Efeitos dos compostos de selênio e zinco nas lesões gastrointestinais induzidas por etanol em ratos
Ano de defesa: | 2012 |
---|---|
Autor(a) principal: | |
Orientador(a): | |
Banca de defesa: | , , , |
Tipo de documento: | Tese |
Tipo de acesso: | Acesso aberto |
Idioma: | por |
Instituição de defesa: |
Universidade Federal de Santa Maria
|
Programa de Pós-Graduação: |
Programa de Pós-Graduação em Ciências Biológicas: Bioquímica Toxicológica
|
Departamento: |
Bioquímica
|
País: |
BR
|
Palavras-chave em Português: | |
Palavras-chave em Inglês: | |
Área do conhecimento CNPq: | |
Link de acesso: | http://repositorio.ufsm.br/handle/1/4456 |
Resumo: | Gastric ulcer is a world widespread illness that affectes a great number of people and it is correlated to life style, food intake, alcohol and smoke in association or not to stress behavior. The lesions are in association with oxygen reactive species (ROS) production. It is been know that some elements, selenium and zinc, shows great effect scavenger in detoxification of ROS production, avoiding many damages caused by ROS. Based on these considerations, the present study intend to investigate the effect of oral administration of diphenyl diselenide (PhSe)2 and zinc chloride (ZnCl2) in an experimental model of gastric lesion induced by oral administration of ethanol 70% in rats and, particularly the involvement of oxidative stress. For this propose we measured TBARS production, reactive species (RS) levels, ascorbic acid content, total e non-protein thiol groups, superoxide dismutase (SOD) and catalase (CAT) activities from stomach and intestine of rats exposed to ethanol additionally, damage in tissues were measure by micro and macroscopic histopathology analyses. The model of gastrointestinal lesions induced by ethanol is widely used by many authors because it is a model that causes various changes in gastric tissue, exacerbated ROS formation, imbalance in antioxidant defenses and modification of the activity of several enzymes involved in ROS detoxification. In this study, oral ethanol 70% was administered in rats to cause gastric lesions and to enhance oxidative stress. Stomach´s micro and macroscopic analyses showed that (PhSe)2 at low doses (0.01 and 1.0 mg/kg) protected and reverted gastric lesions and attenuated the oxidation alterations caused by ethanol. Similar results could be verified when ZnCl2 (27 mg/kg) was administered orally. ZnCl2 demonstrated to be efficient in to protect and reverse the injuries against gastrointestinal damage caused by ethanol. These elements restored the biochemical parameters to normal values. Macroscopic analyses revealed that both elements, selenium and zinc, could protect and re-epithelialize the stomach. Pre- and post-treatment with (PhSe)2 showed benefic effects against lipid peroxidation measured by TBARS production, wich diminished, even as an enhancement of ascorbic acid content and stomach SOD activity when compared to ethanol. It was also verified for ZnCl2 (27 mg/kg), an ability to protect and to reverse against gastrointestinal damages caused by ethanol, even though this element was able to restore biochemical parameters to control values. Macroscopic analyses showed that ZnCl2 had positive results in prevent and re-epithelialize the mucosa against lesions. ZnCl2 significantly protected and reversed gastrointestinal TBARS and RS production that were enhanced by ethanol as well as prevented and reversed for total SH groups. However, ZnCl2 only protected the diminished in gastrointestinal ascorbic acid content and prevented and restored the decreased of stomach and intestine CAT activity. Therefore, this study is a promising field to development of new drugs and new therapies and also can take to a better understanding of mechanism of action involved in the gastric antioxidant process, even though to enhance the research about elements effects in gastrointestinal ulcers. |
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2013-02-252013-02-252012-03-30INEU, Rafael Porto. Effects of selenium and zinc compounds against gastricintestinal lesions induced by ethanol in rats. 2012. 91 f. Tese (Doutorado em Ciências Biológicas) - Universidade Federal de Santa Maria, Santa Maria, 2012.http://repositorio.ufsm.br/handle/1/4456Gastric ulcer is a world widespread illness that affectes a great number of people and it is correlated to life style, food intake, alcohol and smoke in association or not to stress behavior. The lesions are in association with oxygen reactive species (ROS) production. It is been know that some elements, selenium and zinc, shows great effect scavenger in detoxification of ROS production, avoiding many damages caused by ROS. Based on these considerations, the present study intend to investigate the effect of oral administration of diphenyl diselenide (PhSe)2 and zinc chloride (ZnCl2) in an experimental model of gastric lesion induced by oral administration of ethanol 70% in rats and, particularly the involvement of oxidative stress. For this propose we measured TBARS production, reactive species (RS) levels, ascorbic acid content, total e non-protein thiol groups, superoxide dismutase (SOD) and catalase (CAT) activities from stomach and intestine of rats exposed to ethanol additionally, damage in tissues were measure by micro and macroscopic histopathology analyses. The model of gastrointestinal lesions induced by ethanol is widely used by many authors because it is a model that causes various changes in gastric tissue, exacerbated ROS formation, imbalance in antioxidant defenses and modification of the activity of several enzymes involved in ROS detoxification. In this study, oral ethanol 70% was administered in rats to cause gastric lesions and to enhance oxidative stress. Stomach´s micro and macroscopic analyses showed that (PhSe)2 at low doses (0.01 and 1.0 mg/kg) protected and reverted gastric lesions and attenuated the oxidation alterations caused by ethanol. Similar results could be verified when ZnCl2 (27 mg/kg) was administered orally. ZnCl2 demonstrated to be efficient in to protect and reverse the injuries against gastrointestinal damage caused by ethanol. These elements restored the biochemical parameters to normal values. Macroscopic analyses revealed that both elements, selenium and zinc, could protect and re-epithelialize the stomach. Pre- and post-treatment with (PhSe)2 showed benefic effects against lipid peroxidation measured by TBARS production, wich diminished, even as an enhancement of ascorbic acid content and stomach SOD activity when compared to ethanol. It was also verified for ZnCl2 (27 mg/kg), an ability to protect and to reverse against gastrointestinal damages caused by ethanol, even though this element was able to restore biochemical parameters to control values. Macroscopic analyses showed that ZnCl2 had positive results in prevent and re-epithelialize the mucosa against lesions. ZnCl2 significantly protected and reversed gastrointestinal TBARS and RS production that were enhanced by ethanol as well as prevented and reversed for total SH groups. However, ZnCl2 only protected the diminished in gastrointestinal ascorbic acid content and prevented and restored the decreased of stomach and intestine CAT activity. Therefore, this study is a promising field to development of new drugs and new therapies and also can take to a better understanding of mechanism of action involved in the gastric antioxidant process, even though to enhance the research about elements effects in gastrointestinal ulcers.A úlcera gástrica é uma doença que afeta um grande número de pessoas no mundo, sendo conseqüência do estilo de vida, dos hábitos alimentares, do alcoolismo e tabagismo associados ou não ao estresse. Essas lesões estão intimamente associadas à produção de espécies reativas de oxigênio (EROs). Sabe-se que elementos como o selênio e o zinco apresentam grande eficiência em eliminar as EROs, evitando assim uma série de danos causados pela formação das mesmas. Assim, o objetivo desse trabalho foi investigar o efeito da administração oral do disseleneto de difenila (PhSe)2 e do cloreto de zinco (ZnCl2) no modelo experimental de lesão gastrointestinal induzido oralmente por etanol 70% em ratos, avaliando o envolvimento do estresse oxidativo. Foram avaliados a produção de espécies reativas ao ácido tiobarbitúrico (TBARS), os níveis de espécies reativas (RS), o conteúdo de ácido ascórbico e de grupos tióis (SH) totais e não protéicos, a atividade da enzima superóxido dismutase (SOD) e da catalase (CAT), bem como os danos teciduais através de análises micro/macroscópicas e histopatológicas do tecido gastrointestinal. O modelo de indução de lesões gastrointestinais por etanol é bastante utilizado por diversos autores, pois causa diversas alterações no tecido gástrico; formação exacerbada de EROs, desequilíbrio nas defesas antioxidantes e modificação na atividade de diversas enzimas responsáveis pela detoxificação das EROs. Nesse trabalho, o etanol 70% foi administrado aos ratos por via oral a fim de induzir lesões gástricas e aumentar o estresse oxidativo no tecido gastrointestinal. Os resultados mostram que nas análises macro e microscópicas de estômago o (PhSe)2, em baixas doses (0,01 à 1,0 mg/kg), reverteu e protegeu o tecido gástrico frente às lesões. O pré- e o pós-tratamento com (PhSe)2 apresentaram efeitos benéficos contra a peroxidação lipídica através da medida dos níveis de TBARS os quais diminuíram, bem como um aumento no conteúdo de ácido ascórbico e aumento na atividade da SOD de estômago de ratos quando comparados ao etanol. O mesmo ocorreu para o ZnCl2 que na dose de 27 mg/kg demonstrou ser eficaz na proteção e reversão das injúrias gastrointestinais causadas pelo etanol, uma vez que restaurou os parâmetros bioquímicos analisados a níveis normais. Na análise macroscópica, o ZnCl2 apresentou resultados positivos na proteção e na re-epitelização do tecido gástrico frente as lesões. O ZnCl2 protegeu e reverteu significativamente os níveis de TBARS e de RS gastrointestinais que foram aumentados pelo etanol, também preveniu e restaurou o decréscimo nos níveis de grupos SH totais de estômago e intestino. Entretanto, o ZnCl2 somente protegeu a diminuição no conteúdo de ácido ascórbico gastrointestinal. O decréscimo na atividade da CAT de estômago e de intestino foi prevenido e restaurado pelo zinco frente às lesões. Portanto, este trabalho trata de um campo promissor para o desenvolvimento de novos fármacos e de novas terapêuticas e poderá nos levar a uma melhor compreensão dos mecanismos de ação envolvidos no processo antioxidante gástrica, bem como contribuir no avanço das pesquisas contra lesões gastrointestinais.Conselho Nacional de Desenvolvimento Científico e Tecnológicoapplication/pdfporUniversidade Federal de Santa MariaPrograma de Pós-Graduação em Ciências Biológicas: Bioquímica ToxicológicaUFSMBRBioquímicaÚlceraAntioxidanteEstresse oxidativoSelênioZincoEnzimasUlcersAntioxidantOxidative stressSeleniumZincEnzymesCNPQ::CIENCIAS BIOLOGICAS::BIOQUIMICAEfeitos dos compostos de selênio e zinco nas lesões gastrointestinais induzidas por etanol em ratosEffects of selenium and zinc compounds against gastricintestinal lesions induced by ethanol in ratsinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/doctoralThesisPereira, Maria Esterhttp://lattes.cnpq.br/9299114496157799Ávila, Daiana Silva dehttp://lattes.cnpq.br/4355211015887363Moresco, Rafael Noalhttp://lattes.cnpq.br/2269922709577261Loro, Vania Luciahttp://lattes.cnpq.br/6392817606416780Soares, Félix Alexandre Antuneshttp://lattes.cnpq.br/8752453650114092http://lattes.cnpq.br/3668846018750020Ineu, Rafael Porto20080000000240050030050050050050001f81ef8-370b-4663-a6f5-346c4c2115cc5243e0d5-6efd-4813-98fb-cebd9032d3139f9969d1-7d48-45fd-9ea7-9a55acc6fc28265a0834-90e2-4afa-aac5-e50926346010075165f4-0a72-4319-b19d-4517ec7b58fe1109e9df-a90f-4a71-bcc7-a4fabdce89f3info:eu-repo/semantics/openAccessreponame:Biblioteca Digital de Teses e Dissertações do UFSMinstname:Universidade Federal de Santa Maria (UFSM)instacron:UFSMORIGINALINEU, RAFAEL PORTO.pdfTese de Doutoradoapplication/pdf4512583http://repositorio.ufsm.br/bitstream/1/4456/1/INEU%2c%20RAFAEL%20PORTO.pdf2747d6711fa0b956489332703c083a04MD51TEXTINEU, RAFAEL PORTO.pdf.txtINEU, RAFAEL PORTO.pdf.txtExtracted texttext/plain138924http://repositorio.ufsm.br/bitstream/1/4456/2/INEU%2c%20RAFAEL%20PORTO.pdf.txt231101c138bf5ff7daecfaad7d0c1d60MD52THUMBNAILINEU, RAFAEL PORTO.pdf.jpgINEU, RAFAEL PORTO.pdf.jpgIM Thumbnailimage/jpeg5488http://repositorio.ufsm.br/bitstream/1/4456/3/INEU%2c%20RAFAEL%20PORTO.pdf.jpgab0f3afb3b12afc9e170214fca2160eaMD531/44562023-05-30 10:30:51.013oai:repositorio.ufsm.br:1/4456Biblioteca Digital de Teses e Dissertaçõeshttps://repositorio.ufsm.br/ONGhttps://repositorio.ufsm.br/oai/requestatendimento.sib@ufsm.br||tedebc@gmail.comopendoar:2023-05-30T13:30:51Biblioteca Digital de Teses e Dissertações do UFSM - Universidade Federal de Santa Maria (UFSM)false |
dc.title.por.fl_str_mv |
Efeitos dos compostos de selênio e zinco nas lesões gastrointestinais induzidas por etanol em ratos |
dc.title.alternative.eng.fl_str_mv |
Effects of selenium and zinc compounds against gastricintestinal lesions induced by ethanol in rats |
title |
Efeitos dos compostos de selênio e zinco nas lesões gastrointestinais induzidas por etanol em ratos |
spellingShingle |
Efeitos dos compostos de selênio e zinco nas lesões gastrointestinais induzidas por etanol em ratos Ineu, Rafael Porto Úlcera Antioxidante Estresse oxidativo Selênio Zinco Enzimas Ulcers Antioxidant Oxidative stress Selenium Zinc Enzymes CNPQ::CIENCIAS BIOLOGICAS::BIOQUIMICA |
title_short |
Efeitos dos compostos de selênio e zinco nas lesões gastrointestinais induzidas por etanol em ratos |
title_full |
Efeitos dos compostos de selênio e zinco nas lesões gastrointestinais induzidas por etanol em ratos |
title_fullStr |
Efeitos dos compostos de selênio e zinco nas lesões gastrointestinais induzidas por etanol em ratos |
title_full_unstemmed |
Efeitos dos compostos de selênio e zinco nas lesões gastrointestinais induzidas por etanol em ratos |
title_sort |
Efeitos dos compostos de selênio e zinco nas lesões gastrointestinais induzidas por etanol em ratos |
author |
Ineu, Rafael Porto |
author_facet |
Ineu, Rafael Porto |
author_role |
author |
dc.contributor.advisor1.fl_str_mv |
Pereira, Maria Ester |
dc.contributor.advisor1Lattes.fl_str_mv |
http://lattes.cnpq.br/9299114496157799 |
dc.contributor.referee1.fl_str_mv |
Ávila, Daiana Silva de |
dc.contributor.referee1Lattes.fl_str_mv |
http://lattes.cnpq.br/4355211015887363 |
dc.contributor.referee2.fl_str_mv |
Moresco, Rafael Noal |
dc.contributor.referee2Lattes.fl_str_mv |
http://lattes.cnpq.br/2269922709577261 |
dc.contributor.referee3.fl_str_mv |
Loro, Vania Lucia |
dc.contributor.referee3Lattes.fl_str_mv |
http://lattes.cnpq.br/6392817606416780 |
dc.contributor.referee4.fl_str_mv |
Soares, Félix Alexandre Antunes |
dc.contributor.referee4Lattes.fl_str_mv |
http://lattes.cnpq.br/8752453650114092 |
dc.contributor.authorLattes.fl_str_mv |
http://lattes.cnpq.br/3668846018750020 |
dc.contributor.author.fl_str_mv |
Ineu, Rafael Porto |
contributor_str_mv |
Pereira, Maria Ester Ávila, Daiana Silva de Moresco, Rafael Noal Loro, Vania Lucia Soares, Félix Alexandre Antunes |
dc.subject.por.fl_str_mv |
Úlcera Antioxidante Estresse oxidativo Selênio Zinco Enzimas |
topic |
Úlcera Antioxidante Estresse oxidativo Selênio Zinco Enzimas Ulcers Antioxidant Oxidative stress Selenium Zinc Enzymes CNPQ::CIENCIAS BIOLOGICAS::BIOQUIMICA |
dc.subject.eng.fl_str_mv |
Ulcers Antioxidant Oxidative stress Selenium Zinc Enzymes |
dc.subject.cnpq.fl_str_mv |
CNPQ::CIENCIAS BIOLOGICAS::BIOQUIMICA |
description |
Gastric ulcer is a world widespread illness that affectes a great number of people and it is correlated to life style, food intake, alcohol and smoke in association or not to stress behavior. The lesions are in association with oxygen reactive species (ROS) production. It is been know that some elements, selenium and zinc, shows great effect scavenger in detoxification of ROS production, avoiding many damages caused by ROS. Based on these considerations, the present study intend to investigate the effect of oral administration of diphenyl diselenide (PhSe)2 and zinc chloride (ZnCl2) in an experimental model of gastric lesion induced by oral administration of ethanol 70% in rats and, particularly the involvement of oxidative stress. For this propose we measured TBARS production, reactive species (RS) levels, ascorbic acid content, total e non-protein thiol groups, superoxide dismutase (SOD) and catalase (CAT) activities from stomach and intestine of rats exposed to ethanol additionally, damage in tissues were measure by micro and macroscopic histopathology analyses. The model of gastrointestinal lesions induced by ethanol is widely used by many authors because it is a model that causes various changes in gastric tissue, exacerbated ROS formation, imbalance in antioxidant defenses and modification of the activity of several enzymes involved in ROS detoxification. In this study, oral ethanol 70% was administered in rats to cause gastric lesions and to enhance oxidative stress. Stomach´s micro and macroscopic analyses showed that (PhSe)2 at low doses (0.01 and 1.0 mg/kg) protected and reverted gastric lesions and attenuated the oxidation alterations caused by ethanol. Similar results could be verified when ZnCl2 (27 mg/kg) was administered orally. ZnCl2 demonstrated to be efficient in to protect and reverse the injuries against gastrointestinal damage caused by ethanol. These elements restored the biochemical parameters to normal values. Macroscopic analyses revealed that both elements, selenium and zinc, could protect and re-epithelialize the stomach. Pre- and post-treatment with (PhSe)2 showed benefic effects against lipid peroxidation measured by TBARS production, wich diminished, even as an enhancement of ascorbic acid content and stomach SOD activity when compared to ethanol. It was also verified for ZnCl2 (27 mg/kg), an ability to protect and to reverse against gastrointestinal damages caused by ethanol, even though this element was able to restore biochemical parameters to control values. Macroscopic analyses showed that ZnCl2 had positive results in prevent and re-epithelialize the mucosa against lesions. ZnCl2 significantly protected and reversed gastrointestinal TBARS and RS production that were enhanced by ethanol as well as prevented and reversed for total SH groups. However, ZnCl2 only protected the diminished in gastrointestinal ascorbic acid content and prevented and restored the decreased of stomach and intestine CAT activity. Therefore, this study is a promising field to development of new drugs and new therapies and also can take to a better understanding of mechanism of action involved in the gastric antioxidant process, even though to enhance the research about elements effects in gastrointestinal ulcers. |
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2012 |
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2012-03-30 |
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2013-02-25 |
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2013-02-25 |
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INEU, Rafael Porto. Effects of selenium and zinc compounds against gastricintestinal lesions induced by ethanol in rats. 2012. 91 f. Tese (Doutorado em Ciências Biológicas) - Universidade Federal de Santa Maria, Santa Maria, 2012. |
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http://repositorio.ufsm.br/handle/1/4456 |
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INEU, Rafael Porto. Effects of selenium and zinc compounds against gastricintestinal lesions induced by ethanol in rats. 2012. 91 f. Tese (Doutorado em Ciências Biológicas) - Universidade Federal de Santa Maria, Santa Maria, 2012. |
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http://repositorio.ufsm.br/handle/1/4456 |
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