Efeito clínico do plasma rico em plaquetas, autólogo e homólogo, em gel, na cicatrização cutânea em equinos

• Ano de defesa: 2022
• Autor(a) principal: Mucha, João Vicente Gonçales
• Orientador(a): De La Côrte, Flávio Desessards
• Banca de defesa: Pozzobon, Ricardo, Azevedo, Marcos da Silva
• Tipo de documento: Dissertação
• Tipo de acesso: Acesso aberto
• Idioma: por
• Instituição de defesa: Universidade Federal de Santa Maria; Centro de Ciências Rurais
• Programa de Pós-Graduação: Programa de Pós-Graduação em Medicina Veterinária
• Departamento: Medicina Veterinária
• País: Brasil
• Palavras-chave em Português: Feridas cutâneas; Plasma rico em plaquetas; Cicatrização
• Palavras-chave em Inglês: Skin wounds; Platelet-rich plasma; Healing
• Área do conhecimento CNPq: CNPQ::CIENCIAS AGRARIAS::MEDICINA VETERINARIA
• Link de acesso: http://repositorio.ufsm.br/handle/1/24292

In equine medicine, cutaneous injuries, especially distal limb, are part of the main challenges and their resolutions involve high costs, with impacts both on the individual, reducing their quality of life, and economic, for the breeders and owners of these animals. There are numerous studies demonstrating the use of PRP and its effectiveness in the healing of these injuries, but in these studies the blood of the animal itself to be treated is used, and the PRP is performed at the same time of application. Due to the reality of the veterinarian who works in the field of bringing barriers to the implementation of this process, and its use depending on numerous applications, this study aims to measure the feasibility of using homologous blood to carry out the application of PRP in order to facilitate the completion of the process. The objectives of this study were to evaluate, through macroscopy and microscopy, the healing process of wounds in horses, treated with autologous and homologous PRP. Six horses were selected, 5 animals were submitted to surgical wounds, and in each animal three wounds were made, which were treated with autologous PPR, homologous PRP and saline solution, and the 6th animal served as a universal donor for the treatment with homologous PRP. There was no statistical difference in the reduction of the lesion area at 15 and 30 days of treatment (p > 0.05), even though visually the groups treated with the different forms of PRP were smaller than those of the control group. As for the macroscopic evaluations, no wound presented secretion as well as signs of infection, no animal also presented exuberant granulation tissue. Homologous PRP was as efficient as autologous PRP in its ability to increase wound healing speed, allowing healing of very similar quality and without any adverse effects.