Estudo farmacológico da Vitex agnus-castus L (ação antinociceptiva e toxicidade aguda do extrato aquoso)
Ano de defesa: | 2005 |
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Autor(a) principal: | |
Orientador(a): | |
Banca de defesa: | |
Tipo de documento: | Dissertação |
Tipo de acesso: | Acesso aberto |
Idioma: | por |
Instituição de defesa: |
Universidade Federal de Sergipe
|
Programa de Pós-Graduação: |
Pós-Graduação em Ciências da Saúde
|
Departamento: |
Não Informado pela instituição
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País: |
BR
|
Palavras-chave em Português: | |
Palavras-chave em Inglês: | |
Área do conhecimento CNPq: | |
Link de acesso: | https://ri.ufs.br/handle/riufs/3920 |
Resumo: | Since ancient times men have been using plants as food, and also for medicine preparation, for its necessity to cure diseases or alleviate pains. Innumerable scientific studies have been carried out aiming to validate popular information about the use of medicinal plants. The importance of this study is real for the following reasons: pain is one of the most complex problems that affect human beings, the costs of industrialized medicines are prohibitive, and the fact that Brazil as a developing country has 60% of the industrialized remedies being consumed by only 23% of the Brazilian population. This research may reduce costs of public health programs and consequently, be a way of extending the number of benefits and users of these programs. The present work of experimental research aimed at evaluating antinociceptive action and acute toxicity of the watery extract taken from leaves of Vitex agnuscastus L, known, in caatinga of the state of Sergipe-Br, as chasteberry, a very common plant in this area, used for pain relief through the use of its leaves. The anti-nociceptive effect of the watery extract of Vitex agnus-castus leaves was tested through the experimental models of nociception in mice. The hydrous extract (200 and 400mg/Kg) decreased the acid nociception, produced by the ascetic acid (0.6%), in 46.5% and 70.7% and increased latency period (s) of the mice in the hot plate test. In the formalin test (1%) the extract (400mg/Kg) reduced the nociception in 59.6%. The anti-nociceptive effect of the plant was reverted by naloxone (5mg/Kg). The hydrous extract of V. agnus-castus did not have reach DL50 until the dose of 5g/Kg, indicating low acute toxicity in mice. The anti-nociceptive effect of this plant is associated with the opioid system. |
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Oliveira, José Carlos Martins dehttp://lattes.cnpq.br/5200992527769641Antoniolli, Ângelo Robertohttp://lattes.cnpq.br/14663474382616342017-09-26T12:19:06Z2017-09-26T12:19:06Z2005-07-21OLIVEIRA, José Carlos Martins de. ESTUDO FARMACOLÓGICO DA VITEX AGNUS-CASTUS L (AÇÃO ANTINOCICEPTIVA E TOXICIDADE AGUDA DO EXTRATO AQUOSO). 2005. 60 f. Dissertação (Mestrado em Ciências da Saúde) - Universidade Federal de Sergipe, Aracaju, 2005.https://ri.ufs.br/handle/riufs/3920Since ancient times men have been using plants as food, and also for medicine preparation, for its necessity to cure diseases or alleviate pains. Innumerable scientific studies have been carried out aiming to validate popular information about the use of medicinal plants. The importance of this study is real for the following reasons: pain is one of the most complex problems that affect human beings, the costs of industrialized medicines are prohibitive, and the fact that Brazil as a developing country has 60% of the industrialized remedies being consumed by only 23% of the Brazilian population. This research may reduce costs of public health programs and consequently, be a way of extending the number of benefits and users of these programs. The present work of experimental research aimed at evaluating antinociceptive action and acute toxicity of the watery extract taken from leaves of Vitex agnuscastus L, known, in caatinga of the state of Sergipe-Br, as chasteberry, a very common plant in this area, used for pain relief through the use of its leaves. The anti-nociceptive effect of the watery extract of Vitex agnus-castus leaves was tested through the experimental models of nociception in mice. The hydrous extract (200 and 400mg/Kg) decreased the acid nociception, produced by the ascetic acid (0.6%), in 46.5% and 70.7% and increased latency period (s) of the mice in the hot plate test. In the formalin test (1%) the extract (400mg/Kg) reduced the nociception in 59.6%. The anti-nociceptive effect of the plant was reverted by naloxone (5mg/Kg). The hydrous extract of V. agnus-castus did not have reach DL50 until the dose of 5g/Kg, indicating low acute toxicity in mice. The anti-nociceptive effect of this plant is associated with the opioid system.O homem usa as plantas desde os primórdios para alimentação, como também, para preparação de medicamentos, pela sua necessidade de curar ou aliviar seus males e suas dores. Inúmeros estudos científicos vêm sendo realizados no sentido de validar as informações populares referentes ao uso de plantas medicinais. Como a dor é um dos maiores males que atingem o ser humano, e os custos dos medicamentos industrializados não são acessíveis às populações mais carentes e como o Brasil é um país em desenvolvimento, em que 60% dos remédios industrializados são consumidos por apenas 23% da população brasileira, torna-se evidente a importância do estudo científico das plantas medicinais, como forma de baixar os custos dos programas de saúde pública e, conseqüentemente, ampliar o número de benefícios e usuários de seus programas. O presente trabalho de pesquisa experimental teve como objetivo avaliar a ação antinociceptiva e toxicidade aguda do extrato aquoso obtido das folhas da Vitex agnus-castus L, conhecida na caatinga do Estado de Sergipe-BR como pimenta-da-costa , planta muito utilizada pela comunidade para alívio da dor através do uso de suas folhas. O efeito antinociceptivo do extrato aquoso das folhas de Vitex agnus-castus foi testado através dos modelos experimentais de nocicepção em camundongos. O extrato aquoso (200 e 400mg/kg) reduziu em 46.5% e 70.7% a nocicepção produzida pelo ácido acético (0.6%) e aumentou o tempo (s) de latência dos camundongos no teste da placa quente. No teste da formalina (1%) o extrato (400mg/kg) reduziu a nocicepção em 59.6%. O efeito antinociceptivo da planta foi revertido pela naloxona (5mg/kg). O extrato aquoso de V. agnus-castus não apresentou DL50 até a dose de 5g/kg, indicando baixa toxicidade aguda em camundongos. O efeito antinociceptivo desta planta está associado ao sistema opióide.Coordenação de Aperfeiçoamento de Pessoal de Nível Superiorapplication/pdfporUniversidade Federal de SergipePós-Graduação em Ciências da SaúdeUFSBRAntinocicepçãoToxicidade agudaVitex agnus-castus LAnti-nociceptionAcute toxicityVitex agnus-castus LCNPQ::CIENCIAS DA SAUDE::MEDICINAEstudo farmacológico da Vitex agnus-castus L (ação antinociceptiva e toxicidade aguda do extrato aquoso)info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/masterThesisinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UFSinstname:Universidade Federal de Sergipe (UFS)instacron:UFSORIGINALJOSE_CARLOS_MARTINS_OLIVEIRA.pdfapplication/pdf314302https://ri.ufs.br/jspui/bitstream/riufs/3920/1/JOSE_CARLOS_MARTINS_OLIVEIRA.pdf103dac17ec5bec821a032c15abdf9ed5MD51TEXTJOSE_CARLOS_MARTINS_OLIVEIRA.pdf.txtJOSE_CARLOS_MARTINS_OLIVEIRA.pdf.txtExtracted texttext/plain96096https://ri.ufs.br/jspui/bitstream/riufs/3920/2/JOSE_CARLOS_MARTINS_OLIVEIRA.pdf.txt2dc97d5dbbf8fde0a27fc109ea72492eMD52THUMBNAILJOSE_CARLOS_MARTINS_OLIVEIRA.pdf.jpgJOSE_CARLOS_MARTINS_OLIVEIRA.pdf.jpgGenerated Thumbnailimage/jpeg1369https://ri.ufs.br/jspui/bitstream/riufs/3920/3/JOSE_CARLOS_MARTINS_OLIVEIRA.pdf.jpge6dd2938aaec262be9c51bbc60054b96MD53riufs/39202017-11-28 16:44:26.487oai:ufs.br:riufs/3920Repositório InstitucionalPUBhttps://ri.ufs.br/oai/requestrepositorio@academico.ufs.bropendoar:2017-11-28T19:44:26Repositório Institucional da UFS - Universidade Federal de Sergipe (UFS)false |
dc.title.por.fl_str_mv |
Estudo farmacológico da Vitex agnus-castus L (ação antinociceptiva e toxicidade aguda do extrato aquoso) |
title |
Estudo farmacológico da Vitex agnus-castus L (ação antinociceptiva e toxicidade aguda do extrato aquoso) |
spellingShingle |
Estudo farmacológico da Vitex agnus-castus L (ação antinociceptiva e toxicidade aguda do extrato aquoso) Oliveira, José Carlos Martins de Antinocicepção Toxicidade aguda Vitex agnus-castus L Anti-nociception Acute toxicity Vitex agnus-castus L CNPQ::CIENCIAS DA SAUDE::MEDICINA |
title_short |
Estudo farmacológico da Vitex agnus-castus L (ação antinociceptiva e toxicidade aguda do extrato aquoso) |
title_full |
Estudo farmacológico da Vitex agnus-castus L (ação antinociceptiva e toxicidade aguda do extrato aquoso) |
title_fullStr |
Estudo farmacológico da Vitex agnus-castus L (ação antinociceptiva e toxicidade aguda do extrato aquoso) |
title_full_unstemmed |
Estudo farmacológico da Vitex agnus-castus L (ação antinociceptiva e toxicidade aguda do extrato aquoso) |
title_sort |
Estudo farmacológico da Vitex agnus-castus L (ação antinociceptiva e toxicidade aguda do extrato aquoso) |
author |
Oliveira, José Carlos Martins de |
author_facet |
Oliveira, José Carlos Martins de |
author_role |
author |
dc.contributor.author.fl_str_mv |
Oliveira, José Carlos Martins de |
dc.contributor.advisor1Lattes.fl_str_mv |
http://lattes.cnpq.br/5200992527769641 |
dc.contributor.advisor1.fl_str_mv |
Antoniolli, Ângelo Roberto |
dc.contributor.authorLattes.fl_str_mv |
http://lattes.cnpq.br/1466347438261634 |
contributor_str_mv |
Antoniolli, Ângelo Roberto |
dc.subject.por.fl_str_mv |
Antinocicepção Toxicidade aguda Vitex agnus-castus L |
topic |
Antinocicepção Toxicidade aguda Vitex agnus-castus L Anti-nociception Acute toxicity Vitex agnus-castus L CNPQ::CIENCIAS DA SAUDE::MEDICINA |
dc.subject.eng.fl_str_mv |
Anti-nociception Acute toxicity Vitex agnus-castus L |
dc.subject.cnpq.fl_str_mv |
CNPQ::CIENCIAS DA SAUDE::MEDICINA |
description |
Since ancient times men have been using plants as food, and also for medicine preparation, for its necessity to cure diseases or alleviate pains. Innumerable scientific studies have been carried out aiming to validate popular information about the use of medicinal plants. The importance of this study is real for the following reasons: pain is one of the most complex problems that affect human beings, the costs of industrialized medicines are prohibitive, and the fact that Brazil as a developing country has 60% of the industrialized remedies being consumed by only 23% of the Brazilian population. This research may reduce costs of public health programs and consequently, be a way of extending the number of benefits and users of these programs. The present work of experimental research aimed at evaluating antinociceptive action and acute toxicity of the watery extract taken from leaves of Vitex agnuscastus L, known, in caatinga of the state of Sergipe-Br, as chasteberry, a very common plant in this area, used for pain relief through the use of its leaves. The anti-nociceptive effect of the watery extract of Vitex agnus-castus leaves was tested through the experimental models of nociception in mice. The hydrous extract (200 and 400mg/Kg) decreased the acid nociception, produced by the ascetic acid (0.6%), in 46.5% and 70.7% and increased latency period (s) of the mice in the hot plate test. In the formalin test (1%) the extract (400mg/Kg) reduced the nociception in 59.6%. The anti-nociceptive effect of the plant was reverted by naloxone (5mg/Kg). The hydrous extract of V. agnus-castus did not have reach DL50 until the dose of 5g/Kg, indicating low acute toxicity in mice. The anti-nociceptive effect of this plant is associated with the opioid system. |
publishDate |
2005 |
dc.date.issued.fl_str_mv |
2005-07-21 |
dc.date.accessioned.fl_str_mv |
2017-09-26T12:19:06Z |
dc.date.available.fl_str_mv |
2017-09-26T12:19:06Z |
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info:eu-repo/semantics/publishedVersion |
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info:eu-repo/semantics/masterThesis |
format |
masterThesis |
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publishedVersion |
dc.identifier.citation.fl_str_mv |
OLIVEIRA, José Carlos Martins de. ESTUDO FARMACOLÓGICO DA VITEX AGNUS-CASTUS L (AÇÃO ANTINOCICEPTIVA E TOXICIDADE AGUDA DO EXTRATO AQUOSO). 2005. 60 f. Dissertação (Mestrado em Ciências da Saúde) - Universidade Federal de Sergipe, Aracaju, 2005. |
dc.identifier.uri.fl_str_mv |
https://ri.ufs.br/handle/riufs/3920 |
identifier_str_mv |
OLIVEIRA, José Carlos Martins de. ESTUDO FARMACOLÓGICO DA VITEX AGNUS-CASTUS L (AÇÃO ANTINOCICEPTIVA E TOXICIDADE AGUDA DO EXTRATO AQUOSO). 2005. 60 f. Dissertação (Mestrado em Ciências da Saúde) - Universidade Federal de Sergipe, Aracaju, 2005. |
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https://ri.ufs.br/handle/riufs/3920 |
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