Efeito de diferentes protocolos de treinamento físico em modelo experimental de osteoartrite
Ano de defesa: | 2023 |
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Autor(a) principal: | |
Orientador(a): | |
Banca de defesa: | , , , |
Tipo de documento: | Tese |
Tipo de acesso: | Acesso aberto |
Idioma: | por |
Instituição de defesa: |
Universidade Federal de Santa Maria
Centro de Ciências Naturais e Exatas |
Programa de Pós-Graduação: |
Programa de Pós-Graduação em Ciências Biológicas: Bioquímica Toxicológica
|
Departamento: |
Bioquímica
|
País: |
Brasil
|
Palavras-chave em Português: | |
Palavras-chave em Inglês: | |
Área do conhecimento CNPq: | |
Link de acesso: | http://repositorio.ufsm.br/handle/1/30478 |
Resumo: | Osteoarthritis is characterized as a chronic and degenerative joint disease, affecting approximately 50% of the elderly population, being associated with pain and morphological and biochemical alterations. It is known that exercise acts as a non-invasive therapeutic form, through its various benefits, such as improving muscle mass and function, bone remodeling and preservation, among others. However, no proof of benefit is found in the literature when related to aquatic training or strength training, both widely prescribed and indicated for the elderly population and those with osteoarthritis. Our objective was to observe parameters related to painful behavior, edema and bone morphology (article 1), in addition to analyzing the oxidative-antioxidant profile (article 2) in a model of osteoarthritis induced by a single injection of sodium monoiodoacetate, in the knee of male rats, and verify the real and possible benefit of aquatic and strength training on these mentioned parameters. The animals were divided into: control group (C), injury group with sodium monoidoacetate (MIA), M + aquatic training (M+AT), M + strength training (M+ST) and M+ positive control - diclofenac sodium (M+Dic). We observed in article 1 that the animals in group M presented alterations compatible with the human disease, such as pain, edema and bone degradation. The M+AT group was not effective in changing parameters related to pain, edema and bone morphology, while in the M+ST group the analyzed parameters were attenuated, as well as showing an increase in muscle strength and function, not observed by aquatic training. With regard to the M+Dic group, no significant changes were observed when related to behavior, in addition to no changes being observed at histopathological levels. In article 2, we observed that the M group presented similar characteristics to studies in the literature, such as a higher oxidative profile in the liver, kidney, plasma and brainstem. The trainings again presented alterations different from those found in the literature, showing that the M+AT group presented attenuation of the redox status by neutralizing the toxicity of sodium monoidoacetate, observed in the kidney, plasma and brainstem. No alterations were observed in the antioxidant enzymatic activity and in the histopathological parameters evaluated. However, again the M+ST group showed more significant benefits in their results, demonstrating that training reduced oxidative status by the same mechanism as aquatic training, however, with an increase in antioxidant enzymatic activity and an increase in muscle mass, suggesting an improvement in histopathological parameters evaluated through this dataset. Still, we observed specific alterations of training in the liver (M+AT group) and kidney (M+ST) when related to the production of reactive oxygen species, denoting consistency in the characteristics of the proposed exercises. In this sense, we conclude that aquatic training, despite the great clinical consensus demonstrating its superiority for elderly patients with OA, our data suggest that strength training was more effective, improving the evaluated parameters, and through these, preserving greater the bone structure of the animals with osteoarthritis, and therefore suggesting that it is the most suitable training for this specific group. |
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2023-11-10T13:50:03Z2023-11-10T13:50:03Z2023-09-21http://repositorio.ufsm.br/handle/1/30478Osteoarthritis is characterized as a chronic and degenerative joint disease, affecting approximately 50% of the elderly population, being associated with pain and morphological and biochemical alterations. It is known that exercise acts as a non-invasive therapeutic form, through its various benefits, such as improving muscle mass and function, bone remodeling and preservation, among others. However, no proof of benefit is found in the literature when related to aquatic training or strength training, both widely prescribed and indicated for the elderly population and those with osteoarthritis. Our objective was to observe parameters related to painful behavior, edema and bone morphology (article 1), in addition to analyzing the oxidative-antioxidant profile (article 2) in a model of osteoarthritis induced by a single injection of sodium monoiodoacetate, in the knee of male rats, and verify the real and possible benefit of aquatic and strength training on these mentioned parameters. The animals were divided into: control group (C), injury group with sodium monoidoacetate (MIA), M + aquatic training (M+AT), M + strength training (M+ST) and M+ positive control - diclofenac sodium (M+Dic). We observed in article 1 that the animals in group M presented alterations compatible with the human disease, such as pain, edema and bone degradation. The M+AT group was not effective in changing parameters related to pain, edema and bone morphology, while in the M+ST group the analyzed parameters were attenuated, as well as showing an increase in muscle strength and function, not observed by aquatic training. With regard to the M+Dic group, no significant changes were observed when related to behavior, in addition to no changes being observed at histopathological levels. In article 2, we observed that the M group presented similar characteristics to studies in the literature, such as a higher oxidative profile in the liver, kidney, plasma and brainstem. The trainings again presented alterations different from those found in the literature, showing that the M+AT group presented attenuation of the redox status by neutralizing the toxicity of sodium monoidoacetate, observed in the kidney, plasma and brainstem. No alterations were observed in the antioxidant enzymatic activity and in the histopathological parameters evaluated. However, again the M+ST group showed more significant benefits in their results, demonstrating that training reduced oxidative status by the same mechanism as aquatic training, however, with an increase in antioxidant enzymatic activity and an increase in muscle mass, suggesting an improvement in histopathological parameters evaluated through this dataset. Still, we observed specific alterations of training in the liver (M+AT group) and kidney (M+ST) when related to the production of reactive oxygen species, denoting consistency in the characteristics of the proposed exercises. In this sense, we conclude that aquatic training, despite the great clinical consensus demonstrating its superiority for elderly patients with OA, our data suggest that strength training was more effective, improving the evaluated parameters, and through these, preserving greater the bone structure of the animals with osteoarthritis, and therefore suggesting that it is the most suitable training for this specific group.A osteoartritre é caracterizada como uma doença articular crônica e degenerativa, afetando cerca de 50% da população idosa, sendo associada à dor e alterações morfológicas e bioquímicas. Sabe-se que o exercício atua como forma terapêutica não invasiva, através dos seus diversos benefícios, como melhora da massa e função muscular, remodelação e preservação óssea, entre outros. No entanto, não são encontrados na literatura comprovação do benefício quando relacionado o treinamento aquático, ou treinamento de força, ambos amplamente prescritos e indicados para a população idosa e com osteoartrite. Nosso objetivo foi de observar parâmetros relacionados ao comportamento doloroso, edema e morfologia óssea (artigo 1), além de analisar o perfil oxidativo-antioxidante (artigo 2) em um modelo de osteoartrite induzida por uma única injeção de monoiodoacetato de sódio, no joelho de ratos machos, e verificar o real e possível benefício do treinamento aquático e de força sobre estes parâmetros mencionados. Os animais foram divididos em: grupo controle (C), grupo lesão com monoidoacetato de sódio (MIA), M + treinamento aquático (M+AT), M + treinamento de força (M+ST) e M+ controle positivo – Diclofenaco de sódio (M+Dic). Observamos no artigo 1 que os animais do grupo M apresentaram alterações compatíveis com a doença humana, como dor, edema e degradação óssea. O grupo M+AT não foi eficaz em alterar parâmetros relacionados a dor, edema e morfologia óssea, enquanto que no grupo M+ST os parâmetros analisados foram atenuados, bem como apresentaram aumento na força e função muscular, não observados pelo treinamento aquático. Com relação ao grupo M+Dic, não foram observadas alterações significantes quando relacionados com ao comportamento, além de não ser observado alterações a níveis histopatológicos. No artigo 2, observamos que o grupo M apresentou características semelhantes a estudos da literatura, como maior perfil oxidativo em fígado, rim, plasma e tronco encefálico. Os treinamentos novamente apresentaram alterações diferentes das encontradas na literatura, mostrando que o grupo M+AT apresentou atenuação do status redox pela neutralização da toxicidade do monoidoacetato de sódio, observada em rim, plasma e tronco encefálico. Não foram observadas alterações na atividade enzimática antioxidante e nos parâmetros histopatológicos avaliados. No entanto, novamente o grupo M+ST apresentou benefícios mais significativos nos seus resultados, demonstrando que o treinamento reduziu status oxidativo pelo mesmo mecanismo do treinamento aquático, porém, com aumento na atividade enzimática antioxidante e no aumento da massa muscular, sugerindo a melhora dos parâmetros histopatológicos avaliados, através deste conjunto de dados. Ainda, observamos alterações especificas dos treinamentos em fígado (grupo M+AT) e rim (M+ST) quando relacionados com a produção de espécies reativas de oxigênio, denotando a consistência nas características dos exercícios propostos. Neste sentido, concluímos que o treinamento aquático, apesar do grande consenso clinico demonstrar sua superioridade para pacientes idosos com OA, nossos dados sugerem que o treinamento de força foi mais efetivo, melhorando os parâmetros avaliados, e através destes, preservando maior a estrutura óssea dos animais com osteoartite, e sugerindo, portanto, ser o treinamento mais indicado para este grupo em especifico.Coordenação de Aperfeiçoamento de Pessoal de Nível Superior - CAPESporUniversidade Federal de Santa MariaCentro de Ciências Naturais e ExatasPrograma de Pós-Graduação em Ciências Biológicas: Bioquímica ToxicológicaUFSMBrasilBioquímicaAttribution-NonCommercial-NoDerivatives 4.0 Internationalhttp://creativecommons.org/licenses/by-nc-nd/4.0/info:eu-repo/semantics/openAccessOsteoartriteMonoiodoacetato de sódioTreinamento aquáticoTreinamento de forçaEstresse oxidativoHistopatoloiaOsteoarthritisSodium monoiodoacetateAquatic trainingStrength trainingOxidative stressHistopathologyCNPQ::CIENCIAS BIOLOGICAS::BIOQUIMICAEfeito de diferentes protocolos de treinamento físico em modelo experimental de osteoartriteEvaluation of pain, histopathology and oxidative profile of rats in an osteoarthritis model and the effect of physical exerciseinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/doctoralThesisSoares, Félix Alexandre Antuneshttp://lattes.cnpq.br/8752453650114092Royes, Luiz Fernando FreireLima, Frederico DinizSilva, Morgana Duarte daBertol, Charise Dallazemhttp://lattes.cnpq.br/3587592287456403Silva, Julia Spanhol da2008000000026006006006006006006003aef53b7-b173-4c56-a944-bed2de5e5ddadeab4ee1-af40-45c4-802a-f508dda932c52b2f2704-9d5e-442c-87a2-913405cada4a09597606-19d6-4a21-a6bd-cbbcd63b51187871a359-5522-4c97-a619-b136195d971616beb97e-b94c-49df-8949-e991fe8dbb2dreponame:Manancial - Repositório Digital da UFSMinstname:Universidade Federal de Santa Maria (UFSM)instacron:UFSMCC-LICENSElicense_rdflicense_rdfapplication/rdf+xml; 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dc.title.por.fl_str_mv |
Efeito de diferentes protocolos de treinamento físico em modelo experimental de osteoartrite |
dc.title.alternative.eng.fl_str_mv |
Evaluation of pain, histopathology and oxidative profile of rats in an osteoarthritis model and the effect of physical exercise |
title |
Efeito de diferentes protocolos de treinamento físico em modelo experimental de osteoartrite |
spellingShingle |
Efeito de diferentes protocolos de treinamento físico em modelo experimental de osteoartrite Silva, Julia Spanhol da Osteoartrite Monoiodoacetato de sódio Treinamento aquático Treinamento de força Estresse oxidativo Histopatoloia Osteoarthritis Sodium monoiodoacetate Aquatic training Strength training Oxidative stress Histopathology CNPQ::CIENCIAS BIOLOGICAS::BIOQUIMICA |
title_short |
Efeito de diferentes protocolos de treinamento físico em modelo experimental de osteoartrite |
title_full |
Efeito de diferentes protocolos de treinamento físico em modelo experimental de osteoartrite |
title_fullStr |
Efeito de diferentes protocolos de treinamento físico em modelo experimental de osteoartrite |
title_full_unstemmed |
Efeito de diferentes protocolos de treinamento físico em modelo experimental de osteoartrite |
title_sort |
Efeito de diferentes protocolos de treinamento físico em modelo experimental de osteoartrite |
author |
Silva, Julia Spanhol da |
author_facet |
Silva, Julia Spanhol da |
author_role |
author |
dc.contributor.advisor1.fl_str_mv |
Soares, Félix Alexandre Antunes |
dc.contributor.advisor1Lattes.fl_str_mv |
http://lattes.cnpq.br/8752453650114092 |
dc.contributor.referee1.fl_str_mv |
Royes, Luiz Fernando Freire |
dc.contributor.referee2.fl_str_mv |
Lima, Frederico Diniz |
dc.contributor.referee3.fl_str_mv |
Silva, Morgana Duarte da |
dc.contributor.referee4.fl_str_mv |
Bertol, Charise Dallazem |
dc.contributor.authorLattes.fl_str_mv |
http://lattes.cnpq.br/3587592287456403 |
dc.contributor.author.fl_str_mv |
Silva, Julia Spanhol da |
contributor_str_mv |
Soares, Félix Alexandre Antunes Royes, Luiz Fernando Freire Lima, Frederico Diniz Silva, Morgana Duarte da Bertol, Charise Dallazem |
dc.subject.por.fl_str_mv |
Osteoartrite Monoiodoacetato de sódio Treinamento aquático Treinamento de força Estresse oxidativo Histopatoloia |
topic |
Osteoartrite Monoiodoacetato de sódio Treinamento aquático Treinamento de força Estresse oxidativo Histopatoloia Osteoarthritis Sodium monoiodoacetate Aquatic training Strength training Oxidative stress Histopathology CNPQ::CIENCIAS BIOLOGICAS::BIOQUIMICA |
dc.subject.eng.fl_str_mv |
Osteoarthritis Sodium monoiodoacetate Aquatic training Strength training Oxidative stress Histopathology |
dc.subject.cnpq.fl_str_mv |
CNPQ::CIENCIAS BIOLOGICAS::BIOQUIMICA |
description |
Osteoarthritis is characterized as a chronic and degenerative joint disease, affecting approximately 50% of the elderly population, being associated with pain and morphological and biochemical alterations. It is known that exercise acts as a non-invasive therapeutic form, through its various benefits, such as improving muscle mass and function, bone remodeling and preservation, among others. However, no proof of benefit is found in the literature when related to aquatic training or strength training, both widely prescribed and indicated for the elderly population and those with osteoarthritis. Our objective was to observe parameters related to painful behavior, edema and bone morphology (article 1), in addition to analyzing the oxidative-antioxidant profile (article 2) in a model of osteoarthritis induced by a single injection of sodium monoiodoacetate, in the knee of male rats, and verify the real and possible benefit of aquatic and strength training on these mentioned parameters. The animals were divided into: control group (C), injury group with sodium monoidoacetate (MIA), M + aquatic training (M+AT), M + strength training (M+ST) and M+ positive control - diclofenac sodium (M+Dic). We observed in article 1 that the animals in group M presented alterations compatible with the human disease, such as pain, edema and bone degradation. The M+AT group was not effective in changing parameters related to pain, edema and bone morphology, while in the M+ST group the analyzed parameters were attenuated, as well as showing an increase in muscle strength and function, not observed by aquatic training. With regard to the M+Dic group, no significant changes were observed when related to behavior, in addition to no changes being observed at histopathological levels. In article 2, we observed that the M group presented similar characteristics to studies in the literature, such as a higher oxidative profile in the liver, kidney, plasma and brainstem. The trainings again presented alterations different from those found in the literature, showing that the M+AT group presented attenuation of the redox status by neutralizing the toxicity of sodium monoidoacetate, observed in the kidney, plasma and brainstem. No alterations were observed in the antioxidant enzymatic activity and in the histopathological parameters evaluated. However, again the M+ST group showed more significant benefits in their results, demonstrating that training reduced oxidative status by the same mechanism as aquatic training, however, with an increase in antioxidant enzymatic activity and an increase in muscle mass, suggesting an improvement in histopathological parameters evaluated through this dataset. Still, we observed specific alterations of training in the liver (M+AT group) and kidney (M+ST) when related to the production of reactive oxygen species, denoting consistency in the characteristics of the proposed exercises. In this sense, we conclude that aquatic training, despite the great clinical consensus demonstrating its superiority for elderly patients with OA, our data suggest that strength training was more effective, improving the evaluated parameters, and through these, preserving greater the bone structure of the animals with osteoarthritis, and therefore suggesting that it is the most suitable training for this specific group. |
publishDate |
2023 |
dc.date.accessioned.fl_str_mv |
2023-11-10T13:50:03Z |
dc.date.available.fl_str_mv |
2023-11-10T13:50:03Z |
dc.date.issued.fl_str_mv |
2023-09-21 |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/doctoralThesis |
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doctoralThesis |
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publishedVersion |
dc.identifier.uri.fl_str_mv |
http://repositorio.ufsm.br/handle/1/30478 |
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http://repositorio.ufsm.br/handle/1/30478 |
dc.language.iso.fl_str_mv |
por |
language |
por |
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200800000002 |
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600 600 600 600 600 600 600 |
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Attribution-NonCommercial-NoDerivatives 4.0 International http://creativecommons.org/licenses/by-nc-nd/4.0/ info:eu-repo/semantics/openAccess |
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Attribution-NonCommercial-NoDerivatives 4.0 International http://creativecommons.org/licenses/by-nc-nd/4.0/ |
eu_rights_str_mv |
openAccess |
dc.publisher.none.fl_str_mv |
Universidade Federal de Santa Maria Centro de Ciências Naturais e Exatas |
dc.publisher.program.fl_str_mv |
Programa de Pós-Graduação em Ciências Biológicas: Bioquímica Toxicológica |
dc.publisher.initials.fl_str_mv |
UFSM |
dc.publisher.country.fl_str_mv |
Brasil |
dc.publisher.department.fl_str_mv |
Bioquímica |
publisher.none.fl_str_mv |
Universidade Federal de Santa Maria Centro de Ciências Naturais e Exatas |
dc.source.none.fl_str_mv |
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http://repositorio.ufsm.br/bitstream/1/30478/2/license_rdf http://repositorio.ufsm.br/bitstream/1/30478/1/TES_PPGBT_2023_SILVA_JULIA.pdf http://repositorio.ufsm.br/bitstream/1/30478/3/license.txt |
bitstream.checksum.fl_str_mv |
4460e5956bc1d1639be9ae6146a50347 d67eec6c8c86d4ed0edba757ec043075 2f0571ecee68693bd5cd3f17c1e075df |
bitstream.checksumAlgorithm.fl_str_mv |
MD5 MD5 MD5 |
repository.name.fl_str_mv |
Manancial - Repositório Digital da UFSM - Universidade Federal de Santa Maria (UFSM) |
repository.mail.fl_str_mv |
|
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1794524349600890880 |