Efeito da doxiciclina na resistência de união à dentina de um sistema adesivo etch-and-rinse
Ano de defesa: | 2012 |
---|---|
Autor(a) principal: | |
Orientador(a): | |
Banca de defesa: | , |
Tipo de documento: | Dissertação |
Tipo de acesso: | Acesso aberto |
Idioma: | por |
Instituição de defesa: |
Universidade Federal de Santa Maria
|
Programa de Pós-Graduação: |
Programa de Pós-Graduação em Ciências Odontológicas
|
Departamento: |
Odontologia
|
País: |
BR
|
Palavras-chave em Português: | |
Palavras-chave em Inglês: | |
Área do conhecimento CNPq: | |
Link de acesso: | http://repositorio.ufsm.br/handle/1/6083 |
Resumo: | This study evaluated as overall purpose the influence of doxycycline used as a matrix metalloproteinase (MMPs) inhibitor on the microtensile bond strength (μTBS) of a total etching adhesive system to dentin, considering two formulations (different pHs) and two substrates (source and demineralized) of primary and permanent teeth. The study is divided into two articles, the aim of the first article was to evaluate the application s effect of acidic or neutral doxycycline on the μTBS to dentin. Twenty extracted noncarious third molars were divided into 4 groups (doxycycline acidic pH, doxycycline neutral pH, chlorhexidine and control - no treatment). A flat dentin surface was exposed, wet grinding and submitted to: acid etch, application of the substance corresponding treatment group, application of adhesive system and resin composite. The specimens were stored (24 h in distilled water) and sectioned to obtain sticks (cross-sectional area of approximately 0.9 mm2). The sticks were submitted to tensile test. The mean μTBS were submitted to a one-way ANOVA and Tukey s test (α = 0.05). No significant difference of immediate μTBS (MPa) was observed between the neutral and acidic doxycycline, furthermore the solutions of different pH values were statistically similar to control and chlorhexidine groups. For the second study 30 permanent molars and 30 second primary molars were divided into 12 experimental groups (n = 5) according to the surface treatment after etching: doxycycline, chlorhexidine and control, and the condition substrate: sound and demineralized (pH cycling). The specimens preparation, restorative procedures and tensile test were performed in the same way as in the previous study. The μTBS were subjected to a two-way ANOVA and Tukey's test (α = 0.05), considering separately primary and permanent teeth. For both teeth types the application of doxycycline did not affect the immediate μTBS, while the demineralized substrate values were statistically lower than the sound group. The doxycycline solution, even at acidic pH, does not seem to affect the immediate bond strength to dentin, while demineralized substrate needs attention by presenting μTBS immediately reduced compared to sound. |
id |
UFSM-20_a6b761fa31aaeaef749b6a58f9f5d2fe |
---|---|
oai_identifier_str |
oai:repositorio.ufsm.br:1/6083 |
network_acronym_str |
UFSM-20 |
network_name_str |
Manancial - Repositório Digital da UFSM |
repository_id_str |
|
spelling |
2012-10-092012-10-092012-02-08OLIVEIRA, Héllen de Lacerda.Effect of doxycycline on the microtensile bond strength of a etch-and-rinse adhesive system to dentin. 2012. 56 f. Dissertação (Mestrado em Odontologia) - Universidade Federal de Santa Maria, Santa Maria, 2012.http://repositorio.ufsm.br/handle/1/6083This study evaluated as overall purpose the influence of doxycycline used as a matrix metalloproteinase (MMPs) inhibitor on the microtensile bond strength (μTBS) of a total etching adhesive system to dentin, considering two formulations (different pHs) and two substrates (source and demineralized) of primary and permanent teeth. The study is divided into two articles, the aim of the first article was to evaluate the application s effect of acidic or neutral doxycycline on the μTBS to dentin. Twenty extracted noncarious third molars were divided into 4 groups (doxycycline acidic pH, doxycycline neutral pH, chlorhexidine and control - no treatment). A flat dentin surface was exposed, wet grinding and submitted to: acid etch, application of the substance corresponding treatment group, application of adhesive system and resin composite. The specimens were stored (24 h in distilled water) and sectioned to obtain sticks (cross-sectional area of approximately 0.9 mm2). The sticks were submitted to tensile test. The mean μTBS were submitted to a one-way ANOVA and Tukey s test (α = 0.05). No significant difference of immediate μTBS (MPa) was observed between the neutral and acidic doxycycline, furthermore the solutions of different pH values were statistically similar to control and chlorhexidine groups. For the second study 30 permanent molars and 30 second primary molars were divided into 12 experimental groups (n = 5) according to the surface treatment after etching: doxycycline, chlorhexidine and control, and the condition substrate: sound and demineralized (pH cycling). The specimens preparation, restorative procedures and tensile test were performed in the same way as in the previous study. The μTBS were subjected to a two-way ANOVA and Tukey's test (α = 0.05), considering separately primary and permanent teeth. For both teeth types the application of doxycycline did not affect the immediate μTBS, while the demineralized substrate values were statistically lower than the sound group. The doxycycline solution, even at acidic pH, does not seem to affect the immediate bond strength to dentin, while demineralized substrate needs attention by presenting μTBS immediately reduced compared to sound.Este trabalho teve como objetivo geral, avaliar a influência de uma substância inibidora de metaloproteinases (MMPs), a doxiciclina, na resistência de união (RU) à dentina de um sistema adesivo com condicionamento prévio, considerando duas formulações (diferentes pHs) e dois substratos (hígido e desmineralizado) de dentes decíduos e permanentes. O trabalho está dividido em dois artigos, sendo o primeiro realizado com o intuito de avaliar o efeito da aplicação da doxiciclina ácida ou neutra na RU à dentina. Para isso, foram selecionados 20 terceiros molares hígidos, os quais foram divididos em 4 grupos experimentais (doxiciclina pH ácido, doxiciclina pH neutro, clorexidina e controle nenhum tratamento). Os dentes foram seccionados próximo ao terço médio da coroa para obtenção de uma superfície dentinária plana, a qual foi submetida a: condicionamento ácido, tratamento de acordo com o grupo, ou seja, aplicação da substância correspondente na superfície condicionada, aplicação do sistema adesivo e restauração com resina composta. Após armazenamento (24h em água destilada a 37°C) os espécimes foram seccionados para obtenção de palitos (área de secção transversal de aproximadamente 0,9mm2), os quais foram submetidos a ensaio de tração. Os valores médios de RU foram submetidos à análise de variância com um fator e ao teste de Tukey (α=0,05). Os valores de RU (em MPa) obtidos para os grupos tratados com as soluções de doxiciclina em diferentes pHs apresentaram valores de RU estatisticamente semelhantes entre si e aos grupos controle e clorexidina. Para o segundo estudo, foram selecionados 30 terceiros molares permanentes e 30 segundos molares decíduos hígidos, os quais foram divididos em 12 grupos experimentais (n=5) de acordo com o tratamento da superfície após condicionamento ácido: doxiciclina, clorexidina e controle, e a condição do substrato: hígido e desmineralizado (ciclagem de pH). O preparo dos espécimes, procedimentos restauradores e ensaio de tração foram realizados da mesma forma que no estudo anterior. Os valores de RU obtidos foram submetidos à análise de variância de dois fatores e ao teste de Tukey (α=0,05), considerando separadamente dentes decíduos e permanentes. Para os dois tipos de dentes, a aplicação de solução de doxiciclina não afetou a resistência de união imediata, enquanto o substrato desmineralizado apresentou valores estatisticamente inferiores ao grupo hígido. A solução de doxiciclina, mesmo em pH ácido, parece não afetar a resistência de união imediata à dentina, sendo que o substrato desmineralizado merece atenção por apresentar valores de RU imediata reduzidos comparado ao hígido.Coordenação de Aperfeiçoamento de Pessoal de Nível Superiorapplication/pdfporUniversidade Federal de Santa MariaPrograma de Pós-Graduação em Ciências OdontológicasUFSMBROdontologiaClorexidinaDoxiciclinaMetaloproteinasesResistência de união pHChlorhexidineDoxycyclineMetalloproteinaseBond strength pHCNPQ::CIENCIAS DA SAUDE::ODONTOLOGIAEfeito da doxiciclina na resistência de união à dentina de um sistema adesivo etch-and-rinseEffect of doxycycline on the microtensile bond strength of a etch-and-rinse adhesive system to dentininfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/masterThesisRocha, Rachel de Oliveirahttp://lattes.cnpq.br/0239294008628766Rodrigues Filho, Leonardo Eloyhttp://lattes.cnpq.br/6444824364259285Susin, Alexandre Henriquehttp://lattes.cnpq.br/5531102975088516http://lattes.cnpq.br/4964843234828418Oliveira, Héllen de Lacerda400200000000400300300300300dedb7061-bb6a-4580-b6de-543a59d023b2150afc70-4d32-44fa-b634-cbbdbd98760389424b84-1957-46bb-b7b4-d69747c06b1fed90e2df-d3a2-4fb1-bdec-0b4064121a21info:eu-repo/semantics/openAccessreponame:Manancial - Repositório Digital da UFSMinstname:Universidade Federal de Santa Maria (UFSM)instacron:UFSMORIGINALOLIVEIRA, HELLEN DE LACERDA.pdfapplication/pdf1041970http://repositorio.ufsm.br/bitstream/1/6083/1/OLIVEIRA%2c%20HELLEN%20DE%20LACERDA.pdff86f0db3caab50f03020d45abc82d167MD51TEXTOLIVEIRA, HELLEN DE LACERDA.pdf.txtOLIVEIRA, HELLEN DE LACERDA.pdf.txtExtracted texttext/plain89297http://repositorio.ufsm.br/bitstream/1/6083/2/OLIVEIRA%2c%20HELLEN%20DE%20LACERDA.pdf.txt6c77a53afd872fbbc5f96f1cdc271672MD52THUMBNAILOLIVEIRA, HELLEN DE LACERDA.pdf.jpgOLIVEIRA, HELLEN DE LACERDA.pdf.jpgIM Thumbnailimage/jpeg5253http://repositorio.ufsm.br/bitstream/1/6083/3/OLIVEIRA%2c%20HELLEN%20DE%20LACERDA.pdf.jpg31b6d808fafafb823c2b4ff2501be8ceMD531/60832022-05-12 08:50:18.569oai:repositorio.ufsm.br:1/6083Repositório Institucionalhttp://repositorio.ufsm.br/PUBhttp://repositorio.ufsm.br/oai/requestopendoar:39132022-05-12T11:50:18Manancial - Repositório Digital da UFSM - Universidade Federal de Santa Maria (UFSM)false |
dc.title.por.fl_str_mv |
Efeito da doxiciclina na resistência de união à dentina de um sistema adesivo etch-and-rinse |
dc.title.alternative.eng.fl_str_mv |
Effect of doxycycline on the microtensile bond strength of a etch-and-rinse adhesive system to dentin |
title |
Efeito da doxiciclina na resistência de união à dentina de um sistema adesivo etch-and-rinse |
spellingShingle |
Efeito da doxiciclina na resistência de união à dentina de um sistema adesivo etch-and-rinse Oliveira, Héllen de Lacerda Clorexidina Doxiciclina Metaloproteinases Resistência de união pH Chlorhexidine Doxycycline Metalloproteinase Bond strength pH CNPQ::CIENCIAS DA SAUDE::ODONTOLOGIA |
title_short |
Efeito da doxiciclina na resistência de união à dentina de um sistema adesivo etch-and-rinse |
title_full |
Efeito da doxiciclina na resistência de união à dentina de um sistema adesivo etch-and-rinse |
title_fullStr |
Efeito da doxiciclina na resistência de união à dentina de um sistema adesivo etch-and-rinse |
title_full_unstemmed |
Efeito da doxiciclina na resistência de união à dentina de um sistema adesivo etch-and-rinse |
title_sort |
Efeito da doxiciclina na resistência de união à dentina de um sistema adesivo etch-and-rinse |
author |
Oliveira, Héllen de Lacerda |
author_facet |
Oliveira, Héllen de Lacerda |
author_role |
author |
dc.contributor.advisor1.fl_str_mv |
Rocha, Rachel de Oliveira |
dc.contributor.advisor1Lattes.fl_str_mv |
http://lattes.cnpq.br/0239294008628766 |
dc.contributor.referee1.fl_str_mv |
Rodrigues Filho, Leonardo Eloy |
dc.contributor.referee1Lattes.fl_str_mv |
http://lattes.cnpq.br/6444824364259285 |
dc.contributor.referee2.fl_str_mv |
Susin, Alexandre Henrique |
dc.contributor.referee2Lattes.fl_str_mv |
http://lattes.cnpq.br/5531102975088516 |
dc.contributor.authorLattes.fl_str_mv |
http://lattes.cnpq.br/4964843234828418 |
dc.contributor.author.fl_str_mv |
Oliveira, Héllen de Lacerda |
contributor_str_mv |
Rocha, Rachel de Oliveira Rodrigues Filho, Leonardo Eloy Susin, Alexandre Henrique |
dc.subject.por.fl_str_mv |
Clorexidina Doxiciclina Metaloproteinases Resistência de união pH |
topic |
Clorexidina Doxiciclina Metaloproteinases Resistência de união pH Chlorhexidine Doxycycline Metalloproteinase Bond strength pH CNPQ::CIENCIAS DA SAUDE::ODONTOLOGIA |
dc.subject.eng.fl_str_mv |
Chlorhexidine Doxycycline Metalloproteinase Bond strength pH |
dc.subject.cnpq.fl_str_mv |
CNPQ::CIENCIAS DA SAUDE::ODONTOLOGIA |
description |
This study evaluated as overall purpose the influence of doxycycline used as a matrix metalloproteinase (MMPs) inhibitor on the microtensile bond strength (μTBS) of a total etching adhesive system to dentin, considering two formulations (different pHs) and two substrates (source and demineralized) of primary and permanent teeth. The study is divided into two articles, the aim of the first article was to evaluate the application s effect of acidic or neutral doxycycline on the μTBS to dentin. Twenty extracted noncarious third molars were divided into 4 groups (doxycycline acidic pH, doxycycline neutral pH, chlorhexidine and control - no treatment). A flat dentin surface was exposed, wet grinding and submitted to: acid etch, application of the substance corresponding treatment group, application of adhesive system and resin composite. The specimens were stored (24 h in distilled water) and sectioned to obtain sticks (cross-sectional area of approximately 0.9 mm2). The sticks were submitted to tensile test. The mean μTBS were submitted to a one-way ANOVA and Tukey s test (α = 0.05). No significant difference of immediate μTBS (MPa) was observed between the neutral and acidic doxycycline, furthermore the solutions of different pH values were statistically similar to control and chlorhexidine groups. For the second study 30 permanent molars and 30 second primary molars were divided into 12 experimental groups (n = 5) according to the surface treatment after etching: doxycycline, chlorhexidine and control, and the condition substrate: sound and demineralized (pH cycling). The specimens preparation, restorative procedures and tensile test were performed in the same way as in the previous study. The μTBS were subjected to a two-way ANOVA and Tukey's test (α = 0.05), considering separately primary and permanent teeth. For both teeth types the application of doxycycline did not affect the immediate μTBS, while the demineralized substrate values were statistically lower than the sound group. The doxycycline solution, even at acidic pH, does not seem to affect the immediate bond strength to dentin, while demineralized substrate needs attention by presenting μTBS immediately reduced compared to sound. |
publishDate |
2012 |
dc.date.accessioned.fl_str_mv |
2012-10-09 |
dc.date.available.fl_str_mv |
2012-10-09 |
dc.date.issued.fl_str_mv |
2012-02-08 |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/masterThesis |
format |
masterThesis |
status_str |
publishedVersion |
dc.identifier.citation.fl_str_mv |
OLIVEIRA, Héllen de Lacerda.Effect of doxycycline on the microtensile bond strength of a etch-and-rinse adhesive system to dentin. 2012. 56 f. Dissertação (Mestrado em Odontologia) - Universidade Federal de Santa Maria, Santa Maria, 2012. |
dc.identifier.uri.fl_str_mv |
http://repositorio.ufsm.br/handle/1/6083 |
identifier_str_mv |
OLIVEIRA, Héllen de Lacerda.Effect of doxycycline on the microtensile bond strength of a etch-and-rinse adhesive system to dentin. 2012. 56 f. Dissertação (Mestrado em Odontologia) - Universidade Federal de Santa Maria, Santa Maria, 2012. |
url |
http://repositorio.ufsm.br/handle/1/6083 |
dc.language.iso.fl_str_mv |
por |
language |
por |
dc.relation.cnpq.fl_str_mv |
400200000000 |
dc.relation.confidence.fl_str_mv |
400 300 300 300 300 |
dc.relation.authority.fl_str_mv |
dedb7061-bb6a-4580-b6de-543a59d023b2 150afc70-4d32-44fa-b634-cbbdbd987603 89424b84-1957-46bb-b7b4-d69747c06b1f ed90e2df-d3a2-4fb1-bdec-0b4064121a21 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Universidade Federal de Santa Maria |
dc.publisher.program.fl_str_mv |
Programa de Pós-Graduação em Ciências Odontológicas |
dc.publisher.initials.fl_str_mv |
UFSM |
dc.publisher.country.fl_str_mv |
BR |
dc.publisher.department.fl_str_mv |
Odontologia |
publisher.none.fl_str_mv |
Universidade Federal de Santa Maria |
dc.source.none.fl_str_mv |
reponame:Manancial - Repositório Digital da UFSM instname:Universidade Federal de Santa Maria (UFSM) instacron:UFSM |
instname_str |
Universidade Federal de Santa Maria (UFSM) |
instacron_str |
UFSM |
institution |
UFSM |
reponame_str |
Manancial - Repositório Digital da UFSM |
collection |
Manancial - Repositório Digital da UFSM |
bitstream.url.fl_str_mv |
http://repositorio.ufsm.br/bitstream/1/6083/1/OLIVEIRA%2c%20HELLEN%20DE%20LACERDA.pdf http://repositorio.ufsm.br/bitstream/1/6083/2/OLIVEIRA%2c%20HELLEN%20DE%20LACERDA.pdf.txt http://repositorio.ufsm.br/bitstream/1/6083/3/OLIVEIRA%2c%20HELLEN%20DE%20LACERDA.pdf.jpg |
bitstream.checksum.fl_str_mv |
f86f0db3caab50f03020d45abc82d167 6c77a53afd872fbbc5f96f1cdc271672 31b6d808fafafb823c2b4ff2501be8ce |
bitstream.checksumAlgorithm.fl_str_mv |
MD5 MD5 MD5 |
repository.name.fl_str_mv |
Manancial - Repositório Digital da UFSM - Universidade Federal de Santa Maria (UFSM) |
repository.mail.fl_str_mv |
|
_version_ |
1794524290756902912 |