Desenvolvimento de revestimentos híbridos aplicados aos substratos de Ti-6Al-4V para aplicações biomédicas
Ano de defesa: | 2019 |
---|---|
Autor(a) principal: | |
Orientador(a): | |
Banca de defesa: | |
Tipo de documento: | Tese |
Tipo de acesso: | Acesso aberto |
Idioma: | por |
Instituição de defesa: |
Não Informado pela instituição
|
Programa de Pós-Graduação: |
Pós-Graduação em Química
|
Departamento: |
Não Informado pela instituição
|
País: |
Não Informado pela instituição
|
Palavras-chave em Português: | |
Palavras-chave em Inglês: | |
Área do conhecimento CNPq: | |
Link de acesso: | http://ri.ufs.br/jspui/handle/riufs/11202 |
Resumo: | The Ti-6Al-4V alloy is one of the most widely used metallic biomaterials due to the corrosion resistance, high static and fatigue strength, relatively low elasticity modulus, low weight, high biocompatibility and direct bone apposition. However, the exposure this alloy to body fluid for a long period of time, has low wear resistance and allows the release of Al and V ions may cause adverse reactions in tissues and neurological disorders. In an attempt to overcome these problems, hybrid Siloxane-PMMA coatings were synthesized by the sol-gel method and deposited by immersion on the surface alloy Ti-6Al-4V treated. Calcium chloride was added to some compositions to facilitate the formation of hydroxyapatite and promote osteosynthesis. At the start, was studied the hybrids formation by means of the FTIR and TG techniques and it was observed that the addition of the calcium salt to the hybrid matrix favored the formation of more regular polymer chains, influenced in hydrolysis and condensation reactions, besides having higher thermal resistance to hybrids. As regards morphological tests, these showed the formation of homogeneous, low thickness, substrate adherent, hydrophilic coatings with some micro-roughness as the molar ratio of calcium salt to the composition was increased. Electrochemical simulated body fluid (SBF) tests at 37 °C and monitored by electrochemical techniques indicated higher corrosion resistance for the hybrid coatings than for the uncoated alloy in the first few hours of immersion, however, the film without addition of salt showed is more resistive during longer immersion time due to the more compact silica network. In vitro bioactivity assays demonstrated that hybrid coatings further the formation of hydroxyapatite in SBF. While viability and cell density using murine osteoblastic MC3T3 cells, demonstrated high cell viability and non-toxic effect for all systems and high cell proliferation for the system without addition of calcium chloride. Finally, the results showed that hybrid coating without calcium chloride effectively improved the bioactivity, biocompatibility and corrosion resistance of Ti-6Al-4V substrates. |
id |
UFS-2_a8654ac5928971d2de47f3591a6f839d |
---|---|
oai_identifier_str |
oai:ufs.br:riufs/11202 |
network_acronym_str |
UFS-2 |
network_name_str |
Repositório Institucional da UFS |
repository_id_str |
|
spelling |
Santana, Joseane de AndradeSarmento, Victor Hugo VitorinoKunst, Sandra Raquel2019-05-27T19:47:02Z2019-05-27T19:47:02Z2019-02-28SANTANA, Joseane de Andrade. Desenvolvimento de revestimentos híbridos aplicados aos substratos de Ti-6Al-4V para aplicações biomédicas. 2019. 112 f. Tese (Doutorado em Química) - Universidade Federal de Sergipe, São Cristóvão, SE, 2019.http://ri.ufs.br/jspui/handle/riufs/11202The Ti-6Al-4V alloy is one of the most widely used metallic biomaterials due to the corrosion resistance, high static and fatigue strength, relatively low elasticity modulus, low weight, high biocompatibility and direct bone apposition. However, the exposure this alloy to body fluid for a long period of time, has low wear resistance and allows the release of Al and V ions may cause adverse reactions in tissues and neurological disorders. In an attempt to overcome these problems, hybrid Siloxane-PMMA coatings were synthesized by the sol-gel method and deposited by immersion on the surface alloy Ti-6Al-4V treated. Calcium chloride was added to some compositions to facilitate the formation of hydroxyapatite and promote osteosynthesis. At the start, was studied the hybrids formation by means of the FTIR and TG techniques and it was observed that the addition of the calcium salt to the hybrid matrix favored the formation of more regular polymer chains, influenced in hydrolysis and condensation reactions, besides having higher thermal resistance to hybrids. As regards morphological tests, these showed the formation of homogeneous, low thickness, substrate adherent, hydrophilic coatings with some micro-roughness as the molar ratio of calcium salt to the composition was increased. Electrochemical simulated body fluid (SBF) tests at 37 °C and monitored by electrochemical techniques indicated higher corrosion resistance for the hybrid coatings than for the uncoated alloy in the first few hours of immersion, however, the film without addition of salt showed is more resistive during longer immersion time due to the more compact silica network. In vitro bioactivity assays demonstrated that hybrid coatings further the formation of hydroxyapatite in SBF. While viability and cell density using murine osteoblastic MC3T3 cells, demonstrated high cell viability and non-toxic effect for all systems and high cell proliferation for the system without addition of calcium chloride. Finally, the results showed that hybrid coating without calcium chloride effectively improved the bioactivity, biocompatibility and corrosion resistance of Ti-6Al-4V substrates.A liga Ti-6Al-4V é um dos biomateriais metálicos mais utilizados, pois possui resistência à corrosão, alta resistência estática e a fadiga, módulo de elasticidade relativamente baixo, baixo peso, alta biocompatibilidade e aposição óssea direta. No entanto, a exposição dessa liga em fluído corpóreo por um longo período de tempo possui baixa resistência ao desgaste, e possibilita a liberação de íons Al e V que podem causar reações adversas nos tecidos e distúrbios a neurológicos. Na tentativa de superar esses problemas, revestimentos híbridos Siloxano- PMMA foram sintetizados pelo método sol-gel e depositados por imersão na liga Ti-6Al-4V tratada superficialmente. Cloreto de cálcio foi adicionado para facilitar a formação de hidroxiapatita e promover a osteossíntese. Inicialmente estudouse a formação dos híbridos por meio das técnicas FTIR e TG e observou-se que a adição do sal de cálcio à matriz híbrida favoreceu a formação de cadeias poliméricas mais regulares, influenciou nas reações de hidrólise e condensação. Os ensaios morfológicos, mostraram a formação de revestimentos híbridos homogêneos, de baixa espessura, com aderência ao substrato, hidrofílicos e com algumas microrugosidades a medida que foi acrescida a razão do sal de cálcio. Os ensaios eletroquímicos em fluido corpóreo simulado (SBF) à 37 ºC e monitorados por técnicas eletroquímicas indicaram cor à corrosão maior para os revestimentos híbridos em comparação a liga sem revestimento nas primeiras horas de imersão. No entanto, o filme sem adição do sal mostrou-se mais resistivo durante maior tempo de imersão devido a rede de sílica mais compacta. Os ensaios in vitro de bioatividade demonstraram que os revestimentos híbridos favorecem a formação da hidroxiapatita em SBF. Enquanto os ensaios de viabilidade e densidade celular usando células do tipo murino MC3T3 E1 da linhagem de células pré-osteoblásticas derivadas da calota craniana de camundongos C57BL/6, demostraram alta viabilidade celular e efeito não tóxido para todos os sistemas e alta densidade celular para o sistema sem adição do cloreto de cálcio. Por fim, os resultados mostraram que o revestimento híbrido na ausência do cloreto de cálcio melhorou efetivamente a bioatividade, biocompatibilidade e resistência à corrosão dos substratos Ti-6Al-4V.Coordenação de Aperfeiçoamento de Pessoal de Nível Superior - CAPESSão Cristóvão, SEporQuímicaImplantes artificiaisCorrosão de alumínioMateriais biomédicosImplantesCorrosãoMateriais híbridosBiocompatibilidadeBioatividadeImplantsCorrosionHybrid materialsBiocompatibilityBioactivityCIENCIAS EXATAS E DA TERRA::QUIMICADesenvolvimento de revestimentos híbridos aplicados aos substratos de Ti-6Al-4V para aplicações biomédicasHybrid coatings development and applied to substrates of Ti-6Al-4V for biomedical applicationsinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/doctoralThesisPós-Graduação em QuímicaUniversidade Federal de Sergipereponame:Repositório Institucional da UFSinstname:Universidade Federal de Sergipe (UFS)instacron:UFSinfo:eu-repo/semantics/openAccessTEXTJOSEANE_ANDRADE_SANTANA.pdf.txtJOSEANE_ANDRADE_SANTANA.pdf.txtExtracted texttext/plain173213https://ri.ufs.br/jspui/bitstream/riufs/11202/4/JOSEANE_ANDRADE_SANTANA.pdf.txt82a1dd182f56c4d83efe9de2acf3dbdcMD54THUMBNAILJOSEANE_ANDRADE_SANTANA.pdf.jpgJOSEANE_ANDRADE_SANTANA.pdf.jpgGenerated Thumbnailimage/jpeg1582https://ri.ufs.br/jspui/bitstream/riufs/11202/5/JOSEANE_ANDRADE_SANTANA.pdf.jpgd6ae1680c38a35db6c6120043c312247MD55ORIGINALJOSEANE_ANDRADE_SANTANA.pdfJOSEANE_ANDRADE_SANTANA.pdfapplication/pdf5118143https://ri.ufs.br/jspui/bitstream/riufs/11202/2/JOSEANE_ANDRADE_SANTANA.pdf0d42a5c4e69de9827ee8af69ad982101MD52LICENSElicense.txtlicense.txttext/plain; charset=utf-81475https://ri.ufs.br/jspui/bitstream/riufs/11202/3/license.txt098cbbf65c2c15e1fb2e49c5d306a44cMD53riufs/112022019-05-27 16:47:03.121oai:ufs.br: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Repositório InstitucionalPUBhttps://ri.ufs.br/oai/requestrepositorio@academico.ufs.bropendoar:2019-05-27T19:47:03Repositório Institucional da UFS - Universidade Federal de Sergipe (UFS)false |
dc.title.pt_BR.fl_str_mv |
Desenvolvimento de revestimentos híbridos aplicados aos substratos de Ti-6Al-4V para aplicações biomédicas |
dc.title.alternative.eng.fl_str_mv |
Hybrid coatings development and applied to substrates of Ti-6Al-4V for biomedical applications |
title |
Desenvolvimento de revestimentos híbridos aplicados aos substratos de Ti-6Al-4V para aplicações biomédicas |
spellingShingle |
Desenvolvimento de revestimentos híbridos aplicados aos substratos de Ti-6Al-4V para aplicações biomédicas Santana, Joseane de Andrade Química Implantes artificiais Corrosão de alumínio Materiais biomédicos Implantes Corrosão Materiais híbridos Biocompatibilidade Bioatividade Implants Corrosion Hybrid materials Biocompatibility Bioactivity CIENCIAS EXATAS E DA TERRA::QUIMICA |
title_short |
Desenvolvimento de revestimentos híbridos aplicados aos substratos de Ti-6Al-4V para aplicações biomédicas |
title_full |
Desenvolvimento de revestimentos híbridos aplicados aos substratos de Ti-6Al-4V para aplicações biomédicas |
title_fullStr |
Desenvolvimento de revestimentos híbridos aplicados aos substratos de Ti-6Al-4V para aplicações biomédicas |
title_full_unstemmed |
Desenvolvimento de revestimentos híbridos aplicados aos substratos de Ti-6Al-4V para aplicações biomédicas |
title_sort |
Desenvolvimento de revestimentos híbridos aplicados aos substratos de Ti-6Al-4V para aplicações biomédicas |
author |
Santana, Joseane de Andrade |
author_facet |
Santana, Joseane de Andrade |
author_role |
author |
dc.contributor.author.fl_str_mv |
Santana, Joseane de Andrade |
dc.contributor.advisor1.fl_str_mv |
Sarmento, Victor Hugo Vitorino |
dc.contributor.advisor-co1.fl_str_mv |
Kunst, Sandra Raquel |
contributor_str_mv |
Sarmento, Victor Hugo Vitorino Kunst, Sandra Raquel |
dc.subject.por.fl_str_mv |
Química Implantes artificiais Corrosão de alumínio Materiais biomédicos Implantes Corrosão Materiais híbridos Biocompatibilidade Bioatividade |
topic |
Química Implantes artificiais Corrosão de alumínio Materiais biomédicos Implantes Corrosão Materiais híbridos Biocompatibilidade Bioatividade Implants Corrosion Hybrid materials Biocompatibility Bioactivity CIENCIAS EXATAS E DA TERRA::QUIMICA |
dc.subject.eng.fl_str_mv |
Implants Corrosion Hybrid materials Biocompatibility Bioactivity |
dc.subject.cnpq.fl_str_mv |
CIENCIAS EXATAS E DA TERRA::QUIMICA |
description |
The Ti-6Al-4V alloy is one of the most widely used metallic biomaterials due to the corrosion resistance, high static and fatigue strength, relatively low elasticity modulus, low weight, high biocompatibility and direct bone apposition. However, the exposure this alloy to body fluid for a long period of time, has low wear resistance and allows the release of Al and V ions may cause adverse reactions in tissues and neurological disorders. In an attempt to overcome these problems, hybrid Siloxane-PMMA coatings were synthesized by the sol-gel method and deposited by immersion on the surface alloy Ti-6Al-4V treated. Calcium chloride was added to some compositions to facilitate the formation of hydroxyapatite and promote osteosynthesis. At the start, was studied the hybrids formation by means of the FTIR and TG techniques and it was observed that the addition of the calcium salt to the hybrid matrix favored the formation of more regular polymer chains, influenced in hydrolysis and condensation reactions, besides having higher thermal resistance to hybrids. As regards morphological tests, these showed the formation of homogeneous, low thickness, substrate adherent, hydrophilic coatings with some micro-roughness as the molar ratio of calcium salt to the composition was increased. Electrochemical simulated body fluid (SBF) tests at 37 °C and monitored by electrochemical techniques indicated higher corrosion resistance for the hybrid coatings than for the uncoated alloy in the first few hours of immersion, however, the film without addition of salt showed is more resistive during longer immersion time due to the more compact silica network. In vitro bioactivity assays demonstrated that hybrid coatings further the formation of hydroxyapatite in SBF. While viability and cell density using murine osteoblastic MC3T3 cells, demonstrated high cell viability and non-toxic effect for all systems and high cell proliferation for the system without addition of calcium chloride. Finally, the results showed that hybrid coating without calcium chloride effectively improved the bioactivity, biocompatibility and corrosion resistance of Ti-6Al-4V substrates. |
publishDate |
2019 |
dc.date.accessioned.fl_str_mv |
2019-05-27T19:47:02Z |
dc.date.available.fl_str_mv |
2019-05-27T19:47:02Z |
dc.date.issued.fl_str_mv |
2019-02-28 |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/doctoralThesis |
format |
doctoralThesis |
status_str |
publishedVersion |
dc.identifier.citation.fl_str_mv |
SANTANA, Joseane de Andrade. Desenvolvimento de revestimentos híbridos aplicados aos substratos de Ti-6Al-4V para aplicações biomédicas. 2019. 112 f. Tese (Doutorado em Química) - Universidade Federal de Sergipe, São Cristóvão, SE, 2019. |
dc.identifier.uri.fl_str_mv |
http://ri.ufs.br/jspui/handle/riufs/11202 |
identifier_str_mv |
SANTANA, Joseane de Andrade. Desenvolvimento de revestimentos híbridos aplicados aos substratos de Ti-6Al-4V para aplicações biomédicas. 2019. 112 f. Tese (Doutorado em Química) - Universidade Federal de Sergipe, São Cristóvão, SE, 2019. |
url |
http://ri.ufs.br/jspui/handle/riufs/11202 |
dc.language.iso.fl_str_mv |
por |
language |
por |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.publisher.program.fl_str_mv |
Pós-Graduação em Química |
dc.publisher.initials.fl_str_mv |
Universidade Federal de Sergipe |
dc.source.none.fl_str_mv |
reponame:Repositório Institucional da UFS instname:Universidade Federal de Sergipe (UFS) instacron:UFS |
instname_str |
Universidade Federal de Sergipe (UFS) |
instacron_str |
UFS |
institution |
UFS |
reponame_str |
Repositório Institucional da UFS |
collection |
Repositório Institucional da UFS |
bitstream.url.fl_str_mv |
https://ri.ufs.br/jspui/bitstream/riufs/11202/4/JOSEANE_ANDRADE_SANTANA.pdf.txt https://ri.ufs.br/jspui/bitstream/riufs/11202/5/JOSEANE_ANDRADE_SANTANA.pdf.jpg https://ri.ufs.br/jspui/bitstream/riufs/11202/2/JOSEANE_ANDRADE_SANTANA.pdf https://ri.ufs.br/jspui/bitstream/riufs/11202/3/license.txt |
bitstream.checksum.fl_str_mv |
82a1dd182f56c4d83efe9de2acf3dbdc d6ae1680c38a35db6c6120043c312247 0d42a5c4e69de9827ee8af69ad982101 098cbbf65c2c15e1fb2e49c5d306a44c |
bitstream.checksumAlgorithm.fl_str_mv |
MD5 MD5 MD5 MD5 |
repository.name.fl_str_mv |
Repositório Institucional da UFS - Universidade Federal de Sergipe (UFS) |
repository.mail.fl_str_mv |
repositorio@academico.ufs.br |
_version_ |
1793351079480524800 |