Dieta hiperlipídica no período perinatal induz disautonomia na prole adulta

• Ano de defesa: 2013
• Autor(a) principal: Santos, Robervan Vidal dos
• Orientador(a): Santana Filho, Valter Joviniano de
• Tipo de documento: Dissertação
• Tipo de acesso: Acesso aberto
• Idioma: por
• Programa de Pós-Graduação: Pós-Graduação em Ciências Fisiológicas
• Palavras-chave em Português: Dietas; Gravidez - Aspectos nutricionais; Obesidade; Hipertensão; Sistema nervoso; Gestação; Dieta hiperlipídica; Sistema nervoso autônomo
• Palavras-chave em Inglês: Diet; Hypertension; Nervous system; Obesity; Pregnancy; High fat; Autonomic nervous system
• Área do conhecimento CNPq: CNPQ::CIENCIAS BIOLOGICAS::FISIOLOGIA
• Link de acesso: https://ri.ufs.br/handle/riufs/3968

An adequate nutritional support is important to ensure a normal development of the fetuses. Changes in the nutritional support during gestation may lead to transitory or permanent structural and functional changes of several organs of the offspring. We aimed to investigate the impact of a high fat diet during the gestation and lactation on anthropometry, cardiovascular, autonomic nervous systems (ANS) and biochemical parameters in the offspring of rats. Wistar rats was used for study. High fat diet was given from day 1 of gestation until weaning of puppies. Anthropometric data of offspring were measured weekly from the 1st postnatal week until the 14th week.Sixty days of life offspring high fat diet group (PH, n= 6) or offspring control (PC, n= 6) had femoral arteries surgically assessed for the measuring of heart rate (HR), mean (MAP), systolic (SAP) and diastolic arterial pressure (DAP), and baroreflex sensitivity (BRS). To investigate the balance of ANS, we established the high (HF) and low frequency (LF) bands of pulse interval (PI) and LF band of SAP spectrum. Biochemical evaluation was performed in three periods at 30, 60 and 90 days of life, through the methodology for Doles kits. From the 5th week postnatal the PH group increased the weight (53 ± 1 vs. 50 ± 1, p<0.05) when compared with PC. PH increased MAP (135 ± 2 vs. 103± 1 mmHg, p<0.05), SAP (160 ± 3 vs. 128 ± 4 mmHg, p<0.05), DAP (111 ± 2 vs. 91 ± 2 mmHg, p<0.05) and HR (417 ± 23 vs. 352 ± 8 bpm, p<0.05) when compared to PC. After spectral analysis of PI and SAP, LF band of SAP spectrum (6.19 ± 0.84 vs. 2.29 ± 0.56 mmHg2, p<0.05) and LF/HF ratio of PI (0.71 ± 0.22 vs. 0.14 ± 0.016 p<0.05) was higher in PH under spontaneous condition. PH presented hyperglycemia starting from day 30 (116.2± 1 vs 97.3 ± 3 mg/dL, p<0.05) and LDL (45 ± 7 vs 28 ± 4 mg/dL, p<0.05). In the day 60 PH showed difference at TAG (64.6 ± 2 vs 49 ± 1 mg/dL, p<0.05), CT (86 ± 2 vs 68 ± 2 mg/dL, p<0.05), VLDL ( 14 ± 1 vs 10 ± 1 mg/dL, p<0.05) and decrease HDL (38 ± 3 vs 55 ± 3 mg/dL , p<0.05), when compared with PC. These findings suggest that high fat diet during pregnancy and lactation leads to autonomic misbalance, dyslipidemia and hypertension in adult offspring rats.