Síntese de uma nova classe de moléculas derivadas do AZT: 5’- arilcalcogenil-3’-(4-fenilselenoalquil-1,2,3-triazol-1-il)-timidina com atividade antitumoral
| Ano de defesa: | 2018 |
|---|---|
| Autor(a) principal: |
Quoos, Natalia
 |
| Orientador(a): |
Rodrigues, Oscar Endrigo Dorneles
|
| Banca de defesa: | , |
| Tipo de documento: | Dissertação |
| Tipo de acesso: | Acesso aberto |
| Idioma: | por |
| Instituição de defesa: |
Universidade Federal de Santa Maria
Centro de Ciências Naturais e Exatas |
| Programa de Pós-Graduação: |
Programa de Pós-Graduação em Química
|
| Departamento: |
Química
|
| País: |
Brasil
|
| Palavras-chave em Português: | |
| Palavras-chave em Inglês: | |
| Área do conhecimento CNPq: | |
| Link de acesso: | http://repositorio.ufsm.br/handle/1/20537 |
Resumo: | Abstract: This work presents the synthesis as well as the antitumor effect in vitro in bladder cancer cells 5637 of a new class of 5'-arylcalcogenyl-3'-(4-phenylselenoalkyl- 1,2,3-triazol-1-yl)-thymidine derivatives of AZT. The optimization of the reaction conditions, such as the catalyst and solvent, for the reaction of 1,3-dipolar cycloaddition in the formation of the 1,2,3-triazole heterocycle was also performed. The synthesis of the new molecules proved to be efficient, being obtained through a convergent route in good to excellent yields (68 - 94%). |
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2021-04-12T18:11:48Z2021-04-12T18:11:48Z2018-02-23http://repositorio.ufsm.br/handle/1/20537Abstract: This work presents the synthesis as well as the antitumor effect in vitro in bladder cancer cells 5637 of a new class of 5'-arylcalcogenyl-3'-(4-phenylselenoalkyl- 1,2,3-triazol-1-yl)-thymidine derivatives of AZT. The optimization of the reaction conditions, such as the catalyst and solvent, for the reaction of 1,3-dipolar cycloaddition in the formation of the 1,2,3-triazole heterocycle was also performed. The synthesis of the new molecules proved to be efficient, being obtained through a convergent route in good to excellent yields (68 - 94%).Este trabalho apresenta a síntese, bem como o efeito antitumoral in vitro em células cancerosas de bexiga 5637, de uma nova classe de compostos 5’- arilcalcogenil-3’-(4-fenilselenoalquil-1,2,3-triazol-1-il)-timidina derivados do AZT. Foi realizada também a otimização das condições reacionais, como o catalisador e solvente, para a reação de cicloadição 1,3-dipolar na formação do heterociclo 1,2,3- triazol. A síntese das novas moléculas demonstrou-se eficiente, sendo obtida através de uma rota convergente em bons a excelentes rendimentos (68 – 94%).Conselho Nacional de Pesquisa e Desenvolvimento Científico e Tecnológico - CNPqporUniversidade Federal de Santa MariaCentro de Ciências Naturais e ExatasPrograma de Pós-Graduação em QuímicaUFSMBrasilQuímicaAttribution-NonCommercial-NoDerivatives 4.0 Internationalhttp://creativecommons.org/licenses/by-nc-nd/4.0/info:eu-repo/semantics/openAccessAnálogos nucleosídicosHeterociclo 1,2,3-triazolOrganocalcogêniosAtividade antitumoralNucleosidic analoguesHeterocycle 1,2,3-triazoleOrganocalcogenAntitumor activityCNPQ::CIENCIAS EXATAS E DA TERRA::QUIMICASíntese de uma nova classe de moléculas derivadas do AZT: 5’- arilcalcogenil-3’-(4-fenilselenoalquil-1,2,3-triazol-1-il)-timidina com atividade antitumoralSnthesis of a new class of molecules derived from AZT: 5'- arilcalcogenyl-3'-(4-phenylselenoalkyl-1,2,3-triazol-1-yl)- timidine with antitumoral activityinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/masterThesisRodrigues, Oscar Endrigo Dorneleshttp://lattes.cnpq.br/6536519955416085Dalcol, Ionara IrionFantinel, Leonardohttp://lattes.cnpq.br/9846078242809498Quoos, Natalia10060000000060009fef019-ac43-4d8b-83d3-3565e4686d7b0f0dd9ef-c9bb-4993-a687-3d01421ecebe2cbacb00-be94-498b-9c77-1d47963baf69079f4612-cd36-4354-af6f-25f7736dccd2reponame:Manancial - Repositório Digital da UFSMinstname:Universidade Federal de Santa Maria (UFSM)instacron:UFSMORIGINALDIS_PPGQUIMICA_2018_QUOOS_NATALIA.pdfDIS_PPGQUIMICA_2018_QUOOS_NATALIA.pdfDissertação de Mestradoapplication/pdf5665231http://repositorio.ufsm.br/bitstream/1/20537/1/DIS_PPGQUIMICA_2018_QUOOS_NATALIA.pdfd90cf202fdbfa77e77cfcf881a857facMD51CC-LICENSElicense_rdflicense_rdfapplication/rdf+xml; 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| dc.title.por.fl_str_mv |
Síntese de uma nova classe de moléculas derivadas do AZT: 5’- arilcalcogenil-3’-(4-fenilselenoalquil-1,2,3-triazol-1-il)-timidina com atividade antitumoral |
| dc.title.alternative.eng.fl_str_mv |
Snthesis of a new class of molecules derived from AZT: 5'- arilcalcogenyl-3'-(4-phenylselenoalkyl-1,2,3-triazol-1-yl)- timidine with antitumoral activity |
| title |
Síntese de uma nova classe de moléculas derivadas do AZT: 5’- arilcalcogenil-3’-(4-fenilselenoalquil-1,2,3-triazol-1-il)-timidina com atividade antitumoral |
| spellingShingle |
Síntese de uma nova classe de moléculas derivadas do AZT: 5’- arilcalcogenil-3’-(4-fenilselenoalquil-1,2,3-triazol-1-il)-timidina com atividade antitumoral Quoos, Natalia Análogos nucleosídicos Heterociclo 1,2,3-triazol Organocalcogênios Atividade antitumoral Nucleosidic analogues Heterocycle 1,2,3-triazole Organocalcogen Antitumor activity CNPQ::CIENCIAS EXATAS E DA TERRA::QUIMICA |
| title_short |
Síntese de uma nova classe de moléculas derivadas do AZT: 5’- arilcalcogenil-3’-(4-fenilselenoalquil-1,2,3-triazol-1-il)-timidina com atividade antitumoral |
| title_full |
Síntese de uma nova classe de moléculas derivadas do AZT: 5’- arilcalcogenil-3’-(4-fenilselenoalquil-1,2,3-triazol-1-il)-timidina com atividade antitumoral |
| title_fullStr |
Síntese de uma nova classe de moléculas derivadas do AZT: 5’- arilcalcogenil-3’-(4-fenilselenoalquil-1,2,3-triazol-1-il)-timidina com atividade antitumoral |
| title_full_unstemmed |
Síntese de uma nova classe de moléculas derivadas do AZT: 5’- arilcalcogenil-3’-(4-fenilselenoalquil-1,2,3-triazol-1-il)-timidina com atividade antitumoral |
| title_sort |
Síntese de uma nova classe de moléculas derivadas do AZT: 5’- arilcalcogenil-3’-(4-fenilselenoalquil-1,2,3-triazol-1-il)-timidina com atividade antitumoral |
| author |
Quoos, Natalia |
| author_facet |
Quoos, Natalia |
| author_role |
author |
| dc.contributor.referee1Lattes.por.fl_str_mv |
|
| dc.contributor.referee2Lattes.por.fl_str_mv |
|
| dc.contributor.advisor1.fl_str_mv |
Rodrigues, Oscar Endrigo Dorneles |
| dc.contributor.advisor1Lattes.fl_str_mv |
http://lattes.cnpq.br/6536519955416085 |
| dc.contributor.referee1.fl_str_mv |
Dalcol, Ionara Irion |
| dc.contributor.referee2.fl_str_mv |
Fantinel, Leonardo |
| dc.contributor.authorLattes.fl_str_mv |
http://lattes.cnpq.br/9846078242809498 |
| dc.contributor.author.fl_str_mv |
Quoos, Natalia |
| contributor_str_mv |
Rodrigues, Oscar Endrigo Dorneles Dalcol, Ionara Irion Fantinel, Leonardo |
| dc.subject.por.fl_str_mv |
Análogos nucleosídicos Heterociclo 1,2,3-triazol Organocalcogênios Atividade antitumoral |
| topic |
Análogos nucleosídicos Heterociclo 1,2,3-triazol Organocalcogênios Atividade antitumoral Nucleosidic analogues Heterocycle 1,2,3-triazole Organocalcogen Antitumor activity CNPQ::CIENCIAS EXATAS E DA TERRA::QUIMICA |
| dc.subject.eng.fl_str_mv |
Nucleosidic analogues Heterocycle 1,2,3-triazole Organocalcogen Antitumor activity |
| dc.subject.cnpq.fl_str_mv |
CNPQ::CIENCIAS EXATAS E DA TERRA::QUIMICA |
| description |
Abstract: This work presents the synthesis as well as the antitumor effect in vitro in bladder cancer cells 5637 of a new class of 5'-arylcalcogenyl-3'-(4-phenylselenoalkyl- 1,2,3-triazol-1-yl)-thymidine derivatives of AZT. The optimization of the reaction conditions, such as the catalyst and solvent, for the reaction of 1,3-dipolar cycloaddition in the formation of the 1,2,3-triazole heterocycle was also performed. The synthesis of the new molecules proved to be efficient, being obtained through a convergent route in good to excellent yields (68 - 94%). |
| publishDate |
2018 |
| dc.date.issued.fl_str_mv |
2018-02-23 |
| dc.date.accessioned.fl_str_mv |
2021-04-12T18:11:48Z |
| dc.date.available.fl_str_mv |
2021-04-12T18:11:48Z |
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info:eu-repo/semantics/publishedVersion |
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info:eu-repo/semantics/masterThesis |
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http://repositorio.ufsm.br/handle/1/20537 |
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por |
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por |
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100600000000 |
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600 |
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Attribution-NonCommercial-NoDerivatives 4.0 International http://creativecommons.org/licenses/by-nc-nd/4.0/ |
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Universidade Federal de Santa Maria Centro de Ciências Naturais e Exatas |
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Programa de Pós-Graduação em Química |
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UFSM |
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Brasil |
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Química |
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Universidade Federal de Santa Maria Centro de Ciências Naturais e Exatas |
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