Desenvolvimento e validação de métodos para avaliação de cloridrato de fexofenadina

• Ano de defesa: 2006
• Autor(a) principal: Oliveira, Daniele Carvalho de
• Orientador(a): Rolim, Clarice Madalena Bueno
• Banca de defesa: Carvalho, Leandro Machado de , Cardoso, Simone Gonçalves
• Tipo de documento: Dissertação
• Tipo de acesso: Acesso aberto
• Idioma: por
• Instituição de defesa: Universidade Federal de Santa Maria
• Programa de Pós-Graduação: Programa de Pós-Graduação em Ciências Farmacêuticas
• Departamento: Farmácia
• País: BR
• Palavras-chave em Português: Fexofenadina; Cromatografia líquida; Eletroforese capilar de zona; Dissolução
• Palavras-chave em Inglês: Fexofenadine; Liquid chromatography; Zone capillary electrophoresis; Dissolution
• Área do conhecimento CNPq: CNPQ::CIENCIAS DA SAUDE::FARMACIA
• Link de acesso: http://repositorio.ufsm.br/handle/1/5872

The fexofenadina is an antihistamine non sedative that acts as antagonistic selective in the outlying receivers H1 of the histamine, being used in the symptomatic treatment of allergic manifestations as medication of first choice. The project in subject has the objective of to determine and to validate methods physical-chemistries, for the evaluation of fexofenadine hydrochloride in covered tablets, for liquid chromatographic of high efficiency and zone capillary electrophoresis, both with detection for diodo array detector, for ends of to accomplish dissolution studies and to compare the quantitative methods. The two quantitative methods presented linearity, accurate, precision, specificity and robust.Dissolution of tablets of 120 and 180 mg was realize utilizing distillate water, HCl 0.1 M, buffer phosphate pH 4.5 and buffer phosphate pH 6,8 with dissolution medium, using apparatus II. The dissolution profiles obtained of each medium were compared through the comparison factors: f1, f2 and ED. Different resultes were obted of the likeness the formulation.The method based on the application of ANOVA in the use of the dissolution efficiency (ED) it is more discriminative than the f-factors. If we used the factor f2 as comparison parameter, all the means don't present difference in the formulations, but only in the medium of HCl 0,1 M, the formulations showed similarity for the parameters f1, f2 and ED, allowing to affirm that the two formulations are similar and with same performance in alive. The described methods, HPLC and CEZ, availability for variance analysis, presented equivalence for quantification of fexofenadine hydrochloride.