Doen?a do armazenamento lisossomal induzida por Sida planicaulis Cav. (Malvaceae) em ovinos no Estado do Rio de Janeiro

Detalhes bibliográficos
Ano de defesa: 2018
Autor(a) principal: Santos, Andr? Marandola dos lattes
Orientador(a): Fran?a, Ticiana do Nascimento lattes
Banca de defesa: Carvalho, Vivian de Assun??o Nogueira, Nascimento, Aparecida Alves do, Helayel, Michel Jos? Sales Abdalla, Brust, Luis Armando Calv?o
Tipo de documento: Tese
Tipo de acesso: Acesso aberto
Idioma: por
Instituição de defesa: Universidade Federal Rural do Rio de Janeiro
Programa de Pós-Graduação: Programa de P?s-Gradua??o em Medicina Veterin?ria (Patologia e Ci?ncias Cl?nicas)
Departamento: Instituto de Veterin?ria
País: Brasil
Palavras-chave em Português:
Armazenamento
swainsonina
lectinas
Palavras-chave em Inglês:
Storage
swainsonin
lectins
Área do conhecimento CNPq:
Medicina Veterin?ria
Link de acesso: https://tede.ufrrj.br/jspui/handle/jspui/4495
Resumo: This paper describes an outbreak of lysosomal storage disease in sheep induced by Sida planicaulis in the state of Rio de Janeiro. The consumption of S. planicaulis is responsible for this disease in cattle, horses, goat, sheep and captive deer, which occurs naturally, when the plant is abundant and there is shortage of other forage. The main toxic compound in this plant, Swainsonine, inhibits ?-manosidasis I e II enzymatic activitiy and causes glycoprotein storage in lysosomes. The storage provokes compression, deficiency in intracytoplasmatic transport, and finally, degenerative changes in various tissues, in which, nervous system is the most affected. Physical examination of the affected animals revealed proprioceptive d?ficit, motor incoordination, staggers and, neck and head intention tremors. ?Head-Raising Test? showed marked increase of head and limb tremors, with sequential difficulty in balance and tumble. Histopathology revealed severe distension of Purkinje cells, with foamy appearance, which eventually progressed to karyolysis and pyknosis, and intense vacuolization of pancreatic acinar and thyroid follicular cells. Additionally, there was vacuolization in neuronal bodies with dissolution of cytoplasm associated with marked proliferation of morphologically atypical astrocytes. Multiple axonal spheroids of variable sizes were noted. Positive reaction in lectin-histochemistry for lectins Con A, WGA, and sWGA was able to characterize the disease as a glycoproteinosis. Ultrastructural evaluation of pancreas sections evidenced numerous vacuoles up to 2,5?m in diameter, circled by 20nm wide membranes in acinar cells. In the present report, diagnosis of S. planicaulis toxicosis was established by epidemiological data, clinical and pathological findings, and confirmed by lectin-histochemistry and ultrastructural evaluation. Natural toxicosis in sheep by Sida planicaulis has not yet been described in the state of Rio de Janeiro.
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spelling Fran?a, Ticiana do Nascimento027897197-05http://lattes.cnpq.br/3545873525091315Peixoto, Paulo VargasArmi?n, An?bal GuillermoCarvalho, Vivian de Assun??o NogueiraNascimento, Aparecida Alves doHelayel, Michel Jos? Sales AbdallaBrust, Luis Armando Calv?o136187587-90http://lattes.cnpq.br/1341170071765519Santos, Andr? Marandola dos2021-03-31T02:14:22Z2018-05-04Santos, Andr? Marandola dos. Doen?a do armazenamento lisossomal induzida por Sida planicaulis Cav. (Malvaceae) em ovinos no Estado do Rio de Janeiro. 2018. [73 f.]. Tese( Programa de P?s-Gradua??o em Medicina Veterin?ria (Patologia e Ci?ncias Cl?nicas) - Universidade Federal Rural do Rio de Janeiro, [Serop?dica - RJ] .https://tede.ufrrj.br/jspui/handle/jspui/4495This paper describes an outbreak of lysosomal storage disease in sheep induced by Sida planicaulis in the state of Rio de Janeiro. The consumption of S. planicaulis is responsible for this disease in cattle, horses, goat, sheep and captive deer, which occurs naturally, when the plant is abundant and there is shortage of other forage. The main toxic compound in this plant, Swainsonine, inhibits ?-manosidasis I e II enzymatic activitiy and causes glycoprotein storage in lysosomes. The storage provokes compression, deficiency in intracytoplasmatic transport, and finally, degenerative changes in various tissues, in which, nervous system is the most affected. Physical examination of the affected animals revealed proprioceptive d?ficit, motor incoordination, staggers and, neck and head intention tremors. ?Head-Raising Test? showed marked increase of head and limb tremors, with sequential difficulty in balance and tumble. Histopathology revealed severe distension of Purkinje cells, with foamy appearance, which eventually progressed to karyolysis and pyknosis, and intense vacuolization of pancreatic acinar and thyroid follicular cells. Additionally, there was vacuolization in neuronal bodies with dissolution of cytoplasm associated with marked proliferation of morphologically atypical astrocytes. Multiple axonal spheroids of variable sizes were noted. Positive reaction in lectin-histochemistry for lectins Con A, WGA, and sWGA was able to characterize the disease as a glycoproteinosis. Ultrastructural evaluation of pancreas sections evidenced numerous vacuoles up to 2,5?m in diameter, circled by 20nm wide membranes in acinar cells. In the present report, diagnosis of S. planicaulis toxicosis was established by epidemiological data, clinical and pathological findings, and confirmed by lectin-histochemistry and ultrastructural evaluation. Natural toxicosis in sheep by Sida planicaulis has not yet been described in the state of Rio de Janeiro.Descreve-se um surto de doen?a do armazenamento lisossomal em ovinos induzida pelo consumo de Sida planicaulis no Estado do Rio de Janeiro. A ingest?o de S. planicaulis Cav. (S. carpinifolia) ? respons?vel pelo aparecimento desta enfermidade em bovinos, equinos, caprinos, ovinos e cerv?deos cativos que ocorre, de forma natural, quando a planta predomina na pastagem e h? baixa oferta de outras forragens. O principal composto t?xico desta planta, a swainsonina, inibe atividade enzim?tica de ?-manosidase I e II que redunda no armazenamento de glicoprote?nas no interior de lisossomos. Este ac?mulo de subst?ncias promove compress?o, defici?ncia no transporte intracitoplasm?tico e finalmente degenera??o em diversos tecidos, dentre os quais o mais afetado ? o nervoso. O exame f?sico dos animais afetados revelou d?ficit proprioceptivo, incoordena??o motora, cambaleio ? movimenta??o e tremores de inten??o e na cabe?a. Houve aumento acentuado dos tremores em cabe?a e membros, com posterior dificuldade de se manter em esta??o e queda ao solo ap?s a realiza??o do ?Head-Raising Test?. A histopatologia evidenciou severa distens?o de neur?nios de Purkinje, com aspecto espumoso e eventual cari?lise ou cariopicnose e intensa vacuoliza??o de c?lulas acinares do p?ncreas e foliculares da tireoide. Adicionalmente, foram observadas vacuoliza??es em grandes corpos de neur?nios com dissolu??o do citoplasma associada ? marcada prolifera??o de astr?citos morfologicamente at?picos. Notou-se tamb?m m?ltiplos esferoides axonais de variados tamanhos. O exame lectino-histoqu?mico positivo para as lectinas Con A, WGA e sWGA foi capaz de caracterizar a enfermidade como uma glicoproteinose. A avalia??o ultraestrutural evidenciou numerosos vac?olos de at? 2,5?m de di?metro, delimitados por membranas de at? 20nm de espessura em c?lulas acinares do p?ncreas. O diagn?stico da intoxica??o por S. planicaulis foi estabelecido atrav?s dos dados epidemiol?gicos, achados cl?nico-patol?gicos e confirmados pelas avalia??es lectino-histoqu?mica e ultraestrutural. A intoxica??o natural por S. planicaulis em ovinos ainda n?o havia sido descrita no estado do Rio de Janeiro.Submitted by Sandra Pereira (srpereira@ufrrj.br) on 2021-03-31T02:14:22Z No. of bitstreams: 1 2018 - Andr? Marandola dos Santos.pdf: 5037218 bytes, checksum: de6ef5cac55ba2c3d0510540e603f3aa (MD5)Made available in DSpace on 2021-03-31T02:14:22Z (GMT). No. of bitstreams: 1 2018 - Andr? Marandola dos Santos.pdf: 5037218 bytes, checksum: de6ef5cac55ba2c3d0510540e603f3aa (MD5) Previous issue date: 2018-05-04Coordena??o de Aperfei?oamento de Pessoal de N?vel Superior, CAPES, Brasil.application/pdfhttps://tede.ufrrj.br/retrieve/64453/2018%20-%20Andr%c3%a9%20Marandola%20dos%20Santos.pdf.jpgporUniversidade Federal Rural do Rio de JaneiroPrograma de P?s-Gradua??o em Medicina Veterin?ria (Patologia e Ci?ncias Cl?nicas)UFRRJBrasilInstituto de Veterin?riaABREU, S.; HAYDEN, J.; BERTHOLD, P.; SHAPIRO, I. M.; DECKER, S.; PATTERSON, D.; HASKINS, M.; Growth plate pathology in feline mucopolysaccharidosis VI. Calcified Tissue International, v. 57, n. 3, p. 185-190, 1995. ALROY, J. ORGAD, U.; UCCI, A. A.; PEREIRA, M. E. Identification of glycoprotein storage diseases by lectins: a new diagnostic method. Journal of Histochemistry & Cytochemistry, v. 32, n. 12, p. 1280-1284, 1984. ALROY, J.; ORGAD, U.; UCCI, A. A.; GAVRIS, V. E. 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Repeated administrations of human umbilical cord blood cells improve disease outcomes in a mouse model of Sanfilippo syndrome type III B. Cell Transplantation, v. 23, n. 12, p. 1613-1630, 2014. WINCHESTER, B.; VELLODI, A.; YOUNG, E. The molecular basis of lysosomal storage diseases and their treatment. Biochemical Society Transactions, v. 28, parte 2, p. 150-154, 2000. XU, M.; MOTABAR, O.; FERRER, M.; MARUGAN, J. J.; ZHENG, W.; OTTINGER, E. A. Disease models for the development of therapies for lysosomal storage diseases. Annals of the New York Academy of Sciences, v. 1371, n. 1, p. 15-29, 2016. YOGALINGAM, G.; POLLARD, T.; GLIDDON, B.; JOLLY, R. D.; HOPWOOD, J. J. Identification of a mutation causing mucopolysaccharidosis type IIIA in New Zealand Huntaway dogs. Genomics, v. 79, n. 2, p. 150-153, 2002. YUZIUK, J. A.; BERTONI, C.; BECCARI, T.; ORLACCHIO, A.; WU, Y.; LI, S.; LI, Y. Specificity of Mouse GM2 Activator Protein and ?-N-Acetylhexosaminidases A and B - Similarities and differences with their human counterparts in the catabolism of GM2. Journal of Biological Chemistry, v. 273, n. 1, p. 66-72, 1998. 73 ZACHARY, J. F. Pathologic Basis of Veterinary Disease-E-Book. Elsevier Health Sciences, 6a ed. 1318p. 2016.ArmazenamentoswainsoninalectinasStorageswainsoninlectinsMedicina Veterin?riaDoen?a do armazenamento lisossomal induzida por Sida planicaulis Cav. (Malvaceae) em ovinos no Estado do Rio de JaneiroLysosomal storage disease induced by Sida planicaulis Cav. (Malvaceae) in sheep in the state of Rio de Janeiroinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/doctoralThesisinfo:eu-repo/semantics/openAccessreponame:Biblioteca Digital de Teses e Dissertações da UFRRJinstname:Universidade Federal Rural do Rio de Janeiro (UFRRJ)instacron:UFRRJTHUMBNAIL2018 - Andr? Marandola dos Santos.pdf.jpg2018 - Andr? 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dc.title.por.fl_str_mv Doen?a do armazenamento lisossomal induzida por Sida planicaulis Cav. (Malvaceae) em ovinos no Estado do Rio de Janeiro
dc.title.alternative.eng.fl_str_mv Lysosomal storage disease induced by Sida planicaulis Cav. (Malvaceae) in sheep in the state of Rio de Janeiro
title Doen?a do armazenamento lisossomal induzida por Sida planicaulis Cav. (Malvaceae) em ovinos no Estado do Rio de Janeiro
spellingShingle Doen?a do armazenamento lisossomal induzida por Sida planicaulis Cav. (Malvaceae) em ovinos no Estado do Rio de Janeiro
Santos, Andr? Marandola dos
Armazenamento
swainsonina
lectinas
Storage
swainsonin
lectins
Medicina Veterin?ria
title_short Doen?a do armazenamento lisossomal induzida por Sida planicaulis Cav. (Malvaceae) em ovinos no Estado do Rio de Janeiro
title_full Doen?a do armazenamento lisossomal induzida por Sida planicaulis Cav. (Malvaceae) em ovinos no Estado do Rio de Janeiro
title_fullStr Doen?a do armazenamento lisossomal induzida por Sida planicaulis Cav. (Malvaceae) em ovinos no Estado do Rio de Janeiro
title_full_unstemmed Doen?a do armazenamento lisossomal induzida por Sida planicaulis Cav. (Malvaceae) em ovinos no Estado do Rio de Janeiro
title_sort Doen?a do armazenamento lisossomal induzida por Sida planicaulis Cav. (Malvaceae) em ovinos no Estado do Rio de Janeiro
author Santos, Andr? Marandola dos
author_facet Santos, Andr? Marandola dos
author_role author
dc.contributor.advisor1.fl_str_mv Fran?a, Ticiana do Nascimento
dc.contributor.advisor1ID.fl_str_mv 027897197-05
dc.contributor.advisor1Lattes.fl_str_mv http://lattes.cnpq.br/3545873525091315
dc.contributor.advisor-co1.fl_str_mv Peixoto, Paulo Vargas
dc.contributor.advisor-co2.fl_str_mv Armi?n, An?bal Guillermo
dc.contributor.referee1.fl_str_mv Carvalho, Vivian de Assun??o Nogueira
dc.contributor.referee2.fl_str_mv Nascimento, Aparecida Alves do
dc.contributor.referee3.fl_str_mv Helayel, Michel Jos? Sales Abdalla
dc.contributor.referee4.fl_str_mv Brust, Luis Armando Calv?o
dc.contributor.authorID.fl_str_mv 136187587-90
dc.contributor.authorLattes.fl_str_mv http://lattes.cnpq.br/1341170071765519
dc.contributor.author.fl_str_mv Santos, Andr? Marandola dos
contributor_str_mv Fran?a, Ticiana do Nascimento
Peixoto, Paulo Vargas
Armi?n, An?bal Guillermo
Carvalho, Vivian de Assun??o Nogueira
Nascimento, Aparecida Alves do
Helayel, Michel Jos? Sales Abdalla
Brust, Luis Armando Calv?o
dc.subject.por.fl_str_mv Armazenamento
swainsonina
lectinas
topic Armazenamento
swainsonina
lectinas
Storage
swainsonin
lectins
Medicina Veterin?ria
dc.subject.eng.fl_str_mv Storage
swainsonin
lectins
dc.subject.cnpq.fl_str_mv Medicina Veterin?ria
description This paper describes an outbreak of lysosomal storage disease in sheep induced by Sida planicaulis in the state of Rio de Janeiro. The consumption of S. planicaulis is responsible for this disease in cattle, horses, goat, sheep and captive deer, which occurs naturally, when the plant is abundant and there is shortage of other forage. The main toxic compound in this plant, Swainsonine, inhibits ?-manosidasis I e II enzymatic activitiy and causes glycoprotein storage in lysosomes. The storage provokes compression, deficiency in intracytoplasmatic transport, and finally, degenerative changes in various tissues, in which, nervous system is the most affected. Physical examination of the affected animals revealed proprioceptive d?ficit, motor incoordination, staggers and, neck and head intention tremors. ?Head-Raising Test? showed marked increase of head and limb tremors, with sequential difficulty in balance and tumble. Histopathology revealed severe distension of Purkinje cells, with foamy appearance, which eventually progressed to karyolysis and pyknosis, and intense vacuolization of pancreatic acinar and thyroid follicular cells. Additionally, there was vacuolization in neuronal bodies with dissolution of cytoplasm associated with marked proliferation of morphologically atypical astrocytes. Multiple axonal spheroids of variable sizes were noted. Positive reaction in lectin-histochemistry for lectins Con A, WGA, and sWGA was able to characterize the disease as a glycoproteinosis. Ultrastructural evaluation of pancreas sections evidenced numerous vacuoles up to 2,5?m in diameter, circled by 20nm wide membranes in acinar cells. In the present report, diagnosis of S. planicaulis toxicosis was established by epidemiological data, clinical and pathological findings, and confirmed by lectin-histochemistry and ultrastructural evaluation. Natural toxicosis in sheep by Sida planicaulis has not yet been described in the state of Rio de Janeiro.
publishDate 2018
dc.date.issued.fl_str_mv 2018-05-04
dc.date.accessioned.fl_str_mv 2021-03-31T02:14:22Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/doctoralThesis
format doctoralThesis
status_str publishedVersion
dc.identifier.citation.fl_str_mv Santos, Andr? Marandola dos. Doen?a do armazenamento lisossomal induzida por Sida planicaulis Cav. (Malvaceae) em ovinos no Estado do Rio de Janeiro. 2018. [73 f.]. Tese( Programa de P?s-Gradua??o em Medicina Veterin?ria (Patologia e Ci?ncias Cl?nicas) - Universidade Federal Rural do Rio de Janeiro, [Serop?dica - RJ] .
dc.identifier.uri.fl_str_mv https://tede.ufrrj.br/jspui/handle/jspui/4495
identifier_str_mv Santos, Andr? Marandola dos. Doen?a do armazenamento lisossomal induzida por Sida planicaulis Cav. (Malvaceae) em ovinos no Estado do Rio de Janeiro. 2018. [73 f.]. Tese( Programa de P?s-Gradua??o em Medicina Veterin?ria (Patologia e Ci?ncias Cl?nicas) - Universidade Federal Rural do Rio de Janeiro, [Serop?dica - RJ] .
url https://tede.ufrrj.br/jspui/handle/jspui/4495
dc.language.iso.fl_str_mv por
language por
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