186, 2003b. KIM, J.; CHAE, C. Optimal enhancement of in situ hybridization for the detection of porcine circov?rus 2 in formalin-fixed, paraffin-wax-embedded tissues using a combined pretreatment of thermocycler and proteinase K. Research in Veterinary Science, v.74, p.235-240, 2003c. KIM, J.; CHOI, C.; CHAE, C. Pathogenesis of postweaning multisystemic wasting syndrome reproduced by co-infection with Korean isolates of porcine circov?rus 2 and porcine parvov?rus. Journal of Comparative Pathology., v.128, p.52-59, 2003a. KIM, J.; CHUNG, H.K.; CHAE, C. Association of porcine circov?rus 2 with porcine respiratory disease complex. Veterinary Journal, v. 166, n.3, p. 251-256, 2003b. KIM, J.; CHAE, C. Concurrent presence of porcine circov?rus type 2 and porcine parvov?rus in retrospective cases of exsudative epidermitis in pigs. Veterinary Journal, v.167, p.104-106, 2004. KIUPEL, M.; STEVENSON, G.W.; MITTAL, SLK.; CLARK, E.G.; HAINES, D.M. Circov?rus-like Viral Associated Disease in Weaned Pigs in Indiana. Veterinary Pathology, v.35, p.303-307, 1998. KRAKOWKA, S. ELLIS, J.A.; MEEHAN, B.; KENNEDY, S.; McNEILLY, F.; ALLAN, G.M. Viral wasting syndrome of swine: experimental reproduction of PMWS in gnotobiotics swine by co-infection with porcine circov?rus-2 (PCV-2) and porcine parvov?rus (PPV). Veterinary Pathology, v.37, p.254-263, 2000. KRAKOWKA, S.; ELLIS, J.A.; McNEILLY, F.; RINGLER, S.; RINGS, D.M.; ALLAN, G. Activation of the immune system is the pivotal event in the production of wasting disease in pigs infected with porcine circov?rus-2 (PCV-2). Veterinary Pathology, v. 38, p.31-42, 2001. KYRIAKIS, S.C.; SAOULIDIS, K.; LEKKAS, S.; MILIOTIS Ch.C.; PAPOUTSIS, P.A.; KENNEDY, S. The effects of immuno-modulation on the clinical and pathological expression of postweaning multisystemic wasting syndrome . Journal of Comparative Pathology, v.126, p.38-46, 2002. LADEKJAER-MIKKELSEN, A.; NIELSEN J.; STORGAARD, T.; BETNER, A.; ALLAN, G.M.; McNEILLY, F. Transplacental infection with PCV-2 associat with reproductive failure in a gilt. Veterinary Record, Letters, p. 759-760, 2001. LADEKJAER-MIKKELSEN, A.; NIELSEN, J.; STADEJEK, T.; STORGAARD, T.; KRAKOWKA, S.; ELLIS, J.; McNEILLY, F.; ALLAN, G.M. BOTNER, A. Reproduction of postweaning multisystemic wasting syndrome (PMWS) in immunostimulated and non-immunostimulated 3-week-old piglets experimentally infected with porcine cirvocirus type 2 (PCV2). Veterinary Microbiology, v.89, n.2-3, p.97, 2002. LAMAR, C.H. Characterizacion of peculiar cellular structures in the spinal corda of pigs affected with myoclonia cong?nita. 1971. West Lafayete, Purdue Univ., M.S.. thesis, 1971. LAROCHELLE, R.; SAUVAGEAU, R.; MAGAR, R. Immunohistochemical detection of swine influenza v?rus and porcine reproductive and respiratory syndrome in porcine proliferative and necrotizing pneumonia cases from Quebec. Canadian Veterinary Journal, v.35, p.513-525, 1994. LAROCHELLE, R.; MORIN, M.; ANTAYA, M.; MAGAR, R. Identification and incidence of porcine circov?rus in routine Field cases in Quebec as determined by PCR. Veterinary Record, v.145, p.140-142, 1999. LAROCHELLE, R.; BIELANSKI, A.; MULLER, P.; MAGAR, R. PCR detection and evidence of shedding of porcine circov?rus type 2 in boars s?men. Journal of Clinical Microbiology, v. 38, p.4629-4632, 2000. LAROCHELLE, R.; MAGAR, R.; D?ALLAIRE, S. Comparative serologic and virologic study of commercial swine herds with and without postweaning multisystemic wasting syndrome. Canadian Journal of Veterinary Research, v. 67, p.114-120, 2003. LATIMER, K.S.; STEFFENS, W.L.; RAKICH, P.M.; NIAGRO, F.D.; KIRCHER, I.M.; LUKERT, P.D. Cryptosporidiosis in four cockatoos with psittacine beak and feather disease. J. Am. Vet. Assoc.; v.5, p.707-710, 1992 (apud LUKERT; ALLAN, 1999). LE TALLEC, B.; POZZI, N.; BLANCHARD, P.; MAH?, D.; JESTIN, A.; GU?RIN, B. Longitudinal study of boars naturally infected by PCV2. In: Proceedings of the European Society on Veterinary Virology, PMWS, 2001, p.120 (apud SEGAL?S et al., 2004). LIN, C.L.; KYONO, W.; TONGSON, J.; CHUA, P.K.; EASA, D. YANAGIHARA, R., NERURKAR, V.R. Fecal excretion of a novel human circov?rus, TT v?rus, in healthy children. Clin. Lab. Imunol, v.7, p.960-963, 2000. LIU, Q.; WANG, L.; WILLSON, P.; O?CONNOR, B.; KEENLISIDE, J.; CHIRINOTREJO, M.; MELENDEZ, R.; BABIUK, L. Seroprevalence of porcine circov?rus type 2 in swine populations in Canada and Costa Rica. Canadian Journal of Veterinary Research, v.66, p.225-231, 2002. LOULA, T. Mystery pig disease. Agri-practice, v. 12, p.23-24, 1991 (apud BENEFIELD et al, 1999). LUKERT, P.; DE BOER, G.F.; DALE, J.L.; KEESE, P.; MCNULTY, M.S.; RANDLES, J.W.; TISCHER, I. Family Circoviridae. In: MURPHY, F. A.; FAUQUET, C.M.; BISHOP, D.H.L.; GHABRIAL, S.A.; JARVIS, A.W,; MARTELLI, G.P.; MAYO, M.A.; SUMMERS, M.D. Virus Taxonomy. Classification and Nomenclature of Viruses, 1995, New York: Sixth Reporto f the International Commitee on Taxonomy of Viruses, 1995, p. 166-168. LUKERT, P.D.; ALLAN, G.M. Porcine Circovirus. In: STRAW, B.E.; D?ALLAIRE, S.; MENGELING, W.L.; TAYLOR, D.J (eds). Disease of Swine, 8th ed., Iowa State: University Press, 1999, p.119-124. MADEC, F.; EVENO, E.; MORVAN, P.; HAMON, L.; BLANCHARD, P.; CARIOLET, R.; AMENNA, N.; MORVAN, H.; TRUONG, C.; MAH?, D.; ALBINA, E..; JESTIn, A. Post-weaning multisystemic wasting syndrome (PMWS) in pigs in France: clinical observations from follow-up studies on affected farms. Livestock Production Science, v.63, p.223-233, 2000. MAES, D. Descriptive epidemiological aspects of the seroprevalence of Five respiratory disease agents in slaughter pigs from fattening herds. Epidemiol. Sant? Anim., v.31, p.31-32, 1997 (apud BENFIELD et al., 1999). MAGAR, R. et al. Immunohistochemical detection of porcine reproductive and respiratory syndrome v?rus using colloidal gold. Canadian Journal of Veterinary Research., v.57, p.300-304, 1993. MAGAR, R.; CARMAN, S.; THOMSON, G.; LAROCHELLE, R. Porcine reproductive and respiratory syndrome v?rus identification in proliferative and necrotizing pneumonia cases from Ontario. Canadian Veterinary Journal, v. 35, p.523-524, 1994. MAGAR, R.; ROBINSON, Y.; DUBUC, C.; LAROCHELLE, R. Isolation and experimental oral transmission in pigs of a porcine reproductive and respiratory syndrome v?rus isolate. In: TALBOT, P.J.; LEVY, G.A. (eds). Corona and Related Viruses, New York: Plenum Press, 1995, p.139-144. MAGAR, R.; LAROCHELLE, R.; THIBAULT, S.; LAMONTAGNE, L. Experimental transmission of porcine circovirus type 2 (PCV2) in weaned pigs: a sequential study. Journal of Comparative Pathology, v.123, n.4, p.258-269, 2000. McNEILLY, F.; ALLAN, G.M.; FOSTER, J.C.; ADAIR, B.M.; McNULTY, M.S. Effect of porcine circovirus infection on porcine alveolar macrophages function. Veterinary Immunology and Immunopathology, v. 49, n.4, p.295-306, 1996. McNEILLY, F.; KENNEDY, S.; MOFFETT, D.; MEEHAN, B.M.; FOSTER, J.C.; CLARKE, E.G.; ELLIS, J.A.; HAINES, D.M.; ADAIR, B.M.; ALLAN, G.M. A comparison of in situ hybridization and immunohistochemistry for the detection of a new porcine circovirus in formalin-fixed tissues from pigs with post-weaning multisystemic wasting syndrome (PMWS). Journal of Virological Methods, v.80, n.2, p.123-128, 1999. MEEHAN, B.M.; CREELAN, J.L.; McNULTY, M.S.; TODD, D. Sequence of porcine circovirus DNA: affinities with plant circoviruses. Journal of General Virology, v.78, p.221-227, 1997 (apud ALLAN et al. 1999). MEEHAN, B.M.; McNEILLY, F..; TODD, D.; KENNEDY, S.; JEWHURST, V.A.; ELLIS, J.A.; HASSARD, L.E.; CLARK, E.G.; HAINES, D.M.; ALLAN, G.M. Characterization of novel circovirus DNAs associated with wasting syndromes in pigs. Journal of General Virology, v.79, p.2171-2179, 1998. MOEN, E.M.; HUANG, L.; GRINDE, B. Molecular epidemilogy of TTV-like mini v?rus in Norway. Archives of Virology, v.147, n.1, p.181-185, 2002. MOLNAR, T.; GLAVITS, R.; SZEREDI, L.; DAN, A. Occurrence of porcine dermatitis and nephropaty syndrome in Hungary. Acta Vet. Hung., v.50, n.1, p.5-16, 2002. MORENO, A.M.; CASTRO, A.M.M.G.; PAIX?O, R.; CORTEZ, A.; DOTO, D.S.; LEOMIL, H.; BACCARO, M.R.; RICHTZENHAIN, L.J. Associa??o entre circov?rus su?no tipo 2 e as doen?as respirat?rias no Brasil. In: Congresso Brasileiro de Veterin?rios Especialistas em su?nos, 11, 2003, Goi?nia, GO. Anais... Conc?rdia: Embrapa de Su?nos e Aves, 2003, p. 101-102. MORI, M.; SATO, K.; AKACHI, A.; ASAHI, S.; TANIGUCHI, S.; NARITA, M. Retrospective study of porcine circov?rus 2 infection in Japan: seven cases in 1989. Veterinary Pathology, v.37, n.6, p.667-669, 2000. MORIN, M.; GIRARD, C.; ELAZHARY, Y.; FAJARDO, R.; DROLET, R.; LAGAC?; A. Severe proliferative and necrotizing pneumonia in pigs: a newly recognized disease. Canadian Veterinary Journal, v.31, p.837-839, 1990. MOROZOV, I.; SIRINARUMITR, T.; SORDEN, S.D.; HALBUR, P.G.; MORGAN, M.K.; YOON, K-J.; PAUL, P.S. Detection of a novel strain of porcine circov?rus in pigs with postweaning multisystemic wasting syndrome. Journal of Clinical Microbiology, v.36, n.9, p.2535-2541, 1998. NAWAGITGUL., P.; MOROZOV, I.; BOLIN, S.R.; HARMS, P.A.; SORDEN, S.D.; PAUL. P.S. Open reading frame 2 of porcine circov?rus type 2 encodes a major capsid protein. Journal of General Virology, v.81, p.2281-2287, 2000. NIELSEN, J.; VINCENT, I.E.; BOTNER, A.; LADEKJAER-MIKKELSEN, A.S.; ALLAN, G.M.; SUMMERFIELD., A.; McCULLOUGH, K.C. Association of lymphopenia with porcine circov?rus type 2 induced postweaning multisystemic wasting syndrome (PMWS). Veterinary Immunology and Immunopathology, v.92, p.97-111, 2003. NISHIZAWA, T.; OKAMOTO, H.; KONISHI, K.; YOSHIZAWA, H.; MIYAKAWA, Y., MAYUMI, M. A novel DNA v?rus (TTV) associated with elevated transaminase levels in posttransfusion hepatitis of Unknown etiology. Biochem Biophys. Res. Commun., V.241, p.241, p. 92-97, 1997. NUNEZ, A.; McNEILLY, F.; PEREA, A.; SANCHEZ-CORDON, P.J., HUERTA, B.; ALLAN, G.M.; CARRASCO, L. Coinfection by Crypotosporidium parvum and porcine circov?rus type 2 in weaned pigs. J. Vet. Med. B. Infect. Dis. Vet. Public Heath, v.50, n.5, p.255-258, 2003. O?CONNOR, B. GAUVREAU, H.; WEST, K.; BOGDAN, J.; AYROUD, M.; CLARK, E.G.; KONOBY, C.; ALLAN, G.M.; ELLIS, J.A. Multiple porcine circov?rus 2 associated abortion and reproductive failure in a multiple-site swine production unit. Canadian Veterinary Journal, v.42, p.551-553, 2001 (apud HARDING, 2004). OHLINGER, V.F.; SCHMIDT, U.; PESCH, S. Studies on pathogenic aspects of the post-weaning multisystemic wasting syndrome (PMWS). In: Proceedings of the 16th International Pig Veterinary Society Congress, 2000. ONUKI, A.; ABE, K.; TOGASHI, K.; KAWASHIMA, K.; TANEICHI, A.; TSUNEMITSU, H. Detection of porcine circov?rus from lesions of a pig with wasting disease in Japan. Journal of Veterinary Medical Science, v.61, n.10, p.1119-1123, 1999. OUARDANI, M.; WILSON, L.; JETT?, R.; MONTPETIT, C.; DEA, S. Multiplex PCR for detection and typing of porcine circoviruses. Journal of Clinical Microbiology, v.37, n.12, p.3917-3924, 1999. PENSAERT, M.B.; S?NCHEZ, R.E.; NAUWYNCK, H.J. Transmission of porcine circov?rus type 2 from the sow to the litter. In: Proceedings of the European Society on Veterinary Virology, PMWS, 2001, p.84-85 (apud SEGAL?S et al., 2004). PENSAERT, M.B.; SANCHEZ, R.E.J. LADEKJAER-MIKKELSEN, A.S.; ALLAN, G.M.; NAUWYNCK, H.J. Viremia and effect of fetal infection with porcine viruses with special reference to porcine circov?rus 2 infection. Veterinary Microbiology, v. 98, n.2, p.175-183, 2004. PESCADOR, C.A.; ROZZA, D.B.; ZLOTOWSKI, P.; BOROWSKI, S.M.; BARCELLOS, D.E., DRIEMEIER, D. Principais les?es histopatol?gicas associadas a circovirose em su?nos das fases de crescimento e termina??o em rebanhos su?nos do Rio Grande do Sul. In: Congresso Brasileiro de Veterin?rios Especialistas em su?nos, 11, 2003, Goi?nia, GO. Anais... Conc?rdia: Embrapa Su?nos e Aves, 2003, p. 105-106 PESCH, S.; SCHMIDT, U.; OHLINGER, V.F. Proliferative necrotizing pneumonia (PNP) is a resulto f coinfection with porcine reproductive and respiratory disease v?rus (PRRSV) and porcine circovirus type 2 (PCV2). In: Proceedings of the 16th International Congresso n Pigs Veterinary Society, 2000, p. 581. PINTO, F.F.; LOBATTO, Z.I.P.; NASCIMENTO, E.F.; ROCHA, M.A.; BARBOSA, C.N. Detec??o do circov?rus su?no 2 (PCV-2) em tecidos coletados de su?nos do Estado de Minas Gerais utilizando a rea??o em cadeia da polimerase (PCR). In: Congresso Brasileiro de Veterin?rios Especialistas em Su?nos, 11, 2003a, Goi?nia, GO. Anais... Conc?rdia: Embrapa de Su?nos e Aves, 2003a, p. 105-106. PINTO, F.F., LOBATO, Z.I.P.; NASCIMENTO, E.F.; ROCHA, M.A.; BARBOSA, C.N. Influ?ncia do processamento tecidual na detec??o do circovirus su?no tipo 2 (PCV-2) utilizando a t?cnica de PCR. In: Congresso Brasileiro de Veterin?rios Especialistas em su?nos, 11, 2003b, Goi?nia, GO. Anais... Conc?rdia: Embrapa Su?nos e Aves, 2003b, p. 103-104. PLAGEMANN, P.G.W. Lactate dehydrogenase-elevating v?rus and related viruses. In Fields Virology, 3 ed. Ed. B. N. Fields, D.M. Howley et al. Philadelphia: Lippincott-Raven, p.1105-1120, 1996 (apud BENFIELD et al. 1999). PLOWRIGHT, W.; THOMSON, G.R. & NESER, J.A. African swine fever. In: Infectious Diseases of Livestock, with special reference to Southern Africa, COETZER, J.A.W.; THOMSON, G.R., TUSTIN, R.C., New York: Oxfor University Press, p.568-599, 1994. PRESCOTT, L.E.; SIMMONDS, P. Global distribution of transfusion-transmitted v?rus. N. Engl. J. Med., v.339, p.776-777, 1998. QUINTANA, J.; SEGAL?S, J.; ROSELL, C.; CALSAMIGLIA, M.; RODRIGUEZ-ARRIOJA, G.M.; CHIANINI, F.; FOLCH, J.M.; MALDONADO, J.; CANAL, M.; PLANA-DURAN, J.; DOMINGO, M. Clinical and pathological observations on pigs with postweaning multisystemic wasting syndrome. Veterinary Record, v.149, 357-361, 2001. RITCHIE, B.V.V.; NIAGRO, F.D.; LUCKERT, P.D.; STEFFENS, W.L.; LATIMER, K.S. Characterization of a new v?rus from cockatoos with psittacine beak and feather disease. Virology, v.171, p.83-88, 1989. RODRIGUEZ-ARRIOJA, G.M.; SEGAL?S, J.; CALSAMIGLIA, M.; RESENDES, A.R.; BALASCH, M.; PLANA-DUR?N, J.; CASAL, J.; DOMINGO, M. Dynamics of porcine circov?rus type 2 infection in a herdo f pigs with postweaning multisystemic wasting syndrome. American Journal Veterinary Research, v.63, n.3, p.354-357, 2002. ROSE, N.; LAROUR, R.; Le DIGUERHER, G.; EVENO, E.J.P. Risk factors for porcine post-weaning multisystemic wasting syndrome (PMWS) in 149 French Farrow-to-finish herds. Preventive Veterinary Medicine, v.61, n.3, p.209-225, 2003. ROSELL, C.; SEGAL?S, J.; PLANA-DUR?N, J.; BALASCH, M.; RODRIGUEZ ARRIOJA, G.M.; KENNEDY, S.; ALLAN, G.M.; McNEILLY, F.; LATIMER, K.S.; DOMINGO, M. Pathological, immunohistochemical, and in-situ hybridization studies of natural cases of postweaning multisystemic wasting syndrome (PMWS) in pigs. Journal of Comparative Pathology, v.120, n.1, p.59-78, 1999. ROSELL, C.; SEGAL?S, J.; DOMINGO, M. Hepatitis and staging of hepatic damage in pigs naturally infected with porcine circov?rus type 2. Veterinary Pathology, v.37, n.6, p.687-692, 2000. ROVIRA, A. BALASCH, M.; SEGAL?S, J.; GARCIA, L.; PLANA-DUR?N, J.; ROSELL, C.; ELLERBROK, H.; MANKERTZ, A.; DOMINGO, M. Experimental inoculation of conventional pigs with porcine reproductive and respiratory syndrome v?rus and Porcine Circov?rus 2. Journal of Virology, v. 76, n.7, p.3232-3239, 2002. SAMBROOK, J.; FRITSCH, E.F.; MANIATIS, T. Molecular cloning, a laboratory manual. 2nd ed. NEW York: Cold Spring Harbor Laboratory, 1989. SANCHEZ-VIZCAINO, J.M. African Swine Fever. In: Straw B.E., D?Allaire S., Mengeling W.L., Taylor D.J (eds). Disease of Swine, 8th ed., Iowa State: Amer. Press, 1999. Cap.5, p.93-102. SANCHEZ, R.E.; MEERTS, P.; NAUWINCK, H.J.;; PENSAERT, M.B. Change of porcine circov?rus 2 target cells in pigs during development from fetal to early postnatal life. Veterinary Microbiology, v. 95, p.15-25, 2003. SANFORD, S.E. PCV-2-related reproductive failure in start-up herds. In: Proceedings of the 17th International Congresso n Pigs Veterinary Society, P.P1, 2002 (apud SEGAL?S et al., 2004). SAOULIDIS, K.; KYRIAKIS, S.C.; KENNEDY, S.; LEKKAS, MILIOTIS, Ch.C.; ALLAN, G.M.; BALKAMOS, G.C.; PAPOUTSIS, P.A. First report of post-weaning multisystemic wasting syndrome and porcine dermatitis and nephropathy syndrome in pigs in Greece. J. Vet. Med. B. Infect Dis. Vet. Public Health., v.49, n.4, p.202-205, 2002. SARLI, G.; MANDRIOLI, L.; LAURENTI, J.; SIDOLI, L.; CERATI, C.; ROLLA, G.,MARCATO, P.S. Immunohistochemical characterization of the lymph node reaction in pig post-weaning multisystemic wasting syndrome (PMWS). Veterinary Immunology and Immunopathology, v.83, n.1-2, p.53-67, 2001. SARRADELL, J.; PEREZ, A.M.; ANDRADA, M.; RODRIGUEZ, F.; FERNANDES, A.; SEGAL?S, J. PMWS in Argentina. Veterinary Record, Letters, v. 9, p.323, 2002. SATO, K.; SHIBAHRA, T.; ISHIKAWA, Y.; KONDO, H.; KUBO, M.; KADOTA, K. Evidence of porcine circov?rus infection in pigs with wasting disease syndrome from 1985 to 1999 in Hokkaido, Japan. Journal of Veterinary Medical Science, v.62, n.6, p.627-633, 2000. SEGAL?S, J.; SITJAR, M.; DOMINGO, M.; DEE, S.; DEL POZO, M.; NOVAL, R.; SACRISTAN, C.; De LAS HERAS, A.; FERRO, A.; LATIMER, K.S. First reporto f post-weaning multisystemic wasting syndrome in pig in Spain. Veterinary Record, v.141: p.600-601. SEGAL?S, J.; PIELLA, J.; MARCO, E.; MATEU-DE-ANTONIO, E.M.; ESPUN?, E.; DOMINGO, M. Porcine dermatitis and nephropathy syndrome in Spain. Veterinary Record, v.142, p.483-486, 1998. SEGAL?S, J.; PASTOR, J.; CUENCA, R.; DOMINGO, M. Haematological parametersin postweaning multisystemic syndrome affected pigs. Veterinary Record, v.146, p.675-676, 2000. SEGAL?S, J.; DOMINGO, M. Postweaning multisystemic wasting syndrome (PMWS) in pigs. A review. Vet. Q., v.24, p.109-124, 2002. SEGAL?S, J. Infection por circov?rus porcino tipo 2 e interaci?n com el sistema immunitario. Barcelona, 2003. Dispon?vel em: http://www.portalveterinaria.com/print.php?artid 222. Acesso em: 9 mar. 2004. SEGAL?S, J. PINEIRO, C.; LAMPREAVE, F.; NOFRAR?AS, M.; ANDR?S, M.; MORALES, J.; DOMINGO, M. acute phase protein concentration are increased in serum of postweaning multisystemic wasting syndrome naturally affected pigs. IN: Porc. Fourth European Colloquium on Acute Phase Proteins, Segovia, 2003, Spain, p.113. SEGAL?S, J.; ROSELL, C.; DOMINGO, M. Pathological findings associated with naturally acquired porcine circov?rus type 2 associated disease. Veterinary Microbiology, v.98, p.137-149, 2004. SHIBAHARA, T.; SATO, K.; ISHIKAWA, Y.; KADOTA, L. Porcine circov?rus induces B lymphocyte depletion in pigs with wasting disease. Journal of Veterinary Medical Science, v.62, p.1125-1131, 2000. SHIBATA, I.; OKUGA, Y.; YAZAWA, S.; ONO, M.; SASAKI, T.; ITAGAKI, M.; NAKAJIMA, N.; OKABE, Y.; HIDEJIMA, I. PCR detection of porcine circov?rus type 2 DNA in whole blood, serum, oropharyngeal swab, and feces from experimentally infected pigs and fields cases. Virology, p.405-408, 2003. SIRINARUMITR, T.; MOROZOV, I.; NAWAGITGUL, P.; SOURDEN, S.D.; HARMS, P.A.; PAUL, P.S. Utilization of a rate enhacement hybridization buffer system for rapid in situ tissues of pigs with postweaning multisystemic wasting syndrome. Journal of Veterinary Diagnostic Investigation, v. 12, n.6. p.562-565, 2000. SMITH, W.J.; THOMSON, J.R.; DONE, S. Dermatitis/nephropathy syndrome of pigs. Veterinary Record, v.132, p.47, 1993 (apud SEGAL?S et al., 2004). SMYTH, J.A.; CARROL, B.P. Circov?rus infection in European Racing pigeons. Veterinary Record, v.136, p.173-174, 1995. SORDEN, S.D. Postweaning multisystemic wasting syndrome (PMWS): a diagnostic perspective. IOWA, 1999. Dispon?vel em: HTTP://animalagriculture.or/Proceedings/1999_NatCon_Animal _Health/PMWS520 A%20diagnostic%20perspective. htm. Acesso em: 11 out. 2002. SORDEN, S.D.; HARMS, P.A.; NAWAGITGUL, P.; CAVANAUGH, D.; PAUL, P.S. Development of a polyclonal-antibody-based immunohistochemical method for the detection of type 2 porcine circov?rus in formalin-fixed, paraffinn-embedded tissue. Journal of Veterinary Diagnostic Investigation, v.11, n.6, p.528-530, 1999. SORDEN, S.D. Update on porcine circov?rus and post-weaning multisystemic wasting syncrome (PMWS). Swine Health Prod., v.8. p.133-136, 2000. STEVENSON, G.W.; KIUPEL, M.; MITTAL, M.S., KANITZ, C.L. Ultrastructure of porcine circov?rus persistently infected PK-15 cells. Veterinary Pathology, v.36, p.368-378, 1999 (apud CHOI et al. 2002a). STEVENSON, G.W.; KIUPEL, M.; MITTAL, S.K.; CHOI, J.; LATIMER, K.S.; KANITZ, C.L. Tissue distribution and genetic typing of porcine circoviruses in pigs with naturally occurring congenital tremors. Journal of Veterinary Diagnostic Investigation, v.13, p.57-62, 2001. TAKAHASHI, K.; HOSHINO, H.; OHTA, Y.; YOSHIDA, N.; MISHIRO, S. Very high prevalence of TT v?rus (TTV) infection in general population of Japan revealed by a nw set of PCR primers. Hepatol. Res., v.12, p.233-239, 1998. TAKAHASHI, K.; IWASA, Y.; HIJIKATA, M.; MISHIRO, S. Identification of a new human DNA v?rus (TTV-like minivirus, TLMV) intermediately related to TT v?rus and chicken anemia v?rus. Archives of Virology, v.145, p.979-993, 2000. THACKER, B.; THACKER, E. The PRDC battle continues. Pig Prog., p.16-18, 2000. THOMSON, J.R..; MacINTYRE, N.; HENDERSON, L.E.A.; MEIKLE, C.S. Detection of Pasteurella multocida in pigs with porcine dermatitis and nephropathy syndrome. Veterinary Record, v.149, p. 412-417, 2001. TISCHER, I.; RASCH, R.; TOCHTERMANN, G. Chacacterization of papovarius and picornavirus-like particles in permanente pig kidney cell lines. Zentralblatt Bakteriologie, Parasitenkund, Infecktionskheiten und Hygiene ? Erste Abteilung Originale ? Reihe A: Medizinische Mikrobiologie und Parasitologie, v.226, n.2, P.153-167, 1974. TISCHER, I.; GELDERBLOM, H.; VETTERMANN, W.; KOCH, M.A. A very small porcine v?rus with circular single-stranded DNA. Nature, v.295, p.64-66, 1982. TISCHER, I., MIELDS, W.; WOLFF, D.; VAGAT, M.; GRIEM, W. Studies on epidemiology and pathogenicity of porcine circovirus. Archives of Virology, v. 91, n.3-4, p.271-276, 1986. TISCHER, I.; PETERS, D.; RASCH, R.; POCIULI, S.; Replication of porcine circovirus: induction by glucosamine and cell cycle dependence. Archives of Virology, v.96, p.39-57, 1987. TISCHER, I.; PETERS, D.; POCIULI, S. Ocurrence and role of na early antigem and evidence for transforming ability of porcine circovirus. Archives of Virology, v.140, p.1799-1816, 1995a. TISCHER, I.; BODE, J.; TIMM, H.; PETERS, D.; RASCH, R.; POCIULI, S.; GERIKE, E. Presence of antibodies reactive with porcine circovirus in ser? of humans, mice and cattle. Archives of Virology, v.140, p.1427-1439, 1995b. TODD, D. Circoviruses: immunosuppressive threats to avian species: a review. Avian Pathology, v.29, p.373-394, 2000. TODD, D. Avian circovirus diseases: lessons for the study of PMWS. Veterinary Microbiology, v.98, p.269-274, 2004. TRUJANO, M.; IGLESIAS, G.; SEGAL?S, J.; PALACIOS, J.M. PCV-2 from emaciated pigs in Mexico. Veterinary Record, Letters, p. 792, 2001. YOO, D.; GIULIVI, A. Xenotransplantation and the potential risk of xenogeneic transmission of porcine viruses. Canadian Journal of Veterinary Research, v.64, n.4, p.193-203, 2000. VASCONCELOS, H.C.F.; MENEZES, M.E.; NIEL, C. TT v?rus infection in children and adults Who visited a general hospital in the South of Brazil for routine procedure. Mem?rias do Instituto Oswaldo Cruz, Rio de Janeiro, v.96, n.4, p.519-522, 2001. VINCENT, I.E.; CARRASCO, C.P.; HERRMANN, B.; MEEHAN, B.; ALLAN, G.M.; SUMMERFIELD, A.; McCULLOUGH, H.C. Dentritic cells: a Trojan horse for porcine circovirus type 2? In: Proc. Fourth International Symposium on Emerging and Re-emerging Pig Diseases, Rome, 2003, University of Pharma, Italy, p. 157, 2003. WATTRANG, E.; McNEILLY, F.; ALLAN, G.M.; GREKO, C.; FOSSUM, C.; WALLGREN, P. Exudative epidermitis and porcine circov?rus-2 infection in a Swedish SPF-herd. Veterinary Microbiology, v.86, n.4, p.281-293, 2002. WELLENBERG, G.J.; PESCH, S.; BERNDSEN, F.W.; STEVERINK, P.J.G.M.; HUNNEMAN, W.; VORST, T.J.K.; PEPERKAMP, N.H.M.T.; OHLINGER, V.F.; SCHIPPERS, R.; OIRSCHOT, J.T. JONG, M.F. Isolation and characterization of porcine circov?rus type 2 from pigs showing signs of post-weaning multisystemic wasting syndrome in The Netherlands. Vet. Quart., v.22, p.167-172, 2000. WEST, K.H.; BYSTROM, J.M.; WOJNAROWICZ, C.; SHANTZ, N.; JACOBSON, M.; ALLAN, G.M.; HAINES, D.M.; CLARK, E.G.; KRAKOWKA, S.; McNEILLY, F.; KONOBY, C.; MARTIN, K.; ELLIS, J.A. Myocarditis and abortidis associated with intrauterine infection of sows with porcine circov?rus 2. J. Vet. Diagn. Invest., v.11, n.6, p.530-532, 1999. WHITE, M.; HIGGINS, R.J. Dermatitis nephropathy syndrome of pigs. Veterinary Record, v.132, p.199, 1993 (apud HARDING, 2004). WOOD, R.L. Erysipelas. In: Diseases of Swine, STRAW, B.E.S.; D?ALLAIRE, S.; MENGELING, W.L.; TAYLOR, D.J. (eds). Iowa State: University Press, Iowa, USA, 8th edition, 1999, p.419-430. ZANELLA. J.R.C.; MOR?S, N. S?ndrome multissist?mica do definhamento do leit?o desmamado (SMDLD) causada por cicov?rus su?no. In: Congresso Mercosur de Producci?n Porcina, 2000, Buenos Aires, Mem?ria... Buenos Aires: Universidade de Buenos Aires, 2000, p.EIP16-EIP-16. ZANELLA, J.R.C.; MOR?S, N. Diagnosis of post-weaning multisystemic wasting syndrome in pigs in Brazil caused by porcine circov?rus. Arquivos Brasileiros de Medicina Veterin?ria e Zootecnia, v.55, n.5, p.522-527, 2003.ZANELLA, J.R.C.; BRASSI, S.S.; ASCOLI, K.; DAHMER, A.; ZANELLA, E.L. Detec??o de circov?rus su?no tipo 2 (PCV2) em s?men de su?nos. In: Congresso Brasileiro de Veterin?rios Especialistas em Su?nos, 11, 2003a, Goi?nia, GO. Anais... Conc?rdia: Embrapa Su?nos e Aves, v.2. p. 97-98. ZANELLA, J.R.C.; MOR?S, N.; AMARAL, A.L. Acompanhamento de um surto de circovirose su?na em granja produtora de leit?es. Ir: Congresso Brasileiro de Veterin?rios Especialistas em Su?nos, 11, 2003b, Goi?nia, GO. Anais... Conc?rdia: Embrapa Su?nos e Aves, v.2, p.99-100. ZANELLA, J.R.C.; MOR?S, N.; FERNANDES, L.T.; BASSI, S.S.; TROMBETTA, C.; SCHIOCHET, M.F. Ocorr?ncia de circov?rus su?no tipo 2 (PCV2) em su?nos ou materiais com suspeita cl?nica de s?ndrome da refugagem multissist?mica (SEM) enviados para diagn?stico. In: Congresso Brasileiro de Veterin?rios Especialistas em Su?nos, 11, 2003c, Goi?nia, GO. Anais... Conc?rdia: Embrapa Su?nos e Aves, 2003b, v.2, p.95-96.Circov?rus porcino tipo 2histopatologiaimunohistoqu?micaPorcine circovirus type 2histopathologyimmunohistochemestryMedicina Veterin?riaSurto de Circovirose (S?ndrome Definhante Multissist?mica de Su?nos Desmamados) no Estado do Rio de JaneiroOutbreak of Circoviruses (Porcine Postweaning Multisystemic Wasting Syndrome) in Rio de Janeiro, Brazil.info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/doctoralThesisinfo:eu-repo/semantics/openAccessreponame:Biblioteca Digital de Teses e Dissertações da UFRRJinstname:Universidade Federal Rural do Rio de Janeiro (UFRRJ)instacron:UFRRJTHUMBNAIL2004 - Ticiana do Nascimento Fran?a.pdf.jpg2004 - Ticiana do Nascimento Fran?a.pdf.jpgimage/jpeg4844http://localhost:8080/tede/bitstream/jspui/3888/4/2004+-+Ticiana+do+Nascimento+Fran%C3%A7a.pdf.jpgb96caebab2dee19d6e966d149a99fce2MD542004 - Ticiana do Nascimento Fran?a .pdf.jpg2004 - Ticiana do Nascimento Fran?a .pdf.jpgimage/jpeg4725http://localhost:8080/tede/bitstream/jspui/3888/7/2004+-+Ticiana+do+Nascimento+Fran%C3%A7a+.pdf.jpg3c1153152f7f35a1e361483e99dec7a1MD57TEXT2004 - Ticiana do Nascimento Fran?a.pdf.txt2004 - Ticiana do Nascimento Fran?a.pdf.txttext/plain120http://localhost:8080/tede/bitstream/jspui/3888/3/2004+-+Ticiana+do+Nascimento+Fran%C3%A7a.pdf.txt0a97b6090fc8bc3f8bd94170ac5d0e6fMD532004 - Ticiana do Nascimento Fran?a .pdf.txt2004 - Ticiana do Nascimento Fran?a .pdf.txttext/plain13560http://localhost:8080/tede/bitstream/jspui/3888/6/2004+-+Ticiana+do+Nascimento+Fran%C3%A7a+.pdf.txt71b976e39d49b906a0328cbfe32de260MD56ORIGINAL2004 - Ticiana do Nascimento Fran?a .pdf2004 - Ticiana do Nascimento Fran?a .pdfapplication/pdf5012630http://localhost:8080/tede/bitstream/jspui/3888/5/2004+-+Ticiana+do+Nascimento+Fran%C3%A7a+.pdf755dba3b504ec8aa5bdee20779a9ca6aMD55LICENSElicense.txtlicense.txttext/plain; charset=utf-82089http://localhost:8080/tede/bitstream/jspui/3888/1/license.txt7b5ba3d2445355f386edab96125d42b7MD51jspui/38882023-09-20 01:00:18.073oai:localhost: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Biblioteca Digital de Teses e Dissertaçõeshttps://tede.ufrrj.br/PUBhttps://tede.ufrrj.br/oai/requestbibliot@ufrrj.br||bibliot@ufrrj.bropendoar:2023-09-20T04:00:18Biblioteca Digital de Teses e Dissertações da UFRRJ - Universidade Federal Rural do Rio de Janeiro (UFRRJ)false
dc.title.por.fl_str_mv Surto de Circovirose (S?ndrome Definhante Multissist?mica de Su?nos Desmamados) no Estado do Rio de Janeiro
dc.title.alternative.eng.fl_str_mv Outbreak of Circoviruses (Porcine Postweaning Multisystemic Wasting Syndrome) in Rio de Janeiro, Brazil.
title Surto de Circovirose (S?ndrome Definhante Multissist?mica de Su?nos Desmamados) no Estado do Rio de Janeiro
spellingShingle Surto de Circovirose (S?ndrome Definhante Multissist?mica de Su?nos Desmamados) no Estado do Rio de Janeiro
Fran?a, Ticiana do Nascimento
Circov?rus porcino tipo 2
histopatologia
imunohistoqu?mica
Porcine circovirus type 2
histopathology
immunohistochemestry
Medicina Veterin?ria
title_short Surto de Circovirose (S?ndrome Definhante Multissist?mica de Su?nos Desmamados) no Estado do Rio de Janeiro
title_full Surto de Circovirose (S?ndrome Definhante Multissist?mica de Su?nos Desmamados) no Estado do Rio de Janeiro
title_fullStr Surto de Circovirose (S?ndrome Definhante Multissist?mica de Su?nos Desmamados) no Estado do Rio de Janeiro
title_full_unstemmed Surto de Circovirose (S?ndrome Definhante Multissist?mica de Su?nos Desmamados) no Estado do Rio de Janeiro
title_sort Surto de Circovirose (S?ndrome Definhante Multissist?mica de Su?nos Desmamados) no Estado do Rio de Janeiro
author Fran?a, Ticiana do Nascimento
author_facet Fran?a, Ticiana do Nascimento
author_role author
dc.contributor.advisor1.fl_str_mv Peixoto, Paulo Fernando de Vargas
dc.contributor.advisor1Lattes.fl_str_mv http://lattes.cnpq.br/3002512195318611
dc.contributor.referee1.fl_str_mv Tokarnia , Carlos M. A. Hubinger
dc.contributor.referee2.fl_str_mv Brito, Marilene de Farias
dc.contributor.referee3.fl_str_mv Dobereiner, Jurguen
dc.contributor.referee4.fl_str_mv Pitombo, Cicero Ara?jo
dc.contributor.authorLattes.fl_str_mv http://lattes.cnpq.br/3545873525091315
dc.contributor.author.fl_str_mv Fran?a, Ticiana do Nascimento
contributor_str_mv Peixoto, Paulo Fernando de Vargas
Tokarnia , Carlos M. A. Hubinger
Brito, Marilene de Farias
Dobereiner, Jurguen
Pitombo, Cicero Ara?jo
dc.subject.por.fl_str_mv Circov?rus porcino tipo 2
histopatologia
imunohistoqu?mica
topic Circov?rus porcino tipo 2
histopatologia
imunohistoqu?mica
Porcine circovirus type 2
histopathology
immunohistochemestry
Medicina Veterin?ria
dc.subject.eng.fl_str_mv Porcine circovirus type 2
histopathology
immunohistochemestry
dc.subject.cnpq.fl_str_mv Medicina Veterin?ria
description The first outbreak of swine circoviruse infection which occurred in the State of Rio de Janeiro was described. The disease which affects mainly weaned pigs, about 4 months old, caused the death of at least 14 animals. The property where the outbreak occurred, had inadequate sanitary and management conditions. Clinically the disease was characterized by wasting, poor development, coughing, tachypnoea, dispnoea, ataxia , tremors after simulation, decubitus and convulsions. The course of the disease was acute to subacute. The most important post-mortem findings were paleness of the body, enlarged lymphnodes, non-colapsed lungs, with consolidated ?reas mainly in the cranial lobes. Histological lesions consisted mainly of lymphohistiocytic infiltration with multinucleate giant cells cells in lymph nodes, spleen, Peyer?s patches, kidney, lungs and liver, depletion and/or lymphoid hyperplasia, as well as lymphohistiocytic intersticial pneumonia and areas of secondary broncopneumonia. The diagnosis was established through observations of the symptoms and typical lesions of Postweaning Multisystemic Wasting Syndrome (PMWS), and was confirmed by immunohistochemical examination and PCR. The objective of this study was to characterize the epidemiological and clinical-pathological aspects of na outbreak of PMWS in Rio de Janeiro, because of its severe direct or indirect economical losses to the world pig industry.
publishDate 2004
dc.date.issued.fl_str_mv 2004-07-08
dc.date.accessioned.fl_str_mv 2020-09-15T19:30:29Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/doctoralThesis
format doctoralThesis
status_str publishedVersion
dc.identifier.citation.fl_str_mv FRAN?A, Ticiana do Nascimento. Surto de Circovirose (S?ndrome definhante multissist?mica de su?nos desmamados) no Estado do Rio de Janeiro. 2004. 110 f. Tese (Doutorado em Ci?ncias Veterin?rias) - Instituto de Veterin?ria, Universidade Federal Rural do Rio de Janeiro, Serop?dica - RJ, 2004.
dc.identifier.uri.fl_str_mv https://tede.ufrrj.br/jspui/handle/jspui/3888
identifier_str_mv FRAN?A, Ticiana do Nascimento. Surto de Circovirose (S?ndrome definhante multissist?mica de su?nos desmamados) no Estado do Rio de Janeiro. 2004. 110 f. Tese (Doutorado em Ci?ncias Veterin?rias) - Instituto de Veterin?ria, Universidade Federal Rural do Rio de Janeiro, Serop?dica - RJ, 2004.
url https://tede.ufrrj.br/jspui/handle/jspui/3888
dc.language.iso.fl_str_mv por
language por
dc.relation.references.por.fl_str_mv ADAIR, B.; McNEILLY, F.; McCONELL, C.D.; TODD, D.; NELSON, R.T.; McNULTY, M.S. Effects of chicken anemia agent on lymphokine production and lymphocyte transformation in experimentally infected chickens. Avian Diseases, v.35, p.783-792, 1991 (apude LUKERT & ALLAN, 1999). ALBINA, E.; TRUONG, C.; HUTET, E.; BLANCHARD, P.; CARIOLES, R.; L?HOSPITALIER, R.; MAH?, D.; ALL?E, C.; MORVAN, H.; AMENNA, N.; Le DIMNA, M.; MADEC, F.; JESTIN, A. Na experimental model for post-weaning multisystemic wasting syndrome (PMWS) in growing piglets. Journal of Comparative Pathology, v.123, p.292-303, 2001. ALLAN, G.M.; MACKIE, D.P.; Mc NAIR, J.; ADAIR, B.M.; McNULTY, M.S. Production, preliminary characterization and applications of monoclonal antibodies to porcine circovirus. Veterinary Immunology and Immunopathology, v.43, p.357-371, 1994a. ALLAN, G.M.; McNELLY, F.; FOSTER, J.C.; ADAIR, B.M. Infection of leucocyte cell cultures from different species with porcine circovirus. Veterinary Microbiology, n.41, p.267-279, 1994b. ALLAN, G.M.; PHENIX, K.V.; TODD, D.; McNULTY, M.S. Some biological and physico-chemical properties of porcine circovirus. Journal of Veterinary Medicine, n.41, p.17-26, 1994c. ALLAN, G.M.; McNEILLY, F.; CASSIDY, J.P.; REILLY, G.A.C.; ADAIR, B.; ELLIS, W.A.; McNULTY, M.S. Pathogenesis of porcine circovirus: experimental infections of colostrum deprived piglets and examination of pig foetal material. Veterinary Microbiology, n.44, p.49-64, 1995. ALLAN, G.M.; McNEILLY, F.; KENNEDY, S.; DAFT, B.; CLARKE, E.G.; ELLIS, J.A.; HAINES, D.M.; MEEHAN, B.M.; ADAIR, B.M. Isolation of porcine circovirus-like viruses from pigs with a wasting disease in the USA and Europe. Jourrnal of Veterinary Diagnostic Investigation, v.10, p.3-10, 1998. ALLAN, G.M.; KENNEDY, S.; McNEILLY, F., FOSTER, J.C.; ELLIS, J.A.; KRAKOWKA, S.J.; MEEHAN, B.M.; ADAIR, B.M. Experimental reproduction of severe wasting disease by co-infection of pigs with porcine circovirus and porcine parvovirus. Journal of Comparative Pathology, v. 121, p. 1-11, 1999a. ALLAN, G.M.; McNEILLY, F.M.; MEEHAN, B.M.; KENNEDY, S.; MACKIE, D.P.; ELLIS, J.A.; CLARK, E.G.; ESPUNA, E.; SAUBI, N.; RIERA, P.; BOETNER, A.; CHARREYRE, C.E. Isolation and characterization of circoviruses from pigs with wasting syndromes in Spain, Denmark and Northern Ireland. Veterinary Microbiology, v. 66, p. 115-123, 1999b. ALLAN, G.M.; ELLIS, J. Porcine circovirus: A review. Journal of Veterinary Diagnostic Investigation, v.12,p.3-14, 2000. ALLAN, G.M.; McNEILLY, F.; ELLIS, J.; KRAKOWKA, S.; MEEHAN, B.; McNAIR, I.; WALKER, I.; KENNEDY, S. Experimental infections of colostrum deprived with porcine circovirus 2 (PCV2) and porcine reproductive and respiratory syndrome v?rus (PRRSV) potentiates PCV2 replication. Archives of Virology, v.145, p.2421-2429, 2000a. ALLAN, G.M.; McNEILLY, F.; McNAIR, I.; CURRAN, M.D.; WALKER, I.; ELLIS, J.; KONOBY, C.; KENNEDY, S.; MEEHAN, B. Absence of evidence for porcine circovirus types 2 in cattle and humans, and lack of seroconversion or lesions in experimentally infected sheep. Archives of Virology, v.145, n.4, p.853-857, 2000b. ALLAN, G.M.; McNEILLY, F.; MEEHAN, B.; KENNEDY, S.; JOHNSTON, D.; ELLIS, J.; KRAKOWKA, S.; FOSSUM, C.; WATTRANG, E.; WALLGREN, P. Reproduction of PMWS with a 1993 Swedish isolate of PCV-2. Veterinary Record, Letters, p.225-256, 2002. BALASCH, M.; SEGAL?S, J.; ROSELI, C.; DOMINGO, M.; MANKERTZ, A.; URNIZA, A.; PLANA-DUR?N, J. Experimental inoculation of conventional pigs with tissue homogenates from pigs with post-weaning multisystemic wasting syndrome Journal of Comparative Pathology, v. 124, p.139-159, 1999. BARKER, I. K.; VAN DREUMEL, A.A.; PALMER, N. The alimentary system IN: JUBB, K.V.F.; KENNEDY, P.C.; PALMER, N. Pathology of domestic animals, 4th Ed., vol.2, San Diego: Academic Press, 1993. P.1-318. BASSAMI, M.R.; YPELLAR, I.; BERRYMAN, D.; WILCOW, G.E.; RAIDAL, S.R. Genetic diversity of beak and feather disease v?rus detected in pisittacine species in Australia. Virology, v.279, n 2, p.392-400, 2001. BENFIELD, D.A.; COLLINS, J.E.; DEE, S.A.; HALBUR, P.G.; JOO, H.S.; LAGER, K.M.; MENGELING, W.L.; MURTAUGH, M.P.; ROSSOW, K.D.; STEVENSON, G.W.; ZIMMERMAN, J.J. Porcine Reproductive and Respiratory Syndrome, In: STRAW, B.E.S.,; D?ALLAIRE, S.; MENGELING, W.L.; TAYLOR, D.J. (Eds). DISEASES of Swine, 8th Ed, Iowa State: University Press, 1999, p.201-276. BIAGINI, P. Human circoviruses. Veterinary Microbiology, v.98, p.95-101, 2004. BAGDAN, J.; WEST, K.; CLARK, E.; KONOBY, C.; HAINES, D.; ALLAN, G.M.; McNEILLY, F.; MEEHAN, B.; KRAKOWKA, S.; ELLIS, J.A. Association of porcine circovirus 2 with reproductive failure in pigs: a retrospective study. Canadian Veterinary Journal, v.42, n.7, p.548-550, 2001. BOLIN, S.R.; STOFREGEN, W.C.; NAYAR, G.P.; HAMEL, A.L. Postweaning multisystemic wasting syndrome induced after experimental inoculation of cesarean-derived, colostrum-deprived piglets with type 2 porcine circovirus. Journal of Veterinary Diagnostic Investigation, v.13, p.185-194, 2001 (apud SEGAL?S, 2003). BUKI, H.J.; TISCHER, I.; KOCH, M.A. Cloning and sequencing of the porcine circovirus PCV genome. Zentralbl. Fur Bakteriol. Mikrobiol. Hyg. Se. A, v. 260, p.465, 1985 (apud ALLAN ET AL., 1999). BUKH, H.J.; BLAD, I.; TISCHER, I. Replication of negative strand DNA of single-stranded porcine circovirus genome. In: Abstr. Joint Meeting of Sektion virologie and Virus Group of Soc. Gen. Microbiol., p.54., 1988 (apud LUKERT; ALLAN, 1999). CALSAMIGLIA, M.; SEGAL?S, J.; ROSELL, C.; DOMINGO, M. Detection of porcine circovirus types 1 and 2 in serum and tissue samples of pigs with and without postweaning wasting syndrome. Journal of Clinical Microbiology, v.40, n.5, p.1848-1850, 2002. CARIOLET, R.; BLANCHARD, P. LeDIMMA, M.; MAH?, D.; JOLLY, J.P.; BOISS?SSION, C.; TRUONG, C.; ECOBICHON, P.; MADEC, F.; JESTIN. A. Experimental infection of pregnant SPF sows with PCV2 through tracheal and muscular routes. In: Proceedings of the European Society on Veterinary Virology, PMWS, 2001a, p. 128 (apud SEGAL?S ET AL., 2004). CARIOLET, R. BLANCHARD, P.; LeDIMMA, M.; MAH?, D.; KERANFLEC?H, A.; JULOU, P.; BEAUREPAIRE, B.; DE BOISS?SON, C.; TRUONG, C.; JESTIN, A. Consequences of PCV2 experimental infection of non immune SPF sows using the intra uterine route. In: Proceedings of the European Society on Veteerinary Virology, PMWS, 2001b, p. 129. (apud SEGAL?S ET AL., 2004). CASTRO, A.M.M.G,; RUIZ, V.L.A.; CASTRO Jr, F.G.; BERSANO, J.G., MORENO, A.M., CORTEZ, A. Detec??o e diferencia??o de circov?rus su?no tipo 1 e 2 (PCV-1 e PCV-2) em su?nos nas fases de creche e crescimento/termina??o em diferentes Estados brasileiros e em su?nos do Estado de S?o Paulo. In: Congresso Brasileiro de Veterin?rios Especialistas em su?nos, 11, 2003, Goi?nia, GO. Anais... Conc?rdia: Embrapa Su?nos e Aves, 2003, p. 107-108. CELERA, V.Jr.; CARASOVA, P. First evidence of porcine circov?rus type 2 (PCV-2) infection of pigs in the Czech Republic by semi-nested PCR. Journal of Veterinary Medicine B, Infectious Disease and Veterinary Public Health, v.49, n.3, p.155-159, 2002. CHIANINI, F.; MAJ?, N.; SEGAL?S, J.; DOM?NGUEZ, M.; DOMINGO, M. Immunohistochemical characterization of PCV2 associate lesions in lymphoid and non-lymphoid tissues of pigs with natural postweaning multisystemic wasting syndrome (PMWS). Veterinary Immunology and Immunopathology, v.94, p.63-75, 2003. CHOI, C.; CHAE, C.; CLARK, E.G. Porcine postweaning multisystemic wasting syndrome in Korean pig: detection of porcine circovirus 2 infection by immunohistochemistry and polymerase chain reaction. Journal of Veterinary Diagnostic Investigation, v. 12, p. 151-153, 2000. CHOI, C.; KIM, J.; KANG, I.J.; CHAE, C. Concurrent outbreak of PMWS and PDNS in a herdo f pigs in Korea. Veterinary Record, v.151, p.484-485, 2002a. CHOI, J.; STEVENSON, G.W.; KIUPEL, M.; HARRACH, B.; ANOTHAYANONTHA, L.; KANITZ, C.L.; MITTAL, S.K. Sequence analysis of old and new strains of porcine circov?rus associated with congenital tremors in pigs and their comparison with strains involved with postweaning multisystemic wasting syndrome. Canadian Journal of Veterinary Research, v.66, p.217-224, 2002b. CLARK, E.G. Post-weaning multisystemic wasting syndrome. Proceedings of the American Association of Swine Practitioners, v.28, p.499-501, 1997. COLES, E.H. Patologia Cl?nica Veterin?ria. Editora Manole, 3a ed., S?o Paulo, Brasil, 1984, p.566. CRAWFORD, G.R. Circoviridae: new viruses of pigs, parrots and chickens. Correspondence. Australian Veterinary Journal, v.71, n.10, p.351, 1994. DARWICH, L.; SEGAL?S, J.; DOMINGO, M.; MATEU, E. Changes in CD4, CD8, CD4, CD*, and immunoglobulin M-Positive peripheral blood mononuclear cells of postweaning multisystemic wasting syndrome-affected pigs and age-matched uninfected wasted and healthy pigs correlate with lesions and Porcine Circov?rus Type 2 load in lymphoid tissues. Clin. Diag. Lab. Immunol, v.9, n.2, p.236-242, 2002. DARWICH, L.; BALASCH, M.; PLANA-DUR?N, J.; SEGAL?S, J.; DOMINGO, M.; MATEU, E. Cytokine profiles of peripheral blood mononuclear cells of pigs suffering from postweaning multisystemic wasting syndrome in response to mitogen, superantingen or recall viral antigens. Journal of General Virology, v.84, p. 3453-3457, 2003a. DARWICH, L.; PIE, S.; ROVIRA, A.; SEGAL?S, J.; DOMINGO, M.; OSWALD, I.P., MATEU, E. Cytokine mRNA expression profiles in lymphoid tissues of pigs naturally affected by postweaning multisystemic wasting syndrome. Journal of General Virology, v.84, p. 2117-2125, 2003b. DARWICH, L.; SEGAL?S, J.; MATEU, E. Pathogenesis of postweaning multisystemic wasting syndrome caused by porcine circov?rus 2: na Immune riddle. Archives of Virology, v.149, n.5, p.857-874, 2004. DAVIDSON, F.; MacDONALD, D.; MOKILI, J.L.; PRESCOTT, L.E.; GRAHAM, S.; SIMMONDS, P. Early acquisition of TT virsus (TTV) in na ?rea endermic for TTV infection. Journal of Infectious Disease, v. 179, p.1070-1076, 1999. DEGUCHI, E.; AKUZAWA, M. Effects of fighting after grouping on plasma cortisol concentration and lymphocytes blastogenesis of peripheral blood mononuclear cells induced by mitogens in piglets. Journal of Veterinary Medical Science, v.60, p.149-153, 1998. DROLET, R.; THIBAULT, S.; D?ALLAIRE, S.; THOMPSON, J.; DONE, S. Porcine dermatitis and nephropathy syndrome (PDNS): na overview of the disease. Swine Health Production, v. 6, p.283-285, 1999. DROLET, R.; D?ALLAIRE, S.; LAROCHELLE, R.; MAGAR, R.; RIBOTTA, M.; HIGGINS, R. ET AL. Infectious agents identified in pigs with multifocal intersticial nephritis at slaughter. Veterinary Record, v.150, n. 5, p.139-143, 2002. DROLET, R.; LAROCHELLE, R.; MORIN, M.; DELISLE, B.; MAGAR, R. Detection rates of porcine reproductive and respiratory syndrome v?rus, Porcine Circov?rus Type 2, and Swine Influenza V?rus in porcine proliferative and necrotizing pneumonia. Veterinary Pathology, v.40, p.143-148, 2003. DULAC, G.C.; AFSHAR, A. Porcine circovirus antigens in PK-15 cell line (ATCC CCL-33) and evidence of antibodies to circovirus in Canadian pigs. Canadian Journal of Veterinary Research., v.53, p.431-433, 1989. DUNGWORTH, D.L. The respiratory system. In: JUBB, K.V.F.; KENNEDY, P.C.; PALMER, N.(eds). Pathology of domestic animals, 4th ed, vol.2, San Diego: Academic Press, 1993, p.539-699. DURAN, C.O.; RAMOS-VARA, J.; RENDER, J.A. Porcine dermatitis and nephropathy syndrome: a new condition to include in the differential diagnosis list for skin discolouration in swine. Swine Health Production, v.5, n.6, p.241-244, 1997 (apud HARDING, 2004). EASTERDAY, B.C.; VAN REETH, K. Swine Influenza. In: STRAW B.E.; D?ALLAIRE S., MENGELING W.L., TAYLOR D.J (eds). Disease of Swine, 8th ed., Iowa State:University Press, 1999, p.277-290. EDWARDS, S.; SANDS. J.J. Evidence of circovirus infection in British pigs. Veterinary Record., v.134, p.680-681, 1994. EDWARDS, M.J.; MULLEY, R.C. Genetic, developmental and neoplastic diseases. In: STRAW, B.E., D?LLAIRE, S., MENGELING, W,L., TAYLOR, DJ. (eds.), Diseases of Swine, 8th ed, Iowa State: University Press, 1999, p.695-721 (apud SEGAL?S ET AL., 2004). ELLIS, J.A.; HASSARD, L.; CLARK, E.; HARDING, J.; ALLAN, G.M.; WILLSON, P.; STROKAPPE, J.; MARTIN, K.; McNEILLY, F.; MEEHAN, B.; TODD, D.; HAINES, D. Isolation of circovirus from lesions of pigs with postweaning multisystemic wasting syndrome. Canadian Veterinary Journal, v.39, n.1, p.44-51, 1998. ELLIS, J.A.; KONOBY, C.; WEST, K.H.; ALLAN, G.M.; KRAKOWKA, S.; McNEILLY, F.; MEEHAN, B.; WALKER, I. Lack of antibodies to porcine circovirus type 2 virus in beef and dairy cattle and horses in western Canada. Canadian Veterinary Journal, v.42, n.6, p.461-464, 2001. FARNHAM, M.W.; CHOI, Y.K.; GOYAL, S.M.; JOO, H.S. Isolation and characterization of porcine circovirus type 2 from ser? of stillborn fetuses. Canadian Journal of Veterinary Research, v. 67, p.108-113, 2003. FENAUX, M.; HALBUR, P.G.; GILL, M.; TOTH, T.E.; MENG, X,J. Genetic characterization of type 2 porcine circovirus (PCV-2) from pigs with postweaning multisystemic wasting syndrome in different geographic regions of North America and development of a differential PCR-restriction fragment Length polymorphism assay to detect and differentiate between infections with PCV-1 and PCV-2. Journal of Clinical Microbiology, v. 38, n.7, p.2494-2503, 2000. FENAUX, M.; HALBUR, P.G.; HAQSHENAS, G.; ROYER, R.; THOMAS, P.; NAWAGITGUL, P.; GILL, M.; TOTH, T.E.; MENG, X.J. Cloned genomic DNA of type 2 porcine circovirus is infectious when injected directly into the liver and lymph nodes of pigs: characterization of clinical disease, v?rus distribution, and pathologic lesions. Journal of Virology, v.76, n.2, P.541-551, 2002. FERNANDES, L.T.; CIACCI-ZANELLA, J.R.; SCHIOCHET, M.F.; TROMBETTA, C. Estudo da permissibilidade de linhagens de cultivo celular ? infec??o por circovirus su?no tipo 1(PCV2). In: Congresso Brasileiro de Veterin?rios Especialistas em Su?nos, 11, 2003?, Goi?nia, GO. Anais... Conc?rdia: Embrapa Su?nos e Aves, 2003a, p.91-92. FERNANDES, L.T.; CIACCI-ZANELLA, J.R.; TROMBETTA, C.; SCHIOCHET, M.F.; KRAMER, B. Estudo da transmiss?o horizontal de circov?rus su?no tipo 2 (PCV2) entre su?nos. In: Congresso Brasileiro de Veterin?rios Especialistas em Su?nos, 11, 2003b, Goi?nia, GO. Anais... Conc?rdia: Embrapa Su?nos e Aves, 2003b, p. 93-94. FERNANDES, L.T.; CIACCI-ZANELLA, J.R.; TROMBETTA, C.; SOBESTIANSKY, J.; OLIVEIRA, S.; BRITO, L.A.B. Avalia??o da patogenicidade do circov?rus su?no tipo 2 (PCV2) isolado no Estado de Santa Catarina atrav?s de coinfec??o experimental com parvov?rus su?no. In: Congresso Brasileiro de Veterin?rios Especialistas em su?nos, 11, 2003c, Goi?nia, GO. Anais... Conc?rdia: Embrapa de Su?nos e Aves, 2003c, p. 89-90. GALLIAN, P.; BIAGINI, P.; ATTOUI, H.; CANTALOUBE, J.F.; DUSSOL, B.; BERLAND, Y.; MICCO, P.; LAMBALLERIE, X. High genetic diversity revealed by the study of TLMV infection in French hemodialysis patiente. Journal of Medical Virology, v.67, n.4, p.630-635, 2002. GILPIN, D.F.; STEVENSON, L.S.; McCULLOUGH, K.; KRAKOWKA, S.; MEEHAN, B.M.; McNEILLY, F.; FOSTER, J.C.; ADAIR, B.; WELSH, M.; ALLAN, G.M. Studies on the in vitro in vivo effect of porcine circovirus type 2 infection of porcine monocytic cells. In: Proc. ssDNA viruses of plants, birds, pigs and primates, 2001, Saint-Malo, ZOOPOLE developpement (ISPAIA), Frances, 2001, p.97. GILPIN, D.F.; McCULH, K.; MEEHAN, B.M.; McNELLY, F.; McNAIR, I.; STEVENSON, L.S.; FOSTER, J.D.; ELLIS, J.A.; KRAKOWKA, S.; ADAIR, B.M.; ALLAN, G.M. In vitro studies on the infection and replication of porcine circov?rus type 2 in cells of the porcine immune system. Veterinary Immunology and Immunopathology, v.94, p.149-161, 2003. GIRARD, C.; MORIN, M.; ELAZHARY, Y. Experimentally induced porcine proliferative and necrotizing pneumonia. Veterinary Record, v.130, p.206-207, 1992 (apud HARDING, 2004). GRESHAM, A.; GILES, N.; WEAVER, J. PMWS and porcine dermatitis nephropathy syndrome in Great Britain. Veterinary Record., v. 147, p.115, 2000 (apud HARDDING, 2004). HAMEL, A.L.; LIN, L.L.; NAYAR, G.P.S. Nucleotide Sequence of Porcine Circov?rus associated with postweaning multisystemic wasting syndrome in pigs. Journal of Virology, v.6, n.72, p.5262-5267, 1998. HARDING, J.C.S. Post-weaning multisystemic wasting syndrome (PMWS): preliminary epidemiology and clinical presentation. Proceedings of the American Association of Swine Practitioners, 28th Annual MEETING, 1997, Quebec City, Canada, 1997, p.503. HARDING, J.C.S.; CLARK, E.G.; STROKAPPE. J.H.; WILLSON, P.I.; ELLIS, J.A. Postweaning multisystemic wasting syndrome: Epidemiological and clinical presentation. Swine Health Production, v.6, p.249-254, 1998. HARDING, J.C.S. The clinical expression and emergence of porcine circov?rus 2. Veterinary Microbiology, v. 98, n.2, p.131-135, 2004. HARMS, P.A.; SORDEN, S.D. Porcine circovirus-associated pneumonia. In: Proceedings of the 16th IPVS on PMWS: a new emerging disease of swine, 2000, p.33-37 (apud SEGAL?S et al., 2004). HARMS, P.A.; SORDEN, S.D.; HALBUR, P.G.; BOLIN, S.R. LAGER, K.M.; MOROZOV, I.; PAUL, P.S. Experimental reproduction of severe disease in CD/CD pigs concurrently infected with type 2 porcine circov?rus and porcine reproductive and respiratory syndrome v?rus. Veterinary Pathology, v.38, n.5, p.528-539, 2001. HINES, R.K. Porcine circov?rus as a cause of congenital tremors Type A-II proved by fulfilling Koch?s postulates. Ph.D. diss., Univ. Georgia, 1994 (apud LUKERT & ALLAN, 1999). HINES, R.K.; LUKERT, P.D. Porcine circov?rus as a cause congenital tremors in newbom pigs. In: Proceedings American Association of Swine Practitioners, 1994, Chicago, USA, 1994, p.344-345. HINES, R.K.; LUKERT, P.D. Porcine circov?rus: A serological survey of swine in the United States. Swine Health and Production, v.3, n.2, p.71-73, 1995. HINES, R.K.; LUKERT, P.D.; DAU, D.; CASE, D. Some effects of porcine circov?rus on performance. Swine Health and Production, v.3, n.6, p.251-255, 1995. HIRAI, T.; NUNOYA, T.; IHARA, T.; KUSANAGI, K.; SHIBUYA, K. Dual infection with PCV-2 and porcine epidemic diarrhea v?rus in neonatal piglets. Veterinary Record, v. 148, p.482-484, 2001. HORNER, G.W. Pig circovirus antibodies present in New Zealand pigs. Surveillance Wellington, v.18, n.5, p.23, 1991. ISSO, K.; SUZUKI, Y.; TAKAYAMA, M. Mother-to-infant transmission of TT v?rus in Japan. Int. J. Gynaecol. Obstet., v.75, p.11-19, 2001. JANKE, B. Case report: porcine circov?rus as a cause of reproductive problems. In: Proceedings of the Iowa Veterinary Medicine Association, 2000, Iowa, USA, 2000, p.101 (apud HARDING, 2004). JOLIE, R.; RUNNELS, P.; McGAVIN, D. Post-weaning multisystemic wasting syndrome in a group of caesarian derived colostrums deprived pigs. In Proceedings of the 16th International Pig Veterinary Society Congress, 2000. KENNEDY, S.; SEGAL?S, J.; ROVIRA, A.; SCHOLES, S.; DOMINGO, M.; MOFFETT, D.; MEEHAN, B.; O?NEILL, R.; McNEILLY, F.; ALLAN, G.M. Absence of evidence of porcine circov?rus infection in piglets with congenital tremors. Journal of Veterinary Diagnostic Investigation, v.15, n.2, p.151-156, 2003. KIATIPATTANASAKUL-BANLUNARA, W.; TANTILERTCHAROEN, R; SUZUKI, K.; ALBARENQUE, S.M.; THANAWONGNUWECH, R.; NAKAYAMA, H.; DOI, K. Detection of porcine circov?rus 2 (PCV-2) DNA by nested PCR from formalina-fixed tissues of post-weaning multisystemic wasting syndrome (PMWS) pigs in Thailand. Journal of Veterinary Medical Science, v.64, n.5, p.449-452, 2002. KIM, J; HAN, D.U.; CHOI, C.; CHAE, C. Differentiation of porcine circov?rus PCV-1 and PCV-2 in boar s?men using a multiplex nested polymerase chain reaction. Journal of Virological Methods, v.98, n.1, p.25-32, 2001. KIM, J.; CHAE, C. Simultaneos detection of porcine circov?rus 2 and porcine parvov?rus in naturally and experimentally coinfected pigs by Double in situ hybridization. Journal of Veterinary Diagnostic Investigation, v.14, n..3, p.236-240, 2002. KIM, J.; CHUNG, H.K.; JUNG, T.; CHO, W.S.; CHOI, C.; CHAE, C.; Postweaning multisystemic wasting syndrome of pigs in Korea: prevalence, microscopic lesions and coexisting microorganisms. Journal of Veterinary Medical Science, v.64, n.1, p.57-62, 2002. KIM, J.; CHAE, C. A comparison of the lymphocyte subpopulations of pigs experimentally infected with porcine circov?rus 2 and or parvov?rus. Veterinary Journal, v.165, p.325-329, 2003a. KIM, J.CHAE, C. Expression of monocyte chemoattactan protein-1 but not interleukin-8 in granulomatous lesions in lymph nodes from pigs with naturally occurring postweaning multisystemic wasting syndrome. Veterinary Pathology, v.40, p.181-186, 2003b. KIM, J.; CHAE, C. Optimal enhancement of in situ hybridization for the detection of porcine circov?rus 2 in formalin-fixed, paraffin-wax-embedded tissues using a combined pretreatment of thermocycler and proteinase K. Research in Veterinary Science, v.74, p.235-240, 2003c. KIM, J.; CHOI, C.; CHAE, C. Pathogenesis of postweaning multisystemic wasting syndrome reproduced by co-infection with Korean isolates of porcine circov?rus 2 and porcine parvov?rus. Journal of Comparative Pathology., v.128, p.52-59, 2003a. KIM, J.; CHUNG, H.K.; CHAE, C. Association of porcine circov?rus 2 with porcine respiratory disease complex. Veterinary Journal, v. 166, n.3, p. 251-256, 2003b. KIM, J.; CHAE, C. Concurrent presence of porcine circov?rus type 2 and porcine parvov?rus in retrospective cases of exsudative epidermitis in pigs. Veterinary Journal, v.167, p.104-106, 2004. KIUPEL, M.; STEVENSON, G.W.; MITTAL, SLK.; CLARK, E.G.; HAINES, D.M. Circov?rus-like Viral Associated Disease in Weaned Pigs in Indiana. Veterinary Pathology, v.35, p.303-307, 1998. KRAKOWKA, S. ELLIS, J.A.; MEEHAN, B.; KENNEDY, S.; McNEILLY, F.; ALLAN, G.M. Viral wasting syndrome of swine: experimental reproduction of PMWS in gnotobiotics swine by co-infection with porcine circov?rus-2 (PCV-2) and porcine parvov?rus (PPV). Veterinary Pathology, v.37, p.254-263, 2000. KRAKOWKA, S.; ELLIS, J.A.; McNEILLY, F.; RINGLER, S.; RINGS, D.M.; ALLAN, G. Activation of the immune system is the pivotal event in the production of wasting disease in pigs infected with porcine circov?rus-2 (PCV-2). Veterinary Pathology, v. 38, p.31-42, 2001. KYRIAKIS, S.C.; SAOULIDIS, K.; LEKKAS, S.; MILIOTIS Ch.C.; PAPOUTSIS, P.A.; KENNEDY, S. The effects of immuno-modulation on the clinical and pathological expression of postweaning multisystemic wasting syndrome . Journal of Comparative Pathology, v.126, p.38-46, 2002. LADEKJAER-MIKKELSEN, A.; NIELSEN J.; STORGAARD, T.; BETNER, A.; ALLAN, G.M.; McNEILLY, F. Transplacental infection with PCV-2 associat with reproductive failure in a gilt. Veterinary Record, Letters, p. 759-760, 2001. LADEKJAER-MIKKELSEN, A.; NIELSEN, J.; STADEJEK, T.; STORGAARD, T.; KRAKOWKA, S.; ELLIS, J.; McNEILLY, F.; ALLAN, G.M. BOTNER, A. Reproduction of postweaning multisystemic wasting syndrome (PMWS) in immunostimulated and non-immunostimulated 3-week-old piglets experimentally infected with porcine cirvocirus type 2 (PCV2). Veterinary Microbiology, v.89, n.2-3, p.97, 2002. LAMAR, C.H. Characterizacion of peculiar cellular structures in the spinal corda of pigs affected with myoclonia cong?nita. 1971. West Lafayete, Purdue Univ., M.S.. thesis, 1971. LAROCHELLE, R.; SAUVAGEAU, R.; MAGAR, R. Immunohistochemical detection of swine influenza v?rus and porcine reproductive and respiratory syndrome in porcine proliferative and necrotizing pneumonia cases from Quebec. Canadian Veterinary Journal, v.35, p.513-525, 1994. LAROCHELLE, R.; MORIN, M.; ANTAYA, M.; MAGAR, R. Identification and incidence of porcine circov?rus in routine Field cases in Quebec as determined by PCR. Veterinary Record, v.145, p.140-142, 1999. LAROCHELLE, R.; BIELANSKI, A.; MULLER, P.; MAGAR, R. PCR detection and evidence of shedding of porcine circov?rus type 2 in boars s?men. Journal of Clinical Microbiology, v. 38, p.4629-4632, 2000. LAROCHELLE, R.; MAGAR, R.; D?ALLAIRE, S. Comparative serologic and virologic study of commercial swine herds with and without postweaning multisystemic wasting syndrome. Canadian Journal of Veterinary Research, v. 67, p.114-120, 2003. LATIMER, K.S.; STEFFENS, W.L.; RAKICH, P.M.; NIAGRO, F.D.; KIRCHER, I.M.; LUKERT, P.D. Cryptosporidiosis in four cockatoos with psittacine beak and feather disease. J. Am. Vet. Assoc.; v.5, p.707-710, 1992 (apud LUKERT; ALLAN, 1999). LE TALLEC, B.; POZZI, N.; BLANCHARD, P.; MAH?, D.; JESTIN, A.; GU?RIN, B. Longitudinal study of boars naturally infected by PCV2. In: Proceedings of the European Society on Veterinary Virology, PMWS, 2001, p.120 (apud SEGAL?S et al., 2004). LIN, C.L.; KYONO, W.; TONGSON, J.; CHUA, P.K.; EASA, D. YANAGIHARA, R., NERURKAR, V.R. Fecal excretion of a novel human circov?rus, TT v?rus, in healthy children. Clin. Lab. Imunol, v.7, p.960-963, 2000. LIU, Q.; WANG, L.; WILLSON, P.; O?CONNOR, B.; KEENLISIDE, J.; CHIRINOTREJO, M.; MELENDEZ, R.; BABIUK, L. Seroprevalence of porcine circov?rus type 2 in swine populations in Canada and Costa Rica. Canadian Journal of Veterinary Research, v.66, p.225-231, 2002. LOULA, T. Mystery pig disease. Agri-practice, v. 12, p.23-24, 1991 (apud BENEFIELD et al, 1999). LUKERT, P.; DE BOER, G.F.; DALE, J.L.; KEESE, P.; MCNULTY, M.S.; RANDLES, J.W.; TISCHER, I. Family Circoviridae. In: MURPHY, F. A.; FAUQUET, C.M.; BISHOP, D.H.L.; GHABRIAL, S.A.; JARVIS, A.W,; MARTELLI, G.P.; MAYO, M.A.; SUMMERS, M.D. Virus Taxonomy. Classification and Nomenclature of Viruses, 1995, New York: Sixth Reporto f the International Commitee on Taxonomy of Viruses, 1995, p. 166-168. LUKERT, P.D.; ALLAN, G.M. Porcine Circovirus. In: STRAW, B.E.; D?ALLAIRE, S.; MENGELING, W.L.; TAYLOR, D.J (eds). Disease of Swine, 8th ed., Iowa State: University Press, 1999, p.119-124. MADEC, F.; EVENO, E.; MORVAN, P.; HAMON, L.; BLANCHARD, P.; CARIOLET, R.; AMENNA, N.; MORVAN, H.; TRUONG, C.; MAH?, D.; ALBINA, E..; JESTIn, A. Post-weaning multisystemic wasting syndrome (PMWS) in pigs in France: clinical observations from follow-up studies on affected farms. Livestock Production Science, v.63, p.223-233, 2000. MAES, D. Descriptive epidemiological aspects of the seroprevalence of Five respiratory disease agents in slaughter pigs from fattening herds. Epidemiol. Sant? Anim., v.31, p.31-32, 1997 (apud BENFIELD et al., 1999). MAGAR, R. et al. Immunohistochemical detection of porcine reproductive and respiratory syndrome v?rus using colloidal gold. Canadian Journal of Veterinary Research., v.57, p.300-304, 1993. MAGAR, R.; CARMAN, S.; THOMSON, G.; LAROCHELLE, R. Porcine reproductive and respiratory syndrome v?rus identification in proliferative and necrotizing pneumonia cases from Ontario. Canadian Veterinary Journal, v. 35, p.523-524, 1994. MAGAR, R.; ROBINSON, Y.; DUBUC, C.; LAROCHELLE, R. Isolation and experimental oral transmission in pigs of a porcine reproductive and respiratory syndrome v?rus isolate. In: TALBOT, P.J.; LEVY, G.A. (eds). Corona and Related Viruses, New York: Plenum Press, 1995, p.139-144. MAGAR, R.; LAROCHELLE, R.; THIBAULT, S.; LAMONTAGNE, L. Experimental transmission of porcine circovirus type 2 (PCV2) in weaned pigs: a sequential study. Journal of Comparative Pathology, v.123, n.4, p.258-269, 2000. McNEILLY, F.; ALLAN, G.M.; FOSTER, J.C.; ADAIR, B.M.; McNULTY, M.S. Effect of porcine circovirus infection on porcine alveolar macrophages function. Veterinary Immunology and Immunopathology, v. 49, n.4, p.295-306, 1996. McNEILLY, F.; KENNEDY, S.; MOFFETT, D.; MEEHAN, B.M.; FOSTER, J.C.; CLARKE, E.G.; ELLIS, J.A.; HAINES, D.M.; ADAIR, B.M.; ALLAN, G.M. A comparison of in situ hybridization and immunohistochemistry for the detection of a new porcine circovirus in formalin-fixed tissues from pigs with post-weaning multisystemic wasting syndrome (PMWS). Journal of Virological Methods, v.80, n.2, p.123-128, 1999. MEEHAN, B.M.; CREELAN, J.L.; McNULTY, M.S.; TODD, D. Sequence of porcine circovirus DNA: affinities with plant circoviruses. Journal of General Virology, v.78, p.221-227, 1997 (apud ALLAN et al. 1999). MEEHAN, B.M.; McNEILLY, F..; TODD, D.; KENNEDY, S.; JEWHURST, V.A.; ELLIS, J.A.; HASSARD, L.E.; CLARK, E.G.; HAINES, D.M.; ALLAN, G.M. Characterization of novel circovirus DNAs associated with wasting syndromes in pigs. Journal of General Virology, v.79, p.2171-2179, 1998. MOEN, E.M.; HUANG, L.; GRINDE, B. Molecular epidemilogy of TTV-like mini v?rus in Norway. Archives of Virology, v.147, n.1, p.181-185, 2002. MOLNAR, T.; GLAVITS, R.; SZEREDI, L.; DAN, A. Occurrence of porcine dermatitis and nephropaty syndrome in Hungary. Acta Vet. Hung., v.50, n.1, p.5-16, 2002. MORENO, A.M.; CASTRO, A.M.M.G.; PAIX?O, R.; CORTEZ, A.; DOTO, D.S.; LEOMIL, H.; BACCARO, M.R.; RICHTZENHAIN, L.J. Associa??o entre circov?rus su?no tipo 2 e as doen?as respirat?rias no Brasil. In: Congresso Brasileiro de Veterin?rios Especialistas em su?nos, 11, 2003, Goi?nia, GO. Anais... Conc?rdia: Embrapa de Su?nos e Aves, 2003, p. 101-102. MORI, M.; SATO, K.; AKACHI, A.; ASAHI, S.; TANIGUCHI, S.; NARITA, M. Retrospective study of porcine circov?rus 2 infection in Japan: seven cases in 1989. Veterinary Pathology, v.37, n.6, p.667-669, 2000. MORIN, M.; GIRARD, C.; ELAZHARY, Y.; FAJARDO, R.; DROLET, R.; LAGAC?; A. Severe proliferative and necrotizing pneumonia in pigs: a newly recognized disease. Canadian Veterinary Journal, v.31, p.837-839, 1990. MOROZOV, I.; SIRINARUMITR, T.; SORDEN, S.D.; HALBUR, P.G.; MORGAN, M.K.; YOON, K-J.; PAUL, P.S. Detection of a novel strain of porcine circov?rus in pigs with postweaning multisystemic wasting syndrome. Journal of Clinical Microbiology, v.36, n.9, p.2535-2541, 1998. NAWAGITGUL., P.; MOROZOV, I.; BOLIN, S.R.; HARMS, P.A.; SORDEN, S.D.; PAUL. P.S. Open reading frame 2 of porcine circov?rus type 2 encodes a major capsid protein. Journal of General Virology, v.81, p.2281-2287, 2000. NIELSEN, J.; VINCENT, I.E.; BOTNER, A.; LADEKJAER-MIKKELSEN, A.S.; ALLAN, G.M.; SUMMERFIELD.,
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Universidade Federal Rural do Rio de Janeiro
dc.publisher.program.fl_str_mv Programa de P?s-Gradua??o em Ci?ncias Veterin?rias
dc.publisher.initials.fl_str_mv UFRRJ
dc.publisher.country.fl_str_mv Brasil
dc.publisher.department.fl_str_mv Instituto de Veterin?ria
publisher.none.fl_str_mv Universidade Federal Rural do Rio de Janeiro
dc.source.none.fl_str_mv reponame:Biblioteca Digital de Teses e Dissertações da UFRRJ
instname:Universidade Federal Rural do Rio de Janeiro (UFRRJ)
instacron:UFRRJ
instname_str Universidade Federal Rural do Rio de Janeiro (UFRRJ)
instacron_str UFRRJ
institution UFRRJ
reponame_str Biblioteca Digital de Teses e Dissertações da UFRRJ
collection Biblioteca Digital de Teses e Dissertações da UFRRJ
bitstream.url.fl_str_mv http://localhost:8080/tede/bitstream/jspui/3888/4/2004+-+Ticiana+do+Nascimento+Fran%C3%A7a.pdf.jpg
http://localhost:8080/tede/bitstream/jspui/3888/7/2004+-+Ticiana+do+Nascimento+Fran%C3%A7a+.pdf.jpg
http://localhost:8080/tede/bitstream/jspui/3888/3/2004+-+Ticiana+do+Nascimento+Fran%C3%A7a.pdf.txt
http://localhost:8080/tede/bitstream/jspui/3888/6/2004+-+Ticiana+do+Nascimento+Fran%C3%A7a+.pdf.txt
http://localhost:8080/tede/bitstream/jspui/3888/5/2004+-+Ticiana+do+Nascimento+Fran%C3%A7a+.pdf
http://localhost:8080/tede/bitstream/jspui/3888/1/license.txt
bitstream.checksum.fl_str_mv b96caebab2dee19d6e966d149a99fce2
3c1153152f7f35a1e361483e99dec7a1
0a97b6090fc8bc3f8bd94170ac5d0e6f
71b976e39d49b906a0328cbfe32de260
755dba3b504ec8aa5bdee20779a9ca6a
7b5ba3d2445355f386edab96125d42b7
bitstream.checksumAlgorithm.fl_str_mv MD5
MD5
MD5
MD5
MD5
MD5
repository.name.fl_str_mv Biblioteca Digital de Teses e Dissertações da UFRRJ - Universidade Federal Rural do Rio de Janeiro (UFRRJ)
repository.mail.fl_str_mv bibliot@ufrrj.br||bibliot@ufrrj.br
_version_ 1797220321061765120

Registros relacionados