Análise fitoquímica e estudo das atividades antimicrobiana, antioxidante e de inibição da enzima acetilcolinesterase das espécies Zanthoxylum rhoifolium e Zanthoxylum hyemale
Ano de defesa: | 2010 |
---|---|
Autor(a) principal: | |
Orientador(a): | |
Banca de defesa: | , |
Tipo de documento: | Dissertação |
Tipo de acesso: | Acesso aberto |
Idioma: | por |
Instituição de defesa: |
Universidade Federal de Santa Maria
|
Programa de Pós-Graduação: |
Programa de Pós-Graduação em Química
|
Departamento: |
Química
|
País: |
BR
|
Palavras-chave em Português: | |
Palavras-chave em Inglês: | |
Área do conhecimento CNPq: | |
Link de acesso: | http://repositorio.ufsm.br/handle/1/10472 |
Resumo: | The present study was designed to evaluate the biological activity from the stem bark of Zanthoxylum rhoifolium and Zanthoxylum hyemale. The neutral methanol extract and fractions of this extract, the basic fractions that were obtained after acid-basic extraction from the methanolic extract, and pure compounds isolated from these fraction, were investigated in vitro for antimicrobial activity, antioxidant potential and for acetylcholinesterase inhibition. From the dichlorometane fraction of Zanthoxylum rhoifolium were isolated three furoquinoline alkaloids: skimianine, 8-hidroxy-4,7-dimetoxy-furoquinoline, and γ-fagarin, four benzophenantridine alkaloids: dihydrocheleritrine, dihydroavicine, zanthoxyline and cheleritrine. From the hexane fraction, the lignanes sesamine and lupeol were also isolated. From the neutral methanol extract were isolates de aporfinic alkaloid magnoflorine. The minimal inhibitory concentration of cheleritrine (MIC =1.50 μg/ml) for all tested bacteria, and between 3.12 and 12.5 μg/ml for the tested yeasts, showed this alkaloid have a excellent antimicrobial activity compared to chloramphenicol (between 3.5 to 6.25 μg/m for bacteria) and nistatin (between 5.5 to 10.3 μg/ml for yeasts). The study highlighted the antimicrobial activity of Z. rhoifolium stem bark. This activity is probably due their higher benzophenantridinic alkaloids level. The furoquinoline alkaloids, despite their insignificant antimicrobial activity, were the most active against the enzime AChE. In addition, in this work, the amide tembamide was isolated from the steam bark of Zanthoxylum hyemale, and their derivatives used for a structure-ativity analysis. |
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2017-05-162017-05-162010-10-22ZANON, Graciane. Phytochemical analisis and antimicrobial activity, antioxidant and acetylcholinesterase inhibition activity study of species Zanthoxylum rhoifolium and Zanthoxylum hyemale. 2010. 174 f. Dissertação (Mestrado em Química) - Universidade Federal de Santa Maria, Santa Maria, 2010.http://repositorio.ufsm.br/handle/1/10472The present study was designed to evaluate the biological activity from the stem bark of Zanthoxylum rhoifolium and Zanthoxylum hyemale. The neutral methanol extract and fractions of this extract, the basic fractions that were obtained after acid-basic extraction from the methanolic extract, and pure compounds isolated from these fraction, were investigated in vitro for antimicrobial activity, antioxidant potential and for acetylcholinesterase inhibition. From the dichlorometane fraction of Zanthoxylum rhoifolium were isolated three furoquinoline alkaloids: skimianine, 8-hidroxy-4,7-dimetoxy-furoquinoline, and γ-fagarin, four benzophenantridine alkaloids: dihydrocheleritrine, dihydroavicine, zanthoxyline and cheleritrine. From the hexane fraction, the lignanes sesamine and lupeol were also isolated. From the neutral methanol extract were isolates de aporfinic alkaloid magnoflorine. The minimal inhibitory concentration of cheleritrine (MIC =1.50 μg/ml) for all tested bacteria, and between 3.12 and 12.5 μg/ml for the tested yeasts, showed this alkaloid have a excellent antimicrobial activity compared to chloramphenicol (between 3.5 to 6.25 μg/m for bacteria) and nistatin (between 5.5 to 10.3 μg/ml for yeasts). The study highlighted the antimicrobial activity of Z. rhoifolium stem bark. This activity is probably due their higher benzophenantridinic alkaloids level. The furoquinoline alkaloids, despite their insignificant antimicrobial activity, were the most active against the enzime AChE. In addition, in this work, the amide tembamide was isolated from the steam bark of Zanthoxylum hyemale, and their derivatives used for a structure-ativity analysis.O presente estudo foi proposto para avaliar a atividade biológica da casca do caule de Zanthoxylum rhoifolium e Zanthoxylum hyemale. O extrato metanólico neutro e as frações deste extrato, as frações básicas obtidas após extração ácido-base do extrato metanólico e os compostos puros isolados dessas frações, foram avaliados in vitro quanto a atividade antimicrobiana, potencial antioxidante e inibição da enzima acetilcolinesterase. Da fração diclorometânica de Zanthoxylum rhoifolium foram isolados três alcalóides furoquinolínicos: skimianina, 8-hidroxi-4,7-dimetoxi-furoquinolinico e γ-fagarina, quatro alcalóides benzofenantridínicos: diidrocheleritrina, diidroavicina, zantoxilina e cheleritrina. Da fração hexânica foram isolados a lignana sesamina e o triterpeno lupeol. A partir do extrato metanólico neutro foi isolado o alcalóide aporfinico magnoflorina. A concentração inibitória mínima de cheleritrina (CIM = 1,50 μg/ml) para todas as bactérias testadas, e entre 3,12 e 12,5 μg/ml para as leveduras testadas, mostraram que este alcalóide possui uma excelente atividade antimicrobiana em comparação ao cloranfenicol (entre 3,5-6,25 μg/ml para as bactérias) e nistatina (entre 5,5-10,3 μg/ml para as leveduras). O estudo evidenciou a atividade antimicrobiana da casca do caule de Z. rhoifolium. Esta atividade é, provavelmente, devido ao seu alto nível de alcalóides benzofenantridínicos. Os alcalóides furoquinolinicos, mostraram pequena atividade antimicrobiana e foram os mais ativos frente a enzima AChE. Além disso, neste trabalho, a amida tembamida foi isolada da casca do caule de Zanthoxylum hyemale e seus derivados utilizados para uma análise de relação estrutura-atividade.application/pdfporUniversidade Federal de Santa MariaPrograma de Pós-Graduação em QuímicaUFSMBRQuímicaZanthoxylum rhoifoliumZanthoxylum hyemaleAlcalóides furoquinolínicos e benzofenantridínicosAtividades biológicasAtividade antioxidanteZanthoxylum rhoifoliumZanthoxylum hyemaleFuroquinoline and benzophenanthridine alkaloidsBiological activitiesAntioxidant potentialCNPQ::CIENCIAS EXATAS E DA TERRA::QUIMICAAnálise fitoquímica e estudo das atividades antimicrobiana, antioxidante e de inibição da enzima acetilcolinesterase das espécies Zanthoxylum rhoifolium e Zanthoxylum hyemalePhytochemical analisis and antimicrobial activity, antioxidant and acetylcholinesterase inhibition activity study of species Zanthoxylum rhoifolium and Zanthoxylum hyemaleinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/masterThesisMorel, Ademir Fariashttp://lattes.cnpq.br/3554994385525333Dalcol, Ionara Irionhttp://lattes.cnpq.br/9769548819312192Maldaner, Gracielahttp://lattes.cnpq.br/6500796131690728http://lattes.cnpq.br/5696888830325410Zanon, Graciane1006000000004005003005005008c99befa-f1b3-4afb-98b8-7fab46c3d493c25ab3c9-65bb-4241-b9b7-1195e50239742cbacb00-be94-498b-9c77-1d47963baf69b662adc2-b8c5-40f5-9505-a588671e05dbinfo:eu-repo/semantics/openAccessreponame:Manancial - Repositório Digital da UFSMinstname:Universidade Federal de Santa Maria (UFSM)instacron:UFSMORIGINALZANON, GRACIANE.pdfapplication/pdf2980829http://repositorio.ufsm.br/bitstream/1/10472/1/ZANON%2c%20GRACIANE.pdf9868a04bff966533b9948d43320b971dMD51TEXTZANON, GRACIANE.pdf.txtZANON, GRACIANE.pdf.txtExtracted texttext/plain216353http://repositorio.ufsm.br/bitstream/1/10472/2/ZANON%2c%20GRACIANE.pdf.txt587191fe50d46122b344bbd5a73f1999MD52THUMBNAILZANON, GRACIANE.pdf.jpgZANON, GRACIANE.pdf.jpgIM Thumbnailimage/jpeg4677http://repositorio.ufsm.br/bitstream/1/10472/3/ZANON%2c%20GRACIANE.pdf.jpg4c0c222ce01abce2b26b7077730bfdfcMD531/104722022-08-11 09:22:25.083oai:repositorio.ufsm.br:1/10472Repositório Institucionalhttp://repositorio.ufsm.br/PUBhttp://repositorio.ufsm.br/oai/requestopendoar:39132022-08-11T12:22:25Manancial - Repositório Digital da UFSM - Universidade Federal de Santa Maria (UFSM)false |
dc.title.por.fl_str_mv |
Análise fitoquímica e estudo das atividades antimicrobiana, antioxidante e de inibição da enzima acetilcolinesterase das espécies Zanthoxylum rhoifolium e Zanthoxylum hyemale |
dc.title.alternative.eng.fl_str_mv |
Phytochemical analisis and antimicrobial activity, antioxidant and acetylcholinesterase inhibition activity study of species Zanthoxylum rhoifolium and Zanthoxylum hyemale |
title |
Análise fitoquímica e estudo das atividades antimicrobiana, antioxidante e de inibição da enzima acetilcolinesterase das espécies Zanthoxylum rhoifolium e Zanthoxylum hyemale |
spellingShingle |
Análise fitoquímica e estudo das atividades antimicrobiana, antioxidante e de inibição da enzima acetilcolinesterase das espécies Zanthoxylum rhoifolium e Zanthoxylum hyemale Zanon, Graciane Zanthoxylum rhoifolium Zanthoxylum hyemale Alcalóides furoquinolínicos e benzofenantridínicos Atividades biológicas Atividade antioxidante Zanthoxylum rhoifolium Zanthoxylum hyemale Furoquinoline and benzophenanthridine alkaloids Biological activities Antioxidant potential CNPQ::CIENCIAS EXATAS E DA TERRA::QUIMICA |
title_short |
Análise fitoquímica e estudo das atividades antimicrobiana, antioxidante e de inibição da enzima acetilcolinesterase das espécies Zanthoxylum rhoifolium e Zanthoxylum hyemale |
title_full |
Análise fitoquímica e estudo das atividades antimicrobiana, antioxidante e de inibição da enzima acetilcolinesterase das espécies Zanthoxylum rhoifolium e Zanthoxylum hyemale |
title_fullStr |
Análise fitoquímica e estudo das atividades antimicrobiana, antioxidante e de inibição da enzima acetilcolinesterase das espécies Zanthoxylum rhoifolium e Zanthoxylum hyemale |
title_full_unstemmed |
Análise fitoquímica e estudo das atividades antimicrobiana, antioxidante e de inibição da enzima acetilcolinesterase das espécies Zanthoxylum rhoifolium e Zanthoxylum hyemale |
title_sort |
Análise fitoquímica e estudo das atividades antimicrobiana, antioxidante e de inibição da enzima acetilcolinesterase das espécies Zanthoxylum rhoifolium e Zanthoxylum hyemale |
author |
Zanon, Graciane |
author_facet |
Zanon, Graciane |
author_role |
author |
dc.contributor.advisor1.fl_str_mv |
Morel, Ademir Farias |
dc.contributor.advisor1Lattes.fl_str_mv |
http://lattes.cnpq.br/3554994385525333 |
dc.contributor.referee1.fl_str_mv |
Dalcol, Ionara Irion |
dc.contributor.referee1Lattes.fl_str_mv |
http://lattes.cnpq.br/9769548819312192 |
dc.contributor.referee2.fl_str_mv |
Maldaner, Graciela |
dc.contributor.referee2Lattes.fl_str_mv |
http://lattes.cnpq.br/6500796131690728 |
dc.contributor.authorLattes.fl_str_mv |
http://lattes.cnpq.br/5696888830325410 |
dc.contributor.author.fl_str_mv |
Zanon, Graciane |
contributor_str_mv |
Morel, Ademir Farias Dalcol, Ionara Irion Maldaner, Graciela |
dc.subject.por.fl_str_mv |
Zanthoxylum rhoifolium Zanthoxylum hyemale Alcalóides furoquinolínicos e benzofenantridínicos Atividades biológicas Atividade antioxidante |
topic |
Zanthoxylum rhoifolium Zanthoxylum hyemale Alcalóides furoquinolínicos e benzofenantridínicos Atividades biológicas Atividade antioxidante Zanthoxylum rhoifolium Zanthoxylum hyemale Furoquinoline and benzophenanthridine alkaloids Biological activities Antioxidant potential CNPQ::CIENCIAS EXATAS E DA TERRA::QUIMICA |
dc.subject.eng.fl_str_mv |
Zanthoxylum rhoifolium Zanthoxylum hyemale Furoquinoline and benzophenanthridine alkaloids Biological activities Antioxidant potential |
dc.subject.cnpq.fl_str_mv |
CNPQ::CIENCIAS EXATAS E DA TERRA::QUIMICA |
description |
The present study was designed to evaluate the biological activity from the stem bark of Zanthoxylum rhoifolium and Zanthoxylum hyemale. The neutral methanol extract and fractions of this extract, the basic fractions that were obtained after acid-basic extraction from the methanolic extract, and pure compounds isolated from these fraction, were investigated in vitro for antimicrobial activity, antioxidant potential and for acetylcholinesterase inhibition. From the dichlorometane fraction of Zanthoxylum rhoifolium were isolated three furoquinoline alkaloids: skimianine, 8-hidroxy-4,7-dimetoxy-furoquinoline, and γ-fagarin, four benzophenantridine alkaloids: dihydrocheleritrine, dihydroavicine, zanthoxyline and cheleritrine. From the hexane fraction, the lignanes sesamine and lupeol were also isolated. From the neutral methanol extract were isolates de aporfinic alkaloid magnoflorine. The minimal inhibitory concentration of cheleritrine (MIC =1.50 μg/ml) for all tested bacteria, and between 3.12 and 12.5 μg/ml for the tested yeasts, showed this alkaloid have a excellent antimicrobial activity compared to chloramphenicol (between 3.5 to 6.25 μg/m for bacteria) and nistatin (between 5.5 to 10.3 μg/ml for yeasts). The study highlighted the antimicrobial activity of Z. rhoifolium stem bark. This activity is probably due their higher benzophenantridinic alkaloids level. The furoquinoline alkaloids, despite their insignificant antimicrobial activity, were the most active against the enzime AChE. In addition, in this work, the amide tembamide was isolated from the steam bark of Zanthoxylum hyemale, and their derivatives used for a structure-ativity analysis. |
publishDate |
2010 |
dc.date.issued.fl_str_mv |
2010-10-22 |
dc.date.accessioned.fl_str_mv |
2017-05-16 |
dc.date.available.fl_str_mv |
2017-05-16 |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/masterThesis |
format |
masterThesis |
status_str |
publishedVersion |
dc.identifier.citation.fl_str_mv |
ZANON, Graciane. Phytochemical analisis and antimicrobial activity, antioxidant and acetylcholinesterase inhibition activity study of species Zanthoxylum rhoifolium and Zanthoxylum hyemale. 2010. 174 f. Dissertação (Mestrado em Química) - Universidade Federal de Santa Maria, Santa Maria, 2010. |
dc.identifier.uri.fl_str_mv |
http://repositorio.ufsm.br/handle/1/10472 |
identifier_str_mv |
ZANON, Graciane. Phytochemical analisis and antimicrobial activity, antioxidant and acetylcholinesterase inhibition activity study of species Zanthoxylum rhoifolium and Zanthoxylum hyemale. 2010. 174 f. Dissertação (Mestrado em Química) - Universidade Federal de Santa Maria, Santa Maria, 2010. |
url |
http://repositorio.ufsm.br/handle/1/10472 |
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por |
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Universidade Federal de Santa Maria |
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Química |
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Universidade Federal de Santa Maria |
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