Alterações bioquímicas e estresse oxidativo associados ao hipotireoidismo
Ano de defesa: | 2010 |
---|---|
Autor(a) principal: | |
Orientador(a): | |
Banca de defesa: | , |
Tipo de documento: | Dissertação |
Tipo de acesso: | Acesso aberto |
Idioma: | por |
Instituição de defesa: |
Universidade Federal de Santa Maria
|
Programa de Pós-Graduação: |
Programa de Pós-Graduação em Farmacologia
|
Departamento: |
Farmacologia
|
País: |
BR
|
Palavras-chave em Português: | |
Palavras-chave em Inglês: | |
Área do conhecimento CNPq: | |
Link de acesso: | http://repositorio.ufsm.br/handle/1/8955 |
Resumo: | Overt hypothyroidism is characterized by decreased of thyroid hormones synthesis, with elevation of thyroid-stimulating hormone (TSH). It s a common disorder in population with highest prevalence in women and with aging. Frequently is associated with lipid metabolism alterations, represented by lipid parameters elevation and consequently with atherosclerosis development. The association between hypercholesterolemia and oxidative stress already well established, however oxidative stress presence in hypothyroidism is controversy. The oxidative stress is characterized by an increase in oxygen reactive species (ROS) generation or antioxidant system deficiency. In the present study were determined biochemical and oxidative stress biomarkers in overt hypothyroidism patients. The biochemical markers, total cholesterol (TC), LDL-cholesterol(C-LDL), cholesterol HDL (C-HDL) and trycerides (TG) were measured in serum samples in these patients. Lipid peroxidation was measured by thiobarbituric acid reactive substances (TBARS) levels. Antioxidant system evaluation was performed by superoxide dismutase (SOD) and catalase (CAT) actvities and non-enzymatic antioxidants levels were evaluated by reduced glutathione (GSH) and vitamin E (VIT E) levels.The results demonstrated an increase in biochemical markers (TC, C-LDL and TG) in hypothyroid group, when compared to control group. In relation to lipid peroxidation, was observed an increased in TBARS levels in patients with hypothyroidism when compared to control group. The same was observed for antioxidants defenses SOD and CAT. Nonenzymatic antioxidants, such vitamin E, were higher in hypothyroid group in relation to controls, while GSH levels remained unchanged with hypothyroidism. These results suggest the association between overt hypothyroidism and hypercholesterolemia and oxidative stress. The high levels of cholesterol presented by hypothyroidism patients, has a stronger influence under oxygen reactive species (ROS) generation and in consequence under the oxidative stress. The increase in SOD and CAT activities, suggest antioxidant system induction as a mechanism to combat the ROS generation and high lipid peroxidation. In conclusion, overt hypothyroidism has association with hypercholesterolemia and oxidative stress biomarkers increase. |
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2013-04-172013-04-172010-03-18SANTI, Adriana. BIOCHEMICAL ALTERATIONS AND OXIDATIVE STRESS ASSOCIATED WITH HYPOTHYROIDISM. 2010. 71 f. Dissertação (Mestrado em Farmácia) - Universidade Federal de Santa Maria, Santa Maria, 2010.http://repositorio.ufsm.br/handle/1/8955Overt hypothyroidism is characterized by decreased of thyroid hormones synthesis, with elevation of thyroid-stimulating hormone (TSH). It s a common disorder in population with highest prevalence in women and with aging. Frequently is associated with lipid metabolism alterations, represented by lipid parameters elevation and consequently with atherosclerosis development. The association between hypercholesterolemia and oxidative stress already well established, however oxidative stress presence in hypothyroidism is controversy. The oxidative stress is characterized by an increase in oxygen reactive species (ROS) generation or antioxidant system deficiency. In the present study were determined biochemical and oxidative stress biomarkers in overt hypothyroidism patients. The biochemical markers, total cholesterol (TC), LDL-cholesterol(C-LDL), cholesterol HDL (C-HDL) and trycerides (TG) were measured in serum samples in these patients. Lipid peroxidation was measured by thiobarbituric acid reactive substances (TBARS) levels. Antioxidant system evaluation was performed by superoxide dismutase (SOD) and catalase (CAT) actvities and non-enzymatic antioxidants levels were evaluated by reduced glutathione (GSH) and vitamin E (VIT E) levels.The results demonstrated an increase in biochemical markers (TC, C-LDL and TG) in hypothyroid group, when compared to control group. In relation to lipid peroxidation, was observed an increased in TBARS levels in patients with hypothyroidism when compared to control group. The same was observed for antioxidants defenses SOD and CAT. Nonenzymatic antioxidants, such vitamin E, were higher in hypothyroid group in relation to controls, while GSH levels remained unchanged with hypothyroidism. These results suggest the association between overt hypothyroidism and hypercholesterolemia and oxidative stress. The high levels of cholesterol presented by hypothyroidism patients, has a stronger influence under oxygen reactive species (ROS) generation and in consequence under the oxidative stress. The increase in SOD and CAT activities, suggest antioxidant system induction as a mechanism to combat the ROS generation and high lipid peroxidation. In conclusion, overt hypothyroidism has association with hypercholesterolemia and oxidative stress biomarkers increase.O hipotireoidismo clínico é caracterizado pela diminuição na síntese dos hormônios tireoideanos, com elevação dos níveis do hormônio tireoestimulante (TSH). É uma desordem comum na população com maior incidência no sexo feminino e com a progressão da idade. Freqüentemente está associado a alterações no metabolismo lipídico, representadas pela elevação nos parâmetros lipídicos e consequentemente com o desenvolvimento de aterosclerose. A associação entre hipercolesterolemia e estresse oxidativo já é bem estabelecida, entretanto a presença de estresse oxidativo no hipotireoidismo é controversa. O estresse oxidativo é caracterizado por um aumento na produção de espécies reativas de oxigênio (ERO) ou deficiência do sistema antioxidante. Neste trabalho determinaram-se marcadores bioquímicos e de estresse oxidativo em pacientes com hipotireoidismo clínico. Os marcadores bioquímicos, colesterol total (CT), colesterol-LDL (LDL-C), colesterol HDL (HDL-C) e triglicerídeos (TG) foram medidos em soro dos pacientes. A peroxidação lipídica foi medida através dos níveis de substâncias reativas ao ácido tiobarbitúrico (TBARS). A avaliação do sistema antioxidante enzimático foi realizada através da medida da atividade das enzimas superóxido dismutase (SOD) e catalase (CAT) e os níveis de antioxidantes não-enzimáticos através dos níveis de tióis totais (SH) e vitamina E (VIT E). Os resultados demonstraram um aumento dos marcadores bioquímicos (CT, LDL-C e TG) no grupo hipotireóideo, com relação ao grupo controle. Em relação a peroxidação lipídica, observou-se um aumento dos níveis séricos de TBARS de pacientes com hipotireoidismo quando comparados com o grupo controle. Esse aumento também foi observado para as defesas antioxidantes enzimáticas, SOD e CAT. Com relação aos antioxidantes não-enzimáticos, ocorreu um aumento nos níveis séricos de VIT E no grupo hipotireóideo com relação ao grupo controle, enquanto que para SH não foi observada diferença entre os grupos estudados. Estes resultados sugerem a associação do hipotireoidismo clínico com hipercolesterolemia e estresse oxidativo. Os altos níveis de colesterol apresentados pelos pacientes com hipotireoidismo, exercem forte influência sobre a geração de espécies reativas de oxigênio (ERO) e por conseqüência sobre o estresse oxidativo. Os aumentos das enzimas SOD e CAT, sugerem a indução do sistema antioxidante enzimático, na tentativa de combater a formação de ERO e a elevada peroxidação lipídica. Concluí-se então, que o hipotireoidismo clínico, está associado à hipercolesterolemia e ao aumento dos biomarcadores de estresse oxidativo.Coordenação de Aperfeiçoamento de Pessoal de Nível Superiorapplication/pdfporUniversidade Federal de Santa MariaPrograma de Pós-Graduação em FarmacologiaUFSMBRFarmacologiaHipotireoidismo clínicoEstresse oxidativoColesterolAntioxidantes enzimáticosAntioxidantes não enzimáticosOvert hypothyroidismOxidative stressCholesterolEnzymatic antioxidantsNon enzymatic antioxidantsCNPQ::CIENCIAS BIOLOGICAS::FARMACOLOGIAAlterações bioquímicas e estresse oxidativo associados ao hipotireoidismoBiochemical alterations and oxidative stress associated with hypothyroidisminfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/masterThesisLoro, Vania Luciahttp://lattes.cnpq.br/6392817606416780Emanuelli, Tatianahttp://lattes.cnpq.br/2165391096880394Fachinetto, Roseleihttp://lattes.cnpq.br/7203076675431306http://lattes.cnpq.br/1925582125591061Santi, Adriana201000000000400500500500500b0918185-c6b7-49df-b8d6-d245d73535b839ee9813-10e6-4e78-9b84-7478ef1454d5139678bd-89b0-44b8-961c-2a123b18d3816a615e4f-285a-4d77-aeb6-a33cd9c07f80info:eu-repo/semantics/openAccessreponame:Biblioteca Digital de Teses e Dissertações do UFSMinstname:Universidade Federal de Santa Maria (UFSM)instacron:UFSMORIGINALDIS_PPGFARMACOLOGIA_2010_SANTI_ADRIANA.pdfDissertação de Mestradoapplication/pdf822198http://repositorio.ufsm.br/bitstream/1/8955/1/DIS_PPGFARMACOLOGIA_2010_SANTI_ADRIANA.pdf6df11642389906ea8e76a47166c7238aMD51TEXTSANTI, ADRIANA.pdf.txtSANTI, ADRIANA.pdf.txtExtracted texttext/plain106167http://repositorio.ufsm.br/bitstream/1/8955/2/SANTI%2c%20ADRIANA.pdf.txt9f6d6d88fb351d5050679eb25c35b5c5MD52DIS_PPGFARMACOLOGIA_2010_SANTI_ADRIANA.pdf.txtDIS_PPGFARMACOLOGIA_2010_SANTI_ADRIANA.pdf.txtExtracted texttext/plain106167http://repositorio.ufsm.br/bitstream/1/8955/4/DIS_PPGFARMACOLOGIA_2010_SANTI_ADRIANA.pdf.txt9f6d6d88fb351d5050679eb25c35b5c5MD54THUMBNAILSANTI, ADRIANA.pdf.jpgSANTI, ADRIANA.pdf.jpgIM Thumbnailimage/jpeg5517http://repositorio.ufsm.br/bitstream/1/8955/3/SANTI%2c%20ADRIANA.pdf.jpgfa96f7b31ff93556649367f86310ec23MD53DIS_PPGFARMACOLOGIA_2010_SANTI_ADRIANA.pdf.jpgDIS_PPGFARMACOLOGIA_2010_SANTI_ADRIANA.pdf.jpgIM Thumbnailimage/jpeg5517http://repositorio.ufsm.br/bitstream/1/8955/5/DIS_PPGFARMACOLOGIA_2010_SANTI_ADRIANA.pdf.jpgfa96f7b31ff93556649367f86310ec23MD551/89552022-05-10 10:19:20.046oai:repositorio.ufsm.br:1/8955Biblioteca Digital de Teses e Dissertaçõeshttps://repositorio.ufsm.br/ONGhttps://repositorio.ufsm.br/oai/requestatendimento.sib@ufsm.br||tedebc@gmail.comopendoar:2022-05-10T13:19:20Biblioteca Digital de Teses e Dissertações do UFSM - Universidade Federal de Santa Maria (UFSM)false |
dc.title.por.fl_str_mv |
Alterações bioquímicas e estresse oxidativo associados ao hipotireoidismo |
dc.title.alternative.eng.fl_str_mv |
Biochemical alterations and oxidative stress associated with hypothyroidism |
title |
Alterações bioquímicas e estresse oxidativo associados ao hipotireoidismo |
spellingShingle |
Alterações bioquímicas e estresse oxidativo associados ao hipotireoidismo Santi, Adriana Hipotireoidismo clínico Estresse oxidativo Colesterol Antioxidantes enzimáticos Antioxidantes não enzimáticos Overt hypothyroidism Oxidative stress Cholesterol Enzymatic antioxidants Non enzymatic antioxidants CNPQ::CIENCIAS BIOLOGICAS::FARMACOLOGIA |
title_short |
Alterações bioquímicas e estresse oxidativo associados ao hipotireoidismo |
title_full |
Alterações bioquímicas e estresse oxidativo associados ao hipotireoidismo |
title_fullStr |
Alterações bioquímicas e estresse oxidativo associados ao hipotireoidismo |
title_full_unstemmed |
Alterações bioquímicas e estresse oxidativo associados ao hipotireoidismo |
title_sort |
Alterações bioquímicas e estresse oxidativo associados ao hipotireoidismo |
author |
Santi, Adriana |
author_facet |
Santi, Adriana |
author_role |
author |
dc.contributor.advisor1.fl_str_mv |
Loro, Vania Lucia |
dc.contributor.advisor1Lattes.fl_str_mv |
http://lattes.cnpq.br/6392817606416780 |
dc.contributor.referee1.fl_str_mv |
Emanuelli, Tatiana |
dc.contributor.referee1Lattes.fl_str_mv |
http://lattes.cnpq.br/2165391096880394 |
dc.contributor.referee2.fl_str_mv |
Fachinetto, Roselei |
dc.contributor.referee2Lattes.fl_str_mv |
http://lattes.cnpq.br/7203076675431306 |
dc.contributor.authorLattes.fl_str_mv |
http://lattes.cnpq.br/1925582125591061 |
dc.contributor.author.fl_str_mv |
Santi, Adriana |
contributor_str_mv |
Loro, Vania Lucia Emanuelli, Tatiana Fachinetto, Roselei |
dc.subject.por.fl_str_mv |
Hipotireoidismo clínico Estresse oxidativo Colesterol Antioxidantes enzimáticos Antioxidantes não enzimáticos |
topic |
Hipotireoidismo clínico Estresse oxidativo Colesterol Antioxidantes enzimáticos Antioxidantes não enzimáticos Overt hypothyroidism Oxidative stress Cholesterol Enzymatic antioxidants Non enzymatic antioxidants CNPQ::CIENCIAS BIOLOGICAS::FARMACOLOGIA |
dc.subject.eng.fl_str_mv |
Overt hypothyroidism Oxidative stress Cholesterol Enzymatic antioxidants Non enzymatic antioxidants |
dc.subject.cnpq.fl_str_mv |
CNPQ::CIENCIAS BIOLOGICAS::FARMACOLOGIA |
description |
Overt hypothyroidism is characterized by decreased of thyroid hormones synthesis, with elevation of thyroid-stimulating hormone (TSH). It s a common disorder in population with highest prevalence in women and with aging. Frequently is associated with lipid metabolism alterations, represented by lipid parameters elevation and consequently with atherosclerosis development. The association between hypercholesterolemia and oxidative stress already well established, however oxidative stress presence in hypothyroidism is controversy. The oxidative stress is characterized by an increase in oxygen reactive species (ROS) generation or antioxidant system deficiency. In the present study were determined biochemical and oxidative stress biomarkers in overt hypothyroidism patients. The biochemical markers, total cholesterol (TC), LDL-cholesterol(C-LDL), cholesterol HDL (C-HDL) and trycerides (TG) were measured in serum samples in these patients. Lipid peroxidation was measured by thiobarbituric acid reactive substances (TBARS) levels. Antioxidant system evaluation was performed by superoxide dismutase (SOD) and catalase (CAT) actvities and non-enzymatic antioxidants levels were evaluated by reduced glutathione (GSH) and vitamin E (VIT E) levels.The results demonstrated an increase in biochemical markers (TC, C-LDL and TG) in hypothyroid group, when compared to control group. In relation to lipid peroxidation, was observed an increased in TBARS levels in patients with hypothyroidism when compared to control group. The same was observed for antioxidants defenses SOD and CAT. Nonenzymatic antioxidants, such vitamin E, were higher in hypothyroid group in relation to controls, while GSH levels remained unchanged with hypothyroidism. These results suggest the association between overt hypothyroidism and hypercholesterolemia and oxidative stress. The high levels of cholesterol presented by hypothyroidism patients, has a stronger influence under oxygen reactive species (ROS) generation and in consequence under the oxidative stress. The increase in SOD and CAT activities, suggest antioxidant system induction as a mechanism to combat the ROS generation and high lipid peroxidation. In conclusion, overt hypothyroidism has association with hypercholesterolemia and oxidative stress biomarkers increase. |
publishDate |
2010 |
dc.date.issued.fl_str_mv |
2010-03-18 |
dc.date.accessioned.fl_str_mv |
2013-04-17 |
dc.date.available.fl_str_mv |
2013-04-17 |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/masterThesis |
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masterThesis |
status_str |
publishedVersion |
dc.identifier.citation.fl_str_mv |
SANTI, Adriana. BIOCHEMICAL ALTERATIONS AND OXIDATIVE STRESS ASSOCIATED WITH HYPOTHYROIDISM. 2010. 71 f. Dissertação (Mestrado em Farmácia) - Universidade Federal de Santa Maria, Santa Maria, 2010. |
dc.identifier.uri.fl_str_mv |
http://repositorio.ufsm.br/handle/1/8955 |
identifier_str_mv |
SANTI, Adriana. BIOCHEMICAL ALTERATIONS AND OXIDATIVE STRESS ASSOCIATED WITH HYPOTHYROIDISM. 2010. 71 f. Dissertação (Mestrado em Farmácia) - Universidade Federal de Santa Maria, Santa Maria, 2010. |
url |
http://repositorio.ufsm.br/handle/1/8955 |
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201000000000 |
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Universidade Federal de Santa Maria |
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Programa de Pós-Graduação em Farmacologia |
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UFSM |
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BR |
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Farmacologia |
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Universidade Federal de Santa Maria |
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